Pool film boiling experiments on a wire in low gravity: preliminary results.

abstract：:Oral and nasal administration of nicotinic acetylcholine receptor (AChR) to Lewis rats prior to myasthenogenic immunization with AChR and complete Freund's adjuvant (CFA) resulted in prevention or marked decrease of the severity of experimental autoimmune myasthenia gravis (EAMG) and suppression of AChR-specific B-cel...

journal_title：Annals of the New York Academy of Sciences

authors： Ma CG,Zhang GX,Xiao BG,Wang ZY,Link J,Olsson T,Link H

更新日期：1996-02-13 00:00:00

abstract：:Lipopolysaccharide (LPS), an endotoxin that elicits the production of several cytokines, induces cardiovascular changes characterized by increased perfusion of immune organs and compensatory sympathetic vasoconstriction in other tissues. We therefore hypothesized that to adapt to altered blood flow distribution follow...

journal_title：Annals of the New York Academy of Sciences

authors： Rogausch H,Vo NT,Del Rey A,Besedovsky HO

更新日期：2000-01-01 00:00:00

abstract：:Cancer chemoprevention entails the ingestion of dietary or pharmaceutical agents that can prevent, delay, or reverse the process of carcinogenesis. With support provided by the National Cancer Institute, we have been actively engaged in the systematic discovery and characterization of natural chemopreventive agents. T...

journal_title：Annals of the New York Academy of Sciences

authors： Pezzuto JM

更新日期：2011-01-01 00:00:00

abstract：:Anemia affects a third of the world's population and contributes to increased morbidity and mortality, decreased work productivity, and impaired neurological development. Understanding anemia's varied and complex etiology is crucial for developing effective interventions that address the context-specific causes of ane...

journal_title：Annals of the New York Academy of Sciences

authors： Chaparro CM,Suchdev PS

更新日期：2019-08-01 00:00:00

abstract：:Animal trials of many pharmacological neuroprotective agents have been quite successful, whereas trials in humans have been uniformly disappointing. A major difference between laboratory research in animals and clinical research in humans is the amount and/or quality of data obtained. The goal of this presentation is ...

journal_title：Annals of the New York Academy of Sciences

authors： Andrews RJ

更新日期：2005-08-01 00:00:00

abstract：:Vitamin E has the ability to scavenge a wide spectrum of free radicals, including singlet oxygen, superoxide, and hydroxyl radicals. It has beneficial effects against several other disorders, such as atherosclerosis and ischemic heart disease, because it acts as a transcriptional regulator for gene expression via a tr...

journal_title：Annals of the New York Academy of Sciences

authors： Al-Shamsi M,Amin A,Adeghate E

更新日期：2006-11-01 00:00:00

abstract：:Donepezil, a choline esterase inhibitor, has been widely used as a medicine for Alzheimer's disease. Recently, a study showed that donepezil inhibited addictive behaviors induced by cocaine, including cocaine-conditioned place preference (CPP) and locomotor sensitization to cocaine. In the present study, we investigat...

journal_title：Annals of the New York Academy of Sciences

authors： Takamatsu Y,Yamanishi Y,Hagino Y,Yamamoto H,Ikeda K

更新日期：2006-08-01 00:00:00

abstract：:In order to analyze neuronal computations in the first olfactory processing center, the olfactory bulb, we measured odor-evoked activity patterns across large numbers of neurons within the intact olfactory bulb of zebrafish using optical and electrophysiological methods. We found that the olfactory bulb performs multi...

journal_title：Annals of the New York Academy of Sciences

authors： Friedrich RW,Yaksi E,Judkewitz B,Wiechert MT

更新日期：2009-07-01 00:00:00

abstract：:1. The flow divider of the brachiocephalic branching of the rabbit aorta had both high and low shear stress regions, each of which was covered by endothelial cells with low and high permeability respectively, even in normolipidemic intact rabbits. When rabbits were placed on an atherogenic diet, low shear regions were...

journal_title：Annals of the New York Academy of Sciences

authors： Yoshida Y,Okano M,Wang S,Kobayashi M,Kawasumi M,Hagiwara H,Mitsumata M

更新日期：1995-01-17 00:00:00

abstract：:B lymphocytes contribute to the pathogenesis of autoimmune disorders since B-cell depletion treatment improves such diseases. However, B cells seem ambivalent. Murine strains of nonorgan-specific as well as organ-specific autoimmune conditions present with aggravated symptoms when B cells are depleted. It is thus like...

journal_title：Annals of the New York Academy of Sciences

authors： Lemoine S,Morva A,Youinou P,Jamin C

更新日期：2009-09-01 00:00:00

abstract：:Significant advances have been made over the past few years concerning the cellular and molecular events underlying neuron death. Recently, it is becoming increasingly clear that some of genes induced during cerebral ischemia may actually serve to rescue the cell from death. However, the injured cell may not be capabl...

journal_title：Annals of the New York Academy of Sciences

authors： Yenari MA,Dumas TC,Sapolsky RM,Steinberg GK

更新日期：2001-06-01 00:00:00

abstract：:Electroporation was used to transform the methylotrophic bacterium Methylobacterium extorquens with broad-host-range plasmid pLA2917, which contains a gene specifying resistance to kanamycin. Plasmid DNA was introduced into M. extorquens in the presence of an electric pulse, and kanamycin-resistant transformants were ...

journal_title：Annals of the New York Academy of Sciences

authors： Ueda S,Matsumoto S,Shimizu S,Yamane T

更新日期：1991-12-27 00:00:00

abstract：:As insulin is a major autoantigen in autoimmune diabetes and because the insulin gene region locus in humans has been linked to diabetes risk, we have bred insulin gene knockouts onto the NOD mouse. Mice differ from humans in terms that they express two nonallelic genes of insulin. Insulin 2 is the murine homologue of...

journal_title：Annals of the New York Academy of Sciences

authors： Paronen J,Moriyama H,Abiru N,Sikora K,Melanitou E,Babu S,Bao F,Liu E,Miao D,Eisenbarth GS

更新日期：2003-11-01 00:00:00

abstract：:Tularemia is a disease caused by several subspecies of Francisella tularensis, although the severity of the disease varies greatly from subspecies to subspecies. Currently, there are four recognized subspecies (tularensis, holarctica, mediasiatica, and novicida), in addition to a second Francisella species, F. philomi...

journal_title：Annals of the New York Academy of Sciences

authors： Keim P,Johansson A,Wagner DM

更新日期：2007-06-01 00:00:00

abstract：:Therapy for mitochondrial diseases is woefully inadequate. How-ever, lack of cure does not equate with lack of treatment. In this review, we consider sequentially several different therapeutic approaches. Palliative therapy is dictated by good medical practice and includes anticonvulsant medication, control of endocri...

journal_title：Annals of the New York Academy of Sciences

authors： Dimauro S,Mancuso M,Naini A

更新日期：2004-04-01 00:00:00

abstract：:This study examined the functional response to human relaxin 2 (H2 relaxin), human relaxin 3 (H3 relaxin), porcine relaxin, and human INSL3 in the cytosensor microphysiometer, using CHO-K1 cells stably expressing human GPCR135. CHO-K1 cells stably expressing GPCR135 were generated by the serial dilution method and rec...

journal_title：Annals of the New York Academy of Sciences

authors： Van der Westhuizen ET,Sexton PM,Bathgate RA,Summers RJ

更新日期：2005-05-01 00:00:00

abstract：:Taken together with electrophysiological data, these results suggest that in states of DA deficiency, systemically administered L-dopa or DA agonist drugs inhibit cell firing in the major output nuclei of the basal ganglia (GPI and SNPR). We propose that DA produces this net effect by a direct influence on the striato...

journal_title：Annals of the New York Academy of Sciences

authors： Wooten GF

更新日期：1997-12-19 00:00:00

abstract：:Although it is now well established that imidazoline receptors and alpha 2-adrenoceptors are discrete entities with distinct endogenous ligands, the two receptor classes apparently have several common features. While the catecholamines stimulate alpha 2-adrenoceptors but not imidazoline receptors, agmatine, a guanidin...

journal_title：Annals of the New York Academy of Sciences

authors： Hieble JP,Ruffolo RR Jr

更新日期：1995-07-12 00:00:00

abstract：:Clumps of corona cells were separated from oocytes at the moment of fertilization control and were subsequently processed and cut into 1-mu sections to study their general morphologic patterns. This study revealed an extensive phagocytosis of spermatozoa by corona cells. Clumps of mural granulosa cells of comparable s...

journal_title：Annals of the New York Academy of Sciences

authors： Pijnenborg R,Gordts S,Ongkowidjojo R,Brosens I

更新日期：1985-01-01 00:00:00

abstract：:Opsoclonus-myoclonus syndrome (OMS) is a rare neurologic disorder comprising the main symptoms of eye-movement disturbances, muscle jerks, and severe ataxia. In children and adults, some cases are associated with a tumor as a paraneoplastic syndrome, whereas in children the paraneoplastic form is almost exclusively as...

journal_title：Annals of the New York Academy of Sciences

authors： Kirsten A,Beck S,Fühlhuber V,Kaps M,Kreutz T,Korfei M,Schmitt S,Preissner KT,Blaes F

更新日期：2007-09-01 00:00:00

abstract：:Developing limb or differentiating neural and blood cells are traditional models used to study programmed cell death in mammals. The developing mouse dentition can also be an attractive model for studying apoptosis regulation. Apoptosis is most extant during early odontogenesis in mice. The embryonic tooth pattern is ...

journal_title：Annals of the New York Academy of Sciences

authors： Peterková R,Peterka M,Lesot H

更新日期：2003-12-01 00:00:00

abstract：:Transcription regulatory factors are rapidly induced in brain by a wide variety of stimuli and may be important in coordinating changes in gene expression under-lying neuronal plasticity. Using in situ hybridization, we found that acute cocaine administration (20 mg/kg, intraperitoneally (i.p.)) produced a robust indu...

journal_title：Annals of the New York Academy of Sciences

authors： Humblot N,Thiriet N,Gobaille S,Aunis D,Zwiller J

更新日期：1998-05-30 00:00:00

abstract：:SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates dif...

journal_title：Annals of the New York Academy of Sciences

authors： Corradini I,Verderio C,Sala M,Wilson MC,Matteoli M

更新日期：2009-01-01 00:00:00

abstract：:Hypoxia is a common physiologic and pathophysiologic stimulus that activates the expression of genes through oxygen-sensitive transcription factors including the hypoxia-inducible factor (HIF) and nuclear factor-kappaB (NF-kappaB). Hypoxia-dependent gene expression can have important physiologic or pathophysiologic co...

journal_title：Annals of the New York Academy of Sciences

authors： Taylor CT,Cummins EP

更新日期：2009-10-01 00:00:00

abstract：:The superior soft tissue contrast and multiplanar capability of magnetic resonance imaging has contributed to earlier diagnosis and implementation of effective treatment for a variety of arthropathies. Owing to overlapping clinical signs and symptoms, MRI plays a role in delineating the features and stages of these co...

journal_title：Annals of the New York Academy of Sciences

authors： Momeni M,Brindle K

更新日期：2009-02-01 00:00:00

abstract：:Aging is the major risk factor for both the development of chronic diseases and loss of functional capacity. Geroscience provides links among the biology of aging, the biology of disease, and the physiology of frailty, three fields where enormous progress has been made in the last few decades. While, previously, the f...

journal_title：Annals of the New York Academy of Sciences

authors： Kohanski RA,Deeks SG,Gravekamp C,Halter JB,High K,Hurria A,Fuldner R,Green P,Huebner R,Macchiarini F,Sierra F

更新日期：2016-12-01 00:00:00

abstract：:Indirect and direct experimental evidence demonstrates that both the entry of extracellular calcium and the liberation of calcium from intracellular stores can contribute to an increase in free cytoplasmic calcium concentration in endothelial cells, which seems to be an essential step in the synthesis and/or release o...

journal_title：Annals of the New York Academy of Sciences

authors： Rubanyi GM,Vanhoutte PM

更新日期：1988-01-01 00:00:00

abstract：:Rapidly industrializing India is described by the International Monetary Fund as a young, disciplined, and vibrant economy with a projected growth of 6.7% for 2005. The total workforce of 397 million has only 7% of workers employed in the organized sector with construction, where asbestos exposure is prevalent, employ...

journal_title：Annals of the New York Academy of Sciences

authors： Joshi TK,Bhuva UB,Katoch P

更新日期：2006-09-01 00:00:00

abstract：:It is known that hepatocytes show the different morphology depending on the surface condition of cultural substratum. The cells form a floating cell-aggregate called spheroid on proteoglycan-coated or positively charged dishes. The liver cell functions are generally high and maintained for the long-term in the spheroi...

journal_title：Annals of the New York Academy of Sciences

authors： Kamihira M,Yamada K,Hamamoto R,Iijima S

更新日期：1997-12-31 00:00:00

abstract：:We have previously identified 30 differentially expressed genes when comparing recently diagnosed type 1 diabetes mellitus (DM-1) patients and controls paired for sex, age, and ethnic background. In this article we performed the hierarchical clustering of these genes taking into account the human-leukocyte-antigen (HL...

journal_title：Annals of the New York Academy of Sciences

authors： Rassi DM,Junta CM,Fachin AL,Sandrin-Garcia P,Mello SS,Fernandes AP,Deghaide NN,Foss-Freitas MC,Foss MC,Sakamoto-Hojo ET,Passos GA,Donadi EA

更新日期：2006-10-01 00:00:00