Changes in the vestibulo-ocular reflex after plugging of the semicircular canals.

Abstract:

:The gain of the angular vestibulo-ocular reflex (aVOR) was determined in monkeys by rotation about a spatial vertical axis while upright or statically tilted forward and backward. Horizontal, vertical, and roll gains were determined at each head orientation and plotted as a function of head tilt. Before canal plugging, animals had maximal (spatial) horizontal gains when upright (spatial phase 0 degrees) and maximal roll gains when tilted forward or backward 90 degrees. Plugging caused striking changes in the characteristics of the aVOR gains at low frequencies. After plugging of the vertical canals, maximal horizontal and roll gains both occurred at head tilts of approximately 30 degrees forward. When the lateral canals were plugged, maximal horizontal and roll responses occurred when the head was tilted back approximately 50 degrees. The aVOR gains of the canal-plugged animals were also affected by stimulus frequency. In every instance, as stimulus frequency increased, the spatial phases shifted toward the normal response, that is, the response before plugging. This normalization effect was observed even in the animals with all six semicircular canals plugged, indicating that normalization was not due to spatial adaptation. A three-dimensional dynamic and kinematic model of the aVOR was able to account for all types of canal plugging by a simple change in the dominant time constant of the plugged canals from 3 s to 5 s to approximately 0.07 s. The model accurately predicted responses of the normal and canal-plugged animals at all frequencies. These data show that the central vestibular system does not spatially adapt to losses resulting from canal plugging.

journal_name

Ann N Y Acad Sci

authors

Yakushin SB,Dai M,Raphan T,Suzuki J,Arai Y,Cohen B

doi

10.1111/j.1749-6632.2001.tb03753.x

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

287-99

eissn

0077-8923

issn

1749-6632

journal_volume

942

pub_type

杂志文章
  • The involvement of audio-motor coupling in the music-supported therapy applied to stroke patients.

    abstract::Music-supported therapy (MST) has been developed recently to improve the use of the affected upper extremity after stroke. MST uses musical instruments, an electronic piano and an electronic drum set emitting piano sounds, to retrain fine and gross movements of the paretic upper extremity. In this paper, we first desc...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2011.06425.x

    authors: Rodriguez-Fornells A,Rojo N,Amengual JL,Ripollés P,Altenmüller E,Münte TF

    更新日期:2012-04-01 00:00:00

  • Factors affecting tracking of coronary heart disease risk factors in children. The Muscatine Study.

    abstract::The public health implications of reducing or preventing the excess increase in blood pressure and the acquisition of obesity during childhood years are important. Many children with high blood pressure, particularly those who are initially obese or become obese as young adults and those with excess left ventricular m...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1991.tb43723.x

    authors: Mahoney LT,Lauer RM,Lee J,Clarke WR

    更新日期:1991-01-01 00:00:00

  • The Maillard hypothesis on aging: time to focus on DNA.

    abstract::Aging is the outcome of the contest between chemistry and biology in living systems. Chronic, cumulative chemical modifications compromise the structure and function of biomolecules throughout the body. Proteins with long life spans serve as cumulators of exposure to chemical damage, which is detectable in the form of...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb02107.x

    authors: Baynes JW

    更新日期:2002-04-01 00:00:00

  • Development of macitentan for the treatment of pulmonary arterial hypertension.

    abstract::Pulmonary arterial hypertension (PAH) is a serious, chronic condition that, without early recognition and treatment, leads to progressive right heart failure and death. The dual endothelin receptor antagonist macitentan was designed through a deliberate discovery process to maximize endothelin-axis blockade while impr...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12856

    authors: Selej M,Romero AJ,Channick RN,Clozel M

    更新日期:2015-11-01 00:00:00

  • Characterization of the mouse and rat relaxin receptors.

    abstract::Rodent models have been used for many years to probe the actions of relaxin. Identification of the orthologs of human leucine-rich repeat-containing g-protein-coupled receptor 7 (LGR7), the relaxin receptor, in mouse and rat will enable characterization of the response of LGR7 to relaxin in these species. Partial LGR7...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1282.002

    authors: Scott DJ,Layfield S,Riesewijk A,Morita H,Tregear GW,Bathgate RA

    更新日期:2005-05-01 00:00:00

  • Auditory perception and speech evolution.

    abstract::Human speech perception seems to involve the ability to recognize groupings of speech sounds rather than component phonemes, and to distinguish between permuted orders of items within sequences as holistic entities. Humans can use this Holistic Pattern Recognition (HPR) not only with speech and music, but also with se...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1976.tb25532.x

    authors: Warren RM

    更新日期:1976-01-01 00:00:00

  • Onset of odorant receptors.

    abstract::Odorant receptors are thought to be critical determinants of olfactory sensory neuron axon targeting and organization. Nonetheless, a systematic characterization of the onset of odorant receptor expression has not yet been done in the main olfactory epithelium. Here, we briefly review our current understanding regardi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.04366.x

    authors: Rodriguez-Gil DJ,Treloar HB,Miller A,Two A,Iwema C,Greer CA

    更新日期:2009-07-01 00:00:00

  • Sarcomere mechanics in uniform and nonuniform cardiac muscle: a link between pump function and arrhythmias.

    abstract::Starling's law and the end-systolic pressure-volume relationship (ESPVR) reflect the effect of sarcomere length (SL) on the development of stress (sigma) and shortening by myocytes in the uniform ventricle. We show here that tetanic contractions of rat cardiac trabeculae exhibit a sigma-SL relationship at saturating [...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1420.010

    authors: Ter Keurs HE,Shinozaki T,Zhang YM,Wakayama Y,Sugai Y,Kagaya Y,Miura M,Boyden PA,Stuyvers BD,Landesberg A

    更新日期:2008-03-01 00:00:00

  • Metabolically healthy obesity across the life course: epidemiology, determinants, and implications.

    abstract::In recent years, different subphenotypes of obesity have been described, including metabolically healthy obesity (MHO), in which a proportion of obese individuals, despite excess body fat, remain free of metabolic abnormalities and increased cardiometabolic risk. In the absence of a universally accepted set of criteri...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13230

    authors: Phillips CM

    更新日期:2017-03-01 00:00:00

  • Arterial aneurysms in HIV patients: molecular mimicry versus direct infection?

    abstract::There is growing literature on the subject of aneurysmal degeneration of arteries in patients who are infected with HIV. A patient recently seen at our medical center with an aneurysm of the carotid artery stimulated our interest in reviewing the mechanisms by which HIV may initiate or predispose to these pathologies....

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1383.018

    authors: Tilson MD 3rd,Withers L

    更新日期:2006-11-01 00:00:00

  • A potential role for estrogen in experimental autoimmune encephalomyelitis and multiple sclerosis.

    abstract::The extensive literature and the work from our laboratory illustrate the large number of complex processes affected by estrogen that might contribute to the striking ability of 17-beta estradiol (E2) and its derivatives to inhibit clinical and histological signs of experimental autoimmune encephalomyelitis (EAE) in mi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1386.021

    authors: Offner H,Polanczyk M

    更新日期:2006-11-01 00:00:00

  • The role of the calcium release channel of skeletal muscle sarcoplasmic reticulum in malignant hyperthermia.

    abstract::In this short review, we have described studies that have identified Arg415 in the Ca2+ release channel as a residue that influences channel sensitivity to Ca2+ induced Ca2+ release, rate of Ca2+ release, and channel closing. We have also described studies that confirm Dr. Numa's predictions that residues 4246-4267, 4...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1993.tb38060.x

    authors: MacLennan DH,Chen SR

    更新日期:1993-12-20 00:00:00

  • Pressure study on symmetric and asymmetric phospholipid bilayers: effect of vesicle size on Prodan fluorescence.

    abstract::The bilayer phase behavior of symmetric and asymmetric phosphatidylcholines (PCs), 1,2-diheptadecanoyl-PC (C17PC), 1-palmitoyl-2-stearoyl-PC (PSPC), and 1-stearoyl-2-palmitoyl-PC (SPPC), with different vesicle sizes were investigated by a high-pressure fluorescence method using the polarity-sensitive fluorescent probe...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.05202.x

    authors: Goto M,Kusube M,Nishimoto M,Tamai N,Matsuki H,Kaneshina S

    更新日期:2010-02-01 00:00:00

  • Reperfusion of chronic tissue ischemia: nitrite and dipyridamole regulation of innate immune responses.

    abstract::Chronic and intermittent ischemic vascular disorders represent a burgeoning clinical challenge. Previous studies have focused on the idea that therapeutic angiogenesis strategies could alleviate tissue ischemia; however, it is now appreciated that vascular disease is not simply limited to vascular wall cells but also ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05737.x

    authors: Pattillo CB,Fang K,Terracciano J,Kevil CG

    更新日期:2010-10-01 00:00:00

  • Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration.

    abstract::Mitochondrial dysfunction is a common characteristic of all neurodegenerative diseases. However, the cause of this dysfunction remains a mystery. Here, we discuss the potential role of mitochondrial fission and fusion in the onset and progression of neurodegenerative diseases. Specifically, we propose that an imbalanc...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1427.030

    authors: Knott AB,Bossy-Wetzel E

    更新日期:2008-12-01 00:00:00

  • The neuropeptide alpha-MSH in HIV infection and other disorders in humans.

    abstract::We measured plasma concentration of alpha-melanocyte-stimulating hormone (alpha-MSH), a proopiomelanocortin derivative that modulates pyrogenic and proinflammatory effects of cytokines, in infectious and inflammatory disorders in humans to learn if changes in this peptide take place in naturally occurring disease. alp...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb09622.x

    authors: Catania A,Airaghi L,Garofalo L,Cutuli M,Lipton JM

    更新日期:1998-05-01 00:00:00

  • Human fertility and population equilibrium.

    abstract::In preindustrial settings, biological, economic, and social mechanisms caused fertility to respond to feedback signals from population size variation in such a way as to steer populations toward equilibrium levels. It is unlikely that the relevant signal was population density; more plausibly the signal was economic w...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1994.tb30425.x

    authors: Lee R

    更新日期:1994-02-18 00:00:00

  • Prediction of pressure loss and heat transfer in internal cooling passages.

    abstract::This paper reports CFD-simulations of the turbulent flow, pressure loss and heat transfer occurring in ribbed passages. The channel section is rectangular, with an aspect ratio of 2.04. Ribs are square cross-section, their height is 10% of the channel height, and their inclination is varied from 90 degrees to 33 degre...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2001.tb05882.x

    authors: Hermanson K,Parneix S,von Wolfersdorf J,Semmler K

    更新日期:2001-05-01 00:00:00

  • DNA repair: the link between primary immunodeficiency and cancer.

    abstract::The adaptive component of the immune system depends greatly on the generation of genetic diversity provided by lymphocyte-specific genomic rearrangements. V(D)J recombination, class switch recombination (CSR), and somatic hypermutation (SHM) constitute complex and vulnerable processes that are orchestrated by a multit...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2011.06322.x

    authors: de Miranda NF,Björkman A,Pan-Hammarström Q

    更新日期:2011-12-01 00:00:00

  • The substance P and somatostatin interferon-gamma immunoregulatory circuit.

    abstract::Murine schistosomiasis mansoni is a parasitic disease in which flukes living in the portal vein of the host produce ova that deposit in the liver and intestines. In these organs, ova release antigens that induce chronic, focal granulomatous inflammation. IFN-gamma is an inflammatory cytokine important in macrophage ac...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb09592.x

    authors: Weinstock JV,Elliott D

    更新日期:1998-05-01 00:00:00

  • Sex hormones and risk of liver tumor.

    abstract::The liver is morphologically and functionally modulated by sex hormones. Long-term use of oral contraceptives (OCs) and anabolic androgenic steroids (AASs) can induce both benign (hemangioma, adenoma, and focal nodular hyperplasia [FNH]) and malignant (hepatocellular carcinoma [HCC]) hepatocellular tumors. Hepatic ade...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1386.044

    authors: Giannitrapani L,Soresi M,La Spada E,Cervello M,D'Alessandro N,Montalto G

    更新日期:2006-11-01 00:00:00

  • A method for characterization of total circulating DNA.

    abstract::Although much work has been done in the field of circulating DNA, no definitive information on sequencing data of total circulating DNA is available. Characterization of total circulating DNA by sequence analysis may give valuable information about the origin and function of these nucleic acid molecules. Circulating D...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1448.031

    authors: van der Vaart M,Pretorius PJ

    更新日期:2008-08-01 00:00:00

  • Caloric restriction in primates.

    abstract::Caloric restriction (CR) remains the only nongenetic intervention that reproducibly extends mean and maximal life span in short-lived mammalian species. This nutritional intervention also delays the onset, or slows the progression, of many age-related disease processes. The diverse effects of CR have been demonstrated...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb05658.x

    authors: Lane MA,Black A,Handy A,Tilmont EM,Ingram DK,Roth GS

    更新日期:2001-04-01 00:00:00

  • Overexpression of the natural tetrapeptide acetyl-N-ser-asp-lys-pro derived from thymosin beta4 in neoplastic diseases.

    abstract::The natural tetrapeptide acetyl-ser-asp-lys-pro (AcSDKP) is formed in vivo by enzymatic cleavage of the N terminus of thymosin beta4 by prolyl oligopeptidase (POP). Recently, AcSDKP was shown to promote angiogenesis. Because of the critical role of neovascularization in cancer development, the levels of AcSDKP and POP...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05488.x

    authors: Liu JM,Garcia-Alvarez MC,Bignon J,Kusinski M,Kuzdak K,Riches A,Wdzieczak-Bakala J

    更新日期:2010-04-01 00:00:00

  • [3H]cirazoline as a tool for the characterization of imidazoline sites.

    abstract::Recent studies have shown that cirazoline, an alpha 1-adrenoceptor agonist, has greater affinity than do other imidazoline or guanidinium compounds at imidazoline recognition sites. In this report we used [3H]cirazoline as a probe to characterize imidazoline recognition sites present in membrane homogenates of rat bra...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1995.tb32396.x

    authors: Angel I,Le Rouzic M,Pimoule C,Graham D,Arbilla S

    更新日期:1995-07-12 00:00:00

  • Geometrical factors in conductance through molecular films.

    abstract::We have studied the conductance of molecular films as a function of orientation of the molecules in the film with respect to electrodes. Depending on the angle between the axis of the molecules and the normal to the electrode, the conductance may change by more than an order of magnitude. This is a consequence of the ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb03034.x

    authors: Kornilovitch PE,Bratkovsky AM

    更新日期:2002-04-01 00:00:00

  • Strategies for balance rehabilitation: fall risk and treatment.

    abstract::Identification of fall risk for patients with known vestibular hypofunction is important because it affects the management and the level of independence of these patients. Patients with bilateral vestibular loss, overall, have a greater incidence of falls than the general community-dwelling population over the age of ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Herdman SJ,Schubert MC,Tusa RJ

    更新日期:2001-10-01 00:00:00

  • Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses.

    abstract::Plasmacytoid dendritic cells (pDCs) are a rare population of circulating cells that selectively express Toll-like receptors (TLR)7 and TLR9 and have the capacity to produce large amounts of type I interferons (IFNs) in response to viruses or host-derived nucleic acid-containing complexes. Through the production of typ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.05152.x

    authors: Lande R,Gilliet M

    更新日期:2010-01-01 00:00:00

  • CGRP as a marker of the climbing fibers during the development of the cerebellum in the rat.

    abstract::Olivary fibers express CGRP-LI until the nest phase of their development and never in the next postnatal steps, that is, the "capuchon" stage. Together with other results presented in this volume regarding the postnatal development of CGRP binding sites in the cerebellar cortex, these immunohistologic findings suggest...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1992.tb22800.x

    authors: Morara S,Rosina A,Provini L

    更新日期:1992-06-30 00:00:00

  • Screwworm eradication in the Americas.

    abstract::The screwworm fly, Cochliomyia hominivorax (Coquerel), is a parasite that attacks all warm-blooded animals including humans. This parasite has caused significant losses to the livestock industries of the Americas. Since the screwworm eradication program was initiated in the Southeastern United States in 1957, the erad...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb05289.x

    authors: Wyss JH

    更新日期:2000-01-01 00:00:00