9-Nitrocamptothecin liposome aerosol treatment of human cancer subcutaneous xenografts and pulmonary cancer metastases in mice.

abstract：:Tocopherols are known to undergo metabolism to phytyl chain-shortened metabolites excreted in urine. We sought to characterize the pathway, including associated enzymes, involved in this biotransformation. We previously found that human hepatoblastoma (HepG2) cultures metabolized tocopherols to their corresponding sho...

journal_title：Annals of the New York Academy of Sciences

authors： Parker RS,Sontag TJ,Swanson JE,McCormick CC

更新日期：2004-12-01 00:00:00

abstract：:Bone marrow transplantation (BMT) is currently a procedure that is associated with high morbidity and mortality. Thus, the clinical application of this technique is limited to the treatment of life-threatening hematopoietic malignancies. The morbidity and mortality of BMT is mainly related to graft-versus-host disease...

journal_title：Annals of the New York Academy of Sciences

authors： Exner BG,Domenick MA,Bergheim M,Mueller YM,Ildstad ST

更新日期：1999-04-30 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the beta cells in the pancreas are destroyed by the body's own immune system. IL12 plays a role in pathological situations, such as septic shock, tissue damage during inflammation, and organ-specific autoimmune diseases. In NOD mice, administration of I...

journal_title：Annals of the New York Academy of Sciences

authors： Holm P,Luthman H,Kockum I

更新日期：2003-11-01 00:00:00

abstract：:Auditory brainstem potentials were recorded from various scalp and nasopharyngeal sites referenced both to a noncephalic site and to certain scalp locations in normal humans. The distribution of amplitudes and latencies of the components were defined. There were significant amplitude, polarity, and latency asymmetries...

journal_title：Annals of the New York Academy of Sciences

authors： Starr A,Squires K

更新日期：1982-01-01 00:00:00

abstract：:While each region of the world faces unique public health challenges, environmental threats to vulnerable populations in Asia constitute a significant global public health challenge. Environmental threats to health are widespread and are increasing as nations in the region undergo rapid industrial development. One of ...

journal_title：Annals of the New York Academy of Sciences

authors： Suk WA,Davis EA

更新日期：2008-10-01 00:00:00

abstract：:Hypoxia is a common physiologic and pathophysiologic stimulus that activates the expression of genes through oxygen-sensitive transcription factors including the hypoxia-inducible factor (HIF) and nuclear factor-kappaB (NF-kappaB). Hypoxia-dependent gene expression can have important physiologic or pathophysiologic co...

journal_title：Annals of the New York Academy of Sciences

authors： Taylor CT,Cummins EP

更新日期：2009-10-01 00:00:00

abstract：:The osteoclast (OCL) is derived from the cells in monocyte-macrophage lineage. The earliest identifiable OCL precursor is the granulocyte-macrophage colony-forming unit (CFU-GM), which gives rise to granulocytes, monocytes, and OCL. CFU-GM-derived cells then differentiate to committed OCL precursors, which are post-mi...

journal_title：Annals of the New York Academy of Sciences

authors： Roodman GD

更新日期：2006-04-01 00:00:00

abstract：:Chemical hypoxia produces depletion of ATP, intracellular Ca2+ overload, and cell death. The role of Na+/Ca2+ exchanger (NCX), the major plasma membrane Ca2+ extruding system, has been explored in chemical hypoxia using BHK cells stably transfected with the three mammalian NCX isoforms: NCX1, NCX2, and NCX3. Here we r...

journal_title：Annals of the New York Academy of Sciences

authors： Secondo A,Staiano IR,Scorziello A,Sirabella R,Boscia F,Adornetto A,Canzoniero LM,Di Renzo G,Annunziato L

更新日期：2007-03-01 00:00:00

abstract：:Severely inflamed colonic sections of IL-2 (-/-) mice showed up to 19-fold increased iNOS mRNA levels. The level of iNOS protein expression corresponded to the increased iNOS mRNA levels as detected by means of Western blot analysis. There was a clear, positive relationship between the level of iNOS expression and the...

journal_title：Annals of the New York Academy of Sciences

authors： Harren M,Schönfelder G,Paul M,Horak I,Riecken EO,Wiedenmann B,John M

更新日期：1998-11-17 00:00:00

abstract：:The comparative study of vertebrate brains is inherently dependent upon access to a sufficient number of species and specimens to perform meaningful comparisons. Although many studies rely on compiling published information, continued specimen collection, in addition to more extensive use of existing brain collections...

journal_title：Annals of the New York Academy of Sciences

authors： Iwaniuk AN

更新日期：2011-05-01 00:00:00

abstract：:Long-lived proteins undergo age-related postsynthetic modifications by glycation and advanced glycation end products (AGEs), which destabilize them by altering their conformation and charge. It was accidentally discovered that ornithine (orn) increased with age in acid hydrolyzates of human skin collagen and lens crys...

journal_title：Annals of the New York Academy of Sciences

authors： Sell DR,Monnier VM

更新日期：2005-06-01 00:00:00

abstract：:Substantial evidence suggests that stress can alter the general toxicological properties of the substituted amphetamines (AMPs) as well as their psychostimulant properties. Research concerning the interactions between stress and the neurotoxicity associated with the AMPs is, however, limited. Our previous work demonst...

journal_title：Annals of the New York Academy of Sciences

authors： Miller DB,O'Callaghan JP

更新日期：1996-10-31 00:00:00

abstract：:Circadian and other rhythmic changes in biological susceptibility and response of organisms to a large variety of physical as well as chemical agents including medications and foods are rather common phenomena. Modern chronopharmacology investigates drug effects (a) as a function of biological timing and (b) upon para...

journal_title：Annals of the New York Academy of Sciences

authors： Reinberg AE

更新日期：1991-01-01 00:00:00

abstract：:The contact area of bubbles with a transparent heating surface was optically measured during subcooled pool boiling of water on the ground. In the experiments, boiling bubbles were attached to the heating surface with a bubble holder and nearly reproduced the bubble behavior observed in low gravity. DC power was appli...

journal_title：Annals of the New York Academy of Sciences

authors： Suzuki K,Takahashi S,Ohta H

更新日期：2004-11-01 00:00:00

abstract：:We found that gamma-tocopherol, the predominant vitamin E form in diets, but not alpha-tocopherol, which is the exclusive form of vitamin E in most supplements, exhibited antiproliferation effect on prostate (PC-3, LNCaP) and lung (A549) cancer cells. gamma-Tocopherol induced apoptosis in androgen-sensitive LNCaP but ...

journal_title：Annals of the New York Academy of Sciences

authors： Jiang Q,Wong J,Ames BN

更新日期：2004-12-01 00:00:00

abstract：:The relationship between the concentration of cell-free DNA (cfDNA) and the number of proliferating/apoptotic lymphocytes in peripheral blood of premature newborns of different gestation age and full-term newborns was determined. The experiments were performed using fluorescent spectrophotometry (with Hoechst 33342), ...

journal_title：Annals of the New York Academy of Sciences

authors： Tuaeva NO,Abramova ZI,Sofronov VV

更新日期：2008-08-01 00:00:00

abstract：:The fracture of bone is clearly a major health concern, especially for the elderly. Medical therapies to reduce the possibility of bone fracture to date have principally centered on treating the loss in bone mass (bone mineral density) that accompanies aging (i.e., addressing the loss in bone quantity). However, it is...

journal_title：Annals of the New York Academy of Sciences

authors： Ritchie RO

更新日期：2010-03-01 00:00:00

abstract：:Reactive oxygen species have been known to cause DNA damage and induce apoptosis. During DNA damage, DNA repair proteins Ku70 and Ku80 prevent cell death, but severe DNA damage beyond the repair capacity of the DNA repair proteins triggers necrosis or apoptosis. Recent reports have shown that NF-kappaB plays a critica...

journal_title：Annals of the New York Academy of Sciences

authors： Song JY,Lim JW,Kim H,Kim KH

更新日期：2003-12-01 00:00:00

abstract：:Papillomaviruses are widespread, sexually transmitted agents with an increasing prevalence. They are associated with a significant risk of genital carcinoma in infected women. Because they can be transmitted to the fetus before or during birth, they are also a risk to the infant born to an infected woman. Laryngeal HP...

journal_title：Annals of the New York Academy of Sciences

authors： Steinberg BM

更新日期：1988-01-01 00:00:00

abstract：:Despite advances in technology and medicine, death itself remains an immutable certainty. Indeed, the acceptance and understanding of our mortality are among the enduring metaphysical challenges that have confronted human beings from the beginning of time. How have we sought to cope with the inevitability of our morta...

journal_title：Annals of the New York Academy of Sciences

authors： Paulson S,Kellehear A,Kripal JJ,Leary L

更新日期：2014-11-01 00:00:00

abstract：:Beta-amyloid (Abeta) is a main component of senile plaques in Alzheimer's disease (AD) that induces neuronal cell death. Since reactive oxygen species (ROS) have been implicated in Abeta-induced neurotoxicity, considerable attention has recently been focused on identifying naturally occurring antioxidative phenolic ph...

journal_title：Annals of the New York Academy of Sciences

authors： Kim HJ,Lee KW,Lee HJ

更新日期：2007-01-01 00:00:00

abstract：:The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations. While the blood group antigen A is considered the ancestral primordial structure, under the selective pressure of life-threatening diseases blood group O(H) came to dominate as the most frequently ...

journal_title：Annals of the New York Academy of Sciences

authors： Arend P

更新日期：2018-08-01 00:00:00

abstract：:CDP-choline was given to patients with Alzheimer's disease (AD) at a daily dose of 1000 mg/day p.o. for one month. This compound slightly improved mental performance, tended to reduce theta activity in fronto-temporal regions, increasing alpha power in occipital areas, and enhanced cerebrovascular perfusion by increas...

journal_title：Annals of the New York Academy of Sciences

authors： Cacabelos R,Caamaño J,Gómez MJ,Fernández-Novoa L,Franco-Maside A,Alvarez XA

更新日期：1996-01-17 00:00:00

abstract：:Our previous studies of anti-DNA antibodies in SLE have demonstrated a preferential use of V kappa I and V lambda II gene families to encode light chains of antibodies that express the anti-DNA-associated 3I and 8.12 idiotypes, respectively. In this study, we employed PCR to obtain V kappa I and V lambda II germline g...

journal_title：Annals of the New York Academy of Sciences

authors： Manheimer-Lory A,Irigoyen M,Gaynor B,Monhian R,Splaver A,Diamond B

更新日期：1995-09-29 00:00:00

abstract：:Prodigiosin (PG) is an active component of bacterial origin, with reported apoptotic effects. We examined the activation of caspases-9, -8, and -3 in PG-treated Jurkat cells in a dose-response study. These caspases were activated in apoptotic cells, as judged by the appearance of cleavage products from procaspases, an...

journal_title：Annals of the New York Academy of Sciences

authors： Montaner B,Perez-Tomas R

更新日期：2002-11-01 00:00:00

abstract：:Recent immunologic studies have provided important new information about the nature of AHF deficiency diseases and the structure and synthesis of this protein. They provide, moreover, a considerably improved ability to identify the carrier state in hemophilia A. Additional progress may be possible in the identificatio...

journal_title：Annals of the New York Academy of Sciences

authors： Hoyer LW,Rick ME

更新日期：1975-01-20 00:00:00

abstract：:Apoptosis protease-activating factor-1 (Apaf-1), which plays a central role in the formation of the apoptosome, is absent or poorly expressed (because of a transcriptional silencing by methylation) in a substantial percentage of metastatic melanomas and melanoma cell lines, which are unable to activate caspase-9 and e...

journal_title：Annals of the New York Academy of Sciences

authors： Del Bello B,Valentini MA,Comporti M,Maellaro E

更新日期：2003-12-01 00:00:00

abstract：:Conventional and thiophosphonate-derivatized oligonucleotides were employed to specifically regulate functional gene expression in murine T-cell hybridomas. For example, induction of apoptotic cell death following activation of T-cell hybridomas was examined using antisense oligonucleotides corresponding to several pr...

journal_title：Annals of the New York Academy of Sciences

authors： Green DR,Zheng H,Shi Y

更新日期：1992-10-28 00:00:00

abstract：:Ticks do not usually infest sympatric hosts species according to their availability in a given environment, and it has been suggested that habitat use by hosts is a major determinant of tick burdens. The knowledge of such infestation patterns and their relationship with host habitat use is important for the control of...

journal_title：Annals of the New York Academy of Sciences

authors： De Garine-Wichatitsky M

更新日期：2002-10-01 00:00:00

abstract：:One of the most remarkable aspects of the immune system is its ability to fashion an immune response most appropriate to the activating stimulus. Although the immune system possesses a number of adaptations to accomplish this, an important theme is local immune regulation by site-specific expression of receptors and l...

journal_title：Annals of the New York Academy of Sciences

authors： Shao L,Allez M,Park MS,Mayer L

更新日期：2006-08-01 00:00:00