Abstract：
:Patients with vascular dementia are frequently encountered in Japan reaching nearly 50% of those with senile dementia, which is equal to or even slightly higher than patients with Alzheimer's disease. This contrasts with a much lower ratio of patients with vascular dementia in the United States. The majority of vascular dementia seen in Japan is of the multiple lacunar type or Binswanger disease, often without any episode of stroke. Clinically, those patients tend to have attention deficit and reduction of spontaneous activities. The observed characteristics of vascular dementia likely reflect the main type of cerebrovascular disease prevalent in Japan since the majority of cerebral infarction in Japan is of lacunar type in contrast to that in the United States and Europe. For patients without any episode of stroke, it is important to differentiate from Alzheimer's disease. As in the United States and Europe, mixed dementia exists in Japan with Alzheimer's disease and vascular dementia together and poses problems in clinical diagnosis because many patients may not have any episode of stroke, but they have neuroimaging characteristics compatible with both. The number of patients with atherosclerosis in large cervical and cerebral arteries is said to be increasing in Japan, and vascular dementia in Japan may present with different clinical pictures in the future.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Yanagihara Tdoi
10.1111/j.1749-6632.2002.tb04795.xsubject
Has Abstractpub_date
2002-11-01 00:00:00pages
24-8eissn
0077-8923issn
1749-6632journal_volume
977pub_type
杂志文章abstract：:Phyloproteomics indicate common viral origin from ancient cells before archaea, bacteria, and eukaryota split and subsequent size and complexity reductions occurred. Further independent evidence for the cellular origin of viruses is reviewed for the virus order Megavirales, focusing on the family Poxviridae. Megaviral...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1111/nyas.14022
更新日期：2019-07-01 00:00:00
abstract：:One in 12 people worldwide suffers from diabetes and more than 90% of affected adult individuals are diagnosed with type 2 diabetes mellitus (T2DM). Obesity adds to the personal risk to develop T2DM, and both metabolic diseases are rampantly increasing worldwide. Over recent years, primary cilia have moved into the fo...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1111/nyas.13216
更新日期：2017-03-01 00:00:00
abstract：:The ability to recognize and discriminate conspecific faces and facial expressions has played a critical role in the evolution of social communication. Darwin was one of the first to speculate that human and nonhuman primate facial expressions share similar mechanisms for production and functions in expressing emotion...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1196/annals.1280.005
更新日期：2003-12-01 00:00:00
abstract：:An apparently macromolecular factor is isolated from aqueous skin extracts which inhibits DNA synthesis in vivo and in vitro with high efficacy (ID50 in vivo 0.2 pmol/g, in vitro 0.2 pM) and in a highly specific manner showing a point of attack in the late G1-phase of the cell cycle (epidermal G1-chalone). Preliminary...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1111/j.1749-6632.1988.tb18808.x
更新日期：1988-01-01 00:00:00
abstract：:Proopiomelanocortin (POMC) and proenkephalin (PE) are synthesized at the endoplasmic reticulum and transported to the trans-Golgi network (TGN) where they are sorted and packaged into dense-core granules of the regulated secretory pathway (RSP). The mechanism of sorting POMC and PE to the RSP in neuroendocrine cells w...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1111/j.1749-6632.2002.tb04504.x
更新日期：2002-10-01 00:00:00
abstract：:During neuronal circuit formation, axons are guided to their targets by the help of axon guidance molecules, which are required for establishing functional circuits. A promising system to dissect the development and functionalities of neuronal circuitry is the spinal cord central pattern generator (CPG) for locomotion...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1111/j.1749-6632.2012.06801.x
更新日期：2013-03-01 00:00:00
abstract：:Studies in humans and in animal models have demonstrated that the receptor-dependent actions of 1,25-dihydroxyvitamin D are required for normal skeletal growth and maturation. Investigations were undertaken to address which consequences of vitamin D receptor deficiency are a direct result of impaired receptor-dependen...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1196/annals.1346.026
更新日期：2006-04-01 00:00:00
abstract：:In this chapter we examine whether rapists are sexually aroused by coercive, nonconsensual sex. This question is theoretically important because it speaks to a potential sexual motivation underlying rape. It is also clinically important in that it may reveal an important assessment and treatment target. We first revis...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.2003.tb07307.x
更新日期：2003-06-01 00:00:00
abstract：:Cognitive enhancement, the amplification or extension of core capacities of the mind, has become a major topic in bioethics. But cognitive enhancement is a prime example of a converging technology where individual disciplines merge and issues transcend particular local discourses. This article reviews currently availa...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1196/annals.1382.015
更新日期：2006-12-01 00:00:00
abstract：:Structural analysis of secretin in solution has demonstrated extended helical domains within both amino- and carboxyl-terminal halves, with a possible turn in between. However, the conformation of this peptide as it resides in its binding site within the receptor has not been established. In the work reported here, we...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.2000.tb07000.x
更新日期：2000-01-01 00:00:00
abstract：:Tocopherols and tocotrienols (vitamin E) and ascorbic acid (vitamin C) as well as the carotenoids react with free radicals, notably peroxyl radicals, and with singlet molecular oxygen (1O2), this being the basis of their function as antioxidants. RRR-alpha-tocopherol is the major peroxyl radical scavenger in biologica...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1111/j.1749-6632.1992.tb17085.x
更新日期：1992-09-30 00:00:00
abstract：:In order to analyze neuronal computations in the first olfactory processing center, the olfactory bulb, we measured odor-evoked activity patterns across large numbers of neurons within the intact olfactory bulb of zebrafish using optical and electrophysiological methods. We found that the olfactory bulb performs multi...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.2009.04010.x
更新日期：2009-07-01 00:00:00
abstract：:Oropharyngeal dysphagia (OD) is a swallowing disorder caused by congenital abnormalities and structural damage and disease-associated damage of the oral cavity, pharynx, and upper esophageal sphincter. Patients with OD lack the protective mechanisms necessary for effective swallowing, exhibiting difficulty controlling...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1111/nyas.12234
更新日期：2013-10-01 00:00:00
abstract：:This review outlines the scientific rationale supporting the potential use of deep-brain electrical stimulation (DBS) in the central thalamus as a method to improve behavioral responsiveness following severe brain injury. Neurons within the central thalamus are selectively vulnerable to disconnection and dysfunction f...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1111/j.1749-6632.2008.04123.x
更新日期：2009-03-01 00:00:00
abstract：:The asymmetric inheritance of NUMB during mitosis determines future daughter cell fates in multiple model organisms. NUMB asymmetric inheritance has also been postulated for hematopoietic stem cell (HSC) divisions but remained controversial until recently. To reconcile conflicting reports, we revisited the evidence fo...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/nyas.14284
更新日期：2020-04-01 00:00:00
abstract：:1. There are several endogenous ligands that bind to I-receptors of both the I1 and I2 subclass. These include: (a) classic CDS, a partially purified entity isolated by the criteria that it displaces binding ligands to alpha 2- and I-receptors; (b) immunoreactive (ir)-CDS, a moiety that binds to antibodies raised agai...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1111/j.1749-6632.1995.tb32416.x
更新日期：1995-07-12 00:00:00
abstract：:In common marmoset monkeys (Callithrix jacchus, order Primates), infants aged 2-28 days were deprived of parental care for 30-120 min/day in order to investigate the long-term effects of this neglect-stress model on affect and cognition in a primate species. Basal morning levels of urinary cortisol across the first ye...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1196/annals.1314.030
更新日期：2004-12-01 00:00:00
abstract：:Mouse Schwann cells and rat RN22 schwannoma cells cultured in the absence of neurons and fibroblasts produce typical basement membrane proteins. Heparan sulfate proteoglycan (low density form), nidogen, and protein BM-40 were identified by radioimmunoassays, immunoblotting, and by immunoprecipitation after metabolic l...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1986.tb48078.x
更新日期：1986-01-01 00:00:00
abstract：:Galanin is widely distributed in enteric nerves and nerve terminals throughout the gastrointestinal (GI) tract. Within the GI tract galanin is best known for its ability to alter smooth muscle contractility and regulate intestinal motility. However, recent studies also indicate that galanin can modulate epithelial ion...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1998.tb10684.x
更新日期：1998-12-21 00:00:00
abstract：:Advanced glycation endproducts (AGEs) and oxidative stress (OS) contribute to the development and progression of diabetic complications. We have reported that dietary AGEs and OS induce acute endothelial dysfunction in vivo, but little is known about their effects on adipokines. Twenty inpatients with type 2 diabetes ...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1196/annals.1433.042
更新日期：2008-04-01 00:00:00
abstract：:Morphogenesis in the animal kingdom is closely coupled with the intracellular synthesis and the extracellular deposition of collagen. These morphogenetically important events involve multiple steps which begin in compartments inside the cell and continue in compartments outside the cell. The movement of matrix compone...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1985.tb51173.x
更新日期：1985-01-01 00:00:00
abstract：:In this paper, we provide macromolecular comparisons utilizing the 5S ribosomal RNA structure to suggest extant bacteria that are the likely descendants of chloroplast and mitochondria endosymbionts. The genetic stability and near universality of the 5S ribosomal gene allows for a useful means to study ancient evolut...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1987.tb40601.x
更新日期：1987-01-01 00:00:00
abstract：:In an ever-changing environment, animals must learn new behavioral strategies for the successful procurement of food, sex, and other needs. Synaptic plasticity within the mesolimbic system, a key reward circuit, affords an animal the ability to adapt and perform essential goal-directed behaviors. Ironically, drugs of ...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1111/j.1749-6632.2009.05154.x
更新日期：2010-02-01 00:00:00
abstract：:Latent chronic ascorbic acid deficiency provokes in guinea pigs a metabolic disorder in the liver, causing an impaired cholesterol transformation to its principal catabolic product, bile acids. This metabolic disorder induces hypercholesterolemia and accumulation of cholesterol in the liver and slows the release of ch...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1975.tb29299.x
更新日期：1975-09-30 00:00:00
abstract：:In plants, the photons of light are absorbed at the level of the photosystems in the chloroplasts. The functioning of the photosynthetic electron transfer chain linked to this process is required to generate NADPH and ATP. In addition, the light signal promotes a regulatory cascade, situated in the stroma, that involv...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1111/j.1749-6632.2002.tb04692.x
更新日期：2002-11-01 00:00:00
abstract：:Exposure of quail eggs 4 hr per day during the first 5 incubation days at 2450 MHz and in an exposure field of 30 mW/cm-2 and at an absorbed power of 14 mW/g does not cause any great change in body weight, observed gross malformations, rbc, wbc, hematocrit, hemoglobin, or differential wbc percentages. If small differe...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1975.tb36012.x
更新日期：1975-02-28 00:00:00
abstract：:In recent years calcium channel blockers have emerged as a new class of antiarrhythmic agents for the control of certain supraventricular and ventricular arrhythmias. Electrophysiologically, they are heterogeneous but their main action is mediated through a depressant effect on the slow calcium channel in cardiac musc...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1111/j.1749-6632.1988.tb33397.x
更新日期：1988-01-01 00:00:00
abstract：:The Pawtucket Heart Health Program, a research effort testing a process of community activation for cardiovascular risk factor behavior change, risk factor change, and coronary heart disease event rate change, utilizes risk factor behavior change programs for the entire population of a northeastern city. A diversity o...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1991.tb43741.x
更新日期：1991-01-01 00:00:00
abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is well known to protect delayed neuronal cell death in the brain of rodents. In order to investigate the neuroprotective action of PACAP in the retina, we examined the effects of PACAP on kainic acid (KA)-induced neurotoxicity in the rat retina. Many ganglion...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1196/annals.1317.074
更新日期：2006-07-01 00:00:00
abstract：:The relationship between the concentration of cell-free DNA (cfDNA) and the number of proliferating/apoptotic lymphocytes in peripheral blood of premature newborns of different gestation age and full-term newborns was determined. The experiments were performed using fluorescent spectrophotometry (with Hoechst 33342), ...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1196/annals.1448.043
更新日期：2008-08-01 00:00:00
