Prodigiosin induces caspase-9 and caspase-8 activation and cytochrome C release in Jurkat T cells.

Abstract:

:Prodigiosin (PG) is an active component of bacterial origin, with reported apoptotic effects. We examined the activation of caspases-9, -8, and -3 in PG-treated Jurkat cells in a dose-response study. These caspases were activated in apoptotic cells, as judged by the appearance of cleavage products from procaspases, and cytochrome c (cyt c) was released to the cytosol. In addition, PG induced the cleavage of poly (ADP-ribose) polymerase (PARP). This study demonstrates that the activation of caspases-9, -8, and -3 mediates PG-induced apoptosis.

journal_name

Ann N Y Acad Sci

authors

Montaner B,Perez-Tomas R

doi

10.1111/j.1749-6632.2002.tb04642.x

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

246-9

eissn

0077-8923

issn

1749-6632

journal_volume

973

pub_type

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