Bovine brain microvessel endothelial cell monolayers as a model system for the blood-brain barrier.

abstract：:Tazobactam was the most recent β-lactamase inhibitor to be approved in 1993. Since the approval of piperacillin-tazobactam, the complexity of β-lactamase-mediated resistance among Gram-negative bacilli has increased enormously. After more than 20 years since the first such combination, amoxicillin-clavulanic acid, was...

journal_title：Annals of the New York Academy of Sciences

authors： Shlaes DM

更新日期：2013-01-01 00:00:00

abstract：:Semi-conservative replication ensures that the DNA sequence of sister chromatids is identical except for replication errors and variation in the length of telomere repeats resulting from replicative losses and variable end processing. What happens with the various epigenetic marks during DNA replication is less clear....

journal_title：Annals of the New York Academy of Sciences

authors： Lansdorp PM,Falconer E,Tao J,Brind'Amour J,Naumann U

更新日期：2012-08-01 00:00:00

abstract：:Despite the great strides made in understanding the basic biology of cancer and the multiple approaches to cancer therapy that have been utilized, cancer remains a major cause of death worldwide. The two properties that define the most successful tumors are low antigenicity, enabling cancer cells to escape immune syst...

journal_title：Annals of the New York Academy of Sciences

authors： Al-Ramadi BK,Fernandez-Cabezudo MJ,El-Hasasna H,Al-Salam S,Attoub S,Xu D,Chouaib S

更新日期：2008-09-01 00:00:00

abstract：:The SERMs currently in clinical practice or in late stages of clinical development have been studied primarily for their effects on the breast, cardiovascular, bone, and reproductive systems. The effect of SERMs on the hypothalamic-pituitary-gonadal (HPG) axis has not been the primary focus of the studies conducted th...

journal_title：Annals of the New York Academy of Sciences

authors： Plouffe L Jr,Siddhanti S

更新日期：2001-12-01 00:00:00

abstract：:Calcium ions are essential to proper neurotransmission. Impairment in cytosolic Ca(2+) concentration and Ca(2+) signaling disturbs neuronal activity, leading to pathological consequences. In cells, a high-affinity plasma membrane calcium pump (PMCA) keeps free Ca(2+) in the nanomolar range. Among four genes encoding t...

journal_title：Annals of the New York Academy of Sciences

authors： Zylinska L,Kowalska I,Kozaczuk A

更新日期：2008-12-01 00:00:00

abstract：:The gain of the angular vestibulo-ocular reflex (aVOR) was determined in monkeys by rotation about a spatial vertical axis while upright or statically tilted forward and backward. Horizontal, vertical, and roll gains were determined at each head orientation and plotted as a function of head tilt. Before canal plugging...

journal_title：Annals of the New York Academy of Sciences

authors： Yakushin SB,Dai M,Raphan T,Suzuki J,Arai Y,Cohen B

更新日期：2001-10-01 00:00:00

abstract：:In the present study we analyzed the morphology of testes and efferent ducts as well as the localization of androgen receptors (AR) in the tissues of XY, YY, and XX male rainbow trout Oncorhynchus mykiss Walbaum. Testes of the XX trout differed distinctly from those of XY and YY males; the interstitial space was very ...

journal_title：Annals of the New York Academy of Sciences

authors： Galas JF,Hejmej A,Glogowski J,Bilińska B

更新日期：2009-04-01 00:00:00

abstract：:New data on the organization of the intra-amygdaloid circuit is reviewed, beginning with the basolateral (BL) complex, the main input station of the amygdala for sensory afferents, and concluding with the central (CE) nucleus, an important source of projections to brain-stem structures mediating fear responses. The BL...

journal_title：Annals of the New York Academy of Sciences

authors： Paré D,Royer S,Smith Y,Lang EJ

更新日期：2003-04-01 00:00:00

abstract：:While the ovaries are the principal source of systemic estrogen in the premenopausal nonpregnant woman, other sites of estrogen biosynthesis are present throughout the body and these become the major sources of estrogen beyond menopause. These extragonadal sources of estrogen are small, but may play an important, thou...

journal_title：Annals of the New York Academy of Sciences

authors： Simpson ER,Clyne C,Speed C,Rubin G,Bulun S

更新日期：2001-12-01 00:00:00

abstract：:Morphogenesis in the animal kingdom is closely coupled with the intracellular synthesis and the extracellular deposition of collagen. These morphogenetically important events involve multiple steps which begin in compartments inside the cell and continue in compartments outside the cell. The movement of matrix compone...

journal_title：Annals of the New York Academy of Sciences

authors： Birk DE,Trelstad RL

更新日期：1985-01-01 00:00:00

abstract：:Constitutively active GPCR have revealed novel properties of drugs that exhibit classical competitive antagonism at the native forms of GPCR. These drugs reverse basal levels of constitutive activity, indicating that they have inverse agonist activity. We were interested in determining if competitive antagonists of th...

journal_title：Annals of the New York Academy of Sciences

authors： Egan C,Herrick-Davis K,Teitler M

更新日期：1998-12-15 00:00:00

abstract：:The treatment of substance use disorders has always been challenging because multiple neurotransmitters mediate addiction. However, with smoking being the leading cause of preventable death and the recent opioid epidemic in the United States, the search for novel solutions becomes more imperative. In this review, we d...

journal_title：Annals of the New York Academy of Sciences

authors： Xu A,Kosten TR

更新日期：2020-03-08 00:00:00

abstract：:Aged F344 female rats (21 months) showed decreased performance, as compared to young rats (4 months), on an object recognition memory task. Golgi impregnation measured dendritic spine density of pyramidal neurons in the prefrontal cortex (layer II-III), a brain area important for recognition memory. Densities of spine...

journal_title：Annals of the New York Academy of Sciences

authors： Wallace M,Frankfurt M,Arellanos A,Inagaki T,Luine V

更新日期：2007-02-01 00:00:00

abstract：:Inflammation plays a key role in excessive bone loss in conditions such as rheumatoid arthritis and periodontitis. An important paradigm in immunology is that inflammatory factors activate feedback inhibition mechanisms to restrain inflammation and limit associated tissue damage. We hypothesized that inflammatory fact...

journal_title：Annals of the New York Academy of Sciences

authors： Ivashkiv LB,Zhao B,Park-Min KH,Takami M

更新日期：2011-11-01 00:00:00

abstract：:The loss of E-cadherin expression or function in epithelial carcinomas has long been thought as a primary reason for disruption of tight epithelial cell-cell contacts and release of invasive tumor cells from the primary tumor. Indeed, E-cadherin serves as a widely acting suppressor of invasion and growth of epithelial...

journal_title：Annals of the New York Academy of Sciences

authors： Hazan RB,Qiao R,Keren R,Badano I,Suyama K

更新日期：2004-04-01 00:00:00

abstract：:Jopock (Jpk), a transacting factor associated with the position-specific regulatory element of murine Hoxa-7, has shown to induce cell death in both prokaryotic and eukaryotic cells when introduced and overexpressed. Since Jpk protein harbors a transmembrane domain (TM) and a putative endoplasmic reticulum (ER) -reten...

journal_title：Annals of the New York Academy of Sciences

authors： Kim HS,Kong KA,Chung H,Park S,Kim MH

更新日期：2007-01-01 00:00:00

abstract：:Replicative senescence is an in vitro biological phenomenon that results the irreversible growth arrest of mammalian cells. In contrast, cellular quiescence is reversible upon the addition of mitogens or replating. Quiescence is associated with the expression of a particular gene family--the growth arrest specific (GA...

journal_title：Annals of the New York Academy of Sciences

authors： Gonos ES

更新日期：1998-06-30 00:00:00

abstract：:We have presented evidence indicating that P2-purinergic receptors may activate the polyphosphoinositide-phospholipase C in HL60 cells via the mediation of a pertussis-toxin-sensitive GTP-binding protein, which also mediates the actions of chemotactic peptide receptors in these and other phagocytic white blood cells. ...

journal_title：Annals of the New York Academy of Sciences

authors： Dubyak GR,Cowen DS,Lazarus HM

更新日期：1988-01-01 00:00:00

abstract：:3-Nitropropionic acid (3-NPA) is a model mitochondrial inhibitor that causes selective neurodegeneration in brain. 3-NPA-induced neurodegeneration occurs via a secondary neurotoxicity, caused initially by ATP depletion and redox changes in the cell. It is known that the hippocampal degeneration caused by mitochondrial...

journal_title：Annals of the New York Academy of Sciences

authors： Przybyla-Zawislak BD,Thorn BT,Ali SF,Dennis RA,Amato A,Virmani A,Binienda ZK

更新日期：2005-08-01 00:00:00

abstract：:Coccidioidomycosis is a potentially serious fungal infection contracted in endemic areas of the desert southwestern United States. Limited information exists about its incidence and clinical course in patients with rheumatic diseases, who may be at higher risk of symptomatic or disseminated coccidioidomycosis because ...

journal_title：Annals of the New York Academy of Sciences

authors： Mertz LE,Blair JE

更新日期：2007-09-01 00:00:00

abstract：:The fatty acid (FA) compositions of liver and skeletal muscle structural lipids, overall phospholipids and phosphatidylcholine, and triglycerides (TG) were determined in the hereditary hypertriglyceridemic (HTG) rat, a nonobese animal model of the insulin resistance syndrome. Four groups of HTG rats and four groups of...

journal_title：Annals of the New York Academy of Sciences

authors： Bohov P,Seböková E,Gasperíková D,Langer P,Klimes I

更新日期：1997-09-20 00:00:00

abstract：:The results of four randomized controlled trials were examined to assess the efficacy of intravenous immunoglobulin (IVIG) for myasthenia gravis (MG) acute exacerbations. The first trial compared plasma exchange (PE) and IVIG in 87 patients. At day 15, the mean change in the Myasthenic Muscular Score (MMS) was 16.6 (9...

journal_title：Annals of the New York Academy of Sciences

authors： Gajdos P,Chevret S

更新日期：2008-01-01 00:00:00

abstract：:Mammalian spermatogenesis is a complex developmental process. Spermatozoa, like ova, are uniquely capable of supporting embryonic development. Our approach to understanding this process is to identify genes whose developmental pattern of expression suggests that they may play a role in spermatogenesis. Experiments on ...

journal_title：Annals of the New York Academy of Sciences

authors： Duggal RN,Zakeri ZF,Ponzetto C,Wolgemuth DJ

更新日期：1987-01-01 00:00:00

abstract：:The purpose of the Big Data to Knowledge initiative is to develop methods for discovering new knowledge from large amounts of data. However, if the resulting knowledge is so large that it resists comprehension, referred to here as Big Knowledge (BK), how can it be used properly and creatively? We call this secondary c...

journal_title：Annals of the New York Academy of Sciences

authors： Perl Y,Geller J,Halper M,Ochs C,Zheng L,Kapusnik-Uner J

更新日期：2017-01-01 00:00:00

abstract：:One of the most studied effects of verbal working memory (WM) is the influence of the length of the words that compose the list to be remembered. This work aims to investigate the nature of musical WM by replicating the word length effect in the musical domain. Length and rate of presentation were manipulated in a rec...

journal_title：Annals of the New York Academy of Sciences

authors： Akiva-Kabiri L,Vecchi T,Granot R,Basso D,Schön D

更新日期：2009-07-01 00:00:00

abstract：:Thirty percent of 51 obese adolescent girls seeking treatment for their obesity engaged in binge eating. Two psychometric measures, "disinhibition" and "happiness and satisfaction" predicted 63% of the variance in severity of binge eating. There was no difference in the history of dieting between obese subjects who bi...

journal_title：Annals of the New York Academy of Sciences

authors： Berkowitz R,Stunkard AJ,Stallings VA

更新日期：1993-10-29 00:00:00

abstract：:We have successfully expressed the active tyrosinase of Streptomyces antibioticus in Escherichia coli under the control of the trp promoter by fusing the sequence to the ORF438 gene. Because our attempt to connect the polycistronic gene of ORF438 and tyrosinase directly to the trp promoter of E. coli resulted in the e...

journal_title：Annals of the New York Academy of Sciences

authors： Han K,Hong J,Lim HC,Kim CH,Park Y,Cho JM

更新日期：1994-05-02 00:00:00

abstract：:Seleno-glutathione peroxidase (GSHPx) is considered to be the major enzymatic activity in charge of removing excess cytosolic and mitochondrial H2O2 in most tissues including brain. Intracellular GSHPx activity is therefore hypothesized to be one important factor that contributes to minimize hydroxyl radical formation...

journal_title：Annals of the New York Academy of Sciences

authors： Mirault ME,Tremblay A,Furling D,Trepanier G,Dugre F,Puymirat J,Pothier F

更新日期：1994-11-17 00:00:00

abstract：:Five hybridoma cell lines secreting anti-PrP antibodies were established from the fusion between mouse myeloma Sp2/0 and spleen cells from mice immunized with recombinant Chinese Luxi yellow cattle (Bos taurus, Luxi) PrP (24-234) or recombinant Chinese small-tailed Han sheep PrP (94-227). According to their Western bl...

journal_title：Annals of the New York Academy of Sciences

authors： Wu X,Wang Z,Liu Y,Zhang Y,Chen Y,Zou Y

更新日期：2006-10-01 00:00:00

abstract：:The following on molecular mechanisms of Barrett's esophagus and adenocarcinoma contains commentaries on the mechanism of bile and gastric acid induced damage; the roles of BMP-4 and CDX-2 in the development of intestinal metaplasia; the transcription factors driving intestinalization in Barrett's esophagus; the contr...

journal_title：Annals of the New York Academy of Sciences

authors： Dvorak K,Goldman A,Kong J,Lynch JP,Hutchinson L,Houghton JM,Chen H,Chen X,Krishnadath KK,Westra WM

更新日期：2011-09-01 00:00:00