Ecology of avian influenza viruses in a changing world.

Abstract:

:Influenza A virus infections result in approximately 500,000 human deaths per year and many more sublethal infections. Wild birds are recognized as the ancestral host of influenza A viruses, and avian viruses have contributed genetic material to most human viruses, including subtypes H5N1 and H1N1. Thus, influenza virus transmission in wild and domestic animals and humans is intimately connected. Here we review how anthropogenic change, including human population growth, land use, climate change, globalization of trade, agricultural intensification, and changes in vaccine technology may alter the evolution and transmission of influenza viruses. Evidence suggests that viral transmission in domestic poultry, spillover to other domestic animals, wild birds and humans, and the potential for subsequent pandemic spread, are all increasing. We highlight four areas in need of research: drivers of viral subtype dynamics; ecological and evolutionary determinants of transmissibility and virulence in birds and humans; the impact of changing land use and climate on hosts, viruses, and transmission; and the impact of influenza viruses on wild bird hosts, including their ability to migrate while shedding virus.

journal_name

Ann N Y Acad Sci

authors

Vandegrift KJ,Sokolow SH,Daszak P,Kilpatrick AM

doi

10.1111/j.1749-6632.2010.05451.x

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

113-28

eissn

0077-8923

issn

1749-6632

pii

NYAS5451

journal_volume

1195

pub_type

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