Genetic variation influencing hemoglobin levels and risk for anemia across populations.

abstract：:This study describes the features of the marginal zone (MZ) B cells of human tonsils and spleens and compares them with those of the follicular mantle (FM) B cells from the same tissues. The two B cell subpopulations displayed marked differences in phenotype, in response capacity to T cell-independent antigens and pol...

journal_title：Annals of the New York Academy of Sciences

authors： Dono M,Zupo S,Colombo M,Massara R,Gaidano G,Taborelli G,Ceppa P,Burgio VL,Chiorazzi N,Ferrarini M

更新日期：2003-04-01 00:00:00

abstract：:An MRI-pathological correlation study was performed to determine the pathological background of white matter lesions depicted on MR images. The pathological findings were various combinations of myelin loss, axonal loss, scattered microinfarcts, astrogliosis, dilatation of perivascular space, and relative preservation...

journal_title：Annals of the New York Academy of Sciences

authors： Udaka F,Sawada H,Kameyama M

更新日期：2002-11-01 00:00:00

abstract：:Ancestral haplotype (AH) 8.1(HLA-A1, Cw7, B8, TNFAB*a2b3, TNFN*S, C2*C, Bf*s, C4A*Q0, C4B*1, DRB1*0301, DRB3*0101, DQA1*0501, DQB1*0201) seems to be associated with susceptibility to autoimmune diseases. Different mechanisms are probably involved in increasing autoimmunity, such as unbalanced cytokine production and t...

journal_title：Annals of the New York Academy of Sciences

authors： Candore G,Campagna AM,Cuppari I,Di Carlo D,Mineo C,Caruso C

更新日期：2007-09-01 00:00:00

abstract：:Clinical research has demonstrated that increased or decreased estradiol 2-hydroxylation can easily be achieved with a number of experimental approaches. In contrast, estradiol 16 alpha-hydroxylation, which may have potentially deleterious effects in estrogen-dependent tissues, cannot be readily altered. Predictable h...

journal_title：Annals of the New York Academy of Sciences

authors： Michnovicz JJ,Bradlow HL

更新日期：1990-01-01 00:00:00

abstract：:According to the redusome hypothesis, the aging of an organism is determined by the shortening of chronomeres (small perichromosomal linear DNA molecules). In this paper, a presumptive role for infradian hormonal rhythms is considered. Endogenous infradian rhythms are supposed to actively interact with those hormonal ...

journal_title：Annals of the New York Academy of Sciences

authors： Olovnikov A

更新日期：2005-12-01 00:00:00

abstract：:In an effort to identify novel targets for the development of nonhormonal male contraceptives, genome-wide transcriptional profiling of the rat testis was performed. Specifically, enzymatically purified spermatogonia plus early spermatocyctes, pachytene spermatocytes, round spermatids, and Sertoli cells was analyzed a...

journal_title：Annals of the New York Academy of Sciences

authors： Johnston DS,Jelinsky SA,Zhi Y,Finger JN,Kopf GS,Wright WW

更新日期：2007-12-01 00:00:00

abstract：:The invariant nature of body situs within and across vertebrate species implies that a highly conserved pathway controls the specification of the left-right (L/R) axis. Situs-specific morphogenesis begins at the end of this pathway and leads to normal organ arrangement, also known as situs solitus. Occasionally, indiv...

journal_title：Annals of the New York Academy of Sciences

authors： Delhaas T,Decaluwe W,Rubbens M,Kerckhoffs R,Arts T

更新日期：2004-05-01 00:00:00

abstract：:At the alpha(2A)-autoreceptors on the sympathetic nerve terminals of the human atrial appendages and rabbit pulmonary artery, rilmenidine and oxymetazoline exhibit different properties (antagonism and agonism, respectively). These opposite pharmacodynamic properties of alpha(2)-adrenoceptor ligands seem to be due to s...

journal_title：Annals of the New York Academy of Sciences

authors： Molderings GJ,Bonisch H,Bruss M,Gothert M

更新日期：2003-12-01 00:00:00

abstract：:Phosphorus nuclear magnetic resonance studies of various normal and dystrophic muscles have demonstrated differences in phosphodiester contents. Dystrophic chicken pectoralis muscle contains elevated levels of the diester SEP, and Duchenne dystrophic human leg muscle lacks the diester GPC. It is shown that SEP may be ...

journal_title：Annals of the New York Academy of Sciences

authors： Chalovich JM,Burt CT,Danon MJ,Glonek T,Bárány M

更新日期：1979-01-01 00:00:00

abstract：:The following on molecular aspects of esophageal development contains commentaries on esophageal striated myogenesis and transdifferentiation; conversion from columnar into stratified squamous epithelium in the mouse esophagus; the roles for BMP signaling in the developing esophagus and forestomach; and evidence of a ...

journal_title：Annals of the New York Academy of Sciences

authors： Rishniw M,Rodriguez P,Que J,Burke ZD,Tosh D,Chen H,Chen X

更新日期：2011-09-01 00:00:00

abstract：:Preventable chronic diseases are the leading cause of death in the majority of countries throughout the world, and this trend will continue for the foreseeable future. The potential to offset the social, economic, and personal burdens associated with such conditions depends on our ability to influence people's thought...

journal_title：Annals of the New York Academy of Sciences

authors： Hall PA,Bickel WK,Erickson KI,Wagner DD

更新日期：2018-09-01 00:00:00

abstract：:Preliminary reports indicate the influence of oxidative stress and interleukins, particularly TGF-beta1, in maintenance of bone mass. This study was designed to determine any possible variations of cellular lipid peroxidation, the total antioxidant power, and concentration of TGF-beta1 in blood and saliva of osteoporo...

journal_title：Annals of the New York Academy of Sciences

authors： Yousefzadeh G,Larijani B,Mohammadirad A,Heshmat R,Dehghan G,Rahimi R,Abdollahi M

更新日期：2006-12-01 00:00:00

abstract：:A variety of chemical compounds are currently being discussed as novel drug delivery strategies. One promising strategy is to selectively open the paracellular pathway of epithelia for the passage of macromolecules. A prerequisite for this effect is a rapid and reversible action of these compounds, to allow a marked t...

journal_title：Annals of the New York Academy of Sciences

authors： Rosenthal R,Heydt MS,Amasheh M,Stein C,Fromm M,Amasheh S

更新日期：2012-07-01 00:00:00

abstract：:The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the relationship between stem cells, cancer, and the esophagus; the behavior of esophageal stem cells; and the role of genetics and epigenetics in approaches to translational research. ...

journal_title：Annals of the New York Academy of Sciences

authors： Croagh D,Frede J,Jones PH,Kaur P,Partensky C,Phillips WA

更新日期：2014-09-01 00:00:00

abstract：:Our previous studies have demonstrated that the methanol extract of heat-processed Panax ginseng C.A. Meyer exerts antioxidative, antiinflammatory, and anti-tumor-promoting effects. In the present study, we examined the antiinflammatory effects of several ginsenosides (Rb(1), Rc, Re, Rg(1), Rg(3)) derived from P. gins...

journal_title：Annals of the New York Academy of Sciences

authors： Surh YJ,Lee JY,Choi KJ,Ko SR

更新日期：2002-11-01 00:00:00

abstract：:The adrenergic system has long been known to be activated in a situation of stress and thus during opiate withdrawal. A method for detoxification that decreases the stimulation of the sympathetic nervous system will prevent changes of catecholamine levels. Some of such methods have been developed. One of them uses dir...

journal_title：Annals of the New York Academy of Sciences

authors： Macedo TR,Relvas J,Fontes Ribeiro CA,Pacheco F,Morgadinho MT,Pinto CM,Gomes PC,Ventura M,Henriques V,Nunes SV,Ruis GR,Ramalheira C,Boto I,Vale LL

更新日期：2000-09-01 00:00:00

abstract：:Mouse pheochromocytoma cells (MPCs) provide an excellent model system for investigating the effects of hypoxia on catecholamine enzyme genes and on transcription factors mediating stress responses. RT-PCR detects rapid, transient increases in PNMT mRNA in hypoxic MPC 712 cells. Additionally, elevation of mRNAs encodin...

journal_title：Annals of the New York Academy of Sciences

authors： Evinger MJ,Cikos S,Nwafor-Anene V,Powers JF,Tischler AS

更新日期：2002-10-01 00:00:00

abstract：:Both hereditary and environmental factors influence the risk of cancer. Four risk categories, or oncodemes, can exist for a particular kind of cancer, depending upon the presence of neither, one, or both factors: (1) spontaneous, or background; (2) hereditary; (3) environmental; (4) interactive. In the second, mutatio...

journal_title：Annals of the New York Academy of Sciences

authors： Knudson AG

更新日期：1997-12-29 00:00:00

abstract：:Major trauma, shock, sepsis, and other conditions can lead to the acute respiratory distress syndrome (ARDS), which may progress to the highly lethal multiple organ dysfunction syndrome (MODS). Although a number of therapeutic strategies have been initiated, their success has been limited largely due to an incomplete ...

journal_title：Annals of the New York Academy of Sciences

authors： Deitch EA

更新日期：2010-10-01 00:00:00

abstract：:This paper represents a unique effort to elucidate the dynamics of two major types of politically motivated hostage takers. The data presented are derived from an ongoing research project that is gathering extensive interview and psychological test materials from prisoners convicted of politically motivated crimes, bo...

journal_title：Annals of the New York Academy of Sciences

authors： Knutson JN

更新日期：1980-01-01 00:00:00

abstract：:TP73, as a TP53 homologue, drew the attention of tumor biologists because it is rarely mutated in human cancers and can induce cell cycle arrest and apoptosis by activating genes also regulated by p53. However, TP73 harbors an additional promoter that produces a dominant negative p73 protein (deltaNp73) having the opp...

journal_title：Annals of the New York Academy of Sciences

authors： Rossi M,Sayan AE,Terrinoni A,Melino G,Knight RA

更新日期：2004-12-01 00:00:00

abstract：:The xynA gene encoding a major xylanase of Clostridium stercorarium F-9 was sequenced. The structural gene consists of an open reading frame of 1533 bp encoding a protein of 511 amino acids with an M(r) of 56,519. XynA consists of a catalytic domain belonging to family G at the NH2-terminus and two direct repeats of a...

journal_title：Annals of the New York Academy of Sciences

authors： Sakka K,Takada G,Karita S,Ohmiya K

更新日期：1996-05-15 00:00:00

abstract：:Little is known about how mitogenic factors generate growth regulatory signals and how these are mediated within the cell. We have developed three different types of mitogenic stimuli in order to identify the possible existence of common denominators in a complex and perhaps pleiotypic signal-response system. 3T3 cell...

journal_title：Annals of the New York Academy of Sciences

authors： Zetterberg A,Engström W,Larsson O

更新日期：1982-12-10 00:00:00

abstract：:From the time Dan was 12 years old to the present, he always was the explorer of life. He was very fortunate in having an opportunity to see how life exists in several human societies around the world. His many professional foreign travels are presented. Dan went to a 1959 meeting in Argentina, to England in 1963, and...

journal_title：Annals of the New York Academy of Sciences

authors： Gilbert C,Gilbert RL

更新日期：2000-01-01 00:00:00

abstract：:The acquisition of both speech and music uses general principles: learners extract statistical regularities present in the environment. Yet, individuals who suffer from congenital amusia (commonly called tone-deafness) have experienced lifelong difficulties in acquiring basic musical skills, while their language abili...

journal_title：Annals of the New York Academy of Sciences

authors： Peretz I,Saffran J,Schön D,Gosselin N

更新日期：2012-04-01 00:00:00

abstract：:Hyperinsulinemia and hyperglycemia have been associated with vascular injury such as atherosclerosis in diabetes mellitus. Recently, annexin II, a member of annexin family proteins, has been found to work as co-receptor on endothelial cells for plasminogen and tissue plasminogen activator, facilitating plasmin generat...

journal_title：Annals of the New York Academy of Sciences

authors： Ishii H,Yoshida M,Hajjar KA,Tanaka A,Yasukochi Y,Shimokado K,Numano F

更新日期：2001-12-01 00:00:00

abstract：:I2-imidazoline receptors (I2-IR) are characterized by their high affinity for imidazolines and guanidines and medium affinity for imidazolidines. The differential recognition of I2-IR by amiloride led to subtype these sites as amiloride-sensitive (I2A-IR) and amiloride-insensitive (I2B-IR). I2-IR labeled with [3H]idaz...

journal_title：Annals of the New York Academy of Sciences

authors： Olmos G,Alemany R,Boronat MA,García-Sevilla JA

更新日期：1999-06-21 00:00:00

abstract：:Stabilization of images on the fovea during either fore/aft translation of a subject or fore/aft movement of a visual target in front of a stationary observer imposes complex geometrical requirements that depend upon the eccentricity of the object of interest with respect to the eyes. Each eye needs to be rotated inde...

journal_title：Annals of the New York Academy of Sciences

authors： Ramat S,Zee DS

更新日期：2005-04-01 00:00:00

abstract：:The secretory granules function as the major IP(3)-sensitive intracellular Ca(2+) store of secretory cells. Recently it was found that the secretory granules contain three isoforms of inositol 1,4,5-trisphosphate receptor (IP(3)R)/Ca(2+) channels and high-capacity, low-affinity Ca(2+) storage proteins chromogranins A ...

journal_title：Annals of the New York Academy of Sciences

authors： Yoo SH,So SH,Huh YH,Park HY

更新日期：2002-10-01 00:00:00

abstract：:The Buddhist view of the origin of the universe is discussed. One of the basic tenets of Buddhism is the concept of interdependence which says that all things exist only in relationship to others, and that nothing can have an independent and autonomous existence. The world is a vast flow of events that are linked toge...

journal_title：Annals of the New York Academy of Sciences

authors： Thuan TX

更新日期：2001-12-01 00:00:00