The serotonergic system modulates the cocaine-induced expression of the immediate early genes egr-1 and c-fos in rat brain.

Abstract:

:Transcription regulatory factors are rapidly induced in brain by a wide variety of stimuli and may be important in coordinating changes in gene expression under-lying neuronal plasticity. Using in situ hybridization, we found that acute cocaine administration (20 mg/kg, intraperitoneally (i.p.)) produced a robust induction of both c-fos and egr-1 immediate early genes. Egr-1 messenger RNA induction was highest in the caudate putamen and in the shell of the nucleus accumbens. No significant induction was noticed after injection of fluoxetine, a selective inhibitor of serotonin uptake. Cocaine-induced egr-1 and c-fos expression was substantially reduced in the brain areas from rats in which the serotonergic projections were lesioned by injection of the neurotoxin 5,7-dihydroxytryptamine and in rats that have been injected with tropisetron, an antagonist of the 5-hydroxytryptamine (5-HT3) receptor. Conversely, the 5-HT3 receptor agonist 2-methylserotonin induced the expression of these early genes in structures including the caudate putamen and nucleus accumbens.

journal_name

Ann N Y Acad Sci

authors

Humblot N,Thiriet N,Gobaille S,Aunis D,Zwiller J

subject

Has Abstract

pub_date

1998-05-30 00:00:00

pages

7-20

eissn

0077-8923

issn

1749-6632

journal_volume

844

pub_type

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