Protective role of HO-1 against acute kidney injury caused by cutaneous exposure to arsenicals.

Abstract:

:Lewisite and many other similar arsenicals are warfare vesicants developed and weaponized for use in World Wars I and II. These chemicals, when exposed to the skin and other epithelial tissues, cause rapid severe inflammation and systemic damage. Here, we show that topically applied arsenicals in a murine model produce significant acute kidney injury (AKI), as determined by an increase in the AKI biomarkers NGAL and KIM-1. An increase in reactive oxygen species and ER stress proteins, such as ATF4 and CHOP, correlated with the induction of these AKI biomarkers. Also, TUNEL staining of CHOP-positive renal tubular cells suggests CHOP mediates apoptosis in these cells. A systemic inflammatory response characterized by a significant elevation in inflammatory mediators, such as IL-6, IFN-α, and COX-2, in the kidney could be the underlying cause of AKI. The mechanism of arsenical-mediated inflammation involves activation of AMPK/Nrf2 signaling pathways, which regulate heme oxygenase-1 (HO-1). Indeed, HO-1 induction with cobalt protoporphyrin (CoPP) treatment in arsenical-treated HEK293 cells afforded cytoprotection by attenuating CHOP-associated apoptosis and cytokine mRNA levels. These results demonstrate that topical exposure to arsenicals causes AKI and that HO-1 activation may serve a protective role in this setting.

journal_name

Ann N Y Acad Sci

authors

Srivastava RK,Muzaffar S,Khan J,Traylor AM,Zmijewski JW,Curtis LM,George JF,Ahmad A,Antony VB,Agarwal A,Athar M

doi

10.1111/nyas.14475

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

155-169

issue

1

eissn

0077-8923

issn

1749-6632

journal_volume

1480

pub_type

杂志文章
  • The elderly in a period of transition: health, personality, and social aspects of adaptation.

    abstract::The dramatic changes in overall mode of life experienced since 1989 by the people in Central and Eastern Europe (CEE) provides a good opportunity to study the aging processes and the status of the elderly. In the 1980s, CEE countries were already at an advanced stage of demographic aging of their populations. The firs...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1396.041

    authors: Petrov IC

    更新日期:2007-10-01 00:00:00

  • The etiology of anomalous sexual preferences in men.

    abstract::People discover rather than choose their sexual interests. The process of discovery typically begins before the onset of puberty and is associated with an increase in the secretion of sex hormones from the adrenal glands. However, the determinants of the direction of sexual interest, in the sense of preferences for th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb07297.x

    authors: Quinsey VL

    更新日期:2003-06-01 00:00:00

  • Senescence marker protein-30 knockout mouse as an aging model.

    abstract::A mouse strain lacking SMP30 can be regarded as a strain showing ultimate decrease of the SMP30 molecule. After three months of age, SMP30-KO mice had an increased mortality rate, compared with the SMP30-WT mice, all of which remained alive. Electron microscopic observation of the hepatocytes from 12-month-old SMP30-K...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1297.068

    authors: Maruyama N,Ishigami A,Kuramoto M,Handa S,Kubo S,Imasawa T,Seyama K,Shimosawa T,Kasahara Y

    更新日期:2004-06-01 00:00:00

  • Inactive form of carbonic anhydrase I in erythrocytes from primary aldosteronism.

    abstract::An inactive form of erythrocyte CA I was found in patients with primary aldosteronism. The levels of CA I in the patients were within the normal range: however, the specific esterase activity of CA I from three patients was in the range of 0.12-0.26 u/mg CA I (normal control: 0.66 +/- 0.1 u/mg CA I). In one subject, w...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1984.tb12353.x

    authors: Kondo T,Taniguchi N,Hirano T,Kawakami Y

    更新日期:1984-01-01 00:00:00

  • The neuroethology of friendship.

    abstract::Friendship pervades the human social landscape. These bonds are so important that disrupting them leads to health problems, and difficulties forming or maintaining friendships attend neuropsychiatric disorders like autism and depression. Other animals also have friends, suggesting that friendship is not solely a human...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12315

    authors: Brent LJ,Chang SW,Gariépy JF,Platt ML

    更新日期:2014-05-01 00:00:00

  • Differentiated cerebrovascular effects of physostigmine and tacrine in cortical areas deafferented from the nucleus basalis magnocellularis suggest involvement of basalocortical projections to microvessels.

    abstract::Cholinesterase inhibitors used to treat Alzheimer's disease according to the principle of cholinergic replacement therapy have proved to be less beneficial than expected. The present study was designed to investigate the cerebrovascular response to physostigmine and tacrine in the experimental model of lesioning of th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06391.x

    authors: Peruzzi P,von Euw D,Lacombe P

    更新日期:2000-04-01 00:00:00

  • Scleroderma renal crisis, still a life-threatening complication.

    abstract::Scleroderma renal crisis (SRC) is a major complication in patients with systemic sclerosis (SSc). SRC occurs during the first 4 years of disease evolution in more than 75% of the cases, almost exclusively in patients with diffuse SSc. Other risk factors, including preceding corticosteroid therapy, have been associated...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1422.027

    authors: Teixeira L,Mahr A,Berezné A,Noël LH,Guillevin L,Mouthon L

    更新日期:2007-06-01 00:00:00

  • Propositional music from extended musical interface with the human nervous system.

    abstract::Results obtained from projects in which self-organizing musical structures spontaneously arise through electrical interface between the brain and generative musical systems are surveyed. This provides a springboard for examining important paradigm shifts taking place in our thinking about what musical forms can be and...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1284.037

    authors: Rosenboom D

    更新日期:2003-11-01 00:00:00

  • Reversal of immunosuppression induced by murine leukemia viruses.

    abstract::BALB/c mice infected with Rowson-Parr virus, a lymphatic leukemia virus isolated from the Friend complex, undergo a rapid depression of antibody response. Spleen cells from these mice in culture show a similar deficit in the response to stimulation with sheep red cells and inhibit the reactivity of normal splenocytes....

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1976.tb41668.x

    authors: Bendinelli M,Toniolo A

    更新日期:1976-01-01 00:00:00

  • Phase space transport in noisy Hamiltonian systems.

    abstract::This paper analyzes the effect of low amplitude friction and noise in accelerating phase space transport in time-independent Hamiltonian systems that exhibit global stochasticity. Numerical experiments reveal that even very weak non-Hamiltonian perturbations can dramatically increase the rate at which an ensemble of o...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb11267.x

    authors: Kandrup HE

    更新日期:1998-12-30 00:00:00

  • A new look at the cognitive neuroscience of video game play.

    abstract::A growing body of literature has investigated the effects of playing video games on brain function and behavior. One key takeaway from this literature has been that not all entertainment video games are created equal with respect to their effects on cognitive functioning. The majority of the research to date has contr...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.14295

    authors: Dale G,Joessel A,Bavelier D,Green CS

    更新日期:2020-03-01 00:00:00

  • Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats.

    abstract::Formaldehyde was administered for 104 weeks in drinking water supplied ad libitum at concentrations of 1500, 1000, 500, 100, 50, 10, or 0 mg/L to groups of 50 male and 50 female Sprague-Dawley rats beginning at seven weeks of age. Control animals (100 males and 100 females) received tap water only. Acetaldehyde was ad...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04926.x

    authors: Soffritti M,Belpoggi F,Lambertin L,Lauriola M,Padovani M,Maltoni C

    更新日期:2002-12-01 00:00:00

  • Sex-specific prenatal programming: a risk for fibromyalgia?

    abstract::Women are four to eight times more likely to be affected by fibromyalgia syndrome (FMS). A lack of cortisol, potentially due to an adrenocortical deficit is postulated in FMS. The cause of such adrenal insufficiency is unknown. It could be assumed that stress exposure during critical periods contributes to vulnerabili...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1410.020

    authors: Klingmann PO,Kugler I,Steffke TS,Bellingrath S,Kudielka BM,Hellhammer DH

    更新日期:2008-12-01 00:00:00

  • Proteomic technologies to study diseases of the lymphatic vascular system.

    abstract::Now that the human genome has been mapped, a new challenge has emerged: deciphering the various products of individual genes. Consequently, new proteomic technologies are being developed to monitor and identify protein function and interactions responsible for the total activities of the cell. The application of these...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb04881.x

    authors: Leak LV,Petricoin EF 3rd,Jones M,Paweletz CP,Ardekani AM,Fusaro VA,Ross S,Liotta LA

    更新日期:2002-12-01 00:00:00

  • Safety of cyclosporin A in HCV-infected patients: experience with cyclosporin A in patients affected by rheumatological disorders and concomitant HCV infection.

    abstract::Because of the relatively high prevalence of both hepatitis C virus (HCV) infection and autoimmune disorders (ADs), it is not rare to encounter in daily clinical practice patients with ADs also carrying HCV. Corticosteroids and/or immunosuppressant drugs are needed to treat ADs, but they place HCV-infected patients at...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1423.058

    authors: Galeazzi M,Bellisai F,Giannitti C,Manganelli S,Morozzi G,Sebastiani GD

    更新日期:2007-09-01 00:00:00

  • The role of basement membranes in vascular development.

    abstract::Endothelial cells produce and bind to multiple basement membrane components. Fibronectin and interstitial collagens seem to promote migration and proliferation, whereas basement membrane collagen and laminin stimulate attachment and differentiation. Human umbilical vein endothelial cells will rapidly form capillary-li...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1990.tb13197.x

    authors: Grant DS,Kleinman HK,Martin GR

    更新日期:1990-01-01 00:00:00

  • Basic principles for generating motor output in the stomatogastric ganglion.

    abstract::The lobster stomatogastric ganglion contains 30 neurons and when modulated can produce two distinct rhythmic motor patterns--the gastric mill and the pyloric. The complete neural circuitry underlying both patterns is well known. Without modulatory input no patterns are produced, and the neurons fire tonically or are s...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb09037.x

    authors: Selverston A,Elson R,Rabinovich M,Huerta R,Abarbanel H

    更新日期:1998-11-16 00:00:00

  • Apoptosis and autoimmune diseases.

    abstract::Every day billions of cells die in our bodies to eliminate those that are harmful, useless, or senescent. The process can be divided into two steps: cell dying and cell clearance. In the first step, death machinery is activated in the cells and quickly kills them. During the second step, dead cells are engulfed by pha...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05749.x

    authors: Nagata S

    更新日期:2010-10-01 00:00:00

  • CD4(+) CD25(+) regulatory T cell selection.

    abstract::Accumulating evidence indicates that regulatory T cells play a crucial role in preventing autoimmunity. To examine the processes by which regulatory CD4(+) T cells are produced during immune repertoire formation, we have developed transgenic mice that express the influenza virus hemagglutinin (HA) and coexpress major ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1309.028

    authors: Caton AJ,Cozzo C,Larkin J 3rd,Lerman MA,Boesteanu A,Jordan MS

    更新日期:2004-12-01 00:00:00

  • Evaluating the prevalence of olfactory dysfunction in a pediatric population.

    abstract::Although smell loss has several potential etiologies (e.g., head trauma, allergic rhinitis, and enlarged adenoids) that are common among children, studies evaluating the prevalence of olfactory dysfunction in the pediatric population are rare. Several challenges confront the clinician or researcher hoping to evaluate ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.03919.x

    authors: Dalton P,Mennella JA,Cowart BJ,Maute C,Pribitkin EA,Reilly JS

    更新日期:2009-07-01 00:00:00

  • Is PR3-ANCA formation initiated in Wegener's granulomatosis lesions? Granulomas as potential lymphoid tissue maintaining autoantibody production.

    abstract::In Wegener's granulomatosis (WG), antiproteinase 3 (PR3) autoantibodies (PR3-ANCA) are crucial in the development of generalized vasculitis. Wegener's pathognomonic lesion, a granulomatous inflammation of the upper and lower respiratory tract, contains abundant lymphocytes and macrophages. Lymphocyte clusters in germi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1361.042

    authors: Voswinkel J,Müller A,Lamprecht P

    更新日期:2005-06-01 00:00:00

  • A survey of the hormonal factors that control calcium metabolism.

    abstract::(1) Vitamin D is the precursor of an extremely potent calcium regulating hormone, 1,25(OH)2D3, which is secreted by the kidney. (2) The secretion of 1,25(OH)2D3 by the kidney is influenced by the calcium and phosphorus content of the diet, parathyroid hormone, and 1,25(OH)2D3 itself. (3)Prolactin and growth hormone ar...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1978.tb41961.x

    authors: MacIntyre I,Colston KW,Szelke M,Spanos E

    更新日期:1978-04-28 00:00:00

  • Epigenetic regulatory mechanisms during preimplantation embryo development.

    abstract::Within the past few years, developmental scientists have switched their attention from the study of DNA sequencing to the epigenetic state of the genome. Studying epigenetics could present the key to understanding gene expression changes without altering the basic structure of DNA. For example, the blastocyst, trophec...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2010.05937.x

    authors: Palini S,De Stefani S,Scala V,Dusi L,Bulletti C

    更新日期:2011-03-01 00:00:00

  • A sex-balanced rodent model for evaluating phosphine inhalation toxicity.

    abstract::Exposure to phosphine (PH3 ), a common grain fumigant, is characterized by diverse nonspecific symptoms and a high mortality rate. Although PH3 poisoning is thought to target oxidative respiration, the exact mechanism of action remains largely unknown, resulting in limited treatment options. In our study, the effects ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.14343

    authors: Tuet WY,Racine MC,Jennings L,Pierce SA,Tressler J,McCranor BJ,Wong B

    更新日期:2020-11-01 00:00:00

  • Advances in optical imaging of biomedical media.

    abstract::In this article, we have presented an overview of fundamental issues involved in mediphotonic imaging, and reviewed some of the emerging techniques for early-light transillumination imaging of body organs. The results on human breast tissues presented here, together with the data accumulated and advances made by resea...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1997.tb46200.x

    authors: Alfano RR,Demos SG,Gayen SK

    更新日期:1997-05-30 00:00:00

  • Immunogenicity of modified tumor cells in syngenic hosts.

    abstract::Modified tumor cells were used to immunize three murine hosts against syngenic ascitic lymphomas: C3H-6C3HED, BALB/c-P1798, and DBA/2-L1210. When the host was capable of a significant immune response against the malignant cells during progressive tumor growth (e.g., C3H vs. 6C3HED), protective immunization against a l...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1976.tb41636.x

    authors: Prager MD,Gordon WC,Baechtel FS

    更新日期:1976-01-01 00:00:00

  • Development of apixaban: a novel anticoagulant for prevention of stroke in patients with atrial fibrillation.

    abstract::The factor Xa inhibitor apixaban is one of the novel anticoagulants to emerge as alternatives to long-standing standards of care that include low-molecular-weight heparin and warfarin. The development of apixaban reflects a strategy to optimize the clinical pharmacology profile, dosing posology, trial designs, and sta...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12567

    authors: Hanna MS,Mohan P,Knabb R,Gupta E,Frost C,Lawrence JH

    更新日期:2014-11-01 00:00:00

  • Corticotropin and corticosteroids in generalized myasthenia gravis: comparative studies and role in management.

    abstract::The effect of 310 courses of corticotropin, methylprednisolone, prednisone, and dexamethasone were studied in 62 patients with generalized myasthenia gravis who were poorly responsive to anticholinesterase medication and most of whom required assisted respiration. Improvement in strength and response to anticholinest...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1976.tb47717.x

    authors: Brunner NG,Berger CL,Namba T,Grob D

    更新日期:1976-01-01 00:00:00

  • Converging cognitive enhancements.

    abstract::Cognitive enhancement, the amplification or extension of core capacities of the mind, has become a major topic in bioethics. But cognitive enhancement is a prime example of a converging technology where individual disciplines merge and issues transcend particular local discourses. This article reviews currently availa...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1382.015

    authors: Sandberg A,Bostrom N

    更新日期:2006-12-01 00:00:00

  • Environmental protection, inequality, and institutional change.

    abstract::The contemporary world faces an unprecedented environmental challenge. Past international research has amply shown that we cannot afford to wait for a "development path" that automatically takes us on a sustainable future. Whether we look at global or local problems, the international debate increasingly points to the...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05939.x

    authors: Magnani E

    更新日期:2011-02-01 00:00:00