Molecular mechanisms of morning onset of myocardial infarction.

abstract：:The frequency of type 1 diabetes mellitus (T1DM)-associated HLA DQ alleles in the U.S. Pacific Northwest is as high as in Scandinavia, which has the highest T1DM incidence in the world. The high regional rate of islet autoimmunity observed among DPT-1 relatives supports this notion. Fortunately, Washington State archi...

journal_title：Annals of the New York Academy of Sciences

authors： Wion E,Brantley M,Stevens J,Gallinger S,Peng H,Glass M,Hagopian W

更新日期：2003-11-01 00:00:00

abstract：:Activated platelets and leukocytes release potent vasoactive factors that may modulate vascular tone. Activation of normal platelets produces dilatation of normal arteries. Vasodilatation is mediated by adenosine diphosphate (ADP), which releases endothelium-derived relaxing factor (EDRF) from endothelium. In atherosc...

journal_title：Annals of the New York Academy of Sciences

authors： Kaul S,Padgett RC,Heistad DD

更新日期：1994-04-18 00:00:00

abstract：:We review the effects of two transcription factor decoy oligonucleotides on apoptosis of human osteoclasts (OCs). The first decoy molecule was designed to inhibit nuclear factor kappa-B (NF-kappaB) binding to target sequence, the second to increase estrogen receptor (ER) alpha expression. We found that both decoy mole...

journal_title：Annals of the New York Academy of Sciences

authors： Piva R,Penolazzi L,Zennaro M,Bianchini E,Magri E,Borgatti M,Lampronti I,Lambertini E,Tavanti E,Gambari R

更新日期：2006-12-01 00:00:00

abstract：:The prevalence of obesity is rapidly increasing in the United States, particularly among women. Approximately 60-70% of hypertension in adults may be directly attributed to obesity. In addition, maternal obesity is a major risk factor for hypertensive disorders during pregnancy. The underlying mechanisms for the assoc...

journal_title：Annals of the New York Academy of Sciences

authors： Fu Q

更新日期：2019-10-01 00:00:00

abstract：:In electrical impedance cardiography, Kubicek's formula is often used to measure stroke volume from thoracic impedance variations synchronously to heart activity. To calculate stroke volume from impedance variations, the so-called outflow problem should be adequately solved. This outflow problem refers to the joint ca...

journal_title：Annals of the New York Academy of Sciences

authors： Faes TJ,Raaijmakers E,Meijer JH,Goovaerts HG,Heethaar RM

更新日期：1999-04-20 00:00:00

abstract：:In this paper, we develop an agent-based model of social influence on body weight. The model's assumptions are grounded in theory and evidence from physiology, social psychology, and behavioral science, and its outcomes are tested against longitudinal data from American youth. We discuss the implementation of the mode...

journal_title：Annals of the New York Academy of Sciences

authors： Hammond RA,Ornstein JT

更新日期：2014-12-01 00:00:00

abstract：:Throughout this century in the United States, tension has existed between those who believe drug abuse is best combatted through the criminal justice system and those who emphasize a medical/public health model of prevention and treatment. In the last decade this debate has centered around the person of the pregnant a...

journal_title：Annals of the New York Academy of Sciences

authors： Chavkin W,Wise PH,Elman D

更新日期：1998-06-21 00:00:00

abstract：:Asbestos contamination of relatively contained environments within structures can occur under many conditions and in association with various activities. Such contamination persists and can potentially expose all structure users. The more significant contamination levels are associated with disturbance of friable asbe...

journal_title：Annals of the New York Academy of Sciences

authors： Sawyer RN

更新日期：1979-01-01 00:00:00

abstract：:While liver enzyme changes are frequently reported in hyperthyroidism, liver dysfunction itself can lead to alterations in thyroid hormone metabolism. However, the exact relationship between hyperthyroidism and liver dysfunction is unclear. We report an 11-year-old boy presenting with acute hepatitis of unknown etiolo...

journal_title：Annals of the New York Academy of Sciences

authors： Yeliosof O,Marshall I

更新日期：2020-09-23 00:00:00

abstract：:Improved technology and medical advances have increased the lifespan for people with thalassemia. As thalassemia is no longer exclusively a pediatric blood disorder, consideration must now be given to transition planning from pediatric to adult care. The complexity of thalassemia disease, coupled with the changing fac...

journal_title：Annals of the New York Academy of Sciences

authors： Levine L,Levine M

更新日期：2010-08-01 00:00:00

abstract：:It is well known that women with breast cancer who undergo therapies beyond the surgical intervention (adjuvant chemotherapy, hormone therapy, or both) often suffer from the lack of estrogen, manifesting as climacteric symptoms in either treated premenopausal or postmenopausal women. Although HRT (hormone replacement ...

journal_title：Annals of the New York Academy of Sciences

authors： Xydakis AM,Sakkas EG,Mastorakos G

更新日期：2006-12-01 00:00:00

abstract：:Converging lines of evidence indicate that withdrawal from prolonged exposure to stimulants and alcohol results in synaptic deficits of both dopamine (DA) and serotonin (5-HT). According to the dual deficit model proposed by the authors, DA dysfunction during cocaine or alcohol withdrawal underlies anhedonia and psych...

journal_title：Annals of the New York Academy of Sciences

authors： Rothman RB,Partilla JS,Dersch CM,Carroll FI,Rice KC,Baumann MH

更新日期：2000-09-01 00:00:00

abstract：:A triple genetic association between serum IgE levels, mast cell numbers, and susceptibility to oral tolerance was observed in mice genetically selected to extreme phenotypes of oral tolerance (susceptibility and resistance), suggesting a coadaptation of genes controlling these traits. ...

journal_title：Annals of the New York Academy of Sciences

authors： da Silva AC,Silva MF,Bianchi C,Ribeiro RC,Nóbrega A,Sant'anna O

更新日期：2004-12-01 00:00:00

abstract：:A 1.2 kb polymorphic fragment from the Gardel isolate of Ehrlichia (formerly Cowdria) ruminantium was used to isolate a 15kb clone from the E. ruminantium Welgevonden LambdaGEM-11 library. This clone, WL2EL1, was subcloned and sequenced. Eight open reading frames (ORFs) were identified. The ORF in WL2EL1 which contain...

journal_title：Annals of the New York Academy of Sciences

authors： Louw E,Brayton KA,Collins NE,Pretorius A,Van Strijp F,Allsopp BA

更新日期：2002-10-01 00:00:00

abstract：:With the demographic aging of populations worldwide, diseases associated with aging are becoming more prevalent and costly to individuals, families, and healthcare systems. Among aging-related impairments, a decline in cognitive function is of particular concern, as it erodes memory and processing abilities and eventu...

journal_title：Annals of the New York Academy of Sciences

authors： Tucker KL

更新日期：2016-03-01 00:00:00

abstract：:"Vascular anomalies" represents a spectrum of vascular lesions, of unclear etiology and often with unpredictable behavior. Patients with vascular anomalies represent a unique population, in that they have focal aberrations of vascular development (in vascular malformations) or vascular proliferation (in hemangiomas). ...

journal_title：Annals of the New York Academy of Sciences

authors： Blei F

更新日期：2008-01-01 00:00:00

abstract：:In the study reported in this paper, we characterized PACAP in the human fetal adrenal gland and we investigated the effect of PACAP on steroid secretion from cultured fetal adrenal cells. The adrenal gland from 20-week-old fetuses contained substantial concentrations of PACAP-immunoreactive material (88.6 ng/g wet ti...

journal_title：Annals of the New York Academy of Sciences

authors： Breault L,Yon L,Montéro M,Chouinard L,Contesse V,Delarue C,Fournier A,Lehoux JG,Vaudry H,Gallo-Payet N

更新日期：2000-01-01 00:00:00

abstract：:Stationary-phase mutation (a subset of which was previously called adaptive mutation) occurs in apparently nondividing, stationary-phase cells exposed to a nonlethal genetic selection. In one experimental system, stationary-phase reversion of an Escherichia coli F'-borne lac frameshift mutation occurs by a novel molec...

journal_title：Annals of the New York Academy of Sciences

authors： Lombardo MJ,Torkelson J,Bull HJ,McKenzie GJ,Rosenberg SM

更新日期：1999-05-18 00:00:00

abstract：:This article focuses on the importance of social engagement and the behavioral and neurophysiological mechanisms that allow individuals to reduce psychological and physical distance. A model of social engagement derived from the Polyvagal Theory is presented. The model emphasizes phylogeny as an organizing principle a...

journal_title：Annals of the New York Academy of Sciences

authors： Porges SW

更新日期：2003-12-01 00:00:00

abstract：:Lewisite and many other similar arsenicals are warfare vesicants developed and weaponized for use in World Wars I and II. These chemicals, when exposed to the skin and other epithelial tissues, cause rapid severe inflammation and systemic damage. Here, we show that topically applied arsenicals in a murine model produc...

journal_title：Annals of the New York Academy of Sciences

authors： Srivastava RK,Muzaffar S,Khan J,Traylor AM,Zmijewski JW,Curtis LM,George JF,Ahmad A,Antony VB,Agarwal A,Athar M

更新日期：2020-11-01 00:00:00

abstract：:Corticosteroids have potent immunosuppressive and anti-inflammatory effects. Although corticosteroids are an important weapon in the clinical arsenal for treating inflammatory episodes, the mechanisms underlying the actions and regulation of endogenous corticosteroids remain obscure. In the late 1980s and early 1990s,...

journal_title：Annals of the New York Academy of Sciences

authors： Harbuz MS,Chover-Gonzalez AJ,Jessop DS

更新日期：2003-05-01 00:00:00

abstract：:The Na,K-ATPase is composed of two subunits, alpha and beta, and each subunit consists of multiple isoforms. In the case of alpha, four isoforms, alpha1, alpha2, alpha3, and alpha4 are present in mammalian cells. The distribution of these isoforms is tissue- and developmental-specific, suggesting that they may play sp...

journal_title：Annals of the New York Academy of Sciences

authors： Lingrel J,Moseley A,Dostanic I,Cougnon M,He S,James P,Woo A,O'Connor K,Neumann J

更新日期：2003-04-01 00:00:00

abstract：UNLABELLED:A new Biorex molecule, BRX-220, has been shown to be effective in animal models of diabetic neuro- and retinopathy. Recent in vitro studies showed that it might also have an insulin-sensitizing action. Therefore, the effect of BRX-220 on insulin sensitivity was compared with the action of pioglitazone (PGZ) ...

journal_title：Annals of the New York Academy of Sciences

authors： Seböková E,Kürthy M,Mogyorosi T,Nagy K,Demcáková E,Ukropec J,Koranyi L,Klimes I

更新日期：2002-06-01 00:00:00

abstract：:Proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) might be, at least partially, responsible for the development of osteopenia or osteoporosis in Crohn's disease. We investigated whether anti-TNF therapy for Crohn's disease could have any skeletal impact. Therefore, we studied the effects of ...

journal_title：Annals of the New York Academy of Sciences

authors： Pazianas M,Rhim AD,Weinberg AM,Su C,Lichtenstein GR

更新日期：2006-04-01 00:00:00

abstract：:Reprogramming of energy metabolism is one of the hallmarks of cancer. In normal conditions, cells rely on mitochondrial oxidative phosphorylation to provide energy for cellular activities. Cancer cells are characterized by increased glycolysis and reduced mitochondrial respiratory function. In the past decade, somatic...

journal_title：Annals of the New York Academy of Sciences

authors： Kaipparettu BA,Ma Y,Wong LJ

更新日期：2010-07-01 00:00:00

abstract：:Mytilus edulis, a marine bivalve mollusc, contains hemocytes that share certain properties with cells of the human monocyte-macrophage lineage. Because of this and previously reported similar responses to opioids between Mytilus hemocytes and human granulocytes, we determined whether Mytilus might also possess monokin...

journal_title：Annals of the New York Academy of Sciences

authors： Hughes TK Jr,Smith EM,Leung MK,Stefano GB

更新日期：1992-04-15 00:00:00

abstract：:Modern neurostimulation approaches in humans provide controlled inputs into the operations of cortical regions, with highly specific behavioral consequences. This enables causal structure-function inferences, and in combination with neuroimaging, has provided novel insights into the basic mechanisms of action of neuro...

journal_title：Annals of the New York Academy of Sciences

authors： Bestmann S,Feredoes E

更新日期：2013-08-01 00:00:00

abstract：:Social motor coordination (SMC) pertains to the timing of contingent movements during social interactions and is of high relevance for successful social and musical interactions. Semi-automated, objective methods are increasingly being used to analyze SMC, though it is unclear if these methods are feasible in naturali...

journal_title：Annals of the New York Academy of Sciences

authors： Pfeiffer R,Wallace M,Lense M

更新日期：2018-05-04 00:00:00

abstract：:We studied the effects of change of head position in the pitch plane on the ability to hold horizontal eccentric gaze in five patients with cerebellar disorders. All patient showed a change in the time constant of horizontal centripetal drift when the head was pitched forward or back. This result suggests that otolith...

journal_title：Annals of the New York Academy of Sciences

authors： Wilson E,Sng K,Somers JT,Reschke MF,Leigh RJ

更新日期：2005-04-01 00:00:00

abstract：:The purpose of this study was to test the anticancer properties of the water-insoluble derivative of camptothecin, 9-nitrocamptothecin (9NC), administered in a liposome formulation (L-9NC) in aerosol to mice with subcutaneous xenografts of three human cancers and in mice with murine melanoma and human osteosarcoma pul...

journal_title：Annals of the New York Academy of Sciences

authors： Knight V,Kleinerman ES,Waldrep JC,Giovanella BC,Gilbert BE,Koshkina NV

更新日期：2000-01-01 00:00:00