Ascorbic acid in cholesterol and bile acid metabolism.

abstract：:Heart disease is a leading cause of death in newborns and in adults. Efforts to promote cardiac repair by introduction or recruitment of exogenous stem cells hold promise but typically involve isolation and introduction of autologous or donor progenitor cells. We have found that the G-actin-sequestering peptide thymos...

journal_title：Annals of the New York Academy of Sciences

authors： Srivastava D,Saxena A,Michael Dimaio J,Bock-Marquette I

更新日期：2007-09-01 00:00:00

abstract：:Evolutionary theories suggest that the expression of extended longevity depends on the organism's ability to shift energy from reproduction to somatic maintenance. New data led us to reexamine our older data and integrate the two into a larger picture of the genetic and metabolic alterations required if the animal is ...

journal_title：Annals of the New York Academy of Sciences

authors： Arking R,Buck S,Hwangbo DS,Lane M

更新日期：2002-04-01 00:00:00

abstract：:The amyloid-beta protein (A beta), strongly implicated in the etiology of Alzheimer's disease (AD), is formed from the amyloid-beta precursor protein (APP) through sequential proteolysis by beta- and gamma-secretases. Cleavage by gamma-secretase takes place within the middle of the single transmembrane region of APP a...

journal_title：Annals of the New York Academy of Sciences

authors： Moore CL,Diehl TS,Selkoe DJ,Wolfe MS

更新日期：2000-01-01 00:00:00

abstract：:In vitro clonal analyses were performed to gain insight into the mechanisms that control development of neural crest-derived cardiac outflow tract mesenchyme of quail embryos. The cardiac neural crest originates from the posterior rhombencephalic neural tube. The cells leave the neural tube and migrate through the pos...

journal_title：Annals of the New York Academy of Sciences

authors： Sieber-Blum M,Ito K

更新日期：1995-03-27 00:00:00

abstract：:This article reviews research on the Finnish model of peer-group mentoring (PGM). The theoretical foundation of the model is based on the constructivist theory of learning, the concept of autonomy in teaching profession, peer learning, and narrative identity work. The model has been disseminated nationwide in the educ...

journal_title：Annals of the New York Academy of Sciences

authors： Tynjälä P,Pennanen M,Markkanen I,Heikkinen HLT

更新日期：2021-01-01 00:00:00

abstract：:These findings demonstrate that calcium antagonists reverse renal vasoconstriction in a variety of settings. The ability of calcium antagonists to augment GFR of the vasoconstricted kidney is striking and has also been demonstrated in a number of in vivo settings. These observations and others raise the possibility th...

journal_title：Annals of the New York Academy of Sciences

authors： Loutzenhiser R,Epstein M

更新日期：1988-01-01 00:00:00

abstract：:The recording of chemosensory event-related potentials (CSERPs) has been established as an objective method in the assessment of central odor processing in humans. In the present study CSERPs were used to investigate whether human body odor is genetically determined by the major histocompatibility complex (MHC), refer...

journal_title：Annals of the New York Academy of Sciences

authors： Krauel K,Pause BM,Mueller C,Sojka B,Mueller-Ruchholtz W,Ferstl R

更新日期：1998-11-30 00:00:00

abstract：UNLABELLED:Whereas trauma-associated arousal has been linked fairly consistently with elevations in both glucocorticoids and catecholamines, neuroendocrine correlates of hyperarousal in the context of posttraumatic stress disorder (PTSD) have been more variable. Further, neuroendocrine predictors of the development of ...

journal_title：Annals of the New York Academy of Sciences

authors： Bierer LM,Tischler L,Labinsky E,Cahill S,Foa E,Yehuda R

更新日期：2006-07-01 00:00:00

abstract：:Children exposed in utero to cocaine are at risk for long-term neurobehavioral damage not just because of the drug itself, but also because of clustering of other health determinants, including low socioeconomic status, low maternal education, and maternal addiction, to mention a few. One methodologic approach to sepa...

journal_title：Annals of the New York Academy of Sciences

authors： Koren G,Nulman I,Rovet J,Greenbaum R,Loebstein M,Einarson T

更新日期：1998-06-01 00:00:00

abstract：:In plants, the photons of light are absorbed at the level of the photosystems in the chloroplasts. The functioning of the photosynthetic electron transfer chain linked to this process is required to generate NADPH and ATP. In addition, the light signal promotes a regulatory cascade, situated in the stroma, that involv...

journal_title：Annals of the New York Academy of Sciences

authors： Jacquot JP,Rouhier N,Gelhaye E

更新日期：2002-11-01 00:00:00

abstract：:Because of the sedative/hypnotic and euphoric effects of gamma-hydroxybutyric acid (GHB), the recreational use of the drug has increased significantly. In the current study we investigated the sedative and rewarding effects of GHB in Swiss Webster mice. Although the acute administration of GHB (200 mg/kg) caused marke...

journal_title：Annals of the New York Academy of Sciences

authors： Itzhak Y,Ali SF

更新日期：2002-06-01 00:00:00

abstract：:Calpain, an inactive proenzyme, translocates from the cytosol to the membrane upon binding calcium, and is activated at the membrane in the presence of calcium and PIP2. Activated calpain is very unstable and presumably used only once. Thus the primary targets of calpain are considered to be membrane or membrane-assoc...

journal_title：Annals of the New York Academy of Sciences

authors： Suzuki K,Saido TC,Hirai S

更新日期：1992-12-31 00:00:00

abstract：:T1DM is a disease that affects pancreatic beta cells and results in severe insulin depletion. T1DM is a multigenic disease, and the strongest genetic association with this disease is shown by the genes in MHC class II, namely, DQA1 and DQB1. The other gene that has been implicated in susceptibility to T1DM is the MICA...

journal_title：Annals of the New York Academy of Sciences

authors： Nikitina-Zake L,Ghaderi M,Park Y,Babu S,Eisenbarth G,Sanjeevi CB

更新日期：2004-12-01 00:00:00

abstract：:Stroke is a common and serious disease. Most studies have shown that basic public knowledge about what a stroke is, symptoms of a stroke, and the proper reaction to a stroke is quite deficient. The fact that a stroke affects cognitive, communicative, and motor functions may partially explain the poor reaction to acute...

journal_title：Annals of the New York Academy of Sciences

authors： Alberts MJ

更新日期：2012-09-01 00:00:00

abstract：:We review here evidence that a large portion of the caudomedial telencephalon of songbirds, distinct from the song control circuit, is involved in the perceptual processing of birdsong. When songbirds hear song, a number of caudomedial pallial areas are activated, as revealed by expression of the activity-dependent ge...

journal_title：Annals of the New York Academy of Sciences

authors： Mello CV,Velho TA,Pinaud R

更新日期：2004-06-01 00:00:00

abstract：:The counterregulatory response to hypoglycemia is a complex and well-coordinated process. As blood glucose concentration declines, peripheral and central glucose sensors relay this information to central integrative centers to coordinate neuroendocrine, autonomic, and behavioral responses and avert the progression of ...

journal_title：Annals of the New York Academy of Sciences

authors： Tesfaye N,Seaquist ER

更新日期：2010-11-01 00:00:00

abstract：:Membrane bioreactors can be operated with intermittent permeation and continuous aeration. Aeration close to the surface of a submerged membrane helps to maintain a membrane surface that is free from fouling. The conditions under which this occurs depend on the interaction between flux and aeration rate. Increased flu...

journal_title：Annals of the New York Academy of Sciences

authors： Howell JA,Arnot TC,Chua HC

更新日期：2003-03-01 00:00:00

abstract：:We found a novel genetic abnormality, heterozygous C-->T nucleotide substitution at position -1138 bp in the 5'-flanking region of the fibrinogen A alpha gene, in patients with hypofibrinogenemia. Luciferase reporter assay using the pGL3-basic vector and CHO cells indicates that the transcriptional activity of a vecto...

journal_title：Annals of the New York Academy of Sciences

authors： Okumura N,Terasawa F,Yonekawa O,Hamada E,Kaneko H

更新日期：2001-01-01 00:00:00

abstract：:The repeated, intermittent use of cocaine and other drugs of abuse produces profound and often long-lasting alterations in behavior and brain chemistry. It has been suggested that these consequences of drug use play a critical role in drug craving and relapse to addiction. This article reviews the effects of psychosti...

journal_title：Annals of the New York Academy of Sciences

authors： Shippenberg TS,Chefer VI,Zapata A,Heidbreder CA

更新日期：2001-06-01 00:00:00

abstract：:Iddm4 is a dominant non-major histocompatibility complex (MHC) determinant of diabetes susceptibility in BBDR rats treated with poly I:C, plus depletion of regulatory T cells. In congenic MHC-identical normal WF rats, Iddm4(d) sensitively and specifically predicts induced diabetes. We report a new diabetes-susceptible...

journal_title：Annals of the New York Academy of Sciences

authors： Blankenhorn EP,Descipio C,Rodemich L,Cort L,Leif JH,Greiner DL,Mordes JP

更新日期：2007-04-01 00:00:00

abstract：:Stabilization of images on the fovea during either fore/aft translation of a subject or fore/aft movement of a visual target in front of a stationary observer imposes complex geometrical requirements that depend upon the eccentricity of the object of interest with respect to the eyes. Each eye needs to be rotated inde...

journal_title：Annals of the New York Academy of Sciences

authors： Ramat S,Zee DS

更新日期：2005-04-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a chronic inflammatory condition associated with HLA B27. But the association is not absolute. Hence association with other HLA class I antigens and class II alleles was studied in a southern Indian population. Sixty-five patients with primary AS were typed serologically for HLA class I ...

journal_title：Annals of the New York Academy of Sciences

authors： Madhavan R,Parthiban M,Rajendran CP,Chandrasekaran AN,Zake L,Sanjeevi CB

更新日期：2002-04-01 00:00:00

abstract：:Twin and family studies have demonstrated that most cognitive traits are moderately to highly heritable. Neurodevelopmental disorders such as dyslexia, autism, and specific language impairment (SLI) also show strong genetic influence. Nevertheless, it has proved difficult for researchers to identify genes that would e...

journal_title：Annals of the New York Academy of Sciences

authors： Bishop DV

更新日期：2009-03-01 00:00:00

abstract：:The skin immune system includes a complex network of dendritic cells (DCs). In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms that maintain immune homeostasis and in pathogenic chronic inflammation in which immune responses are unrestrained. Harn...

journal_title：Annals of the New York Academy of Sciences

authors： Klechevsky E,Banchereau J

更新日期：2013-05-01 00:00:00

abstract：:We have earlier shown that monkeys reared with daily alternating monocular occlusion for the first few months of life develop large horizontal strabismus, A/V patterns, dissociated vertical deviation (DVD), and dissociated horizontal deviation (DHD). Here, we present results from neurophysiological experiments that sh...

journal_title：Annals of the New York Academy of Sciences

authors： Das VE

更新日期：2011-09-01 00:00:00

abstract：:Humans can discriminate whether a change in the direction of gravito-inertial force (GIF) is caused by body tilt or by linear translation. This ability, attributed to vestibular sensory fusion, is often examined by asking subjects to adjust an indicator to match their subjective earth-fixed vertical (SV). We used two ...

journal_title：Annals of the New York Academy of Sciences

authors： Guenther AL,Bartl K,Nauderer J,Schneider E,Huesmann A,Brandt T,Glasauer S

更新日期：2009-05-01 00:00:00

abstract：:Recent advances in the development of three different types of antiviral drugs, the nucleotide and non-nucleotide analogues acting as reverse transcriptase inhibitors (NRTIs) and the nonpeptidic viral protease inhibitors (PI), and their introduction in the management of patients with AIDS, either alone or in combinati...

journal_title：Annals of the New York Academy of Sciences

authors： Kino T,Chrousos GP

更新日期：2004-06-01 00:00:00

abstract：:Social behavior in most human societies is characterized by the following of moral rules explicitly justified by religious belief systems. These systems constitute the diverse domain of human sacred values. Supernatural entities as founders or warranty of moral principles may be seen as a form of "conversation stopper...

journal_title：Annals of the New York Academy of Sciences

authors： Tófalvy T,Viciana H

更新日期：2009-06-01 00:00:00

abstract：:Despite short halflife in biological fluids, nitric oxide (NO) can produce remote or long lasting effect in the cardiovascular system. Long distance transport or local storage of NO might explain these effects. In blood, recent findings suggest that in addition to being a major consumption pathway, interaction of NO w...

journal_title：Annals of the New York Academy of Sciences

authors： Muller B,Kleschyov AL,Alencar JL,Vanin A,Stoclet JC

更新日期：2002-05-01 00:00:00

abstract：:By a combination of trace techniques and various biochemical methods, information about the characteristics of a 15-kDa selenoprotein was obtained. After labeling of rats in vivo with [(75)Se]selenite, subcellular fractionation of the homogenates of the prostate, lung, brain, thyroid gland, and large intestine, and ge...

journal_title：Annals of the New York Academy of Sciences

authors： Kyriakopoulos A,Bukalis K,Roethlein D,Hoppe B,Graebert A,Behne D

更新日期：2004-12-01 00:00:00