Gene regulatory proteins and their interaction with DNA.

Abstract:

:The selective expression of a gene is achieved through the interaction of protein transcription factors with characteristic DNA sequences located in the regulatory region of the gene, which is usually distinct from the coding region. These proteins contain domains that bind specifically to the DNA sites (or response elements). Some general principles in the design of these DNA-binding domains are described, followed by examples of the different structural classes discovered so far and how they recognize their binding sites.

journal_name

Ann N Y Acad Sci

authors

Klug A

doi

10.1111/j.1749-6632.1995.tb24814.x

subject

Has Abstract

pub_date

1995-06-30 00:00:00

pages

143-60

eissn

0077-8923

issn

1749-6632

journal_volume

758

pub_type

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