Proteomic method for the quantification of methionine sulfoxide.

Abstract:

:Glycoxidation and lipoxidation reactions contribute to the chemical modification of proteins during the Maillard reaction. Reactive oxygen species, produced during the oxidation of sugars and lipids in these processes, irreversibly oxidize proteins. Methionine is particularly susceptible to oxidation, yielding the oxidation product methionine sulfoxide (MetSO). Here we describe a method for the analysis of MetSO using proteomic techniques. Using these techniques, we measured MetSO formation on the model protein RNase during aerobic incubations with glucose and arachidonate. We also evaluated the susceptibility of MetSO to reduction by NaBH4), a commonly used reductant in the analysis of Maillard reaction products.

journal_name

Ann N Y Acad Sci

authors

Brock JW,Cotham WC,Ames JM,Thorpe SR,Baynes JW

doi

10.1196/annals.1333.035

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

284-9

eissn

0077-8923

issn

1749-6632

pii

1043/1/284

journal_volume

1043

pub_type

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