Investigating metabolic regulation using targeted neuromodulation.

abstract：:The data presented above suggest that one possible clinical use of TGF-beta would be to protect the bone marrow from the effects of myelosuppressive chemotherapeutic drugs by preventing entry or removing primitive stem cells from the cell cycle. It may also have the additional benefit of reducing the drug-induced neut...

journal_title：Annals of the New York Academy of Sciences

authors： Ruscetti FW,Jacobsen SE,Birchenall-Roberts M,Broxmeyer HE,Engelmann GL,Dubois C,Keller JR

更新日期：1991-01-01 00:00:00

abstract：:Indirect evidence, including neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-neurotoxicity by nitric oxide synthase (NOS) inhibitors and resistance of transgenic animals deficient in NOS, is controversial. We have reviewed evidence in favor of oxidative stress during the development of MPTP...

journal_title：Annals of the New York Academy of Sciences

authors： Mohanakumar KP,Thomas B,Sharma SM,Muralikrishnan D,Chowdhury R,Chiueh CC

更新日期：2002-05-01 00:00:00

abstract：:The statistical techniques developed herein show strong promise as a nonparametric extension of the classical Wing-Kristofferson decomposition of variance in isochronous tapping to include tempo drift. It is now important to establish the relative role of the three sources of variance in discriminating among unselecte...

journal_title：Annals of the New York Academy of Sciences

authors： Collier GL,Ogden RT

更新日期：2001-06-01 00:00:00

abstract：:This paper reports preliminary results for pool film boiling on a wire immersed in almost saturated FC72 recently obtained during an experimental campaign performed in low gravity on the European Space Agency Zero-G airplane, (reduced gravity level 10(-2)). This is part of a long-term research program on the effect of...

journal_title：Annals of the New York Academy of Sciences

authors： Di Marco P,Grassi W,Trentavizi F

更新日期：2002-10-01 00:00:00

abstract：:Cytokines (IL-1, IL-6, IL-8, IL-11, TNF, IFN-gamma, and TGF-beta) and growth factors (EGF, bFGF, aFGF, and KGF) play an important role in modulation of hormone secretion by directly influencing specific enzyme steps of steroidogenesis in various endocrine cell types. For this tabular data collection, the following enz...

journal_title：Annals of the New York Academy of Sciences

authors： Herrmann M,Scholmerich J,Straub RH

更新日期：2002-06-01 00:00:00

abstract：:Newly molted Boophilus microplus females obtained in a laboratory at 30 degrees C and environmental relative humidity (RH) were employed. An original device was used to hold ticks during feeding. Three groups of 15 ticks each were created: unfed, fed with heparinized blood, and fed with defibrinated blood. Ticks were ...

journal_title：Annals of the New York Academy of Sciences

authors： de la Vega R,Díaz G,Finlay L

更新日期：2000-01-01 00:00:00

abstract：:Manifest pre-eclampsia is associated with activation of peripheral neutrophils as well as elevations in maternal cell-free DNA. For this reason, we were very intrigued by recent reports indicating that activated circulatory neutrophils secrete nuclear DNA to generate extracellular DNA lattices, termed NETs (neutrophil...

journal_title：Annals of the New York Academy of Sciences

authors： Gupta A,Hasler P,Gebhardt S,Holzgreve W,Hahn S

更新日期：2006-09-01 00:00:00

abstract：:The human moral nature has perplexed laymen and academics for millennia. Recent developments in cognitive neuroscience are opening new venues for unveiling the complex psychological and neurobiological mechanisms underling human morality and its impairments. Here we review these lines of evidence and key topics of deb...

journal_title：Annals of the New York Academy of Sciences

authors： Moll J,De Oliveira-Souza R,Zahn R

更新日期：2008-03-01 00:00:00

abstract：:Five hybridoma cell lines secreting anti-PrP antibodies were established from the fusion between mouse myeloma Sp2/0 and spleen cells from mice immunized with recombinant Chinese Luxi yellow cattle (Bos taurus, Luxi) PrP (24-234) or recombinant Chinese small-tailed Han sheep PrP (94-227). According to their Western bl...

journal_title：Annals of the New York Academy of Sciences

authors： Wu X,Wang Z,Liu Y,Zhang Y,Chen Y,Zou Y

更新日期：2006-10-01 00:00:00

abstract：:Evidence is emerging that calcium-activated neutral proteinases (CANPs) not only participate in intracellular protein turnover but help to regulate the functional reorganization of cytoskeletal proteins in response to calcium and second-messenger stimulation. The high concentration of CANPs in certain neurons has sugg...

journal_title：Annals of the New York Academy of Sciences

authors： Nixon RA

更新日期：1989-01-01 00:00:00

abstract：:Departing from the functional parallelism that undoubtedly exists between the nervous and immune system, we suggest that the latter also counts with means for information exchange that may result in a mutual influence of immune processes between nearby individuals. Our concept relies on a molecular interface that is c...

journal_title：Annals of the New York Academy of Sciences

authors： Martín PI,Sánchez PA,Rewald E

更新日期：2009-09-01 00:00:00

abstract：:Rats subjected to various accelerations (+G) exhibited increased levels of plasma epinephrine (EPI), norepinephrine (NE), and corticosterone. However, the collection of blood was performed after a centrifugation finished, and therefore the levels could be affected by the process of deceleration. The aim of this study ...

journal_title：Annals of the New York Academy of Sciences

authors： Petrak J,Mravec B,Jurani M,Baranovska M,Tillinger A,Hapala I,Frollo I,Kvetnanský R

更新日期：2008-12-01 00:00:00

abstract：:Evidence from experimental animal studies show that sex hormones influence the glucocorticoid response to a variety of inflammatory and noninflammatory stimuli. In this study we assessed gender differences in the response of ACTH and cortisol in normal young male and female humans following intravenous infusion of hum...

journal_title：Annals of the New York Academy of Sciences

authors： Silva C,Ines LS,Nour D,Straub RH,da Silva JA

更新日期：2002-06-01 00:00:00

abstract：:The behavior of sadists is bizarre and poorly understood. There are gross endocrine and brain abnormalities in a small number of these men. Approximately two-fifths show subtle temporal lobe brain abnormalities that are logically linked to sexual behavior and require further exploration. It would be interesting to exp...

journal_title：Annals of the New York Academy of Sciences

authors： Langevin R,Bain J,Wortzman G,Hucker S,Dickey R,Wright P

更新日期：1988-01-01 00:00:00

abstract：:The neurotransmitter serotonin (5-HT) has been implicated in the modulation of aggression in animals and humans. A longstanding dogma that aggression and serotonergic activity are inversely related has to be abandoned in light of many new findings. Trait and state aggression are differentially regulated by the 5-HT sy...

journal_title：Annals of the New York Academy of Sciences

authors： Olivier B

更新日期：2004-12-01 00:00:00

abstract：:Long-term exposure to estrogens influences the development of breast cancer in women, but the precise mechanisms involved are not clearly defined. Our working hypothesis is that estrogen modulates this process by two separate processes. One involves the binding of estradiol to estrogen receptor (ER) alpha with stimula...

journal_title：Annals of the New York Academy of Sciences

authors： Santen R,Cavalieri E,Rogan E,Russo J,Guttenplan J,Ingle J,Yue W

更新日期：2009-02-01 00:00:00

abstract：:The quantitative analysis of nerve growth dynamics is critical to our understanding of nerve development and regeneration, but only recently has a quantitative framework begun to emerge to help define key objectives and to direct experimental measurements towards achieving this goal. Conceptually, the framework center...

journal_title：Annals of the New York Academy of Sciences

authors： Buettner HM

更新日期：1994-11-30 00:00:00

abstract：:Twenty-month-old Swiss mice were allocated into three groups: (A) control; (B) infected group; and (C) infected but treated with 5 mg of the phytocompound MMT. Mice were infected intranasally with 30 microL of 75 HA viral units. MMT markedly blunted the nasal signs of virus infection and the febrile response. Formazan...

journal_title：Annals of the New York Academy of Sciences

authors： Cervi J,Marotta F,Bater C,Masulair K,Minelli E,Harada M,Marandola P

更新日期：2006-05-01 00:00:00

abstract：:Major trauma, shock, sepsis, and other conditions can lead to the acute respiratory distress syndrome (ARDS), which may progress to the highly lethal multiple organ dysfunction syndrome (MODS). Although a number of therapeutic strategies have been initiated, their success has been limited largely due to an incomplete ...

journal_title：Annals of the New York Academy of Sciences

authors： Deitch EA

更新日期：2010-10-01 00:00:00

abstract：:Little is known about how mitogenic factors generate growth regulatory signals and how these are mediated within the cell. We have developed three different types of mitogenic stimuli in order to identify the possible existence of common denominators in a complex and perhaps pleiotypic signal-response system. 3T3 cell...

journal_title：Annals of the New York Academy of Sciences

authors： Zetterberg A,Engström W,Larsson O

更新日期：1982-12-10 00:00:00

abstract：:Recent cross-cultural studies of child development reveal that child rearing, while strikingly culturally variable, is everywhere designed to make the child's experience of important lessons constant, to link those lessons to emotional arousal, and to connect them to evaluations of the child's goodness and badness. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Quinn N

更新日期：2003-10-01 00:00:00

abstract：:Diabetes mellitus is one of the most common endocrine disorders affecting almost 6% of the world's population. The number of diabetic patients will reach 300 million in 2025 (International Diabetes Federation, 2001). More than 97% of these patients will have type II diabetes. The projected increase in the number of di...

journal_title：Annals of the New York Academy of Sciences

authors： Adeghate E,Schattner P,Dunn E

更新日期：2006-11-01 00:00:00

abstract：:We have studied the developmental patterns of vasoactive intestinal polypeptide (VIP) binding sites in the human hypothalamus. VIP recognition sites were widely distributed throughout the rostrocaudal extent of the hypothalamus. VIP binding was generally low in the fetal and neonatal periods and a tendency in increasi...

journal_title：Annals of the New York Academy of Sciences

authors： Najimi M,Rachidi F,Afif A,Chigr F

更新日期：2006-07-01 00:00:00

abstract：:Mice deficient for complement factors C3, C4, or C5 are resistant to experimental autoimmune myasthenia gravis (EAMG). Acetylcholine receptor (AChR) immune lymph node cells (LNC) of C3 deficient mice produce less interleukin 6 (IL-6), and EAMG-resistant IL-6 deficient mice have less serum C3. Increased serum C1q-circu...

journal_title：Annals of the New York Academy of Sciences

authors： Christadoss P,Tüzün E,Li J,Saini SS,Yang H

更新日期：2008-01-01 00:00:00

abstract：:Sexual dimorphism is a well-documented phenomenon that is observed at all levels of the animal kingdom. Historically, sex hormones (testosterone and estrogen) have been implicated as key players in a wide array of pathologies displaying sexual dimorphism in their etiology and progression. While these hormones clearly ...

journal_title：Annals of the New York Academy of Sciences

authors： Quinn M,Ramamoorthy S,Cidlowski JA

更新日期：2014-05-01 00:00:00

abstract：:Malignancies have developed several strategies to evade immune surveillance. We have investigated pancreatic cancer cell lines and pancreatic cancer surgical specimens to evaluate possibilities of tumor escape in the Fas system, and local immune suppression. Despite Fas expression the majority of cell lines was resist...

journal_title：Annals of the New York Academy of Sciences

authors： Ungefroren H,Voss M,Bernstorff WV,Schmid A,Kremer B,Kalthoff H

更新日期：1999-06-30 00:00:00

abstract：UNLABELLED:This article suggests eight high-level concepts that can promote convergence by identifying analogies across fields of science and engineering. CONSERVATION: Many properties are conserved, through symmetries, parity laws, and feedback-regulated stabilities in complex adaptive systems. INDECISION: Inconsisten...

journal_title：Annals of the New York Academy of Sciences

authors： Bainbridge WS

更新日期：2006-12-01 00:00:00

abstract：:Glycosylation of alpha-fetoprotein (AFP) by human primary hepatocellular carcinoma (PHC) is abnormal. Concanavalin A (Con A)-affinity molecular variant patterns of serum AFP from patients with PHC are different from those of cord-serum AFP. Different patients with PHC exhibit different Con-A-affinity AFP molecular var...

journal_title：Annals of the New York Academy of Sciences

authors： Smith CJ,Ajdukiewicz A,Kelleher PC

更新日期：1983-01-01 00:00:00

abstract：:Globally, increasing acquired antimicrobial resistance among pathogenic bacteria presents an urgent challenge to human and animal health. As a result, significant efforts, such as the One Health Initiative, are underway to curtail and optimize the use of critically important antimicrobials for human medicine in all ap...

journal_title：Annals of the New York Academy of Sciences

authors： Scott HM,Acuff G,Bergeron G,Bourassa MW,Gill J,Graham DW,Kahn LH,Morley PS,Salois MJ,Simjee S,Singer RS,Smith TC,Storrs C,Wittum TE

更新日期：2019-04-01 00:00:00

abstract：:I(2) site-selective compounds are known to interact with and inhibit monoamine oxidase (MAO), but it remains unclear as to whether this interaction occurs through an allosteric or competitive interaction. This study used the new selective, irreversible I(2) ligand BU99006, to clarify the relationship between MAO and t...

journal_title：Annals of the New York Academy of Sciences

authors： Paterson LM,Tyacke RJ,Nutt DJ,Hudson AL

更新日期：2003-12-01 00:00:00