Abstract:
:The aim of this study was to evaluate the possible neuroprotective effects of thymosin beta(4) in different models of excitotoxicity. The application of thymosin beta(4) significantly attenuated glutamate-induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices. In in vivo experiments, the intracerebroventricular administration of thymosin beta(4) significantly reduced hippocampal neuronal loss induced by kainic acid. These results show that thymosin beta(4) induced a protective effect in models of excitotoxicity. The mechanisms underlying such an effect, as well as the real neuroprotective potential of thymosin beta(4), are worthy of further investigations.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Popoli P,Pepponi R,Martire A,Armida M,Pèzzola A,Galluzzo M,Domenici MR,Potenza RL,Tebano MT,Mollinari C,Merlo D,Garaci Edoi
10.1196/annals.1415.033subject
Has Abstractpub_date
2007-09-01 00:00:00pages
219-24eissn
0077-8923issn
1749-6632pii
1112/1/219journal_volume
1112pub_type
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