Movements of vesicles on microtubules.

abstract：:The distinction between episodic and semantic memory has become very popular since it was first proposed by Tulving in 1972. So far, very few neuropsychological, psychophysical, and imaging studies have related to the mnemonic aspects of music, notably on the long-term memory features, and practically nothing is known...

journal_title：Annals of the New York Academy of Sciences

authors： Platel H

更新日期：2005-12-01 00:00:00

abstract：:Previous studies have suggested that metabolic inhibition is neuroprotective, but little evidence has been provided to support this proposal. Using the in vitro rabbit retina preparation as an established model of the central nervous system (CNS), we measured the rate of glucose utilization and lactate production, and...

journal_title：Annals of the New York Academy of Sciences

authors： Maynard KI,Quiñones-Hinojosa A,Malek JY

更新日期：1999-01-01 00:00:00

abstract：:The Ras proteins, which regulate intracellular signaling by a cyclic process involving interconversion between active GTP-bound and inactive GDP-bound states, play an essential role in controlling the activity of several crucial signaling pathways regulating normal cellular proliferation. Mutational activation of RAS ...

journal_title：Annals of the New York Academy of Sciences

authors： Colombo S,Peri F,Tisi R,Nicotra F,Martegani E

更新日期：2004-12-01 00:00:00

abstract：:We have previously described proopiomelanocortin (POMC) gene-expression in human normal cultured dermal fibroblasts, and its dose- and time-dependent modulation by transforming growth factor-beta (TGF-beta) and tumor necrosis factor-alpha (TNF-alpha). The aim of the work described here was to investigate POMC-derived ...

journal_title：Annals of the New York Academy of Sciences

authors： Teofoli P,Frezzolini A,Puddu P,De Pità O,Mauviel A,Lotti T

更新日期：1999-10-20 00:00:00

abstract：:Transcriptome analysis is a powerful tool to characterize changes in leukocyte gene expression patterns and reveal very early molecular abnormalities in tissue. Herein, we report on characterization of the very earliest abnormalities in the transcriptome of leukocytes from young "prepathologic" NOD and NON female mice...

journal_title：Annals of the New York Academy of Sciences

authors： Gerling IC,Ali C,Lenchik N

更新日期：2003-11-01 00:00:00

abstract：:While the major population of T lymphocytes express T cell receptor (TCR) alpha beta-chains and recognize peptide antigens in association with either Major Histocompatibility Complex class I or class II molecules, a consensus view does not exist concerning either the nature of the antigen recognized or the nature of t...

journal_title：Annals of the New York Academy of Sciences

authors： Roberts K,Shevach EM

更新日期：1991-12-30 00:00:00

abstract：:While each region of the world faces unique public health challenges, environmental threats to vulnerable populations in Asia constitute a significant global public health challenge. Environmental threats to health are widespread and are increasing as nations in the region undergo rapid industrial development. One of ...

journal_title：Annals of the New York Academy of Sciences

authors： Suk WA,Davis EA

更新日期：2008-10-01 00:00:00

abstract：:We compare the evidence from human neuroimaging studies for and against two of the major hypotheses of how alterations in the brain's reward system underlie addiction. One of these, the impulsivity hypothesis, proposes that addiction is characterized by excessive sensitivity to reward combined with a failure of inhibi...

journal_title：Annals of the New York Academy of Sciences

authors： Hommer DW,Bjork JM,Gilman JM

更新日期：2011-01-01 00:00:00

abstract：:Interleukin (IL)-17-producing helper T (Th17) cells serve as a Th subset involved in epithelial cell- and neutrophil-mediated immune responses against extracellular microbes and in the development of various autoimmune diseases. The differentiation of Th17 cells is controlled by a number of intracellular signaling cas...

journal_title：Annals of the New York Academy of Sciences

authors： Nagai S,Kurebayashi Y,Koyasu S

更新日期：2013-03-01 00:00:00

abstract：:Accumulating evidence indicates that regulatory T cells play a crucial role in preventing autoimmunity. To examine the processes by which regulatory CD4(+) T cells are produced during immune repertoire formation, we have developed transgenic mice that express the influenza virus hemagglutinin (HA) and coexpress major ...

journal_title：Annals of the New York Academy of Sciences

authors： Caton AJ,Cozzo C,Larkin J 3rd,Lerman MA,Boesteanu A,Jordan MS

更新日期：2004-12-01 00:00:00

abstract：:There is considerable evidence linking alcohol consumption, sedation, and thyrotropin-releasing hormone (TRH) in the brain septum. We have shown that ethanol in clinically relevant concentrations can in vitro induce TRH release from the septum by a mechanism involving neuronal swelling. Corticotropin-releasing hormone...

journal_title：Annals of the New York Academy of Sciences

authors： Kiss A,Adameová A,Kubovcáková L,Jamal B,Bacová Z,Zórad S,Tybitanclová K,Kvetnanský R,Strbák V

更新日期：2004-06-01 00:00:00

abstract：:At the alpha(2A)-autoreceptors on the sympathetic nerve terminals of the human atrial appendages and rabbit pulmonary artery, rilmenidine and oxymetazoline exhibit different properties (antagonism and agonism, respectively). These opposite pharmacodynamic properties of alpha(2)-adrenoceptor ligands seem to be due to s...

journal_title：Annals of the New York Academy of Sciences

authors： Molderings GJ,Bonisch H,Bruss M,Gothert M

更新日期：2003-12-01 00:00:00

abstract：:A high index of suspicion is essential in arriving at the correct diagnosis of Lambert-Eaton myasthenic syndrome (LEMS). LEMS should be considered in the differential in any patient who has proximal weakness, reduced or absent muscle stretch reflexes, and dry mouth. Weakness predominates in hip and shoulder muscles, b...

journal_title：Annals of the New York Academy of Sciences

authors： Sanders DB

更新日期：2003-09-01 00:00:00

abstract：:Two well-characterized cannabinoid receptors (CBrs), CB1 and CB2, mediate the effects of cannabinoids and marijuana use, with functional evidence for other CBrs. CB1 receptors are expressed primarily in brain and peripheral tissues. For over a decade several laboratories were unable to detect CB2 receptors in brain an...

journal_title：Annals of the New York Academy of Sciences

authors： Onaivi ES,Ishiguro H,Gong JP,Patel S,Perchuk A,Meozzi PA,Myers L,Mora Z,Tagliaferro P,Gardner E,Brusco A,Akinshola BE,Liu QR,Hope B,Iwasaki S,Arinami T,Teasenfitz L,Uhl GR

更新日期：2006-08-01 00:00:00

abstract：:Anaplasma phagocytophilum (A. phagocytophilum, formerly Ehrlichia phagocytophila) is a tick-borne pathogen responsible for tick-borne fever in ruminants, equine granulocytic ehrlichiosis (EGE) in horses, canine granulocytic ehrlichiosis (CGE) in dogs, and for human granulocytic ehrlichiosis (HGE). Human cases have bee...

journal_title：Annals of the New York Academy of Sciences

authors： Alberti A,Sparagano OA

更新日期：2006-10-01 00:00:00

abstract：:The present experiments were conducted to determine the effects of neurotensin on secretion of a variety of anterior pituitary hormones. Conscious rats with indwelling cannulae in the third ventricle and external jugular vein were used and the effects on plasma hormone levels measured by radioimmunoassay. Neurotensin ...

journal_title：Annals of the New York Academy of Sciences

authors： McCann SM,Vijayan E,Koenig J,Krulich L

更新日期：1982-01-01 00:00:00

abstract：:To live beyond the octogenarian years, population and molecular genetic studies of centenarian sibships indicate that genetic factors play an increasingly important role as the limit of life span is approached. These factors are likely to influence basic mechanisms of aging that in turn broadly influence susceptibilit...

journal_title：Annals of the New York Academy of Sciences

authors： Perls T

更新日期：2002-04-01 00:00:00

abstract：:Kinetics of extracellular RNA accumulation in culture medium and at the cell surface along with their composition and distribution among cell-free and cell-surface-bound fractions were investigated in mycoplasma-contaminated and mycoplasma-free HeLa cells. It was shown that the mycoplasma infection influenced the conc...

journal_title：Annals of the New York Academy of Sciences

authors： Morozkin ES,Rykova EY,Vlassov VV,Laktionov PP

更新日期：2006-09-01 00:00:00

abstract：:Agonist interactions with release processes do not validate autoreceptor operation. Instead, the data suggests that autoreceptors function as homoreceptors. Declining efficacy of agonist inhibition of transmitter release with increasing stimulation "intensity" is not assignable to competition with endogenous transmitt...

journal_title：Annals of the New York Academy of Sciences

authors： Kalsner S

更新日期：1990-01-01 00:00:00

abstract：:The melanocortin (MC)-4 receptor participates in regulating body weight homeostasis. We demonstrated early that acute blockage of the MC-4 receptor increases food intake and relieves anorexic conditions in rats. Our recent studies show that 4-week chronic blockage of the MC-4 receptor leads to robust increases in food...

journal_title：Annals of the New York Academy of Sciences

authors： Schiöth HB,Lagerström MC,Watanobe H,Jonsson L,Vergoni AV,Ringholm A,Skarphedinsson JO,Skuladottir GV,Klovins J,Fredriksson R

更新日期：2003-06-01 00:00:00

abstract：:Analysis of the protein profile of mitochondria and its age-dependent variation is a promising approach to unravel mechanisms involved in aging and age-related diseases. Our studies focus on the mammalian mitochondrial membrane proteome, especially of the inner mitochondrial membrane with the respiratory chain complex...

journal_title：Annals of the New York Academy of Sciences

authors： Dencher NA,Frenzel M,Reifschneider NH,Sugawa M,Krause F

更新日期：2007-04-01 00:00:00

abstract：:Cognitive neuroscience research has traditionally overlooked half of the population. Arguing that variability in ovarian hormones confounds empirical findings, girls and women have been excluded from research for decades. But times are changing. This review summarizes historical trends that have led to a knowledge gap...

journal_title：Annals of the New York Academy of Sciences

authors： Beltz AM,Moser JS

更新日期：2020-03-01 00:00:00

abstract：:The adaptation of the vestibulo-ocular reflex (VOR) was studied in 26 normal subjects and 26 patients with cerebellar lesions, using horizontal vision-reversal prisms. In normal subjects, the adaptation of gain after wearing prisms for one hour was approximately 50% of the VOR value in the dark. In contrast to this, p...

journal_title：Annals of the New York Academy of Sciences

authors： Yagi T,Shimizu M,Sekine S,Kamio T,Suzuki JI

更新日期：1981-01-01 00:00:00

abstract：:One of the challenges facing health and welfare policymakers as well as researchers in most developed countries is the increasing demand for aging services and aged care. Low birth rates and rapid increases in the percentages of elderly people make aging and aged care one of the top-priority issues among the national ...

journal_title：Annals of the New York Academy of Sciences

authors： Soar J,Seo Y

更新日期：2007-10-01 00:00:00

abstract：:This paper discusses experimental research aimed at defining a base drag reduction device based on splitter plates. The unsteady three-dimensional nature of the flow is studied by Schlieren photography, particle image velocimetry, and measurement of the total unsteady lift and drag loads. ...

journal_title：Annals of the New York Academy of Sciences

authors： Neau L,Pruvost J,Rodriguez O,Loc TP

更新日期：2002-10-01 00:00:00

abstract：:Over 450 peer-reviewed papers containing the keyword Aspergillus fumigatus were published in 2011. Although this method may be an impossible task, I have selected three clusters of papers describing exciting recent advances in research on A. fumigatus. The first is the novel approach of in vivo imagining of experiment...

journal_title：Annals of the New York Academy of Sciences

authors： Osherov N

更新日期：2012-12-01 00:00:00

abstract：:Most anticancer treatments such as chemo- and radiotherapy induce DNA damage and apoptosis in normal cells. The aim of this study was to assess the induction of single and double DNA strand breaks (ssb and dsb, respectively) and apoptosis in normal human lymphocytes and rat thymocytes subjected to the action of H2O2, ...

journal_title：Annals of the New York Academy of Sciences

authors： Benítez-Bribiesca L,Sánchez-Suárez P

更新日期：1999-01-01 00:00:00

abstract：:Investigations of the I-Ek-restricted, cytochrome c-specific T-cell response in mice show that both T-cell receptor V alpha and V beta CDR3 residues and the use of particular V alpha s and V beta s are necessary for recognition. Data strongly suggest that specific CDR3 residues are important in contacting the peptide....

journal_title：Annals of the New York Academy of Sciences

authors： Davis MM,McHeyzer-Williams M,Chien YH

更新日期：1995-07-07 00:00:00

abstract：:Smooth septate junctions (sSJs) are cell-cell junctions that are thought to regulate the paracellular pathway of the intestine and renal system in arthropods. The detailed mechanism of action of sSJs is not well understood, because their molecular organization has remained elusive for a long time. Recently, two sSJ-sp...

journal_title：Annals of the New York Academy of Sciences

authors： Furuse M,Izumi Y

更新日期：2017-06-01 00:00:00

abstract：:1. The flow divider of the brachiocephalic branching of the rabbit aorta had both high and low shear stress regions, each of which was covered by endothelial cells with low and high permeability respectively, even in normolipidemic intact rabbits. When rabbits were placed on an atherogenic diet, low shear regions were...

journal_title：Annals of the New York Academy of Sciences

authors： Yoshida Y,Okano M,Wang S,Kobayashi M,Kawasumi M,Hagiwara H,Mitsumata M

更新日期：1995-01-17 00:00:00