Gene regulatory proteins and their interaction with DNA.

abstract：:Dr. Josep Font (Barcelona, 1953-2006) devoted his professional career to the care of patients with systemic autoimmune diseases (SAD). In 1995, he created the Department of Autoimmune Diseases at the Hospital Clinic in Barcelona, a pioneering unit in Europe specifically dedicated to the clinical management of these pa...

journal_title：Annals of the New York Academy of Sciences

authors： Ramos-Casals M,Khamashta MA

更新日期：2007-06-01 00:00:00

abstract：:Obesity is a public health epidemic associated with a number of comorbidities, most notably type 2 diabetes and hypertension, as well as elevated all-cause mortality. The treatment for obesity and its associated comorbidities has most recently expanded into the field of bariatric endoscopy. This field bridges a gap be...

journal_title：Annals of the New York Academy of Sciences

authors： Hill C,Khashab MA,Kalloo AN,Kumbhari V

更新日期：2018-01-01 00:00:00

abstract：:The central nervous system (CNS) plays a vital role in regulating energy balance and metabolism. Over the last 50 years, studies in animal models have allowed us to identify critical CNS regions involved in these processes and even crucial cell populations. Now, techniques for genetically and anatomically targeted man...

journal_title：Annals of the New York Academy of Sciences

authors： Devarakonda K,Stanley S

更新日期：2018-01-01 00:00:00

abstract：:Galanin is widely distributed in enteric nerves and nerve terminals throughout the gastrointestinal (GI) tract. Within the GI tract galanin is best known for its ability to alter smooth muscle contractility and regulate intestinal motility. However, recent studies also indicate that galanin can modulate epithelial ion...

journal_title：Annals of the New York Academy of Sciences

authors： Benya RV,Matkowskyj KA,Danilkovich A,Hecht G

更新日期：1998-12-21 00:00:00

abstract：:The recent identification of tumor-associated antigens (TAA) and TAA-derived peptides presented by MHC molecules to T cells has provided the tools to design and test clinical vaccines for treating human malignancies, such as melanoma. While the most effective adjuvant for use in vaccine formulation remains unclear, au...

journal_title：Annals of the New York Academy of Sciences

authors： Zitvogel L,Couderc B,Mayordomo JI,Robbins PD,Lotze MT,Storkus WJ

更新日期：1996-10-31 00:00:00

abstract：:Immune stimulation increases the activity of the HPA axis, a phenomenon directly or indirectly mediated through cytokines. We have used two models, the peripheral administration of endotoxin (LPS) or turpentine-induced tissue injury to show that corticotropin-releasing factor (CRF) and vasopressin (VP), hypothalamic p...

journal_title：Annals of the New York Academy of Sciences

authors： Turnbull AV,Lee S,Rivier C

更新日期：1998-05-01 00:00:00

abstract：:Peripheral sympathetic nerve terminals in many tissues, but not all, are endowed with beta-adrenoceptors. Activation of these result in an enhancement of noradrenaline release evoked by electrical nerve stimulation. These so-called presynaptic beta-adrenoceptors are possibly located on the outer surface of the varicos...

journal_title：Annals of the New York Academy of Sciences

authors： Nedergaard OA,Abrahamsen J

更新日期：1990-01-01 00:00:00

abstract：:The functions of the hypothalamic-pituitary-ovarian and -adrenal axes are intertwined, and molecular defects in either axis may cause ovarian dysfunction. Advances in molecular genetics have allowed new insights into the pathophysiology of ovarian disorders. Specific gene mutations causing delayed puberty and/or ovari...

journal_title：Annals of the New York Academy of Sciences

authors： Kalantaridou SN,Chrousos GP

更新日期：2000-01-01 00:00:00

abstract：:Preclinical safety and efficacy evaluation of a novel bioartificial liver support system (BLSS) was conducted using a D-galactosamine canine liver failure model. The BLSS houses a suspension of porcine hepatocytes in a hollow fiber cartridge with the hepatocytes on one side of the membrane and whole blood flowing on t...

journal_title：Annals of the New York Academy of Sciences

authors： Patzer JF 2nd,Mazariegos GV,Lopez R,Molmenti E,Gerber D,Riddervold F,Khanna A,Yin WY,Chen Y,Scott VL,Aggarwal S,Kramer DJ,Wagner RA,Zhu Y,Fulmer ML,Block GD,Amiot BP

更新日期：1999-06-18 00:00:00

abstract：:Based upon their migrating properties and effector functions, CD8(+) T cells have been further classified into central memory (T(CM)) and two types of effector memory (T(EM) and T(EMRA)) cells. These memory cells display distinct replicative characteristics. Because apoptosis plays an important role in cellular homeos...

journal_title：Annals of the New York Academy of Sciences

authors： Gupta S,Gollapudi S

更新日期：2007-08-01 00:00:00

abstract：:Washington State's law for sexually violent predators was enacted in 1990; since then, 14 other states have passed similar laws authorizing civil commitment for dangerous sexual offenders following their prison terms. Although the law has survived constitutional challenges at both the state and in the U.S. Supreme Cou...

journal_title：Annals of the New York Academy of Sciences

authors： Lieb R

更新日期：2003-06-01 00:00:00

abstract：:The potential of a transdisciplinary research method--Quali-Quantitative Analysis (QQA)--for delivering better evidence for healthy aging is explored. Illustrative reviews from the literature on healthy aging are summarized, as are papers on methodology by Charles Ragin and colleagues. The evidence needs for healthy a...

journal_title：Annals of the New York Academy of Sciences

authors： Bell E

更新日期：2007-10-01 00:00:00

abstract：:Human alpha 2-antiplasmin (alpha 2AP) is the primary inhibitor of plasmin-mediated fibrinolysis and is an efficient substrate of activated factor XIII (FXIIIa). Among 452 amino acid residues in alpha 2AP, Gln2 is believed to be the sole FXIIIa-reactive site that participates in crosslinking alpha 2AP to fibrin. We stu...

journal_title：Annals of the New York Academy of Sciences

authors： Lee KN,Lee CS,Tae WC,Jackson KW,Christiansen VJ,McKee PA

更新日期：2001-01-01 00:00:00

abstract：:We have previously shown that bone marrow will seed and proliferate in normal recipients. Transfusion of 50 million cells on each of 4 or 5 consecutive days, a total of 200-250 million cells, resulted in the recipient's marrow being 20-40% of donor origin. The present paper reported on the marked enhancement of prolif...

journal_title：Annals of the New York Academy of Sciences

authors： Brecher G,Mulcahy K,Tjio JH,Raveché E

更新日期：1985-01-01 00:00:00

abstract：:Thymic pathology occurs in 80-90% of myasthenia gravis patients. Significant associations between different thymic alterations and clinical findings are discussed. To highlight peculiarities in thymoma-associated myasthenia gravis, we briefly review myasthenia gravis associated with thymic lymphofollicular hyperplasia...

journal_title：Annals of the New York Academy of Sciences

authors： Marx A,Müller-Hermelink HK,Ströbel P

更新日期：2003-09-01 00:00:00

abstract：:The discrepancy between dynamical mass measures of objects such as galaxies and the observed distribution of luminous matter in the universe is typically explained by invoking an unseen "dark matter" component. Dark matter must necessarily be nonbaryonic. We introduce a simple hypothesis to do away with the necessity ...

journal_title：Annals of the New York Academy of Sciences

authors： Kinney WH,Brisudova M

更新日期：2001-06-01 00:00:00

abstract：:Teaching primary care is an important, but as yet, incompletely fulfilled responsibility of medical schools. The current surge of interest will not provide the needed personnel if primary care is defined too broadly, and if it is made everybody's business, but nobody's in particular. Primary care must not neglect firs...

journal_title：Annals of the New York Academy of Sciences

authors： Pellegrino ED

更新日期：1978-06-21 00:00:00

abstract：:The aim of this study was to examine the role of activating pathways of plasminogen in the natural history of abdominal aortic aneurysms (AAA). To fulfill this objective 70 male patients with small AAA (> 3 cm) were interviewed and examined. Their blood samples were taken at diagnosis. The patients were scanned annual...

journal_title：Annals of the New York Academy of Sciences

authors： Lindholt JS

更新日期：2006-11-01 00:00:00

abstract：:Pelizaeus-Merzbacher disease (PMD) is a dysmyelinating disorder of the central nervous system typically caused by duplications or missense mutations of the proteolipid protein (PLP) gene. Most investigators have found that peripheral nerve function and structure is normal in PMD patients. We have found that null mutat...

journal_title：Annals of the New York Academy of Sciences

authors： Garbern JY,Cambi F,Lewis R,Shy M,Sima A,Kraft G,Vallat JM,Bosch EP,Hodes ME,Dlouhy S,Raskind W,Bird T,Macklin W,Kamholz J

更新日期：1999-09-14 00:00:00

abstract：:Neurotrophic factors are secreted peptides that when interacting with specific classes of membrane receptors activate intracellular signaling cascades that prevents neuronal death during embryonic development. The establishment of gene-targeted null mutant mice for the neurotrophic factors, brain-derived neurotrophic ...

journal_title：Annals of the New York Academy of Sciences

authors： Agerman K,Canlon B,Duan M,Ernfors P

更新日期：1999-11-28 00:00:00

abstract：:CXC chemokines have been found to be important in the regulation of angiogenesis and tumor-related immunity, and in promoting organ-specific metastases. This review highlights the importance of CXC chemokine ligands and receptors in mediating non-small cell lung cancer tumor-associated angiogenesis, "immunoangiostasis...

journal_title：Annals of the New York Academy of Sciences

authors： Strieter RM,Belperio JA,Burdick MD,Sharma S,Dubinett SM,Keane MP

更新日期：2004-12-01 00:00:00

abstract：:The Mediterranean diet is now recognized as being both limited in toxicity and abundant in nutrient and non-nutrient protective factors. A large body of basic, clinical and epidemiological studies have been developed in recent years to provide evidence of the benefits of the Mediterranean diet or its components on hea...

journal_title：Annals of the New York Academy of Sciences

authors： Covas MI,Marrugat J,Fitó M,Elosua R,de la Torre-Boronat C

更新日期：2002-05-01 00:00:00

abstract：:Nitric oxide (NO) has been implicated as a mediator of vasodilation and neurotransmission in the mammalian cochlea. This is demonstrated by the presence of nitric oxide synthase (NOS) and nitric oxide (NO) in the blood vessels and the organ of Corti in the cochlea. It is not certain if the neurons in the spiral gangli...

journal_title：Annals of the New York Academy of Sciences

authors： Ruan RS

更新日期：2002-05-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1)-positive patients in the late phase of infection develop AIDS dementia complex, an array of neurological complications that include extrapyramidal symptoms, cognitive impairments, and psychiatric disturbances. Brains of these patients exhibit brain injury. The HIV-1 envelope...

journal_title：Annals of the New York Academy of Sciences

authors： Bachis A,Mocchetti I

更新日期：2005-08-01 00:00:00

abstract：:Researchers in Utrecht, the Netherlands have studied the effects of different factors, such as oral contraceptives (OCs), on sex hormone binding globulin (SHBG) levels in blood. The SHBG levels in women who continuously used OCs consisting only of .05 mg of ethinyl estradiol (EE2) rose as high as 260% + or - 25% of t...

journal_title：Annals of the New York Academy of Sciences

authors： Thijssen JH

更新日期：1988-01-01 00:00:00

abstract：:The characteristics of about 2,000 Japanese sarcoidosis cases collected by the Japan Sarcoidosis Committee during the 10-yr period, 1963-1972, were chronological increase with decreasing infectious diseases (represented by tuberculosis), north-to-south decline in sarcoidosis incidence in accordance with the Oxford Atl...

journal_title：Annals of the New York Academy of Sciences

authors： Hosoda Y,Hiraga Y,Odaka M,Yangawa H,Ito Y,Shiegematsu I,Chiba Y

更新日期：1976-01-01 00:00:00

abstract：:This paper represents recent results on the development of optimal analytic solutions to the variation problem of trajectory optimization and their application in the construction of on-board guidance laws. The importance of employing the analytically integrated trajectories in a mission design is discussed. It is ass...

journal_title：Annals of the New York Academy of Sciences

authors： Azimov D,Bishop R

更新日期：2005-12-01 00:00:00

abstract：:Two types of mixed matrix membranes were developed by UOP in the late 1980s. The first type includes adsorbent polymers, such as silicalite-cellulose acetate (CA), NaX-CA, and AgX-CA mixed matrix membranes. The silicalite-CA has a CO(2)/H(2) selectivity of 5.15 +/- 2.2. In contrast, the CA membrane has a CO(2)/H(2) se...

journal_title：Annals of the New York Academy of Sciences

authors： Kulprathipanja S

更新日期：2003-03-01 00:00:00

abstract：:We study the linear coupling between the Marangoni and Cowley-Rosensweig instabilities for a thin layer of ferrofluid subjected to a temperature gradient and a magnetic field. Both are perpendicular to the reference horizontal boundaries, one of which is a rigid plate, while the other is a free surface remaining flat ...

journal_title：Annals of the New York Academy of Sciences

authors： Hennenberg M,Slavtchev S,Weyssow B

更新日期：2009-04-01 00:00:00

abstract：:A broad biological approach makes it possible to understand why aging exists and also why different mammalian species have very different maximum longevities. The adult organism is maintained in a functional state by at least ten major mechanisms, which together constitute a substantial proportion of all biological pr...

journal_title：Annals of the New York Academy of Sciences

authors： Holliday R

更新日期：1998-11-20 00:00:00