Ex vivo expansion and engraftment potential of cord blood-derived CD34+ cells in NOD/SCID mice.

Abstract:

:For more than 10 years umbilical cord blood (UCB) has been used as an alternative source of hematopoietic stem cells for allogeneic transplantation. Although the clinical results are encouraging, UCB is associated with delayed engraftment. To address these issues we have used the NOD/SCID mouse model to study the engraftment potential of cord blood cells in more detail, to assess the engraftment potential of expanded megakaryocytic progenitor cells, and to study the effect of co-transplantation of mesenchymal stem cells on engraftment.

journal_name

Ann N Y Acad Sci

authors

Fibbe WE,Noort WA,Schipper F,Willemze R

doi

10.1111/j.1749-6632.2001.tb03569.x

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

9-17

eissn

0077-8923

issn

1749-6632

journal_volume

938

pub_type

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