Peripheral neuropathy caused by proteolipid protein gene mutations.

abstract：:Donepezil, a choline esterase inhibitor, has been widely used as a medicine for Alzheimer's disease. Recently, a study showed that donepezil inhibited addictive behaviors induced by cocaine, including cocaine-conditioned place preference (CPP) and locomotor sensitization to cocaine. In the present study, we investigat...

journal_title：Annals of the New York Academy of Sciences

authors： Takamatsu Y,Yamanishi Y,Hagino Y,Yamamoto H,Ikeda K

更新日期：2006-08-01 00:00:00

abstract：:Externally guided sensory-motor processes deteriorate with increasing age. Internally guided, for example, predictive, behavior usually helps to overcome sensory-motor delays. We studied whether predictive components of visuomotor transformation decline with age. We investigated smooth pursuit eye movements (SPEM) of ...

journal_title：Annals of the New York Academy of Sciences

authors： Sprenger A,Trillenberg P,Pohlmann J,Herold K,Lencer R,Helmchen C

更新日期：2011-09-01 00:00:00

abstract：:Odorant signals are detected by binding of odor molecules to odorant receptors. These belong to the G protein-coupled receptor family. They in turn couple to G proteins, most of which induce cAMP production. This second messenger activates ion channels to depolarize the olfactory sensory neuron, thus providing a signa...

journal_title：Annals of the New York Academy of Sciences

authors： Wicher D,Schäfer R,Bauernfeind R,Stensmyr MC,Heller R,Heinemann SH,Hansson BS

更新日期：2009-07-01 00:00:00

abstract：:This paper presents a review of the publicly available knowledge base concerning turbine blade tip heat transfer, from the early fundamental research which laid the foundations of our knowledge, to current experimental and numerical studies utilizing engine-scaled blade cascades and turbine rigs. Focus is placed on hi...

journal_title：Annals of the New York Academy of Sciences

authors： Bunker RS

更新日期：2001-05-01 00:00:00

abstract：:Investigations of the I-Ek-restricted, cytochrome c-specific T-cell response in mice show that both T-cell receptor V alpha and V beta CDR3 residues and the use of particular V alpha s and V beta s are necessary for recognition. Data strongly suggest that specific CDR3 residues are important in contacting the peptide....

journal_title：Annals of the New York Academy of Sciences

authors： Davis MM,McHeyzer-Williams M,Chien YH

更新日期：1995-07-07 00:00:00

abstract：:The liver is morphologically and functionally modulated by sex hormones. Long-term use of oral contraceptives (OCs) and anabolic androgenic steroids (AASs) can induce both benign (hemangioma, adenoma, and focal nodular hyperplasia [FNH]) and malignant (hepatocellular carcinoma [HCC]) hepatocellular tumors. Hepatic ade...

journal_title：Annals of the New York Academy of Sciences

authors： Giannitrapani L,Soresi M,La Spada E,Cervello M,D'Alessandro N,Montalto G

更新日期：2006-11-01 00:00:00

abstract：:Here, we analyzed four population-based demographic and health surveys conducted in Bolivia between 1998 and 2016 to understand trends in anemia in children from 6 to 59 months of age by selected sociodemographic characteristics and three categories of altitude: low, medium, and high. Over the 18-year period, the prev...

journal_title：Annals of the New York Academy of Sciences

authors： Cordero D,Aguilar AM,Casanovas C,Vargas E,Lutter CK

更新日期：2019-08-01 00:00:00

abstract：:Recent study demonstrated that M55V variant in SUMO4 at IDDM5 was associated with susceptibility to type 1 diabetes. Subsequent studies, however, showed inconsistency in the association. To clarify the population-wide effect on the association of SUMO4 with type 1 diabetes, we have performed meta-analysis including ou...

journal_title：Annals of the New York Academy of Sciences

authors： Noso S,Ikegami H,Fujisawa T,Kawabata Y,Asano K,Hiromine Y,Sugihara S,Lee I,Kawasaki E,Awata T,Ogihara T

更新日期：2006-10-01 00:00:00

abstract：:Both hereditary and environmental factors influence the risk of cancer. Four risk categories, or oncodemes, can exist for a particular kind of cancer, depending upon the presence of neither, one, or both factors: (1) spontaneous, or background; (2) hereditary; (3) environmental; (4) interactive. In the second, mutatio...

journal_title：Annals of the New York Academy of Sciences

authors： Knudson AG

更新日期：1997-12-29 00:00:00

abstract：:Cyclosporin A (CsA) is an immunosuppressive drug commonly given to transplant patients. Its application is accompanied by severe side effects related to calcium, among them hypertension and nephrotoxicity. The Na+/Ca2+ exchanger (NCX) is a major calcium regulator expressed in the surface membrane of all excitable and ...

journal_title：Annals of the New York Academy of Sciences

authors： Rahamimoff H,Elbaz B,Alperovich A,Kimchi-Sarfaty C,Gottesman MM,Lichtenstein Y,Eskin-Shwartz M,Kasir J

更新日期：2007-03-01 00:00:00

abstract：:We have shown that the medial preoptic area (MPO) in the hypothalamus is a major site where interferon (IFN)-alpha acts to induce suppression of splenic natural killer (NK) cell activity through an activation of sympathetic nervous system (SNS) in rats. Here, we discuss the hypothalamic mechanisms of the cytokine acti...

journal_title：Annals of the New York Academy of Sciences

authors： Katafuchi T,Duan S,Take S,Yoshimura M

更新日期：2009-02-01 00:00:00

abstract：:Pheochromocytoma is a rare, surgically correctable cause of hypertension. Modern medical blockade has significantly improved patient survival and morbidity. The last decade has seen the identification of the genes responsible for several hereditary causes of pheochromocytoma. Evaluation of these patients has demonstra...

journal_title：Annals of the New York Academy of Sciences

authors： Walther MM

更新日期：2002-09-01 00:00:00

abstract：:Membrane processes are receiving increasing attention in the scientific community and in industry because in many cases they offer a favorable alternative to processes that are not easy to achieve by conventional routes. In this context, membranes made with perfluorinated polymers are of particular interest because of...

journal_title：Annals of the New York Academy of Sciences

authors： Arcella V,Ghielmi A,Tommasi G

更新日期：2003-03-01 00:00:00

abstract：:CDP-choline was given to patients with Alzheimer's disease (AD) at a daily dose of 1000 mg/day p.o. for one month. This compound slightly improved mental performance, tended to reduce theta activity in fronto-temporal regions, increasing alpha power in occipital areas, and enhanced cerebrovascular perfusion by increas...

journal_title：Annals of the New York Academy of Sciences

authors： Cacabelos R,Caamaño J,Gómez MJ,Fernández-Novoa L,Franco-Maside A,Alvarez XA

更新日期：1996-01-17 00:00:00

abstract：:The present article investigated clinical symptoms and their longitudinal clinical course following pharmacological treatment in 32 female incarcerated patients suffering from methamphetamine (METH) psychosis who were referred to psychiatric consultation. The length of METH-abuse periods of the patients ranged from 2 ...

journal_title：Annals of the New York Academy of Sciences

authors： Akiyama K

更新日期：2006-08-01 00:00:00

abstract：:The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-beta1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis...

journal_title：Annals of the New York Academy of Sciences

authors： Crivello A,Giacalone A,Scola L,Forte GI,Nuzzo D,Giacconi R,Cipriano C,Candore G,Mocchegiani E,Colonna-Romano G,Lio D,Caruso C

更新日期：2006-05-01 00:00:00

abstract：:1. The flow divider of the brachiocephalic branching of the rabbit aorta had both high and low shear stress regions, each of which was covered by endothelial cells with low and high permeability respectively, even in normolipidemic intact rabbits. When rabbits were placed on an atherogenic diet, low shear regions were...

journal_title：Annals of the New York Academy of Sciences

authors： Yoshida Y,Okano M,Wang S,Kobayashi M,Kawasumi M,Hagiwara H,Mitsumata M

更新日期：1995-01-17 00:00:00

abstract：:Combined dopamine (DA) and 5-hydroxytryptamine (5-HT) releasers such as phentermine (PHEN) and fenfluramine (FEN) are reported, in open label studies, to reduce craving for alcohol and cocaine and to prevent relapse. The objective of the studies reported here was to assess the actions of these agents alone and in comb...

journal_title：Annals of the New York Academy of Sciences

authors： Rothman RB,Elmer GI,Shippenberg TS,Rea W,Baumann MH

更新日期：1998-05-01 00:00:00

abstract：:Older age is associated with functional declines throughout the body, including some aspects of cognitive performance. While dementia develops in only some elderly individuals, declines in cognitive functioning have an impact on daily living for many others. There are individual differences in age-related cognitive ch...

journal_title：Annals of the New York Academy of Sciences

authors： Moffat SD

更新日期：2005-12-01 00:00:00

abstract：:The prevalence of obesity is rapidly increasing in the United States, particularly among women. Approximately 60-70% of hypertension in adults may be directly attributed to obesity. In addition, maternal obesity is a major risk factor for hypertensive disorders during pregnancy. The underlying mechanisms for the assoc...

journal_title：Annals of the New York Academy of Sciences

authors： Fu Q

更新日期：2019-10-01 00:00:00

abstract：:3-Nitropropionic acid (3-NPA) is a model mitochondrial inhibitor that causes selective neurodegeneration in brain. 3-NPA-induced neurodegeneration occurs via a secondary neurotoxicity, caused initially by ATP depletion and redox changes in the cell. It is known that the hippocampal degeneration caused by mitochondrial...

journal_title：Annals of the New York Academy of Sciences

authors： Przybyla-Zawislak BD,Thorn BT,Ali SF,Dennis RA,Amato A,Virmani A,Binienda ZK

更新日期：2005-08-01 00:00:00

abstract：:Protection against stress by glucocorticoids is discussed in relation to their permissive and suppressive actions. Evidence from the last decade is summarized regarding the physiological nature of the suppressive actions, and the hypothesis that they prevent stress-activated defense mechanisms from overshooting and da...

journal_title：Annals of the New York Academy of Sciences

authors： Munck A,Náray-Fejes-Tóth A

更新日期：1994-11-30 00:00:00

abstract：:The proto-oncogene c-myc is involved in multiple cell pathways with opposite effects on cell outcome of death or proliferation. It has been proposed that these different roles depend on the sequestration of c-Myc protein in cellular compartments and/or its phosphorylation. We speculated that subcellular localization o...

journal_title：Annals of the New York Academy of Sciences

authors： Supino R,Favini E,Cuccuru G,Zunino F,Scovassi AI

更新日期：2007-01-01 00:00:00

abstract：:Alexithymia has been associated with both posttraumatic stress disorder and neuroendocrine responses to stress. This study examined the relationship of alexithymia to salivary cortisol and 3-methoxy-4-hydroxy-phenylglycol (MHPG) in a sample of police academy recruits exposed to a video stress challenge. Alexithymia sc...

journal_title：Annals of the New York Academy of Sciences

authors： McCaslin SE,Inslicht SS,Neylan TC,Metzler TJ,Otte C,Lenoci M,Henn-Haase C,Best S,Yehuda R,Marmar CR

更新日期：2006-07-01 00:00:00

abstract：:Hybrid liver systems are being developed as temporary extracorporeal liver support therapy. The overview given here emphasizes the development of both hepatocyte culture models for bioreactors and of systems for clinical therapy. In vitro studies demonstrate long term external metabolic function in isolated primary he...

journal_title：Annals of the New York Academy of Sciences

authors： Sauer IM,Obermeyer N,Kardassis D,Theruvath T,Gerlach JC

更新日期：2001-11-01 00:00:00

abstract：:As a result of intensive investigation, particularly in the pharmaceutical industry, a number of potent and selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonists have been discovered. The structure activity relationship studies that led to the discovery of these mGluR5 antagonists are presented in t...

journal_title：Annals of the New York Academy of Sciences

authors： Carroll FI

更新日期：2008-10-01 00:00:00

abstract：:The ability to alter delayed-type hypersensitivity via hypnotic suggestion was tested in 12 highly hypnotizable, untrained subjects and 30 nonhypnotized controls. Subjects were skin-tested bilaterally with a standardized panel of delayed hypersensitivity antigens and instructed either to enhance or suppress the skin t...

journal_title：Annals of the New York Academy of Sciences

authors： Locke SE,Ransil BJ,Covino NA,Toczydlowski J,Lohse CM,Dvorak HF,Arndt KA,Frankel FH

更新日期：1987-01-01 00:00:00

abstract：:How can people adaptively analyze and "work through" negative feelings without ruminating? This paper will briefly review findings from an integrative program of research, which suggests that a critical factor determining whether people's attempts to adaptively reason about negative experiences succeed or fail is the ...

journal_title：Annals of the New York Academy of Sciences

authors： Kross E

更新日期：2009-06-01 00:00:00

abstract：:Vitamins C and E function as water-soluble and lipid-soluble chain-breaking antioxidants, respectively, and protect lipids, proteins, and membranes from oxidative damage. Vitamin C scavenges oxygen radicals in the aqueous phase, whereas vitamin E scavenges oxygen radicals within the membranes. Vitamin C regenerates vi...

journal_title：Annals of the New York Academy of Sciences

authors： Niki E

更新日期：1987-01-01 00:00:00

abstract：:The melanocortin (MC)-4 receptor participates in regulating body weight homeostasis. We demonstrated early that acute blockage of the MC-4 receptor increases food intake and relieves anorexic conditions in rats. Our recent studies show that 4-week chronic blockage of the MC-4 receptor leads to robust increases in food...

journal_title：Annals of the New York Academy of Sciences

authors： Schiöth HB,Lagerström MC,Watanobe H,Jonsson L,Vergoni AV,Ringholm A,Skarphedinsson JO,Skuladottir GV,Klovins J,Fredriksson R

更新日期：2003-06-01 00:00:00