Neurophysiology and new techniques to assess esophageal sensory function: an update.

abstract：:In this chapter, we will review how signal transduction pathways have been assembled in the past, bringing us to our present understanding of this area of research. The methods employed have relied heavily upon the genetics of yeast, worms, flies, mice, and humans. The use of second site suppressors and epistasis has ...

journal_title：Annals of the New York Academy of Sciences

authors： Levine AJ,Hu W,Feng Z,Gil G

更新日期：2007-12-01 00:00:00

abstract：:Extracellular stress proteins including heat shock proteins (Hsps) and glucose-regulated proteins (Grps) are emerging as important mediators of intercellular signaling and transport. Release of such proteins from cells is triggered by physical trauma and behavioral stress as well as exposure to immunological "danger s...

journal_title：Annals of the New York Academy of Sciences

authors： Calderwood SK,Mambula SS,Gray PJ Jr

更新日期：2007-10-01 00:00:00

abstract：:The striatum is the major input nucleus of the basal ganglia. It is thought to play a key role in learning on the basis of positive reinforcement and in action selection. One view of the striatum conceives it as comprising a reiterated matrix of processing units that perform common operations in different striatal reg...

journal_title：Annals of the New York Academy of Sciences

authors： Wickens JR,Budd CS,Hyland BI,Arbuthnott GW

更新日期：2007-05-01 00:00:00

abstract：:A previous review of alternative treatments (Tx) of ADHD--those other than psychoactive medication and behavioral/psychosocial Tx--was supplemented with an additional literature search focused on adults with ADHD. Twenty-four alternative Tx were identified, ranging in scientific documentation from discrediting control...

journal_title：Annals of the New York Academy of Sciences

authors： Arnold LE

更新日期：2001-06-01 00:00:00

abstract：:Although stress is tightly connected with elevated levels of catecholamines, stress effects on target structures of catecholamine action--adrenoceptors (ARs)--has not been deeply studied yet. Similarly, very little is known about changes of muscarinic receptors (MRs) during stress. We determined changes in these recep...

journal_title：Annals of the New York Academy of Sciences

authors： Myslivecek J,Tillinger A,Novakova M,Kvetnanský R

更新日期：2008-12-01 00:00:00

abstract：:The purpose of this study was to determine whether the previously reported differences in adenylate cyclase activity between the sarcolemma of normal and dystrophic chick muscles are also found in the SR, to search for a possible relationship between the adenylate cyclase changes and the pathophysiology of dystrophy, ...

journal_title：Annals of the New York Academy of Sciences

authors： Rodan GA,Rodan SB,Raible DG,Cutler LS,Wacholtz M,Sha'afi RI

更新日期：1979-01-01 00:00:00

abstract：:Translational medicine describes a bench-to-bedside approach that eventually converts findings from basic scientific studies into real-world clinical research. It encompasses new treatments, advanced equipment, medical procedures, preventive and diagnostic approaches creating a bridge between basic studies and clinica...

journal_title：Annals of the New York Academy of Sciences

authors： Amirmahani F,Ebrahimi N,Molaei F,Faghihkhorasani F,Jamshidi Goharrizi K,Mirtaghi SM,Borjian-Boroujeni M,Hamblin MR

更新日期：2021-01-06 00:00:00

abstract：:The endothelial cells cultured in collagen gel caused upregulation of KDR expression, which resulted in an increase in tube formation. Endothelial cells exposed to high glucose (33 mmol/l) for 30 days increased the tube formation induced by VEGF, but not by serum and bFGF. Immunohistochemical study showed that KDR exp...

journal_title：Annals of the New York Academy of Sciences

authors： Murota SI,Onodera M,Morita I

更新日期：2000-05-01 00:00:00

abstract：:Papillomaviruses are widespread, sexually transmitted agents with an increasing prevalence. They are associated with a significant risk of genital carcinoma in infected women. Because they can be transmitted to the fetus before or during birth, they are also a risk to the infant born to an infected woman. Laryngeal HP...

journal_title：Annals of the New York Academy of Sciences

authors： Steinberg BM

更新日期：1988-01-01 00:00:00

abstract：:Transmission of HIV from mothers to children may occur through the transplacental, intrapartum, or breastfeeding routes. Adequate nutritional status may reduce vertical transmission by affecting several maternal or fetal and child risk factors for transmission including enhancing systemic immune function in the mother...

journal_title：Annals of the New York Academy of Sciences

authors： Fawzi W

更新日期：2000-11-01 00:00:00

abstract：:Although it is now well established that imidazoline receptors and alpha 2-adrenoceptors are discrete entities with distinct endogenous ligands, the two receptor classes apparently have several common features. While the catecholamines stimulate alpha 2-adrenoceptors but not imidazoline receptors, agmatine, a guanidin...

journal_title：Annals of the New York Academy of Sciences

authors： Hieble JP,Ruffolo RR Jr

更新日期：1995-07-12 00:00:00

abstract：:While the ovaries are the principal source of systemic estrogen in the premenopausal nonpregnant woman, other sites of estrogen biosynthesis are present throughout the body and these become the major sources of estrogen beyond menopause. These extragonadal sources of estrogen are small, but may play an important, thou...

journal_title：Annals of the New York Academy of Sciences

authors： Simpson ER,Clyne C,Speed C,Rubin G,Bulun S

更新日期：2001-12-01 00:00:00

abstract：:Primates have stimulated more interest than any other group as humans are ranked in this same mammalian order. Gustatory responses of human and nonhuman primates have already been compared for compounds such as monosaccharides, oligosaccharides, polyols, amino acids, dipeptides, proteins, dihydrochalcones, sulfamates,...

journal_title：Annals of the New York Academy of Sciences

authors： Glaser D,Tinti JM,Nofre C

更新日期：1998-11-30 00:00:00

abstract：:Clinical research has demonstrated that increased or decreased estradiol 2-hydroxylation can easily be achieved with a number of experimental approaches. In contrast, estradiol 16 alpha-hydroxylation, which may have potentially deleterious effects in estrogen-dependent tissues, cannot be readily altered. Predictable h...

journal_title：Annals of the New York Academy of Sciences

authors： Michnovicz JJ,Bradlow HL

更新日期：1990-01-01 00:00:00

abstract：:Over the last years, El Sistema--the Venezuelan project started in 1975 and now acknowledged worldwide as the most significant example of collective music education--has inspired a profusion of remarkable initiatives on all continents. From the original impulse by founder José Antonio Abreu, strong social principles o...

journal_title：Annals of the New York Academy of Sciences

authors： Majno M

更新日期：2012-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease which in Western societies mainly accounts for clinical dementia. A high proportion of women are affected by this disease, especially at a very advanced age, which might to a large extent be associated with the fact that women live l...

journal_title：Annals of the New York Academy of Sciences

authors： Candore G,Balistreri CR,Grimaldi MP,Vasto S,Listì F,Chiappelli M,Licastro F,Lio D,Caruso C

更新日期：2006-11-01 00:00:00

abstract：:We have evaluated different behavioral parameters in ICR (CD1) female mice of three different ages (38-39 weeks: mature; 62 weeks: late mature; 90 weeks: old), and addressed the effects of an enriched housing condition. We employed the following battery of tests: Holeboard, open field, elevated plus-maze (EPM), and fo...

journal_title：Annals of the New York Academy of Sciences

authors： Zambrana C,Marco EM,Arranz L,de Castro NM,Viveros MP,de la Fuente M

更新日期：2007-04-01 00:00:00

abstract：:In his First Law (of thermodynamics), Clausius emphasized the equivalence of heat and work-conservation of energy was mentioned only indirectly. Today, the main emphasis is put on energy conservation, but the equivalence of heat and work has proven not only to be superfluous, but also highly destructive. Because of th...

journal_title：Annals of the New York Academy of Sciences

authors： Job G,Lankau T

更新日期：2003-05-01 00:00:00

abstract：:The control of expression of human class II MHC genes has been studied in lymphoid and melanoma cells. Specific unmethylation of all restriction sites nearby the promoter regions has been detected in all cell lines and tissues studied, irrespective of their ability to express class II MHC products. The main functional...

journal_title：Annals of the New York Academy of Sciences

authors： Gambari R,Barbieri R,Piva R,Tecce R,Fisher PB,Giacomini P,Natali PG

更新日期：1987-01-01 00:00:00

abstract：:The skeletal dysplasias or osteochondrodysplasias are a clinically and genetically heterogeneous group of disorders of bone and/or cartilage. They are characterized by abnormalities in pattering, linear growth, differentiation, and maintenance of the human skeleton. While they have been considered to be generalized di...

journal_title：Annals of the New York Academy of Sciences

authors： Rimoin DL,Cohn D,Krakow D,Wilcox W,Lachman RS,Alanay Y

更新日期：2007-11-01 00:00:00

abstract：:Influenza A virus infections result in approximately 500,000 human deaths per year and many more sublethal infections. Wild birds are recognized as the ancestral host of influenza A viruses, and avian viruses have contributed genetic material to most human viruses, including subtypes H5N1 and H1N1. Thus, influenza vir...

journal_title：Annals of the New York Academy of Sciences

authors： Vandegrift KJ,Sokolow SH,Daszak P,Kilpatrick AM

更新日期：2010-05-01 00:00:00

abstract：:Gene therapy as an immunomodulatory approach has the potential to treat various inherited and acquired immune-based human diseases. However, its clinical application has several challenges, varying from the efficiency of gene transfer, control of gene expression, cell and tissue targeting, and safety concerns associat...

journal_title：Annals of the New York Academy of Sciences

authors： Singh NP,Yolcu ES,Askenasy N,Shirwan H

更新日期：2005-11-01 00:00:00

abstract：:The levels of cellular glutathione (GSH) and reactive oxygen species (ROS) simultaneously determined by fluorometric measurement, may provide important information on pro-oxidative and antioxidative balance. The dual effect of quercetin antioxidant and pro-oxidant activity was proposed from different studies. Our stud...

journal_title：Annals of the New York Academy of Sciences

authors： Kim GN,Jang HD

更新日期：2009-08-01 00:00:00

abstract：:Although much is known about the pleiotropic effects mediated by relaxin, the exact signaling pathways involved remain relatively elusive. This study examines LGR7 and LGR8 signaling using reporter gene technology. The greatest response was observed at the CRE reporter (indicates activation of cAMP-PKA and p38/JNK pat...

journal_title：Annals of the New York Academy of Sciences

authors： Halls ML,Bathgate RA,Roche PJ,Summers RJ

更新日期：2005-05-01 00:00:00

abstract：:An attempt has been made to describe several actions of progesterone related to the preparation of the uterus for decidualization. These actions result from classical ligand-receptor interactions as well as from nonreceptor-mediated changes, that is, those imposed by metabolic inactivation of the steroid. By opposing ...

journal_title：Annals of the New York Academy of Sciences

authors： Yochim JM

更新日期：1986-01-01 00:00:00

abstract：:Every 365.2421999 days--more or less--the earth rotates, revolves, wobbles, and precesses along an elliptical path around the sun. Those of us who survive the journey are a year older: we have aged one solar year. Some years we seem to age faster than other years; some people seem to age faster than other people; some...

journal_title：Annals of the New York Academy of Sciences

authors： Haaga J,O'Connor K,Weinstein M,Wise P

更新日期：2010-08-01 00:00:00

abstract：:The innervation of muscles in patients with the post-polio syndrome (PPS) may differ from limb to limb or even within the same limb because of the segmental nature of the initial involvement and the varying degree of subsequent recovery. Consequently, the compensatory effort of the neighboring muscles varies even in t...

journal_title：Annals of the New York Academy of Sciences

authors： Dalakas MC

更新日期：1995-05-25 00:00:00

abstract：:Here we briefly review our studies that have unraveled an important role for the calcium- and calmodulin-sensitive enzyme calcineurin (CN) in bone remodeling. We find that the genetic deletion of the calcineurin Aalpha isoform results in osteoporosis, which is recapitulated in humans following calcineurin inhibitor th...

journal_title：Annals of the New York Academy of Sciences

authors： Sun L,Zhu LL,Zaidi N,Yang G,Moonga BS,Abe E,Iqbal J,Epstein S,Blair HC,Huang CL,Zaidi M

更新日期：2007-11-01 00:00:00

abstract：:Fibrinogen, a clottable plasma glycoprotein, participates in cell adhesion phenomena involving prokaryotic cells, e.g. staphylococci, and eukaryotic cell fragments, e.g. platelets. Among the three chains (alpha, beta, gamma) of human fibrinogen, the gamma chain bears the main site recognizing the staphylococcal clumpi...

journal_title：Annals of the New York Academy of Sciences

authors： Hawiger J,Kloczewiak M,Timmons S,Strong D,Doolittle RF

更新日期：1983-06-27 00:00:00

abstract：:We evaluated immune and endocrine status following antituberculosis treatment in HIV-negative patients with newly diagnosed tuberculosis (TB). Treatment led to a decrease in IL-6, IL-1β, and C-reactive protein levels. Cortisol levels decreased throughout the anti-TB treatment, particularly after 4 months, but changes ...

journal_title：Annals of the New York Academy of Sciences

authors： Bongiovanni B,Díaz A,D'Attilio L,Santucci N,Dídoli G,Lioi S,Nannini LJ,Gardeñez W,Bogue C,Besedovsky H,del Rey A,Bottasso O,Bay ML

更新日期：2012-07-01 00:00:00