Ketoconazole treatment of coccidioidal meningitis.

abstract：:Nocturnal cortisol release in humans is synergistically regulated by circadian rhythm and sleep. Cortisol concentrations typically reach a nadir during the slow wave sleep-rich periods of early nocturnal sleep, whereas during the late night, when rapid eye movement (REM) sleep predominates, cortisol levels are enhance...

journal_title：Annals of the New York Academy of Sciences

authors： Born J,Wagner U

更新日期：2004-12-01 00:00:00

abstract：:Explanations of the socioeconomic gradient in health status must account for the observations that the gradient cuts across a wide range of disease processes and is capable of replicating itself on new disease processes as they emerge in society. Understanding this pattern requires an understanding of how human organi...

journal_title：Annals of the New York Academy of Sciences

authors： Hertzman C

更新日期：1999-01-01 00:00:00

abstract：:Because of the relatively high prevalence of both hepatitis C virus (HCV) infection and autoimmune disorders (ADs), it is not rare to encounter in daily clinical practice patients with ADs also carrying HCV. Corticosteroids and/or immunosuppressant drugs are needed to treat ADs, but they place HCV-infected patients at...

journal_title：Annals of the New York Academy of Sciences

authors： Galeazzi M,Bellisai F,Giannitti C,Manganelli S,Morozzi G,Sebastiani GD

更新日期：2007-09-01 00:00:00

abstract：:The molecular architecture of biological systems is heavily influenced by the highly polar interactions of water. Thus, macromolecules such as proteins that are highly water soluble must be electrically polar. Energy generation methods needed to support cell metabolic processes depend on compartmentalizing mobile ions...

journal_title：Annals of the New York Academy of Sciences

authors： Lee RC

更新日期：2005-12-01 00:00:00

abstract：:Amyloid precursor proteins (APP) are a member of a larger family of proteins that include the amyloid precursor-like proteins (APLP) APLPI and APLP2. We have examined the expression and metabolism of APLP2 and document that APLP2 is expressed at high levels in the nervous system and in peripheral tissues. Furthermore,...

journal_title：Annals of the New York Academy of Sciences

authors： Sisodia SS,Thinakaran G,Slunt HH,Kitt CA,Von Koch CS,Reed RR,Zheng H,Price DL

更新日期：1996-01-17 00:00:00

abstract：:Cyclosporin A (CsA) is an immunosuppressive drug commonly given to transplant patients. Its application is accompanied by severe side effects related to calcium, among them hypertension and nephrotoxicity. The Na+/Ca2+ exchanger (NCX) is a major calcium regulator expressed in the surface membrane of all excitable and ...

journal_title：Annals of the New York Academy of Sciences

authors： Rahamimoff H,Elbaz B,Alperovich A,Kimchi-Sarfaty C,Gottesman MM,Lichtenstein Y,Eskin-Shwartz M,Kasir J

更新日期：2007-03-01 00:00:00

abstract：:A nonparametric method, isotonic regression, is proposed for analyzing a dose-response relationship and for assessing a threshold value. There are several advantages of this method compared to parametric models. No specific form of the relationship (type of model and use of the covariates) is required. The only assump...

journal_title：Annals of the New York Academy of Sciences

authors： Ulm K

更新日期：1999-01-01 00:00:00

abstract：:Time-resolved confocal microspectrofluorometry and fluorescence microscopy imaging were applied to monitor the cellular uptake of fluorescent-labeled oligonucleotides (ONs) delivered by a porphyrin molecule. The fate of porphyrin-ON complexes inside living cells has also been monitored. Due to intrinsic fluorescence o...

journal_title：Annals of the New York Academy of Sciences

authors： Praus P,Kocisová E,Mojzes P,Stepánek J,Seksek O,Sureau F,Turpin PY

更新日期：2008-01-01 00:00:00

abstract：:At concentrations effecting apoptosis, the alkylphosphocholine ErPC3 induced increased expression of the Rb protein in breast cancer (MCF-7) and leukemia (SKW-3, AR-230) cell lines as well as hypophosphorylation (K-562, CMLT-1, DOHH-2) and fragmentation of Rb (BV-173, SKW-3) in leukemia cell lines. ErPC3 exerts at lea...

journal_title：Annals of the New York Academy of Sciences

authors： Berger MR,Tsoneva I,Konstantinov SM,Eibl H

更新日期：2003-12-01 00:00:00

abstract：:Pharmacological actions of methamphetamine (METH) and phencyclidine (PCP) are different, but both of them can induce similar psychiatric disorders including abuse, intoxication, withdrawal, and psychotic symptoms like those of schizophrenia. These mental disorders are caused not only by their direct pharmacological ef...

journal_title：Annals of the New York Academy of Sciences

authors： Ouchi Y,Kubota Y,Ito C

更新日期：2004-10-01 00:00:00

abstract：:Nitric oxide (NO) bioavailability is crucial for normal vascular endothelial function and health. Recent studies have demonstrated an endocrine role for NO equivalents that may be transported in the blood to peripheral tissue beds, where under hypoxic conditions they can liberate NO and cause vasodilation. Exercise tr...

journal_title：Annals of the New York Academy of Sciences

authors： Stabler T,Kenjale A,Ham K,Jelesoff N,Allen J

更新日期：2010-08-01 00:00:00

abstract：:The accepted dogma has been that a single long-term hematopoietic stem cell (LT-HSC) can reconstitute all components of the immune system. However, our single-cell transfer studies have shown that highly purified LT-HSCs selectively fail to reconstitute B-1a cells in otherwise fully reconstituted hosts (i.e., LT-HSCs ...

journal_title：Annals of the New York Academy of Sciences

authors： Ghosn EE,Yang Y

更新日期：2015-12-01 00:00:00

abstract：:The acquisition of both speech and music uses general principles: learners extract statistical regularities present in the environment. Yet, individuals who suffer from congenital amusia (commonly called tone-deafness) have experienced lifelong difficulties in acquiring basic musical skills, while their language abili...

journal_title：Annals of the New York Academy of Sciences

authors： Peretz I,Saffran J,Schön D,Gosselin N

更新日期：2012-04-01 00:00:00

abstract：:Insulin receptor isoform A (IR-A) is a fetal insulin receptor isoform that is overexpressed in cancer. We investigated whether insulin-like growth factor (IGF)-II may elicit a different gene expression response from insulin in cells expressing only IR-A and lacking IGF-I receptor (R-/IR-A cells). Cells were stimulated...

journal_title：Annals of the New York Academy of Sciences

authors： Pandini G,Conte E,Medico E,Sciacca L,Vigneri R,Belfiore A

更新日期：2004-12-01 00:00:00

abstract：:Here we briefly review our studies that have unraveled an important role for the calcium- and calmodulin-sensitive enzyme calcineurin (CN) in bone remodeling. We find that the genetic deletion of the calcineurin Aalpha isoform results in osteoporosis, which is recapitulated in humans following calcineurin inhibitor th...

journal_title：Annals of the New York Academy of Sciences

authors： Sun L,Zhu LL,Zaidi N,Yang G,Moonga BS,Abe E,Iqbal J,Epstein S,Blair HC,Huang CL,Zaidi M

更新日期：2007-11-01 00:00:00

abstract：:The anesthetic effect of certain steroids in vertebrate systems is well documented, but it is not known if these compounds can cause anesthesia in simpler organisms. To answer this question, ether, short-chain alkanols, and pregnanolone were tested for their ability to induce anesthesia in 20 aquatic species from 7 ph...

journal_title：Annals of the New York Academy of Sciences

authors： Oliver AE,Deamer DW,Akeson M

更新日期：1991-01-01 00:00:00

abstract：:Exosomes are nanovesicles secreted from cells that play key roles in intercellular communication. They carry unique content derived from parental cells and are capable of transferring this cargo between cells. The role and function of exosomes largely depends on the origin and functional status of the parental cells. ...

journal_title：Annals of the New York Academy of Sciences

authors： Cobelli NJ,Leong DJ,Sun HB

更新日期：2017-12-01 00:00:00

abstract：:The loss of E-cadherin expression or function in epithelial carcinomas has long been thought as a primary reason for disruption of tight epithelial cell-cell contacts and release of invasive tumor cells from the primary tumor. Indeed, E-cadherin serves as a widely acting suppressor of invasion and growth of epithelial...

journal_title：Annals of the New York Academy of Sciences

authors： Hazan RB,Qiao R,Keren R,Badano I,Suyama K

更新日期：2004-04-01 00:00:00

abstract：:In two experiments, musically trained and untrained adults were tested on their ability to match spoken utterances with their tonal analogues (tone sequences that retained the pitch and temporal patterns of the utterances). In both cases, musical training was associated with superior performance, indicating an enhance...

journal_title：Annals of the New York Academy of Sciences

authors： Thompson WF,Schellenberg EG,Husain G

更新日期：2003-11-01 00:00:00

abstract：:In this study we investigated the impact of estrogen antagonists and of 16alpha-OHE1 (an estrogen derivative that binds to and induces transactivation of estrogen receptors) on estrogen metabolism in malignant HepG2 human liver cells featured by high estrogen sulfotransferase (EST); our aim was to clarify the potentia...

journal_title：Annals of the New York Academy of Sciences

authors： Campisi I,Granata OM,Cocciadiferro L,Calabrò M,Polito LM,Carruba G

更新日期：2009-02-01 00:00:00

abstract：:Apoptotic cell death is a highly regulated process, which plays a crucial role in many biological events. Etoposide is an antineoplastic drug, which targets the DNA unwinding enzyme, topoisomerase II. The aim of the present research approach to investigate the expression of the apoptosis-related genes BCL2 (Bcl-2), FA...

journal_title：Annals of the New York Academy of Sciences

authors： Floros KV,Thomadaki H,Florou D,Talieri M,Scorilas A

更新日期：2006-12-01 00:00:00

abstract：:The aim of this study was to evaluate the possible neuroprotective effects of thymosin beta(4) in different models of excitotoxicity. The application of thymosin beta(4) significantly attenuated glutamate-induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices. In in vivo experiment...

journal_title：Annals of the New York Academy of Sciences

authors： Popoli P,Pepponi R,Martire A,Armida M,Pèzzola A,Galluzzo M,Domenici MR,Potenza RL,Tebano MT,Mollinari C,Merlo D,Garaci E

更新日期：2007-09-01 00:00:00

abstract：:N. gonorrhoeae initiates infection by adhering to and invading columnar epithelial cells. Over time these activities often induce inflammation, with the influx of neutrophils and serum into the urethral lumen, cervical os, conjunctiva, and the like. At least some of these infected niches contain CMP-NANA (cytidine mon...

journal_title：Annals of the New York Academy of Sciences

authors： Rest RF,Liu J,Talukdar R,Frangipane JV,Simon D

更新日期：1994-08-15 00:00:00

abstract：:The classic cardiac research programs revolved around measurable properties such as pressures, work done, vascular blood flow, electrical propagation, and other such parameters that defined the global heart functions in health and decease. Consistently, the first Henry Goldberg Workshop, held in Haifa in 1984, focused...

journal_title：Annals of the New York Academy of Sciences

authors： Beyar R

更新日期：2005-06-01 00:00:00

abstract：:Ischemic preconditioning (PC) is a polygenic defensive cellular adaptive phenomenon whereby brief ischemic stimuli render the heart resistant to subsequent similar stress. The late phase of ischemic PC lasts for three to four days, protects against both myocardial stunning and infarction, and thus has considerable cli...

journal_title：Annals of the New York Academy of Sciences

authors： Dawn B,Bolli R

更新日期：2002-05-01 00:00:00

abstract：:There is an urgent need for surrogate biomarkers in clinical diagnostics but also preclinical in toxicology of chemicals and efficacy testing of pharmaceuticals. On the background of the emerging fields of systems biology and theranostics, the importance of time scales and the synchronization of complex biological rea...

journal_title：Annals of the New York Academy of Sciences

authors： Schrattenholz A,Soskić V,Groebe K

更新日期：2010-06-01 00:00:00

abstract：:We have developed an assay to detect mucosally delivered antibody to Cryptosporidium parvum sporozoite antigens. We absorbed a recombinant 23-kD sporozoite protein to polystyrene microspheres, and used flow cytometry to detect, titer, and determine the isotype of antibody to p23 that was shed in the feces of experimen...

journal_title：Annals of the New York Academy of Sciences

authors： Wyatt CR,Perryman LE

更新日期：2000-01-01 00:00:00

abstract：:The selective expression of a gene is achieved through the interaction of protein transcription factors with characteristic DNA sequences located in the regulatory region of the gene, which is usually distinct from the coding region. These proteins contain domains that bind specifically to the DNA sites (or response e...

journal_title：Annals of the New York Academy of Sciences

authors： Klug A

更新日期：1995-06-30 00:00:00

abstract：:The International Agency for Research on Cancer has initiated a program to evaluate the carcinogenic risk of chemicals to man. This program is centered on the production of monographs on individual chemicals, consisting of data on use and production, carcinogenicity in experimental animals, epidemiological studies and...

journal_title：Annals of the New York Academy of Sciences

authors： Tomatis L

更新日期：1976-01-01 00:00:00

abstract：:Jopock (Jpk), a transacting factor associated with the position-specific regulatory element of murine Hoxa-7, has shown to induce cell death in both prokaryotic and eukaryotic cells when introduced and overexpressed. Since Jpk protein harbors a transmembrane domain (TM) and a putative endoplasmic reticulum (ER) -reten...

journal_title：Annals of the New York Academy of Sciences

authors： Kim HS,Kong KA,Chung H,Park S,Kim MH

更新日期：2007-01-01 00:00:00