Flavonoids and metabolic syndrome.

abstract：:The effect of carcinogenesis on various hepatic microsomal parameters and related cell functions was studied in two tumor models. Hepatocarcinoma was produced by diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) (Solt-Farber model) and mammary adenocarcinoma using R3230 AC cancer cell line. In these models th...

journal_title：Annals of the New York Academy of Sciences

authors： Feuer G

更新日期：1988-01-01 00:00:00

abstract：:The effects of visual field changes and ocular hypertension on visual evoked potentials were investigated by photopic ERG and by luminance and pattern-reversal EPs on 116 glaucomatous and on 7 normal eyes. The problem was approached by way of four investigations: Firstly, which nerve structures are affected by glaucom...

journal_title：Annals of the New York Academy of Sciences

authors： Bartl G

更新日期：1982-01-01 00:00:00

abstract：:N-type calcium channels both generate the initial calcium signal to trigger neurotransmitter release and also interact with synaptic release proteins at many mammalian central nervous system synapses. Two isoforms of the alpha 1B N-type channel from rat brain (alpha 1B-I and alpha 1B-II) were found to differ in four r...

journal_title：Annals of the New York Academy of Sciences

authors： Stea A,Dubel SJ,Snutch TP

更新日期：1999-04-30 00:00:00

abstract：:The harmful effects of oxidative processes in living organisms, in addition to chemical and biochemical media, can be reduced by antioxidants. The efficacy of an antioxidant depends on its reduction potential and kinetics of elimination of diverse free radicals. Redox potentials and reaction rate constants of selected...

journal_title：Annals of the New York Academy of Sciences

authors： Jovanovic SV,Simic MG

更新日期：2000-01-01 00:00:00

abstract：:Human female reproductive aging consists of multiple processes and interacts with other physiological systems in unique ways. Here we discuss eight recent longitudinal, epidemiologic studies of female reproductive aging that include endocrine data to highlight their contributions to our understanding of these various ...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrell RJ,Sowers M

更新日期：2010-08-01 00:00:00

abstract：:Sixty years ago Hans Selye discovered that the neuroendocrine and immune systems interact during stress. The pathophysiological significance of neuroendocrine-immune interaction during injury has only been recognized recently. Today it is rapidly emerging that, in addition to defense against exogenous pathogenic agent...

journal_title：Annals of the New York Academy of Sciences

authors： Berczi I

更新日期：1998-06-30 00:00:00

abstract：:The primate orbitofrontal cortex (OFC) is often treated as a single entity, but architectonic and connectional neuroanatomy indicate that it has distinguishable parts. Nevertheless, few studies have attempted to dissociate the functions of its subregions. Here we review findings from recent neuropsychological and neur...

journal_title：Annals of the New York Academy of Sciences

authors： Rudebeck PH,Murray EA

更新日期：2011-12-01 00:00:00

abstract：:Weight reduction through caloric restriction (CR) or exercise can have opposite effects on bone. This study investigated the effects of comparable weight reduction through CR and/or exercise on body composition and bone structure in an obese rat model. Male 6-week-old rats were fed either a normal-fat diet for 6 month...

journal_title：Annals of the New York Academy of Sciences

authors： Cao JJ

更新日期：2018-12-01 00:00:00

abstract：:Ischemic stroke is one of the leading causes of death and morbidity worldwide, and systemic thrombolytic treatment is still the first-line therapy within 4.5 h from symptom onset. Selecting patients for treatment response is mandatory in any time window but challenging as well. The authors aim to support stroke physic...

journal_title：Annals of the New York Academy of Sciences

authors： Hametner C,Ringleb PA,Hacke W,Kellert L

更新日期：2012-09-01 00:00:00

abstract：:Modified tumor cells were used to immunize three murine hosts against syngenic ascitic lymphomas: C3H-6C3HED, BALB/c-P1798, and DBA/2-L1210. When the host was capable of a significant immune response against the malignant cells during progressive tumor growth (e.g., C3H vs. 6C3HED), protective immunization against a l...

journal_title：Annals of the New York Academy of Sciences

authors： Prager MD,Gordon WC,Baechtel FS

更新日期：1976-01-01 00:00:00

abstract：:Despite intense efforts, little is known about the etiology of prostate cancer, and treatment of advanced forms of the disease has had limited success. Nonetheless, epidemiologic studies combined with animal model and in vitro experiments indicate that natural components of the diet, including n-3 PUFA, the carotenoid...

journal_title：Annals of the New York Academy of Sciences

authors： Cohen LA

更新日期：2002-06-01 00:00:00

abstract：:Previous studies in postmenopausal women have reported that estrogen treatment (ET) modulates the risk for developing Alzheimer's disease (AD). It has recently been hypothesized that there may be a "critical period" around the time of menopause during which the prescription of ET may reduce the risk of developing AD i...

journal_title：Annals of the New York Academy of Sciences

authors： Craig MC,Murphy DG

更新日期：2010-09-01 00:00:00

abstract：:Coccidioidomycosis is a mild to life-threatening disease in otherwise healthy humans and other mammals caused by the fungus Coccidioides spp. Understanding the development of the unique dimorphic life cycle of Coccidioides spp. and its role in pathogenesis has been an area of research focus. However, nuclear behavior ...

journal_title：Annals of the New York Academy of Sciences

authors： Li L,Schmelz M,Kellner EM,Galgiani JN,Orbach MJ

更新日期：2007-09-01 00:00:00

abstract：:The dynamics and kinematics of saccades in a patient with severe ocular myasthenia were studied before and after treatment with intravenous immunoglobulin (IVIG). Before therapy, horizontal saccades were hypometric, but faster than similar-sized saccades made by normal subjects. During a 5-minute test period, saccades...

journal_title：Annals of the New York Academy of Sciences

authors： Serra A,Thurtell MJ,Leigh RJ

更新日期：2009-05-01 00:00:00

abstract：:Na+/Ca2+-K+ exchangers (NCKX) are plasma membrane transporters that are thought to mainly mediate Ca2+ extrusion (along with K+) at the expense of the Na+ electrochemical gradient. However, because they are bidirectional, most assays have relied on measuring their activity in the reverse (Ca2+ import) mode. Herein we ...

journal_title：Annals of the New York Academy of Sciences

authors： Altimimi HF,Schnetkamp PP

更新日期：2007-03-01 00:00:00

abstract：:The neuroprotective action of l-carnitine (LC) in the rat model of 3-nitropropionic acid (3-NPA)-induced mitochondrial dysfunction was examined. 3-NPA is known to produce decreases in neuronal ATP levels via inhibition of the succinate dehydrogenase (SDH) at complex II of the mitochondrial electron transport chain. SD...

journal_title：Annals of the New York Academy of Sciences

authors： Binienda ZK

更新日期：2003-05-01 00:00:00

abstract：:The lysosomal system has often been considered a prominent morphologic marker of distressed or dying neurons. Lysosomes or their constituent hydrolases have been viewed in different neuropathologic states as either initiators and direct agents of cell death, agents of cellular repair and recompensation, effectors of e...

journal_title：Annals of the New York Academy of Sciences

authors： Nixon RA,Cataldo AM

更新日期：1993-05-28 00:00:00

abstract：:Here we describe the AddNeuroMed multicenter magnetic resonance imaging (MRI) study for longitudinal assessment in Alzheimer's disease (AD). The study is similar to a faux clinical trial and has been established to assess longitudinal MRI changes in AD, mild cognitive impairment (MCI), and healthy control subjects usi...

journal_title：Annals of the New York Academy of Sciences

authors： Simmons A,Westman E,Muehlboeck S,Mecocci P,Vellas B,Tsolaki M,Kłoszewska I,Wahlund LO,Soininen H,Lovestone S,Evans A,Spenger C,AddNeuroMed Consortium.

更新日期：2009-10-01 00:00:00

abstract：:There are several lines of evidence implying the involvement of the central glutamatergic system in morphine dependence. Extracellular glutamate released from nerve terminals is counterbalanced by glutamate transporters in neurons (EAAC1 and EAAT4) and glial cells (GLT-1 and GLAST), thereby modulating the glutamatergi...

journal_title：Annals of the New York Academy of Sciences

authors： Nakagawa T,Satoh M

更新日期：2004-10-01 00:00:00

abstract：:The adaptation of the vestibulo-ocular reflex (VOR) was studied in 26 normal subjects and 26 patients with cerebellar lesions, using horizontal vision-reversal prisms. In normal subjects, the adaptation of gain after wearing prisms for one hour was approximately 50% of the VOR value in the dark. In contrast to this, p...

journal_title：Annals of the New York Academy of Sciences

authors： Yagi T,Shimizu M,Sekine S,Kamio T,Suzuki JI

更新日期：1981-01-01 00:00:00

abstract：:There is now clear evidence that the brain, similar to the adrenal gland, gonads, and placenta, is a steroidogenic organ. Notably in the frog brain, the presence of various steroidogenic enzymes has been detected by immunohistochemistry in specific populations of neurons and/or glial cells. These steroidogenic enzymes...

journal_title：Annals of the New York Academy of Sciences

authors： Do Rego JL,Seong JY,Burel D,Luu-The V,Larhammar D,Tsutsui K,Pelletier G,Tonon MC,Vaudry H

更新日期：2009-04-01 00:00:00

abstract：:Compelling evidence now exists for estrogen's involvement in the regulation of mood and cognitive functions. Serum estrogen levels have been shown to play an important role in the expression of psychiatric disorders such as depression and schizophrenia. We have characterized the distribution of the estrogen receptors,...

journal_title：Annals of the New York Academy of Sciences

authors： Ostlund H,Keller E,Hurd YL

更新日期：2003-12-01 00:00:00

abstract：:Astronomers and physicists of diverse interest are teaming up to study enigmatic cosmic phenomena, such as the life cycle of black holes. A "disruptive innovation" is about to emerge during the next decade: Advanced gravitational-wave observatories. The emergence of gravitational-wave physics as a viable observational...

journal_title：Annals of the New York Academy of Sciences

authors： Márka S

更新日期：2012-07-01 00:00:00

abstract：:The remarkable hemodynamic changes of normal pregnancy are briefly reviewed. In addition, new findings and current concepts related to the underlying hormonal and molecular mechanisms are presented. Finally, work that is in progress as well as future directions is briefly discussed. ...

journal_title：Annals of the New York Academy of Sciences

authors： Conrad KP,Jeyabalan A,Danielson LA,Kerchner LJ,Novak J

更新日期：2005-05-01 00:00:00

abstract：:The availability of new food composition carotenoid values for fruits and vegetables increases our ability to test hypotheses concerning the role of antioxidant nutrients and cancer risk. To estimate the usual carotenoid intakes, a quantitative diet history covering a one-year period is recommended for epidemiologic s...

journal_title：Annals of the New York Academy of Sciences

authors： Hankin JH,Le Marchand L,Kolonel LN,Wilkens LR

更新日期：1993-12-31 00:00:00

abstract：:Clara cell protein (CC16 or CC10) is a 15.8-kDa protein secreted all along the tracheobronchial tree and especially in the terminal bronchioles where Clara cells are localized. Even though the exact in vivo function of CC16 remains to be clarified, evidence is accumulating that CC16 plays an important protective role ...

journal_title：Annals of the New York Academy of Sciences

authors： Broeckaert F,Clippe A,Knoops B,Hermans C,Bernard A

更新日期：2000-01-01 00:00:00

abstract：:The liver is morphologically and functionally modulated by sex hormones. Long-term use of oral contraceptives (OCs) and anabolic androgenic steroids (AASs) can induce both benign (hemangioma, adenoma, and focal nodular hyperplasia [FNH]) and malignant (hepatocellular carcinoma [HCC]) hepatocellular tumors. Hepatic ade...

journal_title：Annals of the New York Academy of Sciences

authors： Giannitrapani L,Soresi M,La Spada E,Cervello M,D'Alessandro N,Montalto G

更新日期：2006-11-01 00:00:00

abstract：:We recently isolated a novel bHLH/PAS protein, CLIF (cycle like factor), by yeast two-hybrid screening of human umbilical endothelial cell cDNA library. CLIF is preferentially expressed in endothelial and neuronal cells. Because CLIF is expressed in vascular endothelial cells and forms a heterodimer with CLOCK, the ke...

journal_title：Annals of the New York Academy of Sciences

authors： Maemura K,Layne MD,Watanabe M,Perrell MA,Nagai R,Lee ME

更新日期：2001-12-01 00:00:00

abstract：:Recent discoveries have demonstrated the extraordinary plasticity of tissue-derived stem cells, raising fundamental questions about cell lineage relationships and suggesting the potential for novel cell-based therapies. We have examined this phenomenon in a potential reciprocal relationship between stem cells derived ...

journal_title：Annals of the New York Academy of Sciences

authors： Goodell MA,Jackson KA,Majka SM,Mi T,Wang H,Pocius J,Hartley CJ,Majesky MW,Entman ML,Michael LH,Hirschi KK

更新日期：2001-06-01 00:00:00

abstract：:The Na,K-ATPase is composed of two subunits, alpha and beta, and each subunit consists of multiple isoforms. In the case of alpha, four isoforms, alpha1, alpha2, alpha3, and alpha4 are present in mammalian cells. The distribution of these isoforms is tissue- and developmental-specific, suggesting that they may play sp...

journal_title：Annals of the New York Academy of Sciences

authors： Lingrel J,Moseley A,Dostanic I,Cougnon M,He S,James P,Woo A,O'Connor K,Neumann J

更新日期：2003-04-01 00:00:00