Effector memory CD8+ T cells are resistant to apoptosis.

Abstract:

:Based upon their migrating properties and effector functions, CD8(+) T cells have been further classified into central memory (T(CM)) and two types of effector memory (T(EM) and T(EMRA)) cells. These memory cells display distinct replicative characteristics. Because apoptosis plays an important role in cellular homeostasis, we have examined the relative sensitivity of naïve (T(N)) and different memory CD8(+) T cells to apoptosis. We show that both T(EM) and T(EMRA) CD8(+) T cells are resistant to apoptosis, whereas T(N) and T(CM) CD8(+) T cells are sensitive to apoptosis.

journal_name

Ann N Y Acad Sci

authors

Gupta S,Gollapudi S

doi

10.1196/annals.1398.017

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

145-50

eissn

0077-8923

issn

1749-6632

pii

1109/1/145

journal_volume

1109

pub_type

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