Vitamin E decreases the hyperglucagonemia of diabetic rats.

abstract：:Enhanced levels of plasminogen activator inhibitor-1 (PAI-1) are considered to be a risk factor for pathological conditions associated with hypoxia or hyperinsulinemia. The expression of the PAI-1 gene is increased by insulin in different cells, although, the molecular mechanisms behind insulin-induced PAI-1 expressio...

journal_title：Annals of the New York Academy of Sciences

authors： Dimova EY,Kietzmann T

更新日期：2006-12-01 00:00:00

abstract：:The 65-kDa isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes, and most patients have serum antibodies reactive with conformational epitopes on the GAD65 molecule. The aims of this study were to prepare mutants of GAD65 to further localize the type 1 diabetes epitope in the region...

journal_title：Annals of the New York Academy of Sciences

authors： Myers MA,Fenalti G,Gray R,Scealy M,Tong JC,El-Kabbani O,Rowley MJ

更新日期：2003-11-01 00:00:00

abstract：:Recent years have witnessed an explosive growth in available biological data. This includes a tremendous quantity of sequence data (e.g., biological structures, genetic and physical maps, pathways) generated by genome and transcriptome projects focused on humans, mice, and a multitude of other species. Diabetes resear...

journal_title：Annals of the New York Academy of Sciences

authors： Petrovsky N,Silva D

更新日期：2004-12-01 00:00:00

abstract：:Natural systems harbor complex interactions that are fundamental parts of ecology and evolution. These interactions challenge our inclinations and training to seek the simplest explanations of patterns in nature. Not least is the likelihood that some complex processes might be missed when their patterns look similar t...

journal_title：Annals of the New York Academy of Sciences

authors： Kinnison MT,Hairston NG Jr,Hendry AP

更新日期：2015-12-01 00:00:00

abstract：:Mass changes of skeletal muscles occur in a variety of species during the migratory period. Phenotypic flexibility of flight muscle mass is considered to represent adaptations of the flight muscle to changing power requirements associated with changes in body mass. We analyzed the relationship between muscle masses an...

journal_title：Annals of the New York Academy of Sciences

authors： Bauchinger U,Biebach H

更新日期：2005-06-01 00:00:00

abstract：:Bacterial cell division is facilitated by the divisome, a dynamic multiprotein assembly localizing at mid-cell to synthesize the stress-bearing peptidoglycan and to constrict all cell envelope layers. Divisome assembly occurs in two steps and involves multiple interactions between more than 20 essential and accessory ...

journal_title：Annals of the New York Academy of Sciences

authors： Egan AJ,Vollmer W

更新日期：2013-01-01 00:00:00

abstract：:VH replacement occurs through RAG-mediated recombination between a cryptic recombination signal sequence (cRSS) presented in a rearranged VH gene and a 23-bp RSS from an upstream VH gene. VH replacement renews the entire VH coding region and extends the immunoglobulin heavy-chain (IgH) CDR3 regions preferentially with...

journal_title：Annals of the New York Academy of Sciences

authors： Liu Y,Fan R,Zhou S,Yu Z,Zhang Z

更新日期：2005-12-01 00:00:00

abstract：:The screwworm fly, Cochliomyia hominivorax (Coquerel), is a parasite that attacks all warm-blooded animals including humans. This parasite has caused significant losses to the livestock industries of the Americas. Since the screwworm eradication program was initiated in the Southeastern United States in 1957, the erad...

journal_title：Annals of the New York Academy of Sciences

authors： Wyss JH

更新日期：2000-01-01 00:00:00

abstract：:Aging is the major risk factor for both the development of chronic diseases and loss of functional capacity. Geroscience provides links among the biology of aging, the biology of disease, and the physiology of frailty, three fields where enormous progress has been made in the last few decades. While, previously, the f...

journal_title：Annals of the New York Academy of Sciences

authors： Kohanski RA,Deeks SG,Gravekamp C,Halter JB,High K,Hurria A,Fuldner R,Green P,Huebner R,Macchiarini F,Sierra F

更新日期：2016-12-01 00:00:00

abstract：:It is often proposed that quinolinic acid (QUIN) contributes to the pathophysiology of neuroinflammation because this kynurenine pathway metabolite is a selective agonist of N-methyl-D-aspartate (NMDA) receptors, and both its brain tissue and cerebrospinal fluid concentrations increase markedly with inflammation. Howe...

journal_title：Annals of the New York Academy of Sciences

authors： Obrenovitch TP

更新日期：2001-06-01 00:00:00

abstract：:The aim of this study was to investigate the influence of long-lasting, extensive rowing training on body fluids in 12 experienced rowers (23.3 +/- 6.3 years, 188.7 +/- 5.9 cm, 82.0 +/- 10.8 kg, body mass index [BMI] 23.7 +/- 2.1). All rowers had a light traditional breakfast about 3 h before the training. The subject...

journal_title：Annals of the New York Academy of Sciences

authors： Jürimäe J,Jürimäe T,Pihl E

更新日期：2000-05-01 00:00:00

abstract：:Our previous studies of anti-DNA antibodies in SLE have demonstrated a preferential use of V kappa I and V lambda II gene families to encode light chains of antibodies that express the anti-DNA-associated 3I and 8.12 idiotypes, respectively. In this study, we employed PCR to obtain V kappa I and V lambda II germline g...

journal_title：Annals of the New York Academy of Sciences

authors： Manheimer-Lory A,Irigoyen M,Gaynor B,Monhian R,Splaver A,Diamond B

更新日期：1995-09-29 00:00:00

abstract：:In order to better understand the enhancing effects of lowered oxygen (O2) tension on the growth in vitro of granulocyte-macrophage progenitor cells (CFU-GM), the effects of oxidizing species derived from molecular O2 were assessed on CFU-GM. Low density or nonadherent low density normal human bone marrow cells were p...

journal_title：Annals of the New York Academy of Sciences

authors： Broxmeyer HE,Cooper S,Gabig T

更新日期：1989-01-01 00:00:00

abstract：:Carnitine and its congeners may regulate the immune networks, and their influence on functions of immune cells predominantly or exclusively relies on carnitine-dependent energy production from fatty acids. A reduced pool of carnitines has been demonstrated in either serum or tissues, or both, from patients with a wide...

journal_title：Annals of the New York Academy of Sciences

authors： Famularo G,De Simone C,Trinchieri V,Mosca L

更新日期：2004-11-01 00:00:00

abstract：:Effects of sunlight have fascinated researchers for decades because nearly every living thing on earth is likely to be exposed to sunlight and the ultraviolet (UV) fraction of it. In addition to detrimental long-term effects such as immunosuppression and skin cancer, premature aging of the skin (photoaging) is a well-...

journal_title：Annals of the New York Academy of Sciences

authors： Brenneisen P,Sies H,Scharffetter-Kochanek K

更新日期：2002-11-01 00:00:00

abstract：:Altered metabolism of the Alzheimer's amyloid precursor protein (APP) appears to be a key event in the pathogenesis of Alzheimer's disease (AD), and both altered phosphorylation and oxidative stress appear to affect the production of the toxic Abeta fragment. Our results show that altered processing of APP was observe...

journal_title：Annals of the New York Academy of Sciences

authors： Domingues SC,Henriques AG,Wu W,Da Cruz e Silva EF,Da Cruz e Silva OA

更新日期：2007-01-01 00:00:00

abstract：:A previous review of alternative treatments (Tx) of ADHD--those other than psychoactive medication and behavioral/psychosocial Tx--was supplemented with an additional literature search focused on adults with ADHD. Twenty-four alternative Tx were identified, ranging in scientific documentation from discrediting control...

journal_title：Annals of the New York Academy of Sciences

authors： Arnold LE

更新日期：2001-06-01 00:00:00

abstract：:We have established several tumor T cell lines, both from the skin and from the blood of a patient with an MHC class II-/class I+, CD4+ cutaneous T cell lymphoma (CTCL). These cell lines, like the initial tumor cells, had a CD3+CD4+CD8- phenotype. We also isolated two cytotoxic T lymphocyte clones from the tumor site ...

journal_title：Annals of the New York Academy of Sciences

authors： Bagot M,Nikolova M,Schirm-Chabanette F,Wechsler J,Boumsell L,Bensussan A

更新日期：2001-09-01 00:00:00

abstract：:Two types of mixed matrix membranes were developed by UOP in the late 1980s. The first type includes adsorbent polymers, such as silicalite-cellulose acetate (CA), NaX-CA, and AgX-CA mixed matrix membranes. The silicalite-CA has a CO(2)/H(2) selectivity of 5.15 +/- 2.2. In contrast, the CA membrane has a CO(2)/H(2) se...

journal_title：Annals of the New York Academy of Sciences

authors： Kulprathipanja S

更新日期：2003-03-01 00:00:00

abstract：:Coccidioides causes coccidioidomycosis in the southwestern United States. Its clinical manifestations range from the primary asymptomatic to progressive pulmonary and extrapulmonary disease. Because of endemicity, frequent relapse, and virulent nature of Coccidioides, there is an urgent need for the development of eff...

journal_title：Annals of the New York Academy of Sciences

authors： Awasthi S

更新日期：2007-09-01 00:00:00

abstract：:Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. The use of herbal drugs is once more escalating in the form of complementary and alternative medicine. The past century...

journal_title：Annals of the New York Academy of Sciences

authors： Cragg GM,Newman DJ

更新日期：2001-12-01 00:00:00

abstract：:Microcinematography was applied to the analysis of the kinetics of apoptotic cell death. Apoptosis was found to be a process that proceeds in different cells at different times after an initial stress, and therefore kinetic studies of apoptotic events in bulk cultures can be problematic. Using single cell analysis we ...

journal_title：Annals of the New York Academy of Sciences

authors： Goldstein JC,Kluck RM,Green DR

更新日期：2000-01-01 00:00:00

abstract：:Spinal cord injury remains with limited natural recovery and only a few general ineffective treatment options. Recent publications have reported enhanced neurologic recovery with the use of methylprednisolone and GM-1 ganglioside. The results of the Maryland GM-1 Ganglioside Study reported a significant drug effect wi...

journal_title：Annals of the New York Academy of Sciences

authors： Geisler FH

更新日期：1998-06-19 00:00:00

abstract：:A brief description of the information content of the experimental methods that are becoming increasingly useful for probing intracellular processes, a framework for interpreting observations, and an example that combines framework results and 13C NMR observations have been presented. Results in terms of structural cr...

journal_title：Annals of the New York Academy of Sciences

authors： Domach MM,Majewski RA

更新日期：1987-01-01 00:00:00

abstract：:The aim of our work was to detect minor loci acting as Alzheimer's disease (AD) genetic markers. We divided 206 AD patients and 186 individuals as controls into six age at onset/age-dependent groups. We studied polymorphisms of the genes of apolipoprotein E (APOE) and its promoter, cathepsin D, butyrylcholinesterase, ...

journal_title：Annals of the New York Academy of Sciences

authors： Beyer K,Lao JI,Latorre P,Ariza A

更新日期：2005-12-01 00:00:00

abstract：:Improved technology and medical advances have increased the lifespan for people with thalassemia. As thalassemia is no longer exclusively a pediatric blood disorder, consideration must now be given to transition planning from pediatric to adult care. The complexity of thalassemia disease, coupled with the changing fac...

journal_title：Annals of the New York Academy of Sciences

authors： Levine L,Levine M

更新日期：2010-08-01 00:00:00

abstract：:The dramatic changes in overall mode of life experienced since 1989 by the people in Central and Eastern Europe (CEE) provides a good opportunity to study the aging processes and the status of the elderly. In the 1980s, CEE countries were already at an advanced stage of demographic aging of their populations. The firs...

journal_title：Annals of the New York Academy of Sciences

authors： Petrov IC

更新日期：2007-10-01 00:00:00

abstract：:Congenital myasthenia (CM) constitutes a heterogeneous group of disorders with different underlying defects. The authors investigated a case of CM, presenting with congenital contractures. Endplate studies in the first year of life showed a developmental disorder of postsynaptic membranes. Clinical follow-up demonstra...

journal_title：Annals of the New York Academy of Sciences

authors： Smit LM,Veldman H,Jennekens FG,Molenaar PC,Oen BS

更新日期：1987-01-01 00:00:00

abstract：:Cystic fibrosis (CF) is associated with abnormal lipid metabolism, intense respiratory tract (RT) infection, and inflammation, eventually resulting in lung tissue destruction and respiratory failure. The CF RT inflammatory milieu, as reflected by airway secretions, includes a complex array of inflammatory mediators, b...

journal_title：Annals of the New York Academy of Sciences

authors： Eiserich JP,Yang J,Morrissey BM,Hammock BD,Cross CE

更新日期：2012-07-01 00:00:00

abstract：:Vitamin E and essential fatty acid status were examined in two groups of patients, one receiving fat-free total parenteral nutrition (TPN) with intravenous all-rac-alpha-tocopherol for vitamin E deficiency and the other receiving routine intravenous fat (Intralipid, 10%) emulsions with TPN to supply both fatty acid an...

journal_title：Annals of the New York Academy of Sciences

authors： Thurlow PM,Grant JP

更新日期：1982-01-01 00:00:00