Mucosal tolerance to experimental autoimmune myasthenia gravis is associated with down-regulation of AChR-specific IFN-gamma-expressing Th1-like cells and up-regulation of TGF-beta mRNA in mononuclear cells.

abstract：:We have evaluated the performance of a novel line-blot immunoassay (LIA; Mikrogen) and compared results with those obtained by CIE (in-house), ELISA (Pharmacia Diagnostics), and FEIA (Pharmacia Diagnostics). Sera from systemic lupus erythematosus (SLE) patients (n = 123), systemic sclerosis patients (n = 25), and heal...

journal_title：Annals of the New York Academy of Sciences

authors： Damoiseaux J,Boesten K,Giesen J,Austen J,Tervaert JW

更新日期：2005-06-01 00:00:00

abstract：:In recent years, vitamin D has been received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries and the identification of extraskeletal effects of vitamin D, suggesting unexpected benefits of vitamin D in health and disease, beyond bone health. The possibility of extra...

journal_title：Annals of the New York Academy of Sciences

authors： Christakos S,Hewison M,Gardner DG,Wagner CL,Sergeev IN,Rutten E,Pittas AG,Boland R,Ferrucci L,Bikle DD

更新日期：2013-05-01 00:00:00

abstract：:One hundred years after Santiago Ramon y Cajal provided critical evidence for the "neuron doctrine," his cellular view of the brain remains the basis of modern neural science. This article begins with a review of how the early work of Ramon y Cajal, Charles Sherrington, and John Eccles and their contemporaries laid ...

journal_title：Annals of the New York Academy of Sciences

authors： Albright TD,Jessell TM,Kandell ER,Posner MI

更新日期：2001-04-01 00:00:00

abstract：:Many cytoplasmic vesicles are observed to move along microtubules. Often, bidirectional movement of particles is observed on a single microtubule. We have isolated one cytoplasmic motor, kinesin, and defined another, the axoplasmic retrograde factor, which are capable of powering anionic latex beads toward the plus an...

journal_title：Annals of the New York Academy of Sciences

authors： Sheetz MP,Vale R,Schnapp B,Schroer T,Reese T

更新日期：1987-01-01 00:00:00

abstract：:By virtue of the progress in proteomics, the involvement of posttranslational modifications in aging has been more clearly demonstrated in recent years. We describe here that (1) carbonylation, a hallmark of protein oxidation in general, is paradoxically decreased in histone with aging and increased by calorie restric...

journal_title：Annals of the New York Academy of Sciences

authors： Nakamura A,Kawakami K,Kametani F,Nakamoto H,Goto S

更新日期：2010-06-01 00:00:00

abstract：:The identification of high-affinity ligands for PPAR gamma has revealed the role of this receptor as the molecular target for the antidiabetic activity of the thiazolidinediones. The surprising observation that agonists of an adipogenic transcription factor reverse the obesity-associated disease of diabetes highlights...

journal_title：Annals of the New York Academy of Sciences

authors： Willson TM,Lehmann JM,Kliewer SA

更新日期：1996-12-27 00:00:00

abstract：:The mechanisms controlling ATP generation in the transition from normal resting conditions to either high work states or ischemia are poorly understood. ATP generation depends upon compartmentation between the mitochondria and cytosol of metabolic pathways and key energy transfer species that cannot be easily assessed...

journal_title：Annals of the New York Academy of Sciences

authors： Zhou L,Yu X,Cabrera ME,Stanley WC

更新日期：2006-10-01 00:00:00

abstract：:After successful marrow transplantation (BMT) iron overload remains an important cause of morbidity in Thalassemia. After BMT, patients have normal erythropoiesis capable of producing a hyperplastic response to phlebotomy so that this procedure can be contemplated as a method of mobilizing iron from overloaded tissues...

journal_title：Annals of the New York Academy of Sciences

authors： Angelucci E,Muretto P,Lucarelli G,Ripalti M,Baronciani D,Erer B,Galimberti M,Annibali M,Giardini C,Gaziev D,Rapa S,Polchi P

更新日期：1998-06-30 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1)-positive patients in the late phase of infection develop AIDS dementia complex, an array of neurological complications that include extrapyramidal symptoms, cognitive impairments, and psychiatric disturbances. Brains of these patients exhibit brain injury. The HIV-1 envelope...

journal_title：Annals of the New York Academy of Sciences

authors： Bachis A,Mocchetti I

更新日期：2005-08-01 00:00:00

abstract：:Stereotactic core needle biopsy has proven to be an accurate technique for evaluation of mammographically detected microcalcification. The development of the Mammotome biopsy system has led many medical centers to use this vacuum-assisted device for the sampling of microcalcifications in mammographically detected nonp...

journal_title：Annals of the New York Academy of Sciences

authors： Faour I,Al-Salam S,El-Terifi H,El Taji H

更新日期：2008-09-01 00:00:00

abstract：:Evidence from experimental animal studies show that sex hormones influence the glucocorticoid response to a variety of inflammatory and noninflammatory stimuli. In this study we assessed gender differences in the response of ACTH and cortisol in normal young male and female humans following intravenous infusion of hum...

journal_title：Annals of the New York Academy of Sciences

authors： Silva C,Ines LS,Nour D,Straub RH,da Silva JA

更新日期：2002-06-01 00:00:00

abstract：:Evolutionary theories suggest that the expression of extended longevity depends on the organism's ability to shift energy from reproduction to somatic maintenance. New data led us to reexamine our older data and integrate the two into a larger picture of the genetic and metabolic alterations required if the animal is ...

journal_title：Annals of the New York Academy of Sciences

authors： Arking R,Buck S,Hwangbo DS,Lane M

更新日期：2002-04-01 00:00:00

abstract：:Microgravity experiments on the constrained vapor bubble heat exchanger (CVB) are being developed for the space station. Herein, ground-based experimental studies on condensate removal in the condenser region of the vertical CVB were conducted and the mechanism of condensate removal in microgravity was found to be the...

journal_title：Annals of the New York Academy of Sciences

authors： Zheng L,Wang Y,Wayner PC Jr,Plawsky JL

更新日期：2002-10-01 00:00:00

abstract：:This review aims to discuss the neurophysiology of the esophagus and new methods to assess esophageal nociception. Pain and other symptoms can be caused by diseases in the mucosa or muscular or sphincter dysfunction, together with abnormal pain processing, either in the peripheral or central nervous systems. Therefore...

journal_title：Annals of the New York Academy of Sciences

authors： Brock C,McCallum RW,Gyawali CP,Farmer AD,Frøkjaer JB,McMahon BP,Drewes AM

更新日期：2016-09-01 00:00:00

abstract：:There is increasing evidence that food is an important factor that influences and shapes the composition and configuration of the gut microbiota. Most studies have focused on macronutrients (fat, carbohydrate, protein) in particular and their effects on the gut microbiota. Although the microbiota can synthesize differ...

journal_title：Annals of the New York Academy of Sciences

authors： Biesalski HK

更新日期：2016-05-01 00:00:00

abstract：:Collagen VI is a large, disulfide-bonded protein complex which is widely distributed in connective tissue. The constituent polypeptide chains (Mr = 110,000-140,000) consist of collagenous and noncollagenous segments, are degraded to chains of about half the size when collagen VI is solubilized by pepsin, and assemble ...

journal_title：Annals of the New York Academy of Sciences

authors： Engel J,Furthmayr H,Odermatt E,von der Mark H,Aumailley M,Fleischmajer R,Timpl R

更新日期：1985-01-01 00:00:00

abstract：:T-lymphocytes from three species of New World monkeys were susceptible to transformation in vitro with human T-cell leukemia virus. Marmoset T-lymphocytes transformed in vitro with HVS or HVA, T-lymphotropic herpesviruses of New World monkeys, were also transformed with HTLV resulting in doubly transformed T-cells. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Falk LA Jr,Byington R,Silva DP

更新日期：1984-01-01 00:00:00

abstract：:Zoonoses are animal and human diseases. Q fever is primarily a zoonosis-an animal disease that can be transmitted to humans under certain conditions. Recent epidemiological studies suggest that Q fever should be considered as a public health problem in many countries where it is present, but unrecognizable due to inad...

journal_title：Annals of the New York Academy of Sciences

authors： Beslagić E,Hamzić S,Beslagić O,Zvizdić S

更新日期：2006-10-01 00:00:00

abstract：:Diverse mutations in the gene encoding the copper transporter ATP7A lead to X-linked recessive Menkes disease or occipital horn syndrome. Recently, two unique ATP7A missense mutations, T994I and P1386S, were shown to cause isolated adult-onset distal motor neuropathy. These mutations induce subtle defects in ATP7A int...

journal_title：Annals of the New York Academy of Sciences

authors： Yi L,Kaler S

更新日期：2014-05-01 00:00:00

abstract：:DNA methylation and histone modification promote changes in chromatin structure that may affect gene expression in a heritable manner without directly altering the genome. As such, these phenomena are considered to be epigenetic in nature and are believed to contribute to the normal processes of human development but ...

journal_title：Annals of the New York Academy of Sciences

authors： Sutherland JE,Costa M

更新日期：2003-03-01 00:00:00

abstract：:Friendship pervades the human social landscape. These bonds are so important that disrupting them leads to health problems, and difficulties forming or maintaining friendships attend neuropsychiatric disorders like autism and depression. Other animals also have friends, suggesting that friendship is not solely a human...

journal_title：Annals of the New York Academy of Sciences

authors： Brent LJ,Chang SW,Gariépy JF,Platt ML

更新日期：2014-05-01 00:00:00

abstract：:The purpose of this paper is to review the advances in electromagnetic levitation techniques as tools for determination of the thermophysical properties of molten metals under standard gravity and microgravity conditions. We show that a combination of containerless processing and microgravity offers the exclusive poss...

journal_title：Annals of the New York Academy of Sciences

authors： Bakhtiyarov SI,Overfelt RA

更新日期：2002-10-01 00:00:00

abstract：:Enhancer DNA decoy oligonucleotides (ODNs) inhibit transcription by competing for transcription factors. A decoy ODN composed of the cAMP response element (CRE) inhibits CRE-directed gene transcription and tumor growth without affecting normal cell growth. We used DNA microarrays to analyze the global gene expression ...

journal_title：Annals of the New York Academy of Sciences

authors： Cho-Chung YS

更新日期：2003-12-01 00:00:00

abstract：:The identification of immunologic biomarkers associated with clinical response after immune intervention for cancer is an area of intensive investigation. The field would benefit from a more systemic and directed approach for biomarker identification and evaluation. Lessons can be learned from other fields, such as ca...

journal_title：Annals of the New York Academy of Sciences

authors： Dang Y,Disis ML

更新日期：2009-09-01 00:00:00

abstract：:Musical enculturation is a complex, multifaceted process that includes the development of perceptual processing specialized for the pitch and rhythmic structures of the musical system in the culture, understanding of esthetic and expressive norms, and learning the pragmatic uses of music in different social situations...

journal_title：Annals of the New York Academy of Sciences

authors： Trainor LJ,Marie C,Gerry D,Whiskin E,Unrau A

更新日期：2012-04-01 00:00:00

abstract：:A small but measurable component of some indoor lighting is ultraviolet radiation (UVR); whether it is sufficient to modify the indoor worker's risk for chronic skin changes is not directly answerable with available technology. A first approach to this question involves a) estimating a range of annual background solar...

journal_title：Annals of the New York Academy of Sciences

authors： Cole C,Forbes PD,Davies RE,Urbach F

更新日期：1985-01-01 00:00:00

abstract：:An EEG profile for cannabis preparations equated for delta 9-THC activity has been defined in occasional cannabis users in New York and in long-term, high-dose hashish users in Athens. The EEG effects of enhanced alpha activity, decreased beta activity, and decreased mean frequency are dose dependent, both in intensit...

journal_title：Annals of the New York Academy of Sciences

authors： Fink M

更新日期：1976-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) have been long proposed to reside in defined anatomical locations within bone marrow (BM) tissues in direct contact or close proximity to nurturing cell types. Imaging techniques that allow the simultaneous mapping of HSCs and interacting cell types have been central to the discovery of...

journal_title：Annals of the New York Academy of Sciences

authors： Gomariz A,Isringhausen S,Helbling PM,Nombela-Arrieta C

更新日期：2020-04-01 00:00:00

abstract：:We reevaluated the exchange stoichiometry of the Na(+)/Ca(2+) exchange current by measuring its reversal potential. The exchange current was measured from the inside-out macropatch excised from intact sarcolemma of guinea pig ventricular myocytes. This method provides more accurate control of extracellular and cytopla...

journal_title：Annals of the New York Academy of Sciences

authors： Matsuoka S

更新日期：2002-11-01 00:00:00

abstract：:We have employed antisense methods to study the transcriptional functions of c-fos protein (Fos). Clones expressing inducible anti-fos RNA have been employed to inhibit c-fos expression, resulting in activation of c-fos transcription by inhibiting its normal repressor function. The sites of negative regulation by Fos ...

journal_title：Annals of the New York Academy of Sciences

authors： Holt JT

更新日期：1992-10-28 00:00:00