Abstract：
:The levels of cellular glutathione (GSH) and reactive oxygen species (ROS) simultaneously determined by fluorometric measurement, may provide important information on pro-oxidative and antioxidative balance. The dual effect of quercetin antioxidant and pro-oxidant activity was proposed from different studies. Our study demonstrated that quercetin acted as an antioxidant in HepG2 cells when cells were treated with 10 and 100 micromol/L quercetin for 30 min, but quercetin acted as a pro-oxidant when cells were incubated at 100 micromol/L quercetin for longer periods (12 and 24 h). Quercetin is capable of reducing H(2)O(2)-induced oxidative stress of HepG2 cells through different mechanisms, such as detoxification of H(2)O(2,) inhibition of ROS generation, and removal of generated ROS. We find that quercetin can block ROS generation through Fenton reaction to produce hydroxyl radicals by chelating with transition metal ions such as Cu(2+). Evidence that quercetin might exert an antioxidant effect by changing generated ROS into less reactive ROS suggests that when quercetin reacts with ROS, it becomes oxidized, which is less harmful but still reactive, and the oxidized quercetin interacts with thiol compounds as reduced GSH to return to the parent compound quercetin. In contrast, the prolonged treatment of quercetin in high concentrations (100 micromol/L) shows that quercetin may act as a pro-oxidant rather than as an antioxidant, resulting in cell death (apoptosis).
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Kim GN,Jang HDdoi
10.1111/j.1749-6632.2009.04690.xsubject
Has Abstractpub_date
2009-08-01 00:00:00pages
530-7eissn
0077-8923issn
1749-6632pii
NYAS4690journal_volume
1171pub_type
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