Rheumatic diseases and Klinefelter's syndrome.

abstract：:Recent advances in the development of three different types of antiviral drugs, the nucleotide and non-nucleotide analogues acting as reverse transcriptase inhibitors (NRTIs) and the nonpeptidic viral protease inhibitors (PI), and their introduction in the management of patients with AIDS, either alone or in combinati...

journal_title：Annals of the New York Academy of Sciences

authors： Kino T,Chrousos GP

更新日期：2004-06-01 00:00:00

abstract：:In epithelia and endothelia, overall resistance (TER) is determined by all ion-conductive structures, such as membrane channels, tight junctions, and the intercellular space, whereas the epithelial capacitance is due to the hydrophobic phase of the plasma membrane. Impedance means alternating current resistance and, i...

journal_title：Annals of the New York Academy of Sciences

authors： Günzel D,Zakrzewski SS,Schmid T,Pangalos M,Wiedenhoeft J,Blasse C,Ozboda C,Krug SM

更新日期：2012-06-01 00:00:00

abstract：:Immunosuppressive therapy and clinical evolution were studied in 49 patients (29 females) with antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. The mean age of patients at presentation was 55 years, and the mean (+/-SD) follow-up was 43 months (+/-33) (range, 3-140). Among the 49 patients, 10 ...

journal_title：Annals of the New York Academy of Sciences

authors： Kokolina E,Alexopoulos E,Dimitriadis C,Vainas A,Giamalis P,Papagianni A,Ekonomidou D,Memmos D

更新日期：2005-06-01 00:00:00

abstract：:The success of embryonic implantation relies on an ideal cross-talk between the embryo and the receptive endometrium. This article focuses on the role of leukemia inhibitory factor (LIF) and its receptors in human embryo implantation. LIF is a secreted glycoprotein first described as a factor that induced the differen...

journal_title：Annals of the New York Academy of Sciences

authors： Aghajanova L

更新日期：2004-12-01 00:00:00

abstract：:Rhythm is fundamental to every motor activity. Neural and physiological mechanisms that underlie rhythmic cognition, in general, and rhythmic pattern generation, in particular, are evolutionarily ancient. As speech production is a kind of motor activity, investigating speech rhythm can provide insight into how general...

journal_title：Annals of the New York Academy of Sciences

authors： Ordin M

更新日期：2019-10-01 00:00:00

abstract：:B lymphocytes contribute to the pathogenesis of autoimmune disorders since B-cell depletion treatment improves such diseases. However, B cells seem ambivalent. Murine strains of nonorgan-specific as well as organ-specific autoimmune conditions present with aggravated symptoms when B cells are depleted. It is thus like...

journal_title：Annals of the New York Academy of Sciences

authors： Lemoine S,Morva A,Youinou P,Jamin C

更新日期：2009-09-01 00:00:00

abstract：:The effect of DHEA administration on the age-associated decline in immunity against influenza vaccine was studied. Increased humoral response was observed in 16- and 24-month-old mice immunized by live A/PR/8/34 (H1N1) influenza virus following DHEA treatment (a single injection adjacent to immunization). Furthermore,...

journal_title：Annals of the New York Academy of Sciences

authors： Danenberg HD,Ben-Yehuda A,Zakay-Rones Z,Friedman G

更新日期：1995-12-29 00:00:00

abstract：:Caloric restriction (CR) remains the only nongenetic intervention that reproducibly extends mean and maximal life span in short-lived mammalian species. This nutritional intervention also delays the onset, or slows the progression, of many age-related disease processes. The diverse effects of CR have been demonstrated...

journal_title：Annals of the New York Academy of Sciences

authors： Lane MA,Black A,Handy A,Tilmont EM,Ingram DK,Roth GS

更新日期：2001-04-01 00:00:00

abstract：:Data on 3080 mother-infant pairs from Cebu in the Philippines were used to conduct a logistics hazards analysis to determine the effect of supplemental calories and the types of supplements that the infant ingests on return to menses. Breast feeding had a significant reduced odds of the mother returning to menses (od...

journal_title：Annals of the New York Academy of Sciences

authors： Zohoori N

更新日期：1994-02-18 00:00:00

abstract：:Iddm4 is a dominant non-major histocompatibility complex (MHC) determinant of diabetes susceptibility in BBDR rats treated with poly I:C, plus depletion of regulatory T cells. In congenic MHC-identical normal WF rats, Iddm4(d) sensitively and specifically predicts induced diabetes. We report a new diabetes-susceptible...

journal_title：Annals of the New York Academy of Sciences

authors： Blankenhorn EP,Descipio C,Rodemich L,Cort L,Leif JH,Greiner DL,Mordes JP

更新日期：2007-04-01 00:00:00

abstract：:The alpha-ketoglutarate dehydrogenase complex (KGDHC) is an important mitochondrial constituent, and deficiency of KGDHC is associated with a number of neurological disorders. KGDHC is composed of three proteins, each encoded on a different and well-characterized gene. The sequences of the human proteins are known. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Sheu KF,Blass JP

更新日期：1999-01-01 00:00:00

abstract：:Clinicians use the combination of Tanner stage 5 (T5) of puberty, final height, and epiphyseal fusion to define maturity. We tested the hypothesis that changes in body composition related to age are identifiable during T5. Asian, Black, Hispanic, and White T5 adolescents (n = 148, 72 females) had measurements taken of...

journal_title：Annals of the New York Academy of Sciences

authors： Horlick M,Thornton J,Wang J,Levine LS,Fedun B,Pierson RN Jr

更新日期：2000-05-01 00:00:00

abstract：:Explicit memory refers to the conscious retrieval of past information or experiences, whereas implicit memory refers to an unintentional or nonconscious form of retrieval. Much of the literature in cognitive psychology and cognitive neuroscience has focused on differences between explicit and implicit memory, and the ...

journal_title：Annals of the New York Academy of Sciences

authors： Dew ITZ,Cabeza R

更新日期：2011-04-01 00:00:00

abstract：:In the present study, we have utilized the transglutaminase (TGase) enzyme to modify the primary structure of VIP with diaminopropane (DAP) at the level of the Gln16. We have investigated the conformational stability of VIP and VIP-DAP in solution by limited proteolysis experiments. The VIP-DAP appears to be more resi...

journal_title：Annals of the New York Academy of Sciences

authors： Caraglia M,Dicitore A,Giuberti G,Cassese D,Lepretti M,Cartenì M,Abbruzzese A,Stiuso P

更新日期：2006-07-01 00:00:00

abstract：:According to the redusome hypothesis, the aging of an organism is determined by the shortening of chronomeres (small perichromosomal linear DNA molecules). In this paper, a presumptive role for infradian hormonal rhythms is considered. Endogenous infradian rhythms are supposed to actively interact with those hormonal ...

journal_title：Annals of the New York Academy of Sciences

authors： Olovnikov A

更新日期：2005-12-01 00:00:00

abstract：:We have presented evidence indicating that P2-purinergic receptors may activate the polyphosphoinositide-phospholipase C in HL60 cells via the mediation of a pertussis-toxin-sensitive GTP-binding protein, which also mediates the actions of chemotactic peptide receptors in these and other phagocytic white blood cells. ...

journal_title：Annals of the New York Academy of Sciences

authors： Dubyak GR,Cowen DS,Lazarus HM

更新日期：1988-01-01 00:00:00

abstract：:Previous studies reported that constitutive androstane receptor (CAR) does not transactivate phenobarbital responsive unit (PBRU)2C1luciferase reporter gene in COS cells in which endogenous CYP2B1 gene is not induced with PB. In order to understand molecular mechanism(s) whereby PBRU is transactivated, this article de...

journal_title：Annals of the New York Academy of Sciences

authors： Min G

更新日期：2006-12-01 00:00:00

abstract：:Rewards can be viewed as probability distributions of reward values. Besides expected (mean) value, a key parameter of such distributions is variance (or standard deviation), which constitutes a measure of risk. Single neurons in orbitofrontal cortex signal risk mostly separately from value. Comparable risk signals in...

journal_title：Annals of the New York Academy of Sciences

authors： Schultz W,O'Neill M,Tobler PN,Kobayashi S

更新日期：2011-12-01 00:00:00

abstract：:Carnitine and its congeners may regulate the immune networks, and their influence on functions of immune cells predominantly or exclusively relies on carnitine-dependent energy production from fatty acids. A reduced pool of carnitines has been demonstrated in either serum or tissues, or both, from patients with a wide...

journal_title：Annals of the New York Academy of Sciences

authors： Famularo G,De Simone C,Trinchieri V,Mosca L

更新日期：2004-11-01 00:00:00

abstract：:Toluene, a volatile hydrocarbon found in a variety of chemical compounds, is misused and abused by inhalation for its euphorigenic effects. Toluene's reinforcing properties may share a common characteristic with other drugs of abuse, namely, activation of the mesolimbic dopamine system. Prior studies in our laboratory...

journal_title：Annals of the New York Academy of Sciences

authors： Riegel AC,Ali SF,Torinese S,French ED

更新日期：2004-10-01 00:00:00

abstract：:CYP21A2 genotyping remains an important element in the diagnosis and management of congenital adrenal hyperplasia, and establishing accurate genotype-phenotype correlations has facillitated adequate genetic counseling and prenatal management for at-risk families. Despite extensive efforts to establish a clear genotype...

journal_title：Annals of the New York Academy of Sciences

authors： Elmougy F,Sharaf S,Hafez M,Khattab A,Abou-Yousef H,Elsharkawy M,Baz H,Ekladious S,Sherif B,Musa N,Elshiwy Y,Afif A,Abdullatif M,Thabet G,Rady N,Ibrahim A,Soliman H

更新日期：2018-03-01 00:00:00

abstract：:GABAA receptor heterogeneity is based on the combinatorial assembly of a large family of subunits into distinct receptor subtypes. A neuron-specific expression pattern of receptor subtypes has been demonstrated in adult rat brain, which can be reproduced in vitro in primary neuron cultures. This suggests that genetic ...

journal_title：Annals of the New York Academy of Sciences

authors： Penschuck S,Paysan J,Giorgetta O,Fritschy JM

更新日期：1999-04-30 00:00:00

abstract：:Sensorimotor learning requires knowledge of the relationship between movements and sensory effects: a sensorimotor map. Generally, these mappings are not innate but have to be learned. During learning, the challenge is to build a continuous map from a set of discrete observations, that is, predict locations of novel t...

journal_title：Annals of the New York Academy of Sciences

authors： van Vugt FT,Ostry DJ

更新日期：2018-03-03 00:00:00

abstract：:Opsoclonus-myoclonus syndrome (OMS) is a rare neurologic disorder comprising the main symptoms of eye-movement disturbances, muscle jerks, and severe ataxia. In children and adults, some cases are associated with a tumor as a paraneoplastic syndrome, whereas in children the paraneoplastic form is almost exclusively as...

journal_title：Annals of the New York Academy of Sciences

authors： Kirsten A,Beck S,Fühlhuber V,Kaps M,Kreutz T,Korfei M,Schmitt S,Preissner KT,Blaes F

更新日期：2007-09-01 00:00:00

abstract：:Efforts using transgenic mice are being made to understand the molecular and structural basis for dementia in Alzheimer's disease. Transgenic mice 12 to 18 months of age with amyloid plaques and impaired cognition show no neuronal or synaptic loss in the CA1 hippocampal subfield. Electrophysiological studies may yield...

journal_title：Annals of the New York Academy of Sciences

authors： Ashe KH

更新日期：2000-01-01 00:00:00

abstract：:High demand of neoplastic tissues for glutamine (Gln) is met by its active transport across cell membranes. Chronic treatment with acrylamide in rodents is associated with an increased incidence of neoplasms, including astrocytomas. In this study, 24-h acrylamide treatment significantly increased the initial rate of l...

journal_title：Annals of the New York Academy of Sciences

authors： Wu Q,Sidoryk M,Mutkus L,Zielińska M,Albrecht J,Aschner M

更新日期：2005-08-01 00:00:00

abstract：:The repeated, intermittent use of cocaine and other drugs of abuse produces profound and often long-lasting alterations in behavior and brain chemistry. It has been suggested that these consequences of drug use play a critical role in drug craving and relapse to addiction. This article reviews the effects of psychosti...

journal_title：Annals of the New York Academy of Sciences

authors： Shippenberg TS,Chefer VI,Zapata A,Heidbreder CA

更新日期：2001-06-01 00:00:00

abstract：:Currently, several rickettsioses are officially being reported in the Russian Federation. These are epidemic typhus and Brill-Zinsser disease, both caused by Rickettsia prowazekii which has a historic prevalence in Russia. Nowadays only single sporadic cases of R. prowazekii infection are reported. The last significan...

journal_title：Annals of the New York Academy of Sciences

authors： Tarasevich IV,Mediannikov OY

更新日期：2006-10-01 00:00:00

abstract：:A mouse strain lacking SMP30 can be regarded as a strain showing ultimate decrease of the SMP30 molecule. After three months of age, SMP30-KO mice had an increased mortality rate, compared with the SMP30-WT mice, all of which remained alive. Electron microscopic observation of the hepatocytes from 12-month-old SMP30-K...

journal_title：Annals of the New York Academy of Sciences

authors： Maruyama N,Ishigami A,Kuramoto M,Handa S,Kubo S,Imasawa T,Seyama K,Shimosawa T,Kasahara Y

更新日期：2004-06-01 00:00:00

abstract：:Nuclear receptors are transcription factors that are activated by ligands and subsequently bind to regulatory regions in target genes, thereby modulating their expression. Nuclear receptors thus allow the organism to integrate signals coming from the environment and to adapt by modifying the expression levels of relev...

journal_title：Annals of the New York Academy of Sciences

authors： Bocher V,Pineda-Torra I,Fruchart JC,Staels B

更新日期：2002-06-01 00:00:00