Abstract:
:Chemical hypoxia produces depletion of ATP, intracellular Ca2+ overload, and cell death. The role of Na+/Ca2+ exchanger (NCX), the major plasma membrane Ca2+ extruding system, has been explored in chemical hypoxia using BHK cells stably transfected with the three mammalian NCX isoforms: NCX1, NCX2, and NCX3. Here we report that the three isoforms show similar activity evaluated as [Ca2+]i increase evoked by Na+-free medium exposure in Fura-2-loaded single cells and NCX3 transfected cells are less vulnerable to chemical hypoxia compared to NCX1- and NCX2-transfected cells, suggesting that NCX3 could play a more relevant protective role during chemical hypoxia.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Secondo A,Staiano IR,Scorziello A,Sirabella R,Boscia F,Adornetto A,Canzoniero LM,Di Renzo G,Annunziato Ldoi
10.1196/annals.1387.052subject
Has Abstractpub_date
2007-03-01 00:00:00pages
481-5eissn
0077-8923issn
1749-6632pii
1099/1/481journal_volume
1099pub_type
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