Steroid hormones and growth factors act in an integrated manner at the levels of hypothalamic astrocytes: a role in the neuroendocrine control of reproduction.

abstract：:While dopamine (DA) receptors mediate acute effects of amphetamine and cocaine, chronic drug administration produces many glutamate-dependent adaptations, including LTP in reward-related neuronal circuits. An important question presents itself: How do DA receptors influence glutamate-dependent synaptic plasticity? Alt...

journal_title：Annals of the New York Academy of Sciences

authors： Wolf ME,Mangiavacchi S,Sun X

更新日期：2003-11-01 00:00:00

abstract：:The most common ototoxic compounds in clinical practice are aminoglycoside antibiotics, cisplatin, and loop diuretics (ethacrynic acid and furosemide). These agents also have substantial renal effects in the form of nephrotoxicity or diuresis. The understanding of these renal effects may provide insight into ototoxic ...

journal_title：Annals of the New York Academy of Sciences

authors： Humes HD

更新日期：1999-11-28 00:00:00

abstract：:Synthetic oligodeoxynucleotides (ODN) capable of "neutralizing" or "inhibiting" immune responses have been described. This review will focus on the properties of phosphorothioate ODN that mimic the immunosuppressive activity of the repetitive TTAGGG motifs present in mammalian telomeres. These TTAGGG multimers block t...

journal_title：Annals of the New York Academy of Sciences

authors： Klinman DM,Tross D,Klaschik S,Shirota H,Sato T

更新日期：2009-09-01 00:00:00

abstract：:The HLA genotype DRB1*03,DQB1*0201/DRB1*04,DQB1*0302 confers a 25-fold increase in the risk of type 1 diabetes. In persons with this genotype, DRB1*0405, *0402, and *0401 subtypes have been reported to further increase risk, whereas the *0403 and *0406 alleles confer a relative protection. We compared the frequencies ...

journal_title：Annals of the New York Academy of Sciences

authors： Rewers A,Babu S,Wang TB,Bugawan TL,Barriga K,Eisenbarth GS,Erlich HA

更新日期：2003-11-01 00:00:00

abstract：:There is growing interest in the use of statins, HMG-CoA reductase inhibitors, for treating specific neurodegenerative diseases (e.g., cerebrovascular disease, Parkinson's disease, Alzheimer's disease, multiple sclerosis) and possibly traumatic brain injury. Neither is there a consensus on the efficacy of statins in t...

journal_title：Annals of the New York Academy of Sciences

authors： Wood WG,Eckert GP,Igbavboa U,Müller WE

更新日期：2010-06-01 00:00:00

abstract：:Thymic pathology occurs in 80-90% of myasthenia gravis patients. Significant associations between different thymic alterations and clinical findings are discussed. To highlight peculiarities in thymoma-associated myasthenia gravis, we briefly review myasthenia gravis associated with thymic lymphofollicular hyperplasia...

journal_title：Annals of the New York Academy of Sciences

authors： Marx A,Müller-Hermelink HK,Ströbel P

更新日期：2003-09-01 00:00:00

abstract：:Results from two similar experimental systems that attempt to create laboratory geophysical analogs in spherical geometry are presented. In the first system, real time holographic interferometry and shadowgraph visualization are used to study convection in the fluid between two concentric spheres when two distinct buo...

journal_title：Annals of the New York Academy of Sciences

authors： Hegseth J,Amara K

更新日期：2002-10-01 00:00:00

abstract：:A method using laser-induced fluorescence (LIF) for in vivo cancer diagnosis of the esophagus is described. Autofluorescence of normal and malignant tissues was measured directly using a fiberoptic probe inserted through an endoscope. The measurements were performed in vivo during routine endoscopy. Measurement of the...

journal_title：Annals of the New York Academy of Sciences

authors： Vo-Dinh T,Panjehpour M,Overholt BF

更新日期：1998-02-09 00:00:00

abstract：:Present information technologies use semiconductor devices and magnetic/optical disks; however, they are all foreseen to face fundamental limitations within a decade. Therefore, superceding devices are required for the next paradigm of high-performance information technologies. The paper first describes architectures ...

journal_title：Annals of the New York Academy of Sciences

authors： Wada Y

更新日期：2002-04-01 00:00:00

abstract：:Photochemical smog is caused by a free-radical chain mechanism which converts NO to NO2. The NO2 further reacts to produce ozone, nitric acid, and peracylnitrates. This chain mechanism can be inhibited by suitable free-radical scavengers. The chemistry and toxicology of one such free-radical scavenger, diethylhydroxyl...

journal_title：Annals of the New York Academy of Sciences

authors： Heicklen J

更新日期：1987-01-01 00:00:00

abstract：:An 8-year follow-up of Ceravital middle ear prostheses showed there was extremely good tolerance in the middle ear space. Incompatibility phenomena were not observed, and inflammatory reactions were neither caused nor supported by the implants. The tympanoplasties were always performed without interposition of cartila...

journal_title：Annals of the New York Academy of Sciences

authors： Reck R,Störkel S,Meyer A

更新日期：1988-01-01 00:00:00

abstract：:The bilayer phase behavior of symmetric and asymmetric phosphatidylcholines (PCs), 1,2-diheptadecanoyl-PC (C17PC), 1-palmitoyl-2-stearoyl-PC (PSPC), and 1-stearoyl-2-palmitoyl-PC (SPPC), with different vesicle sizes were investigated by a high-pressure fluorescence method using the polarity-sensitive fluorescent probe...

journal_title：Annals of the New York Academy of Sciences

authors： Goto M,Kusube M,Nishimoto M,Tamai N,Matsuki H,Kaneshina S

更新日期：2010-02-01 00:00:00

abstract：:Megadose haploidentical transplants, mismatched at three HLA loci, engraft rapidly and durably without induction of graft-versus-host disease (GVHD). In vitro studies suggest that veto cells, contained in the population of hematopoietic progenitors, facilitate this favorable outcome. Cytotoxic T cells, not reactive ag...

journal_title：Annals of the New York Academy of Sciences

authors： Reisner Y

更新日期：2001-06-01 00:00:00

abstract：:The Na,K-ATPase gamma subunit is present primarily in kidney as two splice variants, gammaa and gammab, which differ only at their extracellular N-termini. Two distinct effects of gamma are seen in biochemical Na,K-ATPase assays of mammalian (HeLa) cells transfected with gammaa or gammab, namely, (i) a decrease in K'(...

journal_title：Annals of the New York Academy of Sciences

authors： Blostein R,Pu HX,Scanzano R,Zouzoulas A

更新日期：2003-04-01 00:00:00

abstract：:Recent observations indicate that autoimmune disorders and allergies are more closely connected to each other than traditionally considered. Both diseases are characterized by a break of immunological tolerance and in both Th1- and Th2-driven mechanisms may be involved. Moreover, patients suffering from severe chronic...

journal_title：Annals of the New York Academy of Sciences

authors： Garn H,Mittermann I,Valenta R,Renz H

更新日期：2007-06-01 00:00:00

abstract：:The complex dielectric properties of canine skeletal muscles were measured at 25 degrees C during ischemia in the frequency range from 50 Hz to 200 MHz. The dielectric spectrum of skeletal muscle shows an alpha-dispersion below 1 kHz and a beta-dispersion with a relaxation frequency of about 100 kHz. The alpha-dispers...

journal_title：Annals of the New York Academy of Sciences

authors： Schäfer M,Kirlum HJ,Schlegel C,Gebhard MM

更新日期：1999-04-20 00:00:00

abstract：:Within the past three years there has been a rapid expansion in our knowledge of the role TGF-beta mediates in regulating immune responses in vitro. Whether the TGF-beta will be clinically useful to suppress immune responses to transplanted organs or autoimmune responses is unknown. However, now that highly purified q...

journal_title：Annals of the New York Academy of Sciences

authors： Palladino MA,Morris RE,Starnes HF,Levinson AD

更新日期：1990-01-01 00:00:00

abstract：:Bacteria can exhibit high levels of resistance to one or more environmental stresses such as temperature, osmolarity, radiation, pH, starvation, as well as resistance to noxious chemicals and antibiotics. Yet evolution has not optimized stress resistance in all bacteria to all stresses. Even within a species like Esch...

journal_title：Annals of the New York Academy of Sciences

authors： Ferenci T,Spira B

更新日期：2007-10-01 00:00:00

abstract：:A previous review of alternative treatments (Tx) of ADHD--those other than psychoactive medication and behavioral/psychosocial Tx--was supplemented with an additional literature search focused on adults with ADHD. Twenty-four alternative Tx were identified, ranging in scientific documentation from discrediting control...

journal_title：Annals of the New York Academy of Sciences

authors： Arnold LE

更新日期：2001-06-01 00:00:00

abstract：:Neurotrophic factors are secreted peptides that when interacting with specific classes of membrane receptors activate intracellular signaling cascades that prevents neuronal death during embryonic development. The establishment of gene-targeted null mutant mice for the neurotrophic factors, brain-derived neurotrophic ...

journal_title：Annals of the New York Academy of Sciences

authors： Agerman K,Canlon B,Duan M,Ernfors P

更新日期：1999-11-28 00:00:00

abstract：:Granulosa cells are known to contribute to maturation of oocytes, and most of the growth factors exert their action via granulosa cells. It has been established that granulosa cell death during follicular atresia and luteolysis results from apoptosis. However, the precise mechanistic pathways of granulosa cell apoptos...

journal_title：Annals of the New York Academy of Sciences

authors： Tsai NM,Hsieh RH,Au HK,Shieh MJ,Huang SY,Tzeng CR

更新日期：2005-05-01 00:00:00

abstract：:Two chemical classes of flavonoids, the flavan-3-ols (catechins and proanthocyanidins) and the anthocyanins, are the natural antioxidants present at the highest concentration in red grape and wine. In the berry, the anthocyanins are localized in the skins, similarly to other highly bioactive phenolics of grape such as...

journal_title：Annals of the New York Academy of Sciences

authors： Mattivi F,Zulian C,Nicolini G,Valenti L

更新日期：2002-05-01 00:00:00

abstract：:In this paper, I have introduced and solved a simple deterministic model of eye tracking that produces rich dynamical behavior. Some of its main features, notably the existence of a chaotic regime, are reminiscent of the anomalies reported in smooth pursuit eye tracking experiments with schizophrenia patients. By obta...

journal_title：Annals of the New York Academy of Sciences

authors： Huberman BA

更新日期：1987-01-01 00:00:00

abstract：:The apolipoprotein E (APOE) gene causes a major risk factor for the development of Alzheimer's disease (AD). To study the transcription control of the mouse (m) APOE gene, we first tested the promoter activity of a 721-base-pair (bp) 5'-flanking region, which is located 771 bp upstream from the translation initiation ...

journal_title：Annals of the New York Academy of Sciences

authors： Lahiri DK,Alley GM,Ge YW,Du Y

更新日期：2002-11-01 00:00:00

abstract：:Na+/Ca2+-K+ exchangers (NCKX) are plasma membrane transporters that are thought to mainly mediate Ca2+ extrusion (along with K+) at the expense of the Na+ electrochemical gradient. However, because they are bidirectional, most assays have relied on measuring their activity in the reverse (Ca2+ import) mode. Herein we ...

journal_title：Annals of the New York Academy of Sciences

authors： Altimimi HF,Schnetkamp PP

更新日期：2007-03-01 00:00:00

abstract：:Hypomethylation signifies one end of a spectrum of DNA methylation states. In most cases hypomethylation refers to a relative state that represents a change from the "normal" methylation level. Hypomethylation, when approached from a topographical perspective, has been used to describe either overall decreases in the ...

journal_title：Annals of the New York Academy of Sciences

authors： Dunn BK

更新日期：2003-03-01 00:00:00

abstract：:The entry of resting T cells into the G1 phase of the cell cycle after stimulation by mitogens is controlled by a series of biochemical events that are independent of growth factors. These events follow the initial signals stimulated through the engagement of the T-cell receptor and include activation of the cyclin-de...

journal_title：Annals of the New York Academy of Sciences

authors： Modiano JF,Domenico J,Szepesi A,Terada N,Lucas JJ,Gelfand EW

更新日期：1995-09-07 00:00:00

abstract：:Aging, hypoxia, and thiamin deficiency diminish motor performance. Similar alterations of ACh, DA, and glutamate metabolism accompany hypoxia, thiamin deficiency, and aging. Both aging and hypoxia reduce ACh release and stimulate DA and glutamate release. Presynaptic enhancement of DA and glutamate release may be impo...

journal_title：Annals of the New York Academy of Sciences

authors： Freeman GB,Gibson GE

更新日期：1988-01-01 00:00:00

abstract：:It is known that red wines have antioxidant properties owing to the presence of polyphenols and hydroxycinnamates. It has been reported that these compounds are efficient scavengers of peroxynitrite (ONOO(-)). We assayed the ONOO(-)-scavenging activity of plant polyphenols, hydroxycinnamates, and red wines using a flu...

journal_title：Annals of the New York Academy of Sciences

authors： Valdez LB,Actis-Goretta L,Boveris A

更新日期：2002-05-01 00:00:00

abstract：:Since connective tissue pulleys implement Listing's law by systematically changing rectus extraocular muscle (EOM) pulling directions, non-Listing's law gaze dependence of the vestibulo-ocular reflex is currently inexplicable. Differential activation of compartments within rectus EOMs may endow the ocular motor system...

journal_title：Annals of the New York Academy of Sciences

authors： Demer JL,Clark RA,da Silva Costa RM,Kung J,Yoo L

更新日期：2011-09-01 00:00:00