A new neurotological test for detecting cerebellar dysfunction.

abstract：:The new vogue for systems biology is an important development. It is time to complement reductionist molecular biology by integrative approaches. But this welcome development is in danger of losing its way. Many of the early implementations of the approach are very low level, in some cases hardly more than an extensio...

journal_title：Annals of the New York Academy of Sciences

authors： Noble D

更新日期：2008-03-01 00:00:00

abstract：:As insulin is a major autoantigen in autoimmune diabetes and because the insulin gene region locus in humans has been linked to diabetes risk, we have bred insulin gene knockouts onto the NOD mouse. Mice differ from humans in terms that they express two nonallelic genes of insulin. Insulin 2 is the murine homologue of...

journal_title：Annals of the New York Academy of Sciences

authors： Paronen J,Moriyama H,Abiru N,Sikora K,Melanitou E,Babu S,Bao F,Liu E,Miao D,Eisenbarth GS

更新日期：2003-11-01 00:00:00

abstract：:Complete recovery of ischemic cardiac muscle after myocardial infarction is still an unresolved concern. In recent years, intensive research efforts have focused on mimicking the physical and biological properties of myocardium for cardiac repair. Here we show how heart regeneration approaches have evolved from cell t...

journal_title：Annals of the New York Academy of Sciences

authors： Soler-Botija C,Bagó JR,Bayes-Genis A

更新日期：2012-04-01 00:00:00

abstract：:Nephroblastoma overexpressed (Nov), a member of the CCN family of proteins, is expressed by osteoblasts and its transcription is regulated by transforming growth factor (TGF)-beta and bone morphogenetic proteins (BMP). CCN proteins can interact with TGF-beta, BMPs, and Wnt. We explored the function of Nov in skeletal ...

journal_title：Annals of the New York Academy of Sciences

authors： Canalis E

更新日期：2007-11-01 00:00:00

abstract：:To develop new treatments for beta-thalassemia, it is essential to identify the genes involved in the relevant pathophysiological processes. Iron metabolism in thalassemia mice being investigated, focusing on the expression of a gene called hepcidin (Hamp), which is expressed in the liver and whose product (Hamp) is s...

journal_title：Annals of the New York Academy of Sciences

authors： Breda L,Gardenghi S,Guy E,Rachmilewitz EA,Weizer-Stern O,Adamsky K,Amariglio N,Rechavi G,Giardina PJ,Grady RW,Rivella S

更新日期：2005-01-01 00:00:00

abstract：:Rapid advances in the biomedical sciences are producing new means of intervention against many of the major tropical diseases. The discovery of new drugs, vaccines and diagnostic tests, however, is only the first, though important, step down an often long and difficult road to their effective deployment in disease con...

journal_title：Annals of the New York Academy of Sciences

authors： Smith PG

更新日期：1989-01-01 00:00:00

abstract：:The role of dopaminergic activity in susceptibility of methamphetamine (MAP) psychosis (flashbacks) to subsequent spontaneous recurrences was studied. Plasma monoamine metabolite levels were assayed in 23 flashbackers, of whom 10 experienced a single flashback, 8 exhibited subsequent flashbacks and 5 with the last epi...

journal_title：Annals of the New York Academy of Sciences

authors： Yui K,Goto K,Ikemoto S

更新日期：2004-10-01 00:00:00

abstract：:The electron microscopical studies presented here show that characteristic morphological alterations in mitochondria are a very early hallmark of the hepatocellular apoptotic program. Before chromatin condensation occurs, the outer mitochondrial membrane is focally disrupted and the inner membrane protrudes through th...

journal_title：Annals of the New York Academy of Sciences

authors： Angermüller S,Schümann J,Fahimi HD,Tiegs G

更新日期：1999-01-01 00:00:00

abstract：:Female mosquitoes gorge on vertebrate blood, a rich nutrient source for developing eggs, but gorging meals increase the risk of predation. Mosquitoes are quick to reduce the flight payload with a potent diuresis. Diuretic peptides of the insect kinin family induce a tenfold reduction in the paracellular resistance of ...

journal_title：Annals of the New York Academy of Sciences

authors： Beyenbach KW

更新日期：2012-07-01 00:00:00

abstract：:Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen- and damage-associated molecular patterns into a proinflammatory response. This potent caspase-1-dependent process is capable of activating the innate immune s...

journal_title：Annals of the New York Academy of Sciences

authors： Sutterwala FS,Haasken S,Cassel SL

更新日期：2014-06-01 00:00:00

abstract：:In this article, we have presented an overview of fundamental issues involved in mediphotonic imaging, and reviewed some of the emerging techniques for early-light transillumination imaging of body organs. The results on human breast tissues presented here, together with the data accumulated and advances made by resea...

journal_title：Annals of the New York Academy of Sciences

authors： Alfano RR,Demos SG,Gayen SK

更新日期：1997-05-30 00:00:00

abstract：:The potential impact of atrazine (ATZ) on gonadal malformations in larval Xenopus laevis has been controversially discussed, and a hypothesis has been generated that ATZ might induce the estrogen-synthesizing enzyme aromatase, leading to feminization or demasculinization. Recently, extensive long-term studies clearly ...

journal_title：Annals of the New York Academy of Sciences

authors： Kloas W,Lutz I,Urbatzka R,Springer T,Krueger H,Wolf J,Holden L,Hosmer A

更新日期：2009-04-01 00:00:00

abstract：:Washington State's law for sexually violent predators was enacted in 1990; since then, 14 other states have passed similar laws authorizing civil commitment for dangerous sexual offenders following their prison terms. Although the law has survived constitutional challenges at both the state and in the U.S. Supreme Cou...

journal_title：Annals of the New York Academy of Sciences

authors： Lieb R

更新日期：2003-06-01 00:00:00

abstract：:One of the most remarkable aspects of the immune system is its ability to fashion an immune response most appropriate to the activating stimulus. Although the immune system possesses a number of adaptations to accomplish this, an important theme is local immune regulation by site-specific expression of receptors and l...

journal_title：Annals of the New York Academy of Sciences

authors： Shao L,Allez M,Park MS,Mayer L

更新日期：2006-08-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) play a central role in successful control of HIV. Induction of effective CTL responses may therefore be an essential requirement of HIV vaccines. Knowledge of CTL epitopes targeted either in natural infection or following vaccination will be critical to understanding the anti-HIV immune r...

journal_title：Annals of the New York Academy of Sciences

authors： Goulder PJ

更新日期：2000-11-01 00:00:00

abstract：:Chronic purulent rhinosinusitis (CPR) is an inflammatory condition of unknown origin. Although various medical and surgical treatment modalities are available, 5-10% of patients remain refractory. Immune deficiency is one of the underlying risk factors for this disease. Earlier studies demonstrated disturbances in cel...

journal_title：Annals of the New York Academy of Sciences

authors： Dalm VA,de Wit H,Drexhage HA

更新日期：2012-10-01 00:00:00

abstract：:Emerging evidence suggests that individuals who receive morphine while hospitalized demonstrate a decrease in symptoms of posttraumatic stress disorder (PTSD). However, the mechanisms of effects are not yet well understood. The goal of the current study was to examine three possible mediators for this effect. Sixty-on...

journal_title：Annals of the New York Academy of Sciences

authors： Saxe G,Geary M,Bedard K,Bosquet M,Miller A,Koenen K,Stoddard F,Moulton S

更新日期：2006-07-01 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) are the largest known family of cell surface receptors, and they control many important physiological events, including sensory perception, chemotaxis, neurotransmission, and energy homeostasis. However, GPCR signaling can be difficult to study in vivo because of the multitude of GP...

journal_title：Annals of the New York Academy of Sciences

authors： Srinivasan S,Vaisse C,Conklin BR

更新日期：2003-06-01 00:00:00

abstract：:Human diploid fibroblasts (WI38) were inoculated into Rose multipurpose culture chambers, using a high population density to develop confluency. After 24 hours, cells from a 1 mm swath were scraped from the center of the chamber. This cleared path was positioned to permit an unobstructed transmission of a 0.9 X 20 mm ...

journal_title：Annals of the New York Academy of Sciences

authors： Rounds DE,Olson RS,Booher J

更新日期：1976-01-30 00:00:00

abstract：:Magnetic resonance imaging (MRI) now enables precise visualization of the mechanical state of the living human orbit. Resulting insights have motivated histological re-examination of human and simian orbits, providing abundant consistent evidence for the active pulley hypothesis, a re-formulation of ocular motor physi...

journal_title：Annals of the New York Academy of Sciences

authors： Demer JL

更新日期：2002-04-01 00:00:00

abstract：:The strategy of antigenic variation is to present a constantly changing population phenotype that enhances parasite transmission, through evasion of immunity arising within, or existing between, host animals. Trypanosome antigenic variation occurs through spontaneous switching among members of a silent archive of many...

journal_title：Annals of the New York Academy of Sciences

authors： Barry JD,Hall JP,Plenderleith L

更新日期：2012-09-01 00:00:00

abstract：:The identification of high-affinity ligands for PPAR gamma has revealed the role of this receptor as the molecular target for the antidiabetic activity of the thiazolidinediones. The surprising observation that agonists of an adipogenic transcription factor reverse the obesity-associated disease of diabetes highlights...

journal_title：Annals of the New York Academy of Sciences

authors： Willson TM,Lehmann JM,Kliewer SA

更新日期：1996-12-27 00:00:00

abstract：:Expectation of reward facilitates motor behaviors that enable the animal to approach a location in space where the reward is expected. It is now known that the same expectation of reward profoundly modifies sensory, motor, and cognitive information processing in the brain. However, it is still unclear which brain regi...

journal_title：Annals of the New York Academy of Sciences

authors： Hikosaka O

更新日期：2007-05-01 00:00:00

abstract：:Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease characterized by the destruction of insulin-secreting pancreatic β cells. In humans with T1D and in nonobese diabetic (NOD) mice (a murine model for human T1D), autoreactive T cells cause β-cell destruction, as transfer or deletion of these cells induces or...

journal_title：Annals of the New York Academy of Sciences

authors： Padgett LE,Broniowska KA,Hansen PA,Corbett JA,Tse HM

更新日期：2013-04-01 00:00:00

abstract：:Tight and adherens junctions play critical roles in the barrier, adhesion, and signaling functions of epithelial and endothelial cells. How the molecular organization of these junctions is tuned to the widely diverse physiological requirements of each tissue type is not well understood. Here, we address this question ...

journal_title：Annals of the New York Academy of Sciences

authors： Vasileva E,Sluysmans S,Bochaton-Piallat ML,Citi S

更新日期：2017-10-01 00:00:00

abstract：:Alternative splicing of RNA transcripts is a general characteristic for NCX genes in mammals, mollusks, and arthropods. Among the family of three NCX genes in mammals, the NCX1 gene contains six exons, namely, A, B, C, D, E, and F, that make up the alternatively spliced region. Studies of the NCX1 gene transcripts sug...

journal_title：Annals of the New York Academy of Sciences

authors： Schulze DH,Polumuri SK,Gille T,Ruknudin A

更新日期：2002-11-01 00:00:00

abstract：:Tocopherols, which exist in alpha, beta, gamma, and delta forms, are antioxidative nutrients also known as vitamin E. Although alpha-tocopherol (alpha-T) is the major form of vitamin E found in the blood and tissues, gamma- and delta-T have been suggested to have stronger anti-inflammatory activities. In the present s...

journal_title：Annals of the New York Academy of Sciences

authors： Yang CS,Lu G,Ju J,Li GX

更新日期：2010-08-01 00:00:00

abstract：:Elevated circulating levels of glucocorticoids are associated with psychiatric symptoms across several different conditions. It remains unknown if this hormonal abnormality is a cause or an effect of the psychiatric conditions. For example, the hypercortisolemia observed in a subset of patients with depression may hav...

journal_title：Annals of the New York Academy of Sciences

authors： Wolkowitz OM,Burke H,Epel ES,Reus VI

更新日期：2009-10-01 00:00:00

abstract：:Higher fasting plasma insulin levels and reduced CSF-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patients with Alzheimer's disease (AD) who do not possess an apolipoprotein E (ApoE)-epsilon 4 allele. Insulin has also been implicated in processing of beta-amyloid and amyloid precur...

journal_title：Annals of the New York Academy of Sciences

authors： Craft S,Asthana S,Schellenberg G,Baker L,Cherrier M,Boyt AA,Martins RN,Raskind M,Peskind E,Plymate S

更新日期：2000-04-01 00:00:00

abstract：:The definition of polycystic ovary syndrome in very young girls is complicated by the fact that many features typical of the syndrome can also be seen as physiological stages in the maturation of the hypothalamus-pituitary-ovarian axis. The role of reduced insulin sensitivity in the pathogenesis and evolution of the d...

journal_title：Annals of the New York Academy of Sciences

authors： Bruni V,Dei M,Nannini S,Balzi D,Nuvolone D

更新日期：2010-09-01 00:00:00