Role of transforming growth factor-beta 1 in regulation of hematopoiesis.

Abstract:

:The data presented above suggest that one possible clinical use of TGF-beta would be to protect the bone marrow from the effects of myelosuppressive chemotherapeutic drugs by preventing entry or removing primitive stem cells from the cell cycle. It may also have the additional benefit of reducing the drug-induced neutrophil nadir by stimulating granulopoiesis. The availability of large quantities of recombinant TGF-beta will allow study of the pharmacokinetics with different routes of administration, dosage effects, and details of the pleiotropic effects on other cell systems. Experiments are in progress to determine whether TGF-beta will allow the delivery of higher amounts or more frequent doses of chemotherapeutic drugs and thus allow increased antitumor efficacy in tumor-bearing animals.

journal_name

Ann N Y Acad Sci

authors

Ruscetti FW,Jacobsen SE,Birchenall-Roberts M,Broxmeyer HE,Engelmann GL,Dubois C,Keller JR

doi

10.1111/j.1749-6632.1991.tb17220.x

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

31-43

eissn

0077-8923

issn

1749-6632

journal_volume

628

pub_type

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