Anemia in Bolivian children: a comparative analysis among three regions of different altitudes.

abstract：:We have examined the expression of several genes whose transcripts have increased levels in Alzheimer's disease and have found heterogeneity in these levels in different patients with this condition. The level of expression of these genes was compared to different clinical and pathological aspects of the disease. A ca...

journal_title：Annals of the New York Academy of Sciences

authors： Duguid JR,Trzepacz C,Kemper T,Tourtellote WW,Volicer L

更新日期：1993-05-28 00:00:00

abstract：:Thus, it can be shown that highly theoretical experiments carried out to evaluate the electrochemistry of thrombosis can also be shown to have significance in the generation of new products, which relates the scientific findings to successful modern prosthesis and medically useful devices. ...

journal_title：Annals of the New York Academy of Sciences

authors： Sawyer PN

更新日期：1983-01-01 00:00:00

abstract：:Babesia felis, originally identified in wild cats in the Sudan, was subsequently found to cause clinical disease in domestic cats. Although babesiosis in domestic cats has been reported sporadically from various countries, as a significant disease it appears to be a distinctly South African phenomenon. Apart from an i...

journal_title：Annals of the New York Academy of Sciences

authors： Penzhorn BL,Schoeman T,Jacobson LS

更新日期：2004-10-01 00:00:00

abstract：:Fetal nucleated red blood cells (NRBCs) entering maternal circulation during pregnancy constitute a potential source of material for safe and reliable noninvasive prenatal diagnosis. The increased prevalence of beta-thalassemia mutations in countries like Greece may create a problem, making it difficult to distinguish...

journal_title：Annals of the New York Academy of Sciences

authors： Mavrou A,Kolialexi A,Antsaklis A,Krikos X,Koratzis A,Metaxotou C

更新日期：2001-09-01 00:00:00

abstract：:Intense stress can be detrimental for tissue homeostasis and accelerates aging. On the other hand, repeated mild stresses can have beneficial and even life-prolonging effects. Hypersecretion of glucocorticoids (GCs) represents the major hormonal response to stress. However, besides its life-sustaining role, GC excess ...

journal_title：Annals of the New York Academy of Sciences

authors： Kletsas D,Pratsinis H,Gioni V,Pilichos K,Yiacoumettis AM,Tsagarakis S

更新日期：2007-04-01 00:00:00

abstract：:Recent controversies in the existence of saturable binding of general anesthetics in brain tissues prompted a careful examination of specific binding of anesthetics to neural receptors. We examined the binding of both local and general anesthetics using electron spin resonance and radioligand criteria. Our results sug...

journal_title：Annals of the New York Academy of Sciences

authors： Lin L,Koblin DD,Wang HH

更新日期：1991-01-01 00:00:00

abstract：:The gastrointestinal tract (GIT) appears to be the main site of entry for the pathological isoform of prions (PrP(sc)). To understand how the PrP(sc) internalization process occurs, it is important to characterize the cell types that express normal prion protein (PrP(c)) along the GIT. To do so, we studied the distrib...

journal_title：Annals of the New York Academy of Sciences

authors： Marcos Z,Bodegas ME,Sesma MP,Guembe L

更新日期：2005-04-01 00:00:00

abstract：:Helicobacter pylori is a definite carcinogen whose mechanism of action is still unknown. The aim of this work was (1) to determine the presence of p53 protein and related antibodies in patients affected by various gastric pathologies and chronically infected with H. pylori, and (2) to try to discover a test to be used...

journal_title：Annals of the New York Academy of Sciences

authors： Losi E,Molinari AM,Gazzerro P,Ortega De Luna L,Fera MT,Carbone M,Catania MR,Hasty DL,Rossano F

更新日期：2002-06-01 00:00:00

abstract：:We study the linear coupling between the Marangoni and Cowley-Rosensweig instabilities for a thin layer of ferrofluid subjected to a temperature gradient and a magnetic field. Both are perpendicular to the reference horizontal boundaries, one of which is a rigid plate, while the other is a free surface remaining flat ...

journal_title：Annals of the New York Academy of Sciences

authors： Hennenberg M,Slavtchev S,Weyssow B

更新日期：2009-04-01 00:00:00

abstract：:Analysis of the protein profile of mitochondria and its age-dependent variation is a promising approach to unravel mechanisms involved in aging and age-related diseases. Our studies focus on the mammalian mitochondrial membrane proteome, especially of the inner mitochondrial membrane with the respiratory chain complex...

journal_title：Annals of the New York Academy of Sciences

authors： Dencher NA,Frenzel M,Reifschneider NH,Sugawa M,Krause F

更新日期：2007-04-01 00:00:00

abstract：:5-Lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) are two enzymes that are critical for the synthesis of eicosanoids, the inflammatory metabolites of arachidonic acid. Both 5-LOX and COX-2 are expressed in the brain, including in CNS neurons. The physiologic role of these proteins in neuronal functioning is not clea...

journal_title：Annals of the New York Academy of Sciences

authors： Manev H,Uz T,Manev R,Zhang Z

更新日期：2001-06-01 00:00:00

abstract：:The preventive effects of the phytoalexin trans-resveratrol toward cancer have been largely described at the cellular and molecular levels in both in vivo and in vitro models; however, its primary targets are still poorly identified. In this review, we show the crucial role of cell membrane microdomains, that is, lipi...

journal_title：Annals of the New York Academy of Sciences

authors： Delmas D,Aires V,Colin DJ,Limagne E,Scagliarini A,Cotte AK,Ghiringhelli F

更新日期：2013-07-01 00:00:00

abstract：:Rats subjected to various accelerations (+G) exhibited increased levels of plasma epinephrine (EPI), norepinephrine (NE), and corticosterone. However, the collection of blood was performed after a centrifugation finished, and therefore the levels could be affected by the process of deceleration. The aim of this study ...

journal_title：Annals of the New York Academy of Sciences

authors： Petrak J,Mravec B,Jurani M,Baranovska M,Tillinger A,Hapala I,Frollo I,Kvetnanský R

更新日期：2008-12-01 00:00:00

abstract：:Leptin is the product of the ob gene located in humans on chromosome 7q31.3. It is a 16-kDa protein named after the Greek "leptos," meaning lean, to indicate the function that this adipocyte-secreted protein was thought to have. Since its discovery, in fact, most of the research focused on the role of leptin in body-w...

journal_title：Annals of the New York Academy of Sciences

authors： Ghizzoni L,Mastorakos G

更新日期：2003-11-01 00:00:00

abstract：:Frontal lobe functions include a range of cognitive, emotional, and social abilities that enable goal-directed behavior. Although a number of studies have plotted the development of frontal lobe functions in childhood, few have extended into the adolescent years. There is also little information on which cognitive and...

journal_title：Annals of the New York Academy of Sciences

authors： Rosso IM,Young AD,Femia LA,Yurgelun-Todd DA

更新日期：2004-06-01 00:00:00

abstract：:Accumulating epidemiological, clinical, and experimental evidence supports the conclusion of a critical role of epigenetic factors in immune programming. This understanding provides the basis for elucidating how the intricate interactions of the genome, epigenome, and transcriptome shape immune responses and maintain ...

journal_title：Annals of the New York Academy of Sciences

authors： Zouali M

更新日期：2011-01-01 00:00:00

abstract：:Oral and nasal administration of nicotinic acetylcholine receptor (AChR) to Lewis rats prior to myasthenogenic immunization with AChR and complete Freund's adjuvant (CFA) resulted in prevention or marked decrease of the severity of experimental autoimmune myasthenia gravis (EAMG) and suppression of AChR-specific B-cel...

journal_title：Annals of the New York Academy of Sciences

authors： Ma CG,Zhang GX,Xiao BG,Wang ZY,Link J,Olsson T,Link H

更新日期：1996-02-13 00:00:00

abstract：:In this short review, we have described studies that have identified Arg415 in the Ca2+ release channel as a residue that influences channel sensitivity to Ca2+ induced Ca2+ release, rate of Ca2+ release, and channel closing. We have also described studies that confirm Dr. Numa's predictions that residues 4246-4267, 4...

journal_title：Annals of the New York Academy of Sciences

authors： MacLennan DH,Chen SR

更新日期：1993-12-20 00:00:00

abstract：:Our studies to date indicate that treatment with anti-idiotype to monoclonal anti-MHC antibodies can markedly influence the repertoire of anti-MHC antibodies expressed. The antibodies discussed here appear to represent two classes, one of which is public, probably representing expression of a germ line gene, and the s...

journal_title：Annals of the New York Academy of Sciences

authors： Sachs DH,Bluestone JA,Epstein SL,Rabinowitz R

更新日期：1983-01-01 00:00:00

abstract：:The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations. While the blood group antigen A is considered the ancestral primordial structure, under the selective pressure of life-threatening diseases blood group O(H) came to dominate as the most frequently ...

journal_title：Annals of the New York Academy of Sciences

authors： Arend P

更新日期：2018-08-01 00:00:00

abstract：:Translin and translin-associated factor X (translin/TRAX) proteins have been implicated in a variety of cellular activities central to nucleic acid metabolism. Accumulating evidence indicates that translin/TRAX complexes participate in processes ensuring the replication of DNA, as well as cell division. Significant pr...

journal_title：Annals of the New York Academy of Sciences

authors： Kasai M,Ishida R,Nakahara K,Okumura K,Aoki K

更新日期：2018-06-01 00:00:00

abstract：:The cell nucleus is a prominent target of autoantibodies in systemic autoimmune disorders. Approximately 2% of the population in Europe and North America suffers from systemic rheumatic diseases, such as rheumatoid arthritis, systemic lupus erythematosus (SLE), and scleroderma. The molecular mechanisms of systemic aut...

journal_title：Annals of the New York Academy of Sciences

authors： Chen M,von Mikecz A

更新日期：2005-06-01 00:00:00

abstract：:We measured plasma concentration of alpha-melanocyte-stimulating hormone (alpha-MSH), a proopiomelanocortin derivative that modulates pyrogenic and proinflammatory effects of cytokines, in infectious and inflammatory disorders in humans to learn if changes in this peptide take place in naturally occurring disease. alp...

journal_title：Annals of the New York Academy of Sciences

authors： Catania A,Airaghi L,Garofalo L,Cutuli M,Lipton JM

更新日期：1998-05-01 00:00:00

abstract：:Clara cell protein (CC16 or CC10) is a 15.8-kDa protein secreted all along the tracheobronchial tree and especially in the terminal bronchioles where Clara cells are localized. Even though the exact in vivo function of CC16 remains to be clarified, evidence is accumulating that CC16 plays an important protective role ...

journal_title：Annals of the New York Academy of Sciences

authors： Broeckaert F,Clippe A,Knoops B,Hermans C,Bernard A

更新日期：2000-01-01 00:00:00

abstract：:The song system of oscine birds has become a versatile model system that is used to study diverse problems in neurobiology. Because the song system is often studied with the intention of applying the results to mammalian systems, it is important to place song system brain nuclei in a broader context and to understand ...

journal_title：Annals of the New York Academy of Sciences

authors： Farries MA

更新日期：2004-06-01 00:00:00

abstract：:A remarkable "steroid sparing" effect of Saiboku-to was noted within 6 to 12 months of treatment in steroid-dependent asthmatic patients. Saiboku-to spared the downregulation of glucocorticoid receptor of human lymphocytes, plasma ACTH, and cortisol levels. It also spared downregulation of beta 2 receptor by beta 2 ag...

journal_title：Annals of the New York Academy of Sciences

authors： Nakajima S,Tohda Y,Ohkawa K,Chihara J,Nagasaka Y

更新日期：1993-06-23 00:00:00

abstract：:Proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) might be, at least partially, responsible for the development of osteopenia or osteoporosis in Crohn's disease. We investigated whether anti-TNF therapy for Crohn's disease could have any skeletal impact. Therefore, we studied the effects of ...

journal_title：Annals of the New York Academy of Sciences

authors： Pazianas M,Rhim AD,Weinberg AM,Su C,Lichtenstein GR

更新日期：2006-04-01 00:00:00

abstract：:Obesity has various deleterious effects on health largely associated with metabolic abnormalities including abnormal glucose and lipid homeostasis that are associated with vascular injury and known cardiac, renal, and cerebrovascular complications. Advanced age is also associated with increased adiposity, decreased le...

journal_title：Annals of the New York Academy of Sciences

authors： Lee EB

更新日期：2011-12-01 00:00:00

abstract：:The asymmetric inheritance of NUMB during mitosis determines future daughter cell fates in multiple model organisms. NUMB asymmetric inheritance has also been postulated for hematopoietic stem cell (HSC) divisions but remained controversial until recently. To reconcile conflicting reports, we revisited the evidence fo...

journal_title：Annals of the New York Academy of Sciences

authors： Loeffler D,Schneiter F,Schroeder T

更新日期：2020-04-01 00:00:00

abstract：:Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders that cause individuals to be prone to a variety of clinical manifestations, such as infections, autoimmunity, and malignancies. Early diagnosis and adequate treatment of these disorders can reduce morbidity and mortality and prov...

journal_title：Annals of the New York Academy of Sciences

authors： Rezaei N,Mohammadinejad P,Aghamohammadi A

更新日期：2011-11-01 00:00:00