Altered subcellular distribution of the Alzheimer's amyloid precursor protein under stress conditions.

abstract：:Calpain, an inactive proenzyme, translocates from the cytosol to the membrane upon binding calcium, and is activated at the membrane in the presence of calcium and PIP2. Activated calpain is very unstable and presumably used only once. Thus the primary targets of calpain are considered to be membrane or membrane-assoc...

journal_title：Annals of the New York Academy of Sciences

authors： Suzuki K,Saido TC,Hirai S

更新日期：1992-12-31 00:00:00

abstract：:Parachlamydiaceae are potential emerging pathogens that naturally infect free-living amoebae. We investigated the affects of incubation temperature on the growth and cytopathic effect of P. acanthamoeba in Acanthamoeba polyphaga. A. polyphaga were infected with P. acanthamoeba and incubated at different temperatures f...

journal_title：Annals of the New York Academy of Sciences

authors： Greub G,La Scola B,Raoult D

更新日期：2003-06-01 00:00:00

abstract：:Our data show that when substance abusers are subtyped simultaneously by antisocial personality disorder and the onset of depression relative to alcohol or drug abuse, groups of people with unique personality and affective profiles are identified. The profiles are represented by measures of affect-related personality ...

journal_title：Annals of the New York Academy of Sciences

authors： Epstein EE,Ginsburg BE,Hesselbrock VM,Schwarz JC

更新日期：1994-02-28 00:00:00

abstract：:Hereditary episodic ataxia (EA) syndromes are rare monogenic disorders that are phenotypically and genetically heterogeneous. The number of identified EA phenotypes is expanding. So far, mutations have been identified in four genes, all coding for membrane proteins including ion channels and transporters. The study of...

journal_title：Annals of the New York Academy of Sciences

authors： Jen JC

更新日期：2008-10-01 00:00:00

abstract：:Whole body exposure of rabbits to microwave radiation causes a decrease in ascorbic acid in the lens. In our study, rabbit lenses maintained in culture medium (37 degrees C) were exposed to either pulsed or continuous wave S-band radiation for 10-15 min at power densities between 0 and 200 mW/cm-2. Total ascorbic acid...

journal_title：Annals of the New York Academy of Sciences

authors： Weiter JJ,Finch ED,Schulz W,Frattali V

更新日期：1975-02-28 00:00:00

abstract：:We have shown that the medial preoptic area (MPO) in the hypothalamus is a major site where interferon (IFN)-alpha acts to induce suppression of splenic natural killer (NK) cell activity through an activation of sympathetic nervous system (SNS) in rats. Here, we discuss the hypothalamic mechanisms of the cytokine acti...

journal_title：Annals of the New York Academy of Sciences

authors： Katafuchi T,Duan S,Take S,Yoshimura M

更新日期：2009-02-01 00:00:00

abstract：:As a result of intensive investigation, particularly in the pharmaceutical industry, a number of potent and selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonists have been discovered. The structure activity relationship studies that led to the discovery of these mGluR5 antagonists are presented in t...

journal_title：Annals of the New York Academy of Sciences

authors： Carroll FI

更新日期：2008-10-01 00:00:00

abstract：:It is thought that neuronal activity in orbitofrontal cortex (OFC) represents the value of anticipated reward; however activity in many other brain areas also seems to reflect expected reward value. For example, we have shown that in monkeys performing a memory-guided saccade task for a reward of variable size, activi...

journal_title：Annals of the New York Academy of Sciences

authors： Roesch MR,Olson CR

更新日期：2007-12-01 00:00:00

abstract：:Two major methodological problems that impact clinical research in endometriosis are the absence of a low-cost, highly reliable method for diagnosing endometriosis and the possibility that endometriosis is actually multiple different diseases that we have not yet been able to differentiate. Animal models of endometrio...

journal_title：Annals of the New York Academy of Sciences

authors： Barbieri RL,Missmer S

更新日期：2002-03-01 00:00:00

abstract：:Liquid diffusion experiments conducted on the MIR space station using the Canadian Space Agency QUELD II processing facility and the microgravity isolation mount (MIM) showed that g-jitter significantly increased the measured solute diffusion coefficients. In some experiments, milli-g forced vibration was superimposed...

journal_title：Annals of the New York Academy of Sciences

authors： Smith RW,Yang BJ,Huang WD

更新日期：2004-11-01 00:00:00

abstract：:The objectives of ExoMars are to inject an orbiter around Mars and to land a rover on the surface to look for possible traces of life. During the first stages of the feasibility analysis, the mass margin of the orbiter was very small for a direct transfer in the Soyuz/Fregat scenario. An analysis of the combined use o...

journal_title：Annals of the New York Academy of Sciences

authors： Gil-Fernández J,Van Damme CC,Graziano M,Amata GB,Cogo F,Perino MA

更新日期：2005-12-01 00:00:00

abstract：:Our studies have shown that the acyclic nucleotide analogues PMEA and HPMPC are able to penetrate into cells and are then activated to mono- and diphosphate derivatives. The latter correspond to triphosphate analogues and presumably serve an important role in the biological activity exerted by these antiviral agents. ...

journal_title：Annals of the New York Academy of Sciences

authors： Bronson JJ,Ho HT,De Boeck H,Woods K,Ghazzouli I,Martin JC,Hitchcock MJ

更新日期：1990-01-01 00:00:00

abstract：:In this paper, we develop an agent-based model of social influence on body weight. The model's assumptions are grounded in theory and evidence from physiology, social psychology, and behavioral science, and its outcomes are tested against longitudinal data from American youth. We discuss the implementation of the mode...

journal_title：Annals of the New York Academy of Sciences

authors： Hammond RA,Ornstein JT

更新日期：2014-12-01 00:00:00

abstract：:This paper describes the experimental results of a pilot-scale application of membrane technologies to textile wastewater advanced treatment, downstream of a biological activated sludge process, aimed at water reuse in textile technology processes. The chosen approach consisted of sand filtration as a pretreatment, a ...

journal_title：Annals of the New York Academy of Sciences

authors： Marcucci M,Ciabatti I,Matteucci A,Vernaglione G

更新日期：2003-03-01 00:00:00

abstract：:The influence of either short-term fasting or vitamin E administration on insulin action was studied in two groups of obese Type 2 diabetic patients. Twelve patients underwent 7 days of fasting (group A), whereas 600 mg of vitamin E was administered daily during 3 months in 9 diabetic patients (group B). Insulin actio...

journal_title：Annals of the New York Academy of Sciences

authors： Skrha J,Sindelka G,Hilgertová J

更新日期：1997-09-20 00:00:00

abstract：:BALB/c mice infected with Rowson-Parr virus, a lymphatic leukemia virus isolated from the Friend complex, undergo a rapid depression of antibody response. Spleen cells from these mice in culture show a similar deficit in the response to stimulation with sheep red cells and inhibit the reactivity of normal splenocytes....

journal_title：Annals of the New York Academy of Sciences

authors： Bendinelli M,Toniolo A

更新日期：1976-01-01 00:00:00

abstract：:Stationary-phase mutation (a subset of which was previously called adaptive mutation) occurs in apparently nondividing, stationary-phase cells exposed to a nonlethal genetic selection. In one experimental system, stationary-phase reversion of an Escherichia coli F'-borne lac frameshift mutation occurs by a novel molec...

journal_title：Annals of the New York Academy of Sciences

authors： Lombardo MJ,Torkelson J,Bull HJ,McKenzie GJ,Rosenberg SM

更新日期：1999-05-18 00:00:00

abstract：:The article describes the process of planning the Memorial of Disappeared Detained Citizens in the City of Montevideo, Uruguay, the construction of which was completed in January 2003. It explores the role that memory, planning, and reconciliation carried out in the public realm can play in the context of an urban env...

journal_title：Annals of the New York Academy of Sciences

authors： Kohen M

更新日期：2004-06-01 00:00:00

abstract：:We compare the evidence from human neuroimaging studies for and against two of the major hypotheses of how alterations in the brain's reward system underlie addiction. One of these, the impulsivity hypothesis, proposes that addiction is characterized by excessive sensitivity to reward combined with a failure of inhibi...

journal_title：Annals of the New York Academy of Sciences

authors： Hommer DW,Bjork JM,Gilman JM

更新日期：2011-01-01 00:00:00

abstract：:Advanced glycation endproducts (AGEs) and oxidative stress (OS) contribute to the development and progression of diabetic complications. We have reported that dietary AGEs and OS induce acute endothelial dysfunction in vivo, but little is known about their effects on adipokines. Twenty inpatients with type 2 diabetes ...

journal_title：Annals of the New York Academy of Sciences

authors： Stirban A,Negrean M,Götting C,Uribarri J,Gawlowski T,Stratmann B,Kleesiek K,Koschinsky T,Vlassara H,Tschoepe D

更新日期：2008-04-01 00:00:00

abstract：:A remarkable "steroid sparing" effect of Saiboku-to was noted within 6 to 12 months of treatment in steroid-dependent asthmatic patients. Saiboku-to spared the downregulation of glucocorticoid receptor of human lymphocytes, plasma ACTH, and cortisol levels. It also spared downregulation of beta 2 receptor by beta 2 ag...

journal_title：Annals of the New York Academy of Sciences

authors： Nakajima S,Tohda Y,Ohkawa K,Chihara J,Nagasaka Y

更新日期：1993-06-23 00:00:00

abstract：:Healthy CD45 KO mice show a Th2-type cytokine secretion profile in their small intestines. Dietary supplementation with human infant formula induced colitis and a shift toward a Th1-type profile, suggesting that diet can alter cytokine secretion. ...

journal_title：Annals of the New York Academy of Sciences

authors： Lópeza MC,Holmes N

更新日期：2004-12-01 00:00:00

abstract：:The accepted dogma has been that a single long-term hematopoietic stem cell (LT-HSC) can reconstitute all components of the immune system. However, our single-cell transfer studies have shown that highly purified LT-HSCs selectively fail to reconstitute B-1a cells in otherwise fully reconstituted hosts (i.e., LT-HSCs ...

journal_title：Annals of the New York Academy of Sciences

authors： Ghosn EE,Yang Y

更新日期：2015-12-01 00:00:00

abstract：:In the pancreatic islets, pituitary adenylate cyclase-activating polypeptide (PACAP) is expressed in beta cells and autonomic nerve terminals; the majority of these nerve terminals are parasympathetic. PACAP binds to three types of G protein-coupled receptors (GPCRs): VPAC1 receptors, VPAC2 receptors, and PAC1 recepto...

journal_title：Annals of the New York Academy of Sciences

authors： Ahrén B

更新日期：2008-11-01 00:00:00

abstract：:Interleukin (IL)-17-producing helper T (Th17) cells serve as a Th subset involved in epithelial cell- and neutrophil-mediated immune responses against extracellular microbes and in the development of various autoimmune diseases. The differentiation of Th17 cells is controlled by a number of intracellular signaling cas...

journal_title：Annals of the New York Academy of Sciences

authors： Nagai S,Kurebayashi Y,Koyasu S

更新日期：2013-03-01 00:00:00

abstract：:Current evidence from genetic and epidemiological studies supports the view that Alzheimer's disease (AD) is a heterogeneous disorder. While the disease is pathologically defined by the presence of specified lesions in form of amyloid plaques and neurofibrillary tangles within the parenchyma, other features of patholo...

journal_title：Annals of the New York Academy of Sciences

authors： Cohen DL,Hedera P,Premkumar DR,Friedland RP,Kalaria RN

更新日期：1997-09-26 00:00:00

abstract：:The complex dielectric properties of canine skeletal muscles were measured at 25 degrees C during ischemia in the frequency range from 50 Hz to 200 MHz. The dielectric spectrum of skeletal muscle shows an alpha-dispersion below 1 kHz and a beta-dispersion with a relaxation frequency of about 100 kHz. The alpha-dispers...

journal_title：Annals of the New York Academy of Sciences

authors： Schäfer M,Kirlum HJ,Schlegel C,Gebhard MM

更新日期：1999-04-20 00:00:00

abstract：:This study investigates the complete genome sequences of the Nine Mile, K, and G isolates to improve our understanding of the unique virulence properties of C. burnetii and to provide important insight into the genome architecture and genetic diversity of this pathogen. ...

journal_title：Annals of the New York Academy of Sciences

authors： Beare PA,Porcella SF,Seshadri R,Samuel JE,Heinzen RA

更新日期：2005-12-01 00:00:00

abstract：:Approximately 40 to 50 infants and children with similar epidemiologic, clinical, and laboratory features of AIDS have been described. The occurrence of significant numbers of patients with PAIDS in geographic areas that are associated with similar risk factors and clinical features of AIDS suggests a common cause. Im...

journal_title：Annals of the New York Academy of Sciences

authors： Ammann AJ,Wara DW,Cowan MJ

更新日期：1984-01-01 00:00:00

abstract：:The computation of ITD begins with preservation of the phase angle of spectral components by eighth-nerve fibers and by cells of the nucleus magnocellularis. At the level of the nucleus laminaris, the difference in phase angle of corresponding spectral components in the left and right ears is extracted. At the next le...

journal_title：Annals of the New York Academy of Sciences

authors： Takahashi TT

更新日期：1989-01-01 00:00:00