Possible roles of nitric oxide in the physiology and pathophysiology of the mammalian cochlea.

Abstract:

:Nitric oxide (NO) has been implicated as a mediator of vasodilation and neurotransmission in the mammalian cochlea. This is demonstrated by the presence of nitric oxide synthase (NOS) and nitric oxide (NO) in the blood vessels and the organ of Corti in the cochlea. It is not certain if the neurons in the spiral ganglion produce NO since no fluorescent signal could be detected by 4,5-diaminofluorescein diacetate (DAF-2DA), a fluorescent indicator of NO. To determine if NO/peroxynitrite plays any role in neurodestruction observed in ischemic cochlea of the guinea pig, the effects of NO donors, such as S-nitrosocysteine (S-NC) and nitroglycerine (NTG); peroxynitrite generators, such as 3-morpholinosydnonimine (SIN-1); peroxynitrite inhibitors, such as superoxide dismutase plus catalase (SOD/Cat); and NOS inhibitors, such as N(G)-nitro-L-arginine methyl ether (L-NAME) were tested on normal and ischemic cochleae. The level of NO in the cochlea after 20 to 120 minutes of ischemia was indicated by measurement of nitrites/nitrates in the perilymph. The evidence gathered from these experiments indicates that NO or peroxynitrite is not necessarily destructive to auditory hair cells, and in fact, exogenous NO may protect neural structures in the cochlea from damage under ischemic conditions.

journal_name

Ann N Y Acad Sci

authors

Ruan RS

doi

10.1111/j.1749-6632.2002.tb04073.x

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

260-74

eissn

0077-8923

issn

1749-6632

journal_volume

962

pub_type

杂志文章,评审
  • Immune changes induced by electroconvulsive therapy (ECT).

    abstract::There is a significant increase in the percentage and absolute number of activated lymphocytes (OKT10+, IL2R1+) after ECT treatment of major depressive disorder. There is an acute decrease in the absolute number of total lymphocytes, T8+ and Leu11+ cells one hour after a single ECT. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1992.tb49146.x

    authors: Fischler B,Bocken R,Schneider I,De Waele M,Thielemans K,Derde MP

    更新日期:1992-04-15 00:00:00

  • Discovery of ligands for the nuclear peroxisome proliferator-activated receptors.

    abstract::The identification of high-affinity ligands for PPAR gamma has revealed the role of this receptor as the molecular target for the antidiabetic activity of the thiazolidinediones. The surprising observation that agonists of an adipogenic transcription factor reverse the obesity-associated disease of diabetes highlights...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1996.tb18622.x

    authors: Willson TM,Lehmann JM,Kliewer SA

    更新日期:1996-12-27 00:00:00

  • Effects of cooling on the response of the snail bursting neuron to acetylcholine.

    abstract::The Br-type neuron of the snail Helix pomatia, involved in neuronal regulation of various homeostatic and adaptive mechanisms, represents an interesting model for studying effects of temperature change on neuronal activity of poikilotherms. Acetylcholine induces a transient, inward dose-dependent current in the identi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1342.036

    authors: Nedeljković M,Kartelija G,Radenović L

    更新日期:2005-06-01 00:00:00

  • Neuroendocrine-immune interactions: the role of cortistatin/somatostatin system.

    abstract::Hormones and neuropeptides may influence the activities of lymphoid organs and cells via endocrine and local autocrine/paracrine pathways. A paradigm of the interactions between the neuroendocrine and immune system is sophisticatedly represented in the thymus. Indeed, receptors for these molecules are heterogeneously ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1351.011

    authors: Ferone D,Boschetti M,Resmini E,Giusti M,Albanese V,Goglia U,Albertelli M,Vera L,Bianchi F,Minuto F

    更新日期:2006-06-01 00:00:00

  • Biobehavioral indices of emotion regulation relate to school attitudes, motivation, and behavior problems in a low-income preschool sample.

    abstract::Effective emotion regulation may promote resilience and preschool classroom adjustment by supporting adaptive peer interactions and engagement in learning activities. We investigated how hypothalamus-pituitary-adrenal axis (HPA) regulation, cardiac reactivity, and classroom emotion displays related to adjustment among...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1376.043

    authors: Miller AL,Seifer R,Stroud L,Sheinkopf SJ,Dickstein S

    更新日期:2006-12-01 00:00:00

  • Translocation of imperiled species under changing climates.

    abstract::Conservation translocation of species varies from restoring historic populations to managing the relocation of imperiled species to new locations. We review the literature in three areas--translocation, managed relocation, and conservation decision making--to inform conservation translocation under changing climates. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12050

    authors: Schwartz MW,Martin TG

    更新日期:2013-05-01 00:00:00

  • Neurotoxicity of d-amphetamine in the C57BL/6J and CD-1 mouse. Interactions with stress and the adrenal system.

    abstract::Substantial evidence suggests that stress can alter the general toxicological properties of the substituted amphetamines (AMPs) as well as their psychostimulant properties. Research concerning the interactions between stress and the neurotoxicity associated with the AMPs is, however, limited. Our previous work demonst...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1996.tb17438.x

    authors: Miller DB,O'Callaghan JP

    更新日期:1996-10-31 00:00:00

  • Endocrine regulation of subcutaneous fat metabolism during cold exposure in humans.

    abstract::Increased oxidation of carbohydrates and free fatty acids is a well-known phenomenon during cold stress. Nevertheless, sources of the fuels used have not been fully clarified as yet. Thus, the aim of our study was to evaluate the effect of acute cold exposure on lipid and carbohydrate metabolism in human subcutaneous ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04308.x

    authors: Koska J,Ksinantova L,Seböková E,Kvetnansky R,Klimes I,Chrousos G,Pacak K

    更新日期:2002-06-01 00:00:00

  • Neuroprotective effects of L-carnitine in induced mitochondrial dysfunction.

    abstract::The neuroprotective action of l-carnitine (LC) in the rat model of 3-nitropropionic acid (3-NPA)-induced mitochondrial dysfunction was examined. 3-NPA is known to produce decreases in neuronal ATP levels via inhibition of the succinate dehydrogenase (SDH) at complex II of the mitochondrial electron transport chain. SD...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb07536.x

    authors: Binienda ZK

    更新日期:2003-05-01 00:00:00

  • Structure/function studies of the gamma subunit of the Na,K-ATPase.

    abstract::The Na,K-ATPase gamma subunit is present primarily in kidney as two splice variants, gammaa and gammab, which differ only at their extracellular N-termini. Two distinct effects of gamma are seen in biochemical Na,K-ATPase assays of mammalian (HeLa) cells transfected with gammaa or gammab, namely, (i) a decrease in K'(...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb07224.x

    authors: Blostein R,Pu HX,Scanzano R,Zouzoulas A

    更新日期:2003-04-01 00:00:00

  • Fighting nerve agent chemical weapons with enzyme technology.

    abstract::The extreme toxicity of organophosphorous-based compounds has been known since the late 1930s. Starting in the mid-1940s, many nations throughout the world have been producing large quantities of organophosphorous (OP) nerve agents. Huge stockpiles of nerve agents have since developed. There are reportedly more than 2...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb10298.x

    authors: LeJeune KE,Dravis BC,Yang F,Hetro AD,Doctor BP,Russell AJ

    更新日期:1998-12-13 00:00:00

  • Reproductive aging: theoretical perspectives, mechanisms, nonhuman models, and health correlates.

    abstract::Every 365.2421999 days--more or less--the earth rotates, revolves, wobbles, and precesses along an elliptical path around the sun. Those of us who survive the journey are a year older: we have aged one solar year. Some years we seem to age faster than other years; some people seem to age faster than other people; some...

    journal_title:Annals of the New York Academy of Sciences

    pub_type:

    doi:10.1111/j.1749-6632.2010.05700.x

    authors: Haaga J,O'Connor K,Weinstein M,Wise P

    更新日期:2010-08-01 00:00:00

  • Treatment of suicidality in schizophrenia.

    abstract::Between 4 and 13% of people with schizophrenia commit suicide and between 25 and 50% make a suicide attempt, a reflection of the devastating toll this syndrome takes on the quality of life, that is, the subjective and objective sense of well-being. Many risk factors for suicide in schizophrenia have been identified, t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb05797.x

    authors: Meltzer HY

    更新日期:2001-04-01 00:00:00

  • Prologue: mind over molecule: activating biological demons.

    abstract::The new vogue for systems biology is an important development. It is time to complement reductionist molecular biology by integrative approaches. But this welcome development is in danger of losing its way. Many of the early implementations of the approach are very low level, in some cases hardly more than an extensio...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1420.000

    authors: Noble D

    更新日期:2008-03-01 00:00:00

  • Condensate removal mechanisms in a constrained vapor bubble heat exchanger.

    abstract::Microgravity experiments on the constrained vapor bubble heat exchanger (CVB) are being developed for the space station. Herein, ground-based experimental studies on condensate removal in the condenser region of the vertical CVB were conducted and the mechanism of condensate removal in microgravity was found to be the...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb05913.x

    authors: Zheng L,Wang Y,Wayner PC Jr,Plawsky JL

    更新日期:2002-10-01 00:00:00

  • Cadmium-induced nephropathy in rats is mediated by expression of senescence-associated beta-galactosidase and accumulation of mitochondrial DNA deletion.

    abstract::Long-term exposure to cadmium (Cd) induces perturbation of kidney proximal tubular epithelial cells. Mitochondrial dysfunction in renal cortical cells may contribute to the pathogenesis of Cd-induced nephropathy. In this study, we examined the accumulation of mitochondrial DNA (mtDNA) with a large deletion and cellula...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1007/978-3-662-41088-2_33

    authors: Takaki A,Jimi S,Segawa M,Iwasaki H

    更新日期:2004-04-01 00:00:00

  • Afferent pathways of pyrogen signaling.

    abstract::We and others recently showed that fever induced by intravenously or intraperitoneally injected lipopolysaccharide (LPS) may involve brain signaling via hepatic vagal afferents. This suggests that LPS fever may be initiated by mediators released mainly by cells in the liver, presumably macrophages (Kupffer cells, Kc)....

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb08318.x

    authors: Blatteis CM,Sehic E,Li S

    更新日期:1998-09-29 00:00:00

  • Review of implementation processes for integrated nutrition and psychosocial stimulation interventions.

    abstract::This article reviews the implementation processes for interventions that integrate nutrition and psychosocial stimulation for children under 5 years of age in low- and middle-income countries. We examine the content of these programs, the delivery strategy, intensity and duration, personnel training and supervision, c...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12313

    authors: Yousafzai AK,Aboud F

    更新日期:2014-01-01 00:00:00

  • Exercise and sensory integration. Role of the nucleus tractus solitarius.

    abstract::Since NTS neurons receive synaptic input from many sensory modalities, it is crucial to understand the neuronal mechanisms involved in synaptic processing. We have proposed that GABA-containing neurons in the NTS are the primary target for somatic afferent fibers activated by skeletal muscle contraction. In our model,...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Potts JT

    更新日期:2001-06-01 00:00:00

  • Immunological responses are not abnormal in symptomatic Gulf War veterans.

    abstract::The underlying etiology and pathogenesis of Gulf War veterans' illnesses continue to be under intense investigation. Reports have suggested the basis for these illnesses may be an altered immune system, but compelling evidence is lacking. We sought to determine whether in vitro immune responses were abnormal in sympto...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb04233.x

    authors: Everson MP,Shi K,Aldridge P,Bartolucci AA,Blackburn WD

    更新日期:2002-06-01 00:00:00

  • Congenital lymphatic malformations.

    abstract::"Vascular anomalies" represents a spectrum of vascular lesions, of unclear etiology and often with unpredictable behavior. Patients with vascular anomalies represent a unique population, in that they have focal aberrations of vascular development (in vascular malformations) or vascular proliferation (in hemangiomas). ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1413.016

    authors: Blei F

    更新日期:2008-01-01 00:00:00

  • Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry.

    abstract::This study examined the functional response to human relaxin 2 (H2 relaxin), human relaxin 3 (H3 relaxin), porcine relaxin, and human INSL3 in the cytosensor microphysiometer, using CHO-K1 cells stably expressing human GPCR135. CHO-K1 cells stably expressing GPCR135 were generated by the serial dilution method and rec...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1282.053

    authors: Van der Westhuizen ET,Sexton PM,Bathgate RA,Summers RJ

    更新日期:2005-05-01 00:00:00

  • The effects of visual field changes and ocular hypertension on the visual evoked potential.

    abstract::The effects of visual field changes and ocular hypertension on visual evoked potentials were investigated by photopic ERG and by luminance and pattern-reversal EPs on 116 glaucomatous and on 7 normal eyes. The problem was approached by way of four investigations: Firstly, which nerve structures are affected by glaucom...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1982.tb50794.x

    authors: Bartl G

    更新日期:1982-01-01 00:00:00

  • Balb/c mouse model and real-time quantitative polymerase chain reaction for evaluation of the immunoprotectivity against Q fever.

    abstract::The Balb/c mice were infected with Coxiella burnetii and samples of blood and major organs from the infected mice were collected on days 1 to 14 after infection. The DNAs extracted from the samples were detected by a developed real-time quantitative PCR specific for C. burnetii and high loads of C. burnetii were found...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1355.027

    authors: Zhang J,Wen B,Chen M,Zhang J,Niu D

    更新日期:2005-12-01 00:00:00

  • Measurement of thermal diffusivity of bovine aorta subject to finite deformation.

    abstract::The flash thermal diffusivity measurement technique is applied to tissue for the first time. Making use of its minimal contact with the specimen, the flash technique is extended to allow for well-defined, biaxial, finite strain. As an example application, the radial component of thermal diffusivity of bovine descendin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb10143.x

    authors: Doss DJ,Humphrey JD,Wright NT

    更新日期:1998-09-11 00:00:00

  • In vitro superfusion method to study nerve-immune cell interactions in human synovial membrane in long-standing rheumatoid arthritis or osteoarthritis.

    abstract::Reports on patients with hemiparalysis indicate the importance of the nervous system for the pathophysiology of rheumatoid arthritis (RA) or osteoarthritis (OA). Norepinephrine (NE) and opioids seem to be more antiinflammatory neurotransmitters whereas substance P is proinflammatory. The study aimed to investigate the...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb07649.x

    authors: Miller LE,Wessinghage D,Müller-Ladner U,Schölmerich J,Falk W,Kerner T,Straub RH

    更新日期:1999-06-22 00:00:00

  • Aortic aneurysms as a source of circulating interleukin-6.

    abstract::In keeping with the inflammatory paradigm of abdominal aortic aneurysm (AAA) pathophysiology, in vitro studies suggest that aneurysms secrete the proinflammatory cytokine interleukin-6 (IL-6). Circulating IL-6 levels are higher in patients with AAA with elevated circulating IL-6 an independent risk factor for cardiova...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1383.009

    authors: Dawson J,Cockerill G,Choke E,Loftus I,Thompson MM

    更新日期:2006-11-01 00:00:00

  • Therapeutic approaches to pulmonary hypertension in hemoglobinopathies: Efficacy and safety of sildenafil in the treatment of severe pulmonary hypertension in patients with hemoglobinopathy.

    abstract::New approaches to the treatment of pulmonary arterial hypertension (PH) have increased symptomatic relief and prolonged survival. PH is a common sequela of the hemoglobinopathies, but the use of standard oral treatment options is limited because of toxicity and poor effectiveness. Sildenafil citrate is a selective and...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1345.070

    authors: Derchi G,Forni GL

    更新日期:2005-01-01 00:00:00

  • Origins of the plant chloroplasts and mitochondria based on comparisons of 5S ribosomal RNAs.

    abstract::In this paper, we provide macromolecular comparisons utilizing the 5S ribosomal RNA structure to suggest extant bacteria that are the likely descendants of chloroplast and mitochondria endosymbionts. The genetic stability and near universality of the 5S ribosomal gene allows for a useful means to study ancient evolut...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1987.tb40601.x

    authors: Delihas N,Fox GE

    更新日期:1987-01-01 00:00:00

  • The induction of tolerance to allergenic chemicals.

    abstract::The first recognition of tolerance and partial tolerance to attempted sensitization with simple allergenic chemicals is described. A proper designation would be the Frei-Sulzbeger-Chase phenomenon. Coupling with self occurs in these experiments; there is not only resistance to developing contactant-type sensitivity bu...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1982.tb36110.x

    authors: Chase MW

    更新日期:1982-01-01 00:00:00