Development of apixaban: a novel anticoagulant for prevention of stroke in patients with atrial fibrillation.

abstract：:The aim of the study was to determine the IgG antibody response to spotted fever group Rickettsia (SFGR) R. conorii and R. slovaca, and its specificity and sensitivity in patients with DEBONEL/TIBOLA. A prospective study of 31 patients with DEBONEL was carried out from January 2001 to May 2004. The SFGR serology testi...

journal_title：Annals of the New York Academy of Sciences

authors： Santibáñez S,Ibarra V,Portillo A,Blanco JR,Martínez de Artola V,Guerrero A,Oteo JA

更新日期：2006-10-01 00:00:00

abstract：:The data presented above suggest that one possible clinical use of TGF-beta would be to protect the bone marrow from the effects of myelosuppressive chemotherapeutic drugs by preventing entry or removing primitive stem cells from the cell cycle. It may also have the additional benefit of reducing the drug-induced neut...

journal_title：Annals of the New York Academy of Sciences

authors： Ruscetti FW,Jacobsen SE,Birchenall-Roberts M,Broxmeyer HE,Engelmann GL,Dubois C,Keller JR

更新日期：1991-01-01 00:00:00

abstract：:Current tuberculosis (TB) therapies take too long and the regimens are complex and subject to adverse effects and drug-drug interactions with concomitant medications. The emergence of drug-resistant TB strains exacerbates the situation. Drug discovery for TB has resurged in recent years, generating compounds (hits) wi...

journal_title：Annals of the New York Academy of Sciences

authors： Mdluli K,Kaneko T,Upton A

更新日期：2014-09-01 00:00:00

abstract：:The mandates that control actions in the federal workplace often challenge academic principles of conduct. Particularly vulnerable is the anthropologists' image of themselves as champions of powerless and voiceless groups in an arena perceived as dominated by a hostile government. This is coupled with convictions that...

journal_title：Annals of the New York Academy of Sciences

authors： Crespi M,Mattix C

更新日期：2000-01-01 00:00:00

abstract：:Organophosphorus pesticides (OPs) and nerve agents (NAs) are highly toxic chemicals that pose a significant threat to human health worldwide. These compounds induce status epilepticus (SE) by irreversibly blocking the ability of acetylcholinesterase to break down acetylcholine at neural synapses. Animal models of orga...

journal_title：Annals of the New York Academy of Sciences

authors： McCarren HS,McDonough JH Jr

更新日期：2016-06-01 00:00:00

abstract：:Understanding how the gulf between prokaryotic and eukaryotic cellular design arose is a major challenge. The viral eukaryogenesis (VE) hypothesis addresses the challenge of eukaryotic origins by suggesting the first eukaryotic cell was a multimember consortium consisting of a viral ancestor of the nucleus, an archaea...

journal_title：Annals of the New York Academy of Sciences

authors： Bell PJ

更新日期：2009-10-01 00:00:00

abstract：:Cytokine-based therapies have the potential to provide novel treatments for cancer, autoimmune diseases, and many types of infectious disease. However, to date, the full clinical potential of cytokines as drugs has been limited by a number of factors. To discuss these limitations and explore ways to overcome them, the...

journal_title：Annals of the New York Academy of Sciences

authors： Donnelly RP,Young HA,Rosenberg AS

更新日期：2009-12-01 00:00:00

abstract：:Mitochondria display considerable structural diversity particularly in terms of the folding of the energy-transducing inner membrane. The hypothesis is forwarded that the topology of the mitochondrial inner membrane is not random but rather is a regulated cell parameter. Its effects on internal diffusion of metabolite...

journal_title：Annals of the New York Academy of Sciences

authors： Mannella CA

更新日期：2008-12-01 00:00:00

abstract：:Since the first detection of highly pathogenic H5N1 avian influenza virus from sick goose in Guangdong province in China in 1996, scientists in China started to develop vaccines for avian influenza pandemic preparedness. An H5N2 inactivated vaccine was produced from a low pathogenic virus, A/turkey/England/N-28/73, an...

journal_title：Annals of the New York Academy of Sciences

authors： Qiao C,Tian G,Jiang Y,Li Y,Shi J,Yu K,Chen H

更新日期：2006-10-01 00:00:00

abstract：:Carnitine and its congeners may regulate the immune networks, and their influence on functions of immune cells predominantly or exclusively relies on carnitine-dependent energy production from fatty acids. A reduced pool of carnitines has been demonstrated in either serum or tissues, or both, from patients with a wide...

journal_title：Annals of the New York Academy of Sciences

authors： Famularo G,De Simone C,Trinchieri V,Mosca L

更新日期：2004-11-01 00:00:00

abstract：:Auditory imagery can represent many aspects of music, such as the starting pitches of a tune or the instrument that typically plays it. In this paper, I concentrate on more dynamic, or time-sensitive aspects of musical imagery, as demonstrated in two recently published studies. The first was a behavioral study that ex...

journal_title：Annals of the New York Academy of Sciences

authors： Halpern AR

更新日期：2012-04-01 00:00:00

abstract：:Mesothelium is the simple squamous epithelium covering all abdominal organs and the coeloms in which those organs reside. While the structural characteristics of this cell type were documented a century ago, its potential in development, disease, and wound healing is only now becoming apparent. In the embryo, mesothel...

journal_title：Annals of the New York Academy of Sciences

authors： Shelton EL,Bader DM

更新日期：2012-10-01 00:00:00

abstract：:The molecular architecture of biological systems is heavily influenced by the highly polar interactions of water. Thus, macromolecules such as proteins that are highly water soluble must be electrically polar. Energy generation methods needed to support cell metabolic processes depend on compartmentalizing mobile ions...

journal_title：Annals of the New York Academy of Sciences

authors： Lee RC

更新日期：2005-12-01 00:00:00

abstract：:Translin and translin-associated factor X (translin/TRAX) proteins have been implicated in a variety of cellular activities central to nucleic acid metabolism. Accumulating evidence indicates that translin/TRAX complexes participate in processes ensuring the replication of DNA, as well as cell division. Significant pr...

journal_title：Annals of the New York Academy of Sciences

authors： Kasai M,Ishida R,Nakahara K,Okumura K,Aoki K

更新日期：2018-06-01 00:00:00

abstract：:We conducted an experimental study of the interaction and coalescence of two drops (of the same fluid) or bubbles translating under the action of buoyancy in a cylindrical tube. The close approach of two Newtonian fluid particles of different size in a non-Newtonian continuous phase was examined using image analysis, ...

journal_title：Annals of the New York Academy of Sciences

authors： Al-Matroushi E,Borhan A

更新日期：2009-04-01 00:00:00

abstract：:Recent advances in the development of three different types of antiviral drugs, the nucleotide and non-nucleotide analogues acting as reverse transcriptase inhibitors (NRTIs) and the nonpeptidic viral protease inhibitors (PI), and their introduction in the management of patients with AIDS, either alone or in combinati...

journal_title：Annals of the New York Academy of Sciences

authors： Kino T,Chrousos GP

更新日期：2004-06-01 00:00:00

abstract：:We and others recently showed that fever induced by intravenously or intraperitoneally injected lipopolysaccharide (LPS) may involve brain signaling via hepatic vagal afferents. This suggests that LPS fever may be initiated by mediators released mainly by cells in the liver, presumably macrophages (Kupffer cells, Kc)....

journal_title：Annals of the New York Academy of Sciences

authors： Blatteis CM,Sehic E,Li S

更新日期：1998-09-29 00:00:00

abstract：:As insulin is a major autoantigen in autoimmune diabetes and because the insulin gene region locus in humans has been linked to diabetes risk, we have bred insulin gene knockouts onto the NOD mouse. Mice differ from humans in terms that they express two nonallelic genes of insulin. Insulin 2 is the murine homologue of...

journal_title：Annals of the New York Academy of Sciences

authors： Paronen J,Moriyama H,Abiru N,Sikora K,Melanitou E,Babu S,Bao F,Liu E,Miao D,Eisenbarth GS

更新日期：2003-11-01 00:00:00

abstract：:The receptive field of a direction-selective unit of any type consists of an excitatory center 3 degrees -5 degrees in size, a near inhibitory surround and a far surround upon which illumination exerts an influence for both spontaneous activity and specific cell response. ...

journal_title：Annals of the New York Academy of Sciences

authors： Golovkin M,Gorbunov V,Maximova E,Maximov V

更新日期：2005-06-01 00:00:00

abstract：:The tick-borne protozoan parasite Theileria annulata causes tropical theileriosis, a severe leukoproliferative disease of cattle, which naive susceptible animals fail to control. The parasite infects and transforms macrophages, developing in the local draining lymph node. IFN gamma has been shown to block parasite dev...

journal_title：Annals of the New York Academy of Sciences

authors： Campbell JD,Nichani AK,Brown DJ,Glass EJ,Spooner RL

更新日期：1998-06-29 00:00:00

abstract：:Adults with better jobs enjoy better health: job title was, in fact, the social gradient metric first used to study the relationship between social class and chronic disease etiology, a core finding now replicated in most developed countries. What has been less well proved is whether this correlation is causal, and if...

journal_title：Annals of the New York Academy of Sciences

authors： Clougherty JE,Souza K,Cullen MR

更新日期：2010-02-01 00:00:00

abstract：:The recent literature providing insights from neuroscience and evolutionary biology into how individuals perceive risky choice situations represents a "second wave" of findings that recapitulates as well as challenges the risk perception research begun in the 1980s, which relied on psychometric survey research. Gleani...

journal_title：Annals of the New York Academy of Sciences

authors： Finkel AM

更新日期：2008-04-01 00:00:00

abstract：:A cardinal feature of neurons is the morphological polarity of neurons with serious functional implications. Typically, a neuron has a single axon and several dendrites. Neuronal polarity is essential for the unidirectional signal flow from somata or dendrites to axons in neurons. The initial event in establishing a p...

journal_title：Annals of the New York Academy of Sciences

authors： Yoshimura T,Arimura N,Kaibuchi K

更新日期：2006-11-01 00:00:00

abstract：:Osteocytes are derived from osteoblasts and make up over 90% of the cells in bone. However, the mechanisms that control the differentiation of osteoblasts into osteocytes embedded in bone matrix are not well understood. With the recent developments of transgenic models for manipulating gene expression in osteocytes an...

journal_title：Annals of the New York Academy of Sciences

authors： Dallas SL,Bonewald LF

更新日期：2010-03-01 00:00:00

abstract：:Compelling evidence now exists for estrogen's involvement in the regulation of mood and cognitive functions. Serum estrogen levels have been shown to play an important role in the expression of psychiatric disorders such as depression and schizophrenia. We have characterized the distribution of the estrogen receptors,...

journal_title：Annals of the New York Academy of Sciences

authors： Ostlund H,Keller E,Hurd YL

更新日期：2003-12-01 00:00:00

abstract：:The predominance of the evidence from our studies indicates that beta 3-adrenergic-mediated thermogenesis in interscapular BAT is impaired with age. Moreover, upon exposure to cold, beta-adrenergic responsiveness in BAT is restored. However, the exact nature of the beta 3-adrenergic upregulation is unknown. When senes...

journal_title：Annals of the New York Academy of Sciences

authors： Scarpace PJ

更新日期：1997-03-15 00:00:00

abstract：:Although drugs of abuse have different chemical structures and interact with different protein targets, all appear to usurp common neuronal systems that regulate reward and motivation. Addiction is a complex disease that is thought to involve drug-induced changes in synaptic plasticity due to alterations in cell signa...

journal_title：Annals of the New York Academy of Sciences

authors： Lee AM,Messing RO

更新日期：2008-10-01 00:00:00

abstract：:The hemorrhagic strokes, intracerebral (ICH) and subarachnoid hemorrhage (SAH), often have poor outcomes. Indeed, the most common hemorrhagic stroke, ICH, has the highest mortality and morbidity rates of any stroke subtype. In this report, we discuss the evidence for the staging of red blood cell removal after ICH and...

journal_title：Annals of the New York Academy of Sciences

authors： Wagner KR,Dwyer BE

更新日期：2004-03-01 00:00:00

abstract：:For more than 10 years umbilical cord blood (UCB) has been used as an alternative source of hematopoietic stem cells for allogeneic transplantation. Although the clinical results are encouraging, UCB is associated with delayed engraftment. To address these issues we have used the NOD/SCID mouse model to study the engr...

journal_title：Annals of the New York Academy of Sciences

authors： Fibbe WE,Noort WA,Schipper F,Willemze R

更新日期：2001-06-01 00:00:00

abstract：:Although evidence for coevolution and geographic variation in its apparent strength is increasing, we still have a relatively poor understanding of why coevolution varies among interactions. Here we review how variation in the occurrence of competitors, resource stability, habitat area, and time has affected the exten...

journal_title：Annals of the New York Academy of Sciences

authors： Benkman CW,Parchman TL,Mezquida ET

更新日期：2010-09-01 00:00:00