Vitamin E decreases the hyperglucagonemia of diabetic rats.

Abstract:

:Vitamin E has the ability to scavenge a wide spectrum of free radicals, including singlet oxygen, superoxide, and hydroxyl radicals. It has beneficial effects against several other disorders, such as atherosclerosis and ischemic heart disease, because it acts as a transcriptional regulator for gene expression via a transcription factor TAP. The beneficial effect of vitamin E on plasma insulin and glucagon levels was examined using radioimmunoassay technique. Diabetes was induced in rats by a single intraperitoneal injection of streptozotocin at a dose of 60 mg/kg body weight. Vitamin E was given at a dose of either 0.2 mg, 0.4 mg, or 0.8 mg per animal 10 days before and after the onset of diabetes. Vitamin E significantly (P < 0.05) increased plasma insulin levels in normal rats but failed to increase the plasma insulin level in diabetic rats. In contrast, vitamin E caused a significant (P < 0.05) reduction in plasma glucagon level in rats treated before and after the onset of diabetes. Vitamin E may ameliorate some diabetic complication via reduction in the level of circulating glucagon.

journal_name

Ann N Y Acad Sci

authors

Al-Shamsi M,Amin A,Adeghate E

doi

10.1196/annals.1372.032

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

432-41

eissn

0077-8923

issn

1749-6632

pii

1084/1/432

journal_volume

1084

pub_type

杂志文章
  • Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma.

    abstract::The immunotherapeutic agent ipilimumab has helped address a significant unmet need in the treatment of advanced melanoma. Ipilimumab is a fully human monoclonal antibody that targets cytotoxic T-lymphocyte antigen-4 (CTLA-4), thereby augmenting antitumor immune responses. After decades in which a number of clinical tr...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12180

    authors: Wolchok JD,Hodi FS,Weber JS,Allison JP,Urba WJ,Robert C,O'Day SJ,Hoos A,Humphrey R,Berman DM,Lonberg N,Korman AJ

    更新日期:2013-07-01 00:00:00

  • Development of the IL-12/23 antagonist ustekinumab in psoriasis: past, present, and future perspectives.

    abstract::The development of ustekinumab as a first-in-class anti-interleukin (IL) 12/23p40 therapeutic agent for psoriasis represents an important example of modern and rational drug design and development. Psoriasis is a chronic, systemic, immune-mediated skin disorder with considerable clinical, psychosocial, and economic bu...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2011.05963.x

    authors: Yeilding N,Szapary P,Brodmerkel C,Benson J,Plotnick M,Zhou H,Goyal K,Schenkel B,Giles-Komar J,Mascelli MA,Guzzo C

    更新日期:2011-03-01 00:00:00

  • Visualization and other emerging technologies as change makers for oral cancer prevention.

    abstract::The genomic era has fueled a rapid emergence of new information at the molecular level with a great potential for developing innovative approaches to detection, risk assessment, and management of oral cancers and premalignant disease. As yet, however, little research has been done on complementary approaches that woul...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1384.039

    authors: Rosin MP,Poh CF,Guillard M,Williams PM,Zhang L,MacaUlay C

    更新日期:2007-03-01 00:00:00

  • Approaches for the integration of big data in translational medicine: single-cell and computational methods.

    abstract::Translational medicine describes a bench-to-bedside approach that eventually converts findings from basic scientific studies into real-world clinical research. It encompasses new treatments, advanced equipment, medical procedures, preventive and diagnostic approaches creating a bridge between basic studies and clinica...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.14544

    authors: Amirmahani F,Ebrahimi N,Molaei F,Faghihkhorasani F,Jamshidi Goharrizi K,Mirtaghi SM,Borjian-Boroujeni M,Hamblin MR

    更新日期:2021-01-06 00:00:00

  • Ixodes ovatus Ehrlichia exhibits unique ultrastructural characteristics in mammalian endothelial and tick-derived cells.

    abstract::Tick-borne pathogens in the genus Ehrlichia cause emerging zoonoses. Although laboratory mice are susceptible to Ehrlichia infections, many isolates do not cause clinical illness. In contrast, the Ixodes ovatus Ehrlichia-like agent (IOE) causes disease and immune responses in mice comparable to the human illness cause...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04520.x

    authors: Munderloh UG,Silverman DJ,MacNamara KC,Ahlstrand GG,Chatterjee M,Winslow GM

    更新日期:2009-05-01 00:00:00

  • Survival and complications in thalassemia.

    abstract::The life expectancy of patients with thalassemia major has significantly increased in recent years, as reported by several groups in different countries. However, complications are still frequent and affect the patients' quality of life. In a recent study from the United Kingdom, it was found that 50% of the patients ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1345.006

    authors: Borgna-Pignatti C,Cappellini MD,De Stefano P,Del Vecchio GC,Forni GL,Gamberini MR,Ghilardi R,Origa R,Piga A,Romeo MA,Zhao H,Cnaan A

    更新日期:2005-01-01 00:00:00

  • Caloric restriction combined with exercise is effective in reducing adiposity and mitigating bone structural deterioration in obese rats.

    abstract::Weight reduction through caloric restriction (CR) or exercise can have opposite effects on bone. This study investigated the effects of comparable weight reduction through CR and/or exercise on body composition and bone structure in an obese rat model. Male 6-week-old rats were fed either a normal-fat diet for 6 month...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.13936

    authors: Cao JJ

    更新日期:2018-12-01 00:00:00

  • Visualization and phase doppler particle analysis measurements of oscillating spray propagation of an airblast atomizer under typical engine conditions.

    abstract::Propagation of a kerosene spray formed by a prefilming airblast atomizer within a pulsating flame has been investigated. The measurements were performed in a 400 kW single combustor rig at typical engine conditions of up to 0.8 MPa inlet pressure and 673 K inlet temperature. The homogeneity of the fuel spray propagati...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04585.x

    authors: Schober P,Meier R,Schäfer O,Wittig S

    更新日期:2002-10-01 00:00:00

  • Antibody W7C5 defines a CD109 epitope expressed on CD34+ and CD34- hematopoietic and mesenchymal stem cell subsets.

    abstract::The cell surface antigen recognized by monoclonal antibody W7C5 is expressed at low levels on human CD34(+) and CD34(-) bone marrow stem cell populations but at high levels on fetal liver CD34(+) cells. To identify the recognized antigen, we performed partial amino acid sequence and MALDI analysis of purified W7C5 ant...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb03250.x

    authors: Giesert C,Marxer A,Sutherland DR,Schuh AC,Kanz L,Buhring HJ

    更新日期:2003-05-01 00:00:00

  • Evaluation of a novel line-blot immunoassay for the detection of antibodies to extractable nuclear antigens.

    abstract::We have evaluated the performance of a novel line-blot immunoassay (LIA; Mikrogen) and compared results with those obtained by CIE (in-house), ELISA (Pharmacia Diagnostics), and FEIA (Pharmacia Diagnostics). Sera from systemic lupus erythematosus (SLE) patients (n = 123), systemic sclerosis patients (n = 25), and heal...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1313.036

    authors: Damoiseaux J,Boesten K,Giesen J,Austen J,Tervaert JW

    更新日期:2005-06-01 00:00:00

  • Role of cellular compartmentation in the metabolic response to stress: mechanistic insights from computational models.

    abstract::The mechanisms controlling ATP generation in the transition from normal resting conditions to either high work states or ischemia are poorly understood. ATP generation depends upon compartmentation between the mitochondria and cytosol of metabolic pathways and key energy transfer species that cannot be easily assessed...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1380.012

    authors: Zhou L,Yu X,Cabrera ME,Stanley WC

    更新日期:2006-10-01 00:00:00

  • Relationship of plasma level of vitamin C to mortality from ischemic heart disease.

    abstract::The present epidemiological data support and extend previous evidence in men and animals. Thus, a poor plasma status of vitamin C (less than 23 microM = 0.4 mg/dl) and/or of cholesterol-standardized vitamin E (less than 20-21.5 microM = 9 mg/l) occurs in westernized countries with an increased risk of IHD. A poor stat...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1987.tb23755.x

    authors: Gey KF,Stähelin HB,Puska P,Evans A

    更新日期:1987-01-01 00:00:00

  • Altered subcellular distribution of the Alzheimer's amyloid precursor protein under stress conditions.

    abstract::Altered metabolism of the Alzheimer's amyloid precursor protein (APP) appears to be a key event in the pathogenesis of Alzheimer's disease (AD), and both altered phosphorylation and oxidative stress appear to affect the production of the toxic Abeta fragment. Our results show that altered processing of APP was observe...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1397.085

    authors: Domingues SC,Henriques AG,Wu W,Da Cruz e Silva EF,Da Cruz e Silva OA

    更新日期:2007-01-01 00:00:00

  • Detection and characterization of membrane-bound selenoproteins in the kidney of the rat.

    abstract::The essential trace element selenium is of fundamental importance to human biology. Information on the membrane-bound selenoproteins was obtained by labeling of rats in vivo with (75)Se-selenite, subcellular fractionation of the tissue homogenates, separation of the proteins by SDS-PAGE, two-dimensional electrophoresi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04652.x

    authors: Kyriakopoulos A,Bertelsmann H,Graebert A,Hoppe B,Kuhbacher M,Behne D

    更新日期:2002-11-01 00:00:00

  • Modeling population dynamics, landscape structure, and management decisions for controlling the spread of invasive plants.

    abstract::Invasive plants cause substantial economic and environmental damage throughout the world. However, eradication of most invasive species is impossible and, in some cases, undesirable. An alternative is to slow the spread of an invasive species, which can delay impacts or reduce their extent. We identify three main area...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2011.06313.x

    authors: Caplat P,Coutts S,Buckley YM

    更新日期:2012-02-01 00:00:00

  • The alpha-ketoglutarate dehydrogenase complex.

    abstract::The alpha-ketoglutarate dehydrogenase complex (KGDHC) is an important mitochondrial constituent, and deficiency of KGDHC is associated with a number of neurological disorders. KGDHC is composed of three proteins, each encoded on a different and well-characterized gene. The sequences of the human proteins are known. Th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1999.tb07818.x

    authors: Sheu KF,Blass JP

    更新日期:1999-01-01 00:00:00

  • Investigating the molecular basis of major depressive disorder etiology: a functional convergent genetic approach.

    abstract::Genes play a major role in behavioral adaptation to challenging environmental stimuli, but the complexity of their contribution remains unclear. There is growing evidence linking disease phenotypes with genes on the one hand, and the genesis of stress-related disorders like major depression, as a result of exposure to...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1410.018

    authors: Jabbi M,Korf J,Ormel J,Kema IP,den Boer JA

    更新日期:2008-12-01 00:00:00

  • Identification and characterization of cellulose-binding domains in xylanase A of Clostridium stercorarium.

    abstract::The xynA gene encoding a major xylanase of Clostridium stercorarium F-9 was sequenced. The structural gene consists of an open reading frame of 1533 bp encoding a protein of 511 amino acids with an M(r) of 56,519. XynA consists of a catalytic domain belonging to family G at the NH2-terminus and two direct repeats of a...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1996.tb40565.x

    authors: Sakka K,Takada G,Karita S,Ohmiya K

    更新日期:1996-05-15 00:00:00

  • Fatty acid composition in fractions of structural and storage lipids in liver and skeletal muscle of hereditary hypertriglyceridemic rats.

    abstract::The fatty acid (FA) compositions of liver and skeletal muscle structural lipids, overall phospholipids and phosphatidylcholine, and triglycerides (TG) were determined in the hereditary hypertriglyceridemic (HTG) rat, a nonobese animal model of the insulin resistance syndrome. Four groups of HTG rats and four groups of...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1997.tb51860.x

    authors: Bohov P,Seböková E,Gasperíková D,Langer P,Klimes I

    更新日期:1997-09-20 00:00:00

  • Pharmacological modification of the Ca2+-pump ATPase activity of human erythrocytes.

    abstract::The Ca2+-pump ATPase of human RBC membranes appears to be exquisitely sensitive to a variety of amphipathic molecules. The acidic protein calmodulin (CaM) activates the enzyme some three- to fivefold with an apparent Kd of approximately 1-5 nM. A variety of other amphipathic anions, such as acidic phospholipids, free ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1982.tb25755.x

    authors: Vincenzi FF

    更新日期:1982-01-01 00:00:00

  • Homing of long-term and short-term engrafting cells in vivo.

    abstract::Long-term repopulating hematopoietic stem cells can be separated from cells which provided radioprotection (short-term repopulating cells) on the basis of size. This might be a result of the quiescent nature of long-term repopulating cells. To define the activity of these populations we utilized a dye, PKH26, which in...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb08452.x

    authors: Lanzkron SM,Collector MI,Sharkis SJ

    更新日期:1999-04-30 00:00:00

  • Neural circuits for taste. Excitation, inhibition, and synaptic plasticity in the rostral gustatory zone of the nucleus of the solitary tract.

    abstract::The rostral nucleus of the solitary tract (rNST) plays a key role in modulating, organizing and distributing the sensory information arriving at the central nervous system from gustatory receptors. However, except for some anatomical studies of rNST synapses, the neural circuits responsible for this first stage in syn...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb10607.x

    authors: Bradley RM,Grabauskas G

    更新日期:1998-11-30 00:00:00

  • IVIG and PLEX in the treatment of myasthenia gravis.

    abstract::Intravenous immunoglobulin (IVIG) and plasma exchange (PLEX) are used to treat myasthenia gravis (MG) but with little trial evidence. While a class I study provided evidence for the efficacy of IVIG treatment, the empirical support for PLEX has been less convincing until recently. In a randomized controlled single-mas...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2012.06767.x

    authors: Bril V,Barnett-Tapia C,Barth D,Katzberg HD

    更新日期:2012-12-01 00:00:00

  • New trends in astrodynamics and applications: optimal trajectories for space guidance.

    abstract::This paper represents recent results on the development of optimal analytic solutions to the variation problem of trajectory optimization and their application in the construction of on-board guidance laws. The importance of employing the analytically integrated trajectories in a mission design is discussed. It is ass...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1370.002

    authors: Azimov D,Bishop R

    更新日期:2005-12-01 00:00:00

  • Signaling pathways of the LGR7 and LGR8 receptors determined by reporter genes.

    abstract::Although much is known about the pleiotropic effects mediated by relaxin, the exact signaling pathways involved remain relatively elusive. This study examines LGR7 and LGR8 signaling using reporter gene technology. The greatest response was observed at the CRE reporter (indicates activation of cAMP-PKA and p38/JNK pat...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1282.043

    authors: Halls ML,Bathgate RA,Roche PJ,Summers RJ

    更新日期:2005-05-01 00:00:00

  • Thermophysical property measurements by electromagnetic levitation melting technique under microgravity.

    abstract::The purpose of this paper is to review the advances in electromagnetic levitation techniques as tools for determination of the thermophysical properties of molten metals under standard gravity and microgravity conditions. We show that a combination of containerless processing and microgravity offers the exclusive poss...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb05903.x

    authors: Bakhtiyarov SI,Overfelt RA

    更新日期:2002-10-01 00:00:00

  • Microparticles and the hygiene hypothesis.

    abstract::Departing from the functional parallelism that undoubtedly exists between the nervous and immune system, we suggest that the latter also counts with means for information exchange that may result in a mutual influence of immune processes between nearby individuals. Our concept relies on a molecular interface that is c...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04920.x

    authors: Martín PI,Sánchez PA,Rewald E

    更新日期:2009-09-01 00:00:00

  • Expression of the growth arrest specific genes in rat embryonic fibroblasts undergoing senescence.

    abstract::Replicative senescence is an in vitro biological phenomenon that results the irreversible growth arrest of mammalian cells. In contrast, cellular quiescence is reversible upon the addition of mitogens or replating. Quiescence is associated with the expression of a particular gene family--the growth arrest specific (GA...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb09024.x

    authors: Gonos ES

    更新日期:1998-06-30 00:00:00

  • Alterations in stress reactivity after long-term treatment with paroxetine in women with posttraumatic stress disorder.

    abstract::Posttraumatic stress disorder (PTSD) is typically accompanied by both acute and chronic alterations in the stress response. These alterations have mostly been described in individuals under baseline conditions, but studies have also used a challenge model to assess the role of the hypothalamic-pituitary-adrenal (HPA) ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.1196/annals.1364.014

    authors: Vermetten E,Vythilingam M,Schmahl C,DE Kloet C,Southwick SM,Charney DS,Bremner JD

    更新日期:2006-07-01 00:00:00

  • Temporal organization of activity in the cerebellar cortex: a manifesto for synchrony.

    abstract::The issues of temporal coding and the temporal organization of activity have aroused a great deal of interest in sensory systems, cortex, thalamus, and hippocampus. Strangely, despite the important timing roles attributed to the cerebellum, little consideration has been given to the organization of activity within the...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb07564.x

    authors: Isope P,Dieudonné S,Barbour B

    更新日期:2002-12-01 00:00:00