Population-wide infant screening for HLA-based type 1 diabetes risk via dried blood spots from the public health infrastructure.

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP), a pleiotropic neuropeptide, exerts a variety of physiological functions through three types of G protein-coupled receptors, PAC1, VPAC1, and VAPC2. Characterization of the molecular forms of PAC1 in mouse heart revealed the presence of four types of variant r...

journal_title：Annals of the New York Academy of Sciences

authors： Ushiyama M,Sugawara H,Inoue K,Kangawa K,Yamada K,Miyata A

更新日期：2006-07-01 00:00:00

abstract：:In the history of science, technical advances often precede periods of rapid accumulation of knowledge. Within the past three decades, discoveries that enabled the noninvasive measurement of the psychobiology of stress (in saliva) have added new dimensions to the study of health and human development. This widespread ...

journal_title：Annals of the New York Academy of Sciences

authors： Granger DA,Kivlighan KT,el-Sheikh M,Gordis EB,Stroud LR

更新日期：2007-03-01 00:00:00

abstract：:The arterial baroreflex has two important functions. First, the arterial baroreflex is a negative feedback reflex that regulates arterial pressure around a preset value called a set or operating point. Second, the arterial baroreflex also establishes the prevailing systemic arterial pressure when the operating point i...

journal_title：Annals of the New York Academy of Sciences

authors： DiCarlo SE,Bishop VS

更新日期：2001-06-01 00:00:00

abstract：:High concentrations of glucose induce insulin resistance and impair insulin secretion in a manner that mirrors type 2 diabetes, a phenomenon known as glucose toxicity. High concentrations of hexosamines mimic these effects, leading to the hypothesis that cells use hexosamine flux as a glucose- and satiety-sensing path...

journal_title：Annals of the New York Academy of Sciences

authors： Cooksey RC,McClain DA

更新日期：2002-06-01 00:00:00

abstract：:We compare diverging evolution of a two-component (gas+stars) galactic disk embedded in a "live" halo with that of an identical pure stellar disk. Our modeling supports the conjecture that the growth of central concentration in galaxies dissolves the main family of regular orbits in the stellar bar and assists in the ...

journal_title：Annals of the New York Academy of Sciences

authors： Shlosman I,Heller C,Berentzen I

更新日期：1998-12-30 00:00:00

abstract：:Successful introduction of nucleic acids into mammalian neurons has revolutionized the analyses of gene regulation and cellular function. Various methods, including viral infection, have been developed to introduce plasmid DNA into primary neuronal cultures. However, transfection of primary cultures of neurons using t...

journal_title：Annals of the New York Academy of Sciences

authors： Anji A,Shaik KA,Kumari M

更新日期：2003-05-01 00:00:00

abstract：:We have successfully expressed the active tyrosinase of Streptomyces antibioticus in Escherichia coli under the control of the trp promoter by fusing the sequence to the ORF438 gene. Because our attempt to connect the polycistronic gene of ORF438 and tyrosinase directly to the trp promoter of E. coli resulted in the e...

journal_title：Annals of the New York Academy of Sciences

authors： Han K,Hong J,Lim HC,Kim CH,Park Y,Cho JM

更新日期：1994-05-02 00:00:00

abstract：:The effects on ex vivo LDL resistance to oxidation and biomarkers of in vivo oxidative stress in response to 3-month dietary vitamin E restriction to 25% of recommended intake and 2-month unrestricted dietary intake and supplementation with 800 IU/d were studied in 100 healthy, nonsmoking 20-75-year-old volunteers. Si...

journal_title：Annals of the New York Academy of Sciences

authors： Winklhofer-Roob BM,Meinitzer A,Maritschnegg M,Roob JM,Khoschsorur G,Ribalta J,Sundl I,Wuga S,Wonisch W,Tiran B,Rock E,VITAGE Study Group.

更新日期：2004-12-01 00:00:00

abstract：:The recording of chemosensory event-related potentials (CSERPs) has been established as an objective method in the assessment of central odor processing in humans. In the present study CSERPs were used to investigate whether human body odor is genetically determined by the major histocompatibility complex (MHC), refer...

journal_title：Annals of the New York Academy of Sciences

authors： Krauel K,Pause BM,Mueller C,Sojka B,Mueller-Ruchholtz W,Ferstl R

更新日期：1998-11-30 00:00:00

abstract：:Our objective was to learn the prevalence of spotted fever group (SFG) Rickettsia detected in ticks in La Rioja, in the north of Spain. From 2001 to 2005, 496 ticks representing 7 tick species were analysed at the Hospital de La Rioja. Ticks were removed from humans with or without rickettsial syndrome (n = 59) or col...

journal_title：Annals of the New York Academy of Sciences

authors： Oteo JA,Portillo A,Santibáñez S,Pérez-Martínez L,Blanco JR,Jiménez S,Ibarra V,Pérez-Palacios A,Sanz M

更新日期：2006-10-01 00:00:00

abstract：:The treatment of substance use disorders has always been challenging because multiple neurotransmitters mediate addiction. However, with smoking being the leading cause of preventable death and the recent opioid epidemic in the United States, the search for novel solutions becomes more imperative. In this review, we d...

journal_title：Annals of the New York Academy of Sciences

authors： Xu A,Kosten TR

更新日期：2020-03-08 00:00:00

abstract：:Investigations of the I-Ek-restricted, cytochrome c-specific T-cell response in mice show that both T-cell receptor V alpha and V beta CDR3 residues and the use of particular V alpha s and V beta s are necessary for recognition. Data strongly suggest that specific CDR3 residues are important in contacting the peptide....

journal_title：Annals of the New York Academy of Sciences

authors： Davis MM,McHeyzer-Williams M,Chien YH

更新日期：1995-07-07 00:00:00

abstract：:Birds, the most species-rich monophyletic group of land vertebrates, have been subject to some of the most intense sequencing efforts to date, making them an ideal case study for recent developments in genomics research. Here, we review how our understanding of bird genomes has changed with the recent sequencing of mo...

journal_title：Annals of the New York Academy of Sciences

authors： Kapusta A,Suh A

更新日期：2017-02-01 00:00:00

abstract：:More than 10% of postmenopausal women in the United States receive thyroid hormone replacement therapy and up to 20% of these women are over-replaced inducing subclinical hyperthyroidism. Because hyperthyroidism and post menopausal osteoporosis overlap in women of advancing age, it is urgent to understand the effect o...

journal_title：Annals of the New York Academy of Sciences

authors： Abe E,Sun L,Mechanick J,Iqbal J,Yamoah K,Baliram R,Arabi A,Moonga BS,Davies TF,Zaidi M

更新日期：2007-11-01 00:00:00

abstract：:Allergic contact dermatitis is a common inflammatory skin disease caused by T cells that recognize environmental and industrial allergens (i.e., haptens). Langerhans' cells (LC), which are skin-specific and "immature" members of the dendritic cell (DC) family of antigen-presenting cells, play crucial roles in the indu...

journal_title：Annals of the New York Academy of Sciences

authors： Takashima A,Mummert M,Kitajima T,Matsue H

更新日期：2000-01-01 00:00:00

abstract：:Aromatase cytochrome P450, the key enzyme of estrogen biosynthesis from androgens, is encoded by CYP19. Its structure shows some peculiarities: exons II to X encode the protein, while multiple alternative exons I encode unique 5'-untranslated regions of the aromatase mRNA transcripts. Immunohistochemistry studies in t...

journal_title：Annals of the New York Academy of Sciences

authors： Galmiche G,Corvaisier S,Kottler ML

更新日期：2006-07-01 00:00:00

abstract：:In adult Lurcher mice virtually all cerebellar Purkinje cells have degenerated as a direct consequence of mutant gene action, providing a natural model for studying the effect of cerebellar cortical lesions on the generation of compensatory eye movements. Lurcher mice possess both optokinetic (OKR) and vestibular (VOR...

journal_title：Annals of the New York Academy of Sciences

authors： Van Alphen AM,Schepers T,Luo C,De Zeeuw CI

更新日期：2002-12-01 00:00:00

abstract：:MRI assessment of myocardial iron and function has revolutionized the treatment of thalassemia major patients. While knowledge of somatic iron stores is vital for iron chelation management, it does not adequately monitor cardiac risk. MRI monitoring of cardiac T2* allows preclinical recognition of myocardial iron, str...

journal_title：Annals of the New York Academy of Sciences

authors： Wood JC,Noetzli L

更新日期：2010-08-01 00:00:00

abstract：:Saliva testing for drugs of abuse can provide both qualitative and quantitative information on the drug status of an individual undergoing testing. Self-administration by the oral, intranasal, and smoking routes often produces "shallow depots" of drug that contaminate the oral cavity. This depot produces elevated drug...

journal_title：Annals of the New York Academy of Sciences

authors： Cone EJ

更新日期：1993-09-20 00:00:00

abstract：:Activated platelets and leukocytes release potent vasoactive factors that may modulate vascular tone. Activation of normal platelets produces dilatation of normal arteries. Vasodilatation is mediated by adenosine diphosphate (ADP), which releases endothelium-derived relaxing factor (EDRF) from endothelium. In atherosc...

journal_title：Annals of the New York Academy of Sciences

authors： Kaul S,Padgett RC,Heistad DD

更新日期：1994-04-18 00:00:00

abstract：:Antioxidant activity of Maillard reaction products (MRPs) derived from four sugar-amino acid Maillard reaction model systems (glucose [Glc] or ribose [Rib] reacted with glycine [Gly] and L-lysine [Lys]) were examined in terms of chemical properties and molecular weight fractionation of reaction products. Rib-amino aci...

journal_title：Annals of the New York Academy of Sciences

authors： Chen XM,Kitts DD

更新日期：2008-04-01 00:00:00

abstract：:Different estrogen-3-sulfates (estrone-3-sulfate, estradiol-3-sulfate, and estriol-3-sulfate) can provoke important biologic responses in different mammary cancer cell lines; there is a significant increase in progesterone receptor. However, no significant effect was observed with estrogen-17-sulfates. The reason for ...

journal_title：Annals of the New York Academy of Sciences

authors： Pasqualini JR,Gelly C,Nguyen BL

更新日期：1990-01-01 00:00:00

abstract：:The cell surface antigen recognized by monoclonal antibody W7C5 is expressed at low levels on human CD34(+) and CD34(-) bone marrow stem cell populations but at high levels on fetal liver CD34(+) cells. To identify the recognized antigen, we performed partial amino acid sequence and MALDI analysis of purified W7C5 ant...

journal_title：Annals of the New York Academy of Sciences

authors： Giesert C,Marxer A,Sutherland DR,Schuh AC,Kanz L,Buhring HJ

更新日期：2003-05-01 00:00:00

abstract：:In the present study, we examined the potential impact of a T-to-C substitution at nucleotide 1519 of the GABA(A)alpha6 receptor subunit gene (GABRA6) on obesity and obesity-related phenotypes as well as circulating hormones, including salivary cortisol, in 284 unrelated Swedish men born in 1944. The subjects were gen...

journal_title：Annals of the New York Academy of Sciences

authors： Rosmond R,Bouchard C,Björntorp P

更新日期：2002-06-01 00:00:00

abstract：:This paper reports the experimental and theoretical investigations of forced liquid flows through open capillary channels under reduced gravity conditions. An open capillary channel is a structure that establishes a liquid flow path at low Bond numbers, when the capillary pressure caused by the surface tension force d...

journal_title：Annals of the New York Academy of Sciences

authors： Haake D,Rosendahl U,Ohlhoff A,Dreyer ME

更新日期：2006-09-01 00:00:00

abstract：:After fertilization, the next major hurdle for human reproduction is trophoblast differentiation, which is required for implantation, followed in lockstep by rapid assembly of these embryonic cells into a functional placenta. During this process, cytotrophoblast stem cells invade the uterus, anchoring the conceptus to...

journal_title：Annals of the New York Academy of Sciences

authors： Zhou Y,Genbacev O,Fisher SJ

更新日期：2003-05-01 00:00:00

abstract：:This chapter examines trends in private and public health coverage, as well as implications for vulnerable populations and health disparities. We find that there has been erosion in employment-based health benefits. Both the percentage of employers offering coverage and the percentage of workers with coverage declined...

journal_title：Annals of the New York Academy of Sciences

authors： Shields AE,McGinn-Shapiro M,Fronstin P

更新日期：2008-01-01 00:00:00

abstract：:Neuropathology is one approach to the effort to elucidate the pathophysiology of suicide. Initial neurochemical studies focusing on the roles of serotonin (5-HT) and noradrenaline (NE) abnormalities in brains of suicide victims have been somewhat inconsistent. More recently developed methodologies, including quantitat...

journal_title：Annals of the New York Academy of Sciences

authors： Bachus SE,Hyde TM,Akil M,Weickert CS,Vawter MP,Kleinman JE

更新日期：1997-12-29 00:00:00

abstract：:Cold-restraint stress reduces gastric blood flow and produces acute gastric ulcers. We studied the role of Angiotensin II (Ang II) on gastric blood flow and gastric ulceration during stress. Spontaneously hypertensive rats, a stress-sensitive strain, were pretreated for 14 days with the AT(1) receptor antagonist cande...

journal_title：Annals of the New York Academy of Sciences

authors： Bregonzio C,Armando I,Ando H,Jezova M,Baiardi G,Saavedra JM

更新日期：2004-06-01 00:00:00

abstract：:The mechanism by which neurons and neurosecretory cells govern the expression and the exocytic discharge of their clear and dense-core vesicles had remained unclear until recently when studies in the neurosecretory cell model PC12 revealed these processes to be orchestrated by the transcriptional repressor neuron rest...

journal_title：Annals of the New York Academy of Sciences

authors： D'Alessandro R,Klajn A,Meldolesi J

更新日期：2009-01-01 00:00:00