Isolation of Rickettsia rickettsii and Rickettsia bellii in cell culture from the tick Amblyomma aureolatum in Brazil.

abstract：:To study the role of the LDL receptor pathway for the maintenance of alpha-tocopherol concentrations in tissues of intact animals, we have compared vitamin E levels in plasma and tissues of normal rabbits and WHHL rabbits. WHHL rabbits are deficient in LDL receptor activity. For WHHL rabbits, alpha-tocopherol plasma c...

journal_title：Annals of the New York Academy of Sciences

authors： Cohn W,Kuhn H

更新日期：1989-01-01 00:00:00

abstract：:The HLA genotype DRB1*03,DQB1*0201/DRB1*04,DQB1*0302 confers a 25-fold increase in the risk of type 1 diabetes. In persons with this genotype, DRB1*0405, *0402, and *0401 subtypes have been reported to further increase risk, whereas the *0403 and *0406 alleles confer a relative protection. We compared the frequencies ...

journal_title：Annals of the New York Academy of Sciences

authors： Rewers A,Babu S,Wang TB,Bugawan TL,Barriga K,Eisenbarth GS,Erlich HA

更新日期：2003-11-01 00:00:00

abstract：:As illustrated in Figure 1, a disturbance of the intracellular Ca2+ homeostasis is thought to be a common pathogenic factor for the generation of secondary nerve cell damage that develops after brain trauma or stroke or during the course of neurodegenerative diseases. A neuronal Ca2+ overload which may result from an ...

journal_title：Annals of the New York Academy of Sciences

authors： Schubert P,Ogata T,Marchini C,Ferroni S,Rudolphi K

更新日期：1997-10-15 00:00:00

abstract：:In this experiment, we investigated the influence of the photoperiod upon androgen receptor (AR) distribution and steroid concentrations in ovaries of 21-day-old bank vole females. Sections (6 mum) were assayed immunohistochemically. ARs were localized in the nuclei of granulosa cells. The strongest immunoreaction was...

journal_title：Annals of the New York Academy of Sciences

authors： Galas J,Slomczynska M,Kwasnik A

更新日期：2005-04-01 00:00:00

abstract：:Mitochondrial dysfunction has been suggested as a causal factor for insulin resistance and diabetes. Previously we have shown a decrease of mitochondrial DNA (mtDNA) content in tissues of diabetic patients. The mitochondrial proteins, which regulate the mitochondrial biogensis, including transcription and replication ...

journal_title：Annals of the New York Academy of Sciences

authors： Choi YS,Ryu BK,Min HK,Lee SW,Pak YK

更新日期：2005-05-01 00:00:00

abstract：:Currently, several rickettsioses are officially being reported in the Russian Federation. These are epidemic typhus and Brill-Zinsser disease, both caused by Rickettsia prowazekii which has a historic prevalence in Russia. Nowadays only single sporadic cases of R. prowazekii infection are reported. The last significan...

journal_title：Annals of the New York Academy of Sciences

authors： Tarasevich IV,Mediannikov OY

更新日期：2006-10-01 00:00:00

abstract：:Pelizaeus-Merzbacher disease (PMD) is a dysmyelinating disorder of the central nervous system typically caused by duplications or missense mutations of the proteolipid protein (PLP) gene. Most investigators have found that peripheral nerve function and structure is normal in PMD patients. We have found that null mutat...

journal_title：Annals of the New York Academy of Sciences

authors： Garbern JY,Cambi F,Lewis R,Shy M,Sima A,Kraft G,Vallat JM,Bosch EP,Hodes ME,Dlouhy S,Raskind W,Bird T,Macklin W,Kamholz J

更新日期：1999-09-14 00:00:00

abstract：:The osteoclast (OCL) is derived from the cells in monocyte-macrophage lineage. The earliest identifiable OCL precursor is the granulocyte-macrophage colony-forming unit (CFU-GM), which gives rise to granulocytes, monocytes, and OCL. CFU-GM-derived cells then differentiate to committed OCL precursors, which are post-mi...

journal_title：Annals of the New York Academy of Sciences

authors： Roodman GD

更新日期：2006-04-01 00:00:00

abstract：:Lewisite and many other similar arsenicals are warfare vesicants developed and weaponized for use in World Wars I and II. These chemicals, when exposed to the skin and other epithelial tissues, cause rapid severe inflammation and systemic damage. Here, we show that topically applied arsenicals in a murine model produc...

journal_title：Annals of the New York Academy of Sciences

authors： Srivastava RK,Muzaffar S,Khan J,Traylor AM,Zmijewski JW,Curtis LM,George JF,Ahmad A,Antony VB,Agarwal A,Athar M

更新日期：2020-11-01 00:00:00

abstract：:The resolution of antibiotic-ribosomal subunit complexes and antibacterial-protein complexes at the atomic level has provided new insights into modifications of clinically relevant antimicrobials and provided new classes that target the protein cellular apparatus. New chemistry platforms that use fragment-based drug d...

journal_title：Annals of the New York Academy of Sciences

authors： Sutcliffe JA

更新日期：2011-12-01 00:00:00

abstract：:Recent years have witnessed an explosive growth in available biological data. This includes a tremendous quantity of sequence data (e.g., biological structures, genetic and physical maps, pathways) generated by genome and transcriptome projects focused on humans, mice, and a multitude of other species. Diabetes resear...

journal_title：Annals of the New York Academy of Sciences

authors： Petrovsky N,Silva D

更新日期：2004-12-01 00:00:00

abstract：:Neuromodulation denotes controlled electrical stimulation of the central or peripheral nervous system. The three forms of neuromodulation described in this paper-deep brain stimulation, vagus nerve stimulation, and transcranial magnetic stimulation-were chosen primarily for their demonstrated or potential clinical use...

journal_title：Annals of the New York Academy of Sciences

authors： Andrews RJ

更新日期：2003-05-01 00:00:00

abstract：:For more than 10 years umbilical cord blood (UCB) has been used as an alternative source of hematopoietic stem cells for allogeneic transplantation. Although the clinical results are encouraging, UCB is associated with delayed engraftment. To address these issues we have used the NOD/SCID mouse model to study the engr...

journal_title：Annals of the New York Academy of Sciences

authors： Fibbe WE,Noort WA,Schipper F,Willemze R

更新日期：2001-06-01 00:00:00

abstract：:Pregnancy at high altitude (>2700 m) is associated with higher rates of fetal growth restriction and preeclampsia as well as alterations in placentation, including increased villous vascularization and reduced remodeling of maternal spiral arteries. Because circulatory fetal DNA concentrations were shown to be enhance...

journal_title：Annals of the New York Academy of Sciences

authors： Zhong XY,Wang Y,Chen S,Labu,Pubuzhuoma,Gesangzhuogab,Ouzhuwangmu,Hahn C,Holzgreve W,Hahn S

更新日期：2004-06-01 00:00:00

abstract：:Fibrinogen has been the plasma protein most frequently studied after tissue injury. This report presents evidence that leukocytic endogenous mediator (LEM) from macrophages promotes fibrinogen synthesis. LEM has a molecular weight of 13,000-16,000, an isoelectric point (pI) at pH 7.3, is heat labile, and is inactivate...

journal_title：Annals of the New York Academy of Sciences

authors： Kampschmidt RF,Upchurch HF,Pulliam LA

更新日期：1982-01-01 00:00:00

abstract：:Two major methodological problems that impact clinical research in endometriosis are the absence of a low-cost, highly reliable method for diagnosing endometriosis and the possibility that endometriosis is actually multiple different diseases that we have not yet been able to differentiate. Animal models of endometrio...

journal_title：Annals of the New York Academy of Sciences

authors： Barbieri RL,Missmer S

更新日期：2002-03-01 00:00:00

abstract：:The implications of recent precision Z-pole, W mass, and weak neutral current data for testing the standard electroweak model, constraining that t quark and Higgs masses, αs (MZ), and grand unification are discussed. A fit to all data yields sin(2)θw(MZ)= 0.2325 ± 0.0024 (on-shell), where the uncertainties are mainly ...

journal_title：Annals of the New York Academy of Sciences

authors： Langacker P

更新日期：1993-06-01 00:00:00

abstract：:Since his presidency of the Carnegie Corporation of New York and co-chairmanship of the Carnegie Commission on Preventing Deadly Conflict, David Hamburg has been actively engaged in projects related to the prevention of genocide and other mass violence. In these remarks to the Association for Research in Nervous and M...

journal_title：Annals of the New York Academy of Sciences

authors： Hamburg DA

更新日期：2010-10-01 00:00:00

abstract：:In the late 1970s, Wally Welker and his colleagues published a series of papers describing the first high-resolution physiological maps of tactile mossy fiber projections to the granule cell layer of the rat. Over the subsequent decade, his laboratory continued to explore the implications of these results for cerebell...

journal_title：Annals of the New York Academy of Sciences

authors： Bower JM

更新日期：2011-04-01 00:00:00

abstract：:The cell surface antigen recognized by monoclonal antibody W7C5 is expressed at low levels on human CD34(+) and CD34(-) bone marrow stem cell populations but at high levels on fetal liver CD34(+) cells. To identify the recognized antigen, we performed partial amino acid sequence and MALDI analysis of purified W7C5 ant...

journal_title：Annals of the New York Academy of Sciences

authors： Giesert C,Marxer A,Sutherland DR,Schuh AC,Kanz L,Buhring HJ

更新日期：2003-05-01 00:00:00

abstract：:A four- to fivefold overexpression of the gene for the Alzheimer beta/A4 amyloid precursor protein (APP) in individuals with Down's Syndrome (DS) appears to be responsible for the fifty year earlier onset of Alzheimer's disease (AD) pathology in DS compared to the normal population. It is therefore likely that a dereg...

journal_title：Annals of the New York Academy of Sciences

authors： Beyreuther K,Pollwein P,Multhaup G,Mönning U,König G,Dyrks T,Schubert W,Masters CL

更新日期：1993-09-24 00:00:00

abstract：:Signal hyperintensities on magnetic resonance imaging (MRI) are increased in the white matter (WMH) and deep gray matter in dementia and depression and may have similar pathologies. However, no previous study has examined WMH in subjects with major depression. We carried out in vitro MRI on brain tissue from elderly s...

journal_title：Annals of the New York Academy of Sciences

authors： Thomas AJ,Perry R,Barber R,Kalaria RN,O'Brien JT

更新日期：2002-11-01 00:00:00

abstract：:The invariant nature of body situs within and across vertebrate species implies that a highly conserved pathway controls the specification of the left-right (L/R) axis. Situs-specific morphogenesis begins at the end of this pathway and leads to normal organ arrangement, also known as situs solitus. Occasionally, indiv...

journal_title：Annals of the New York Academy of Sciences

authors： Delhaas T,Decaluwe W,Rubbens M,Kerckhoffs R,Arts T

更新日期：2004-05-01 00:00:00

abstract：:The results of this study indicate that the presence of plants did enhance TNT and TNB removal from IAAP groundwater. Most effective at 25 degrees C were reed canary grass, coontail and pondweed. Groundwater and plant tissue analyses indicate that in presence of the plants tested TNT is degraded to reduced by-products...

journal_title：Annals of the New York Academy of Sciences

authors： Best EP,Zappi ME,Fredrickson HL,Sprecher SL,Larson SL,Ochman M

更新日期：1997-11-21 00:00:00

abstract：:Current evidence from genetic and epidemiological studies supports the view that Alzheimer's disease (AD) is a heterogeneous disorder. While the disease is pathologically defined by the presence of specified lesions in form of amyloid plaques and neurofibrillary tangles within the parenchyma, other features of patholo...

journal_title：Annals of the New York Academy of Sciences

authors： Cohen DL,Hedera P,Premkumar DR,Friedland RP,Kalaria RN

更新日期：1997-09-26 00:00:00

abstract：:Neovascularization is a hallmark of cancer progression. Suppression of the angiogenic response in tumors has been associated with inhibition and even regression of total tumor mass. Therefore, the derivation of synthetic or natural products that could interfere with proangiogenic signaling pathways can greatly impact ...

journal_title：Annals of the New York Academy of Sciences

authors： Iruela-Arispe ML,Carpizo D,Luque A

更新日期：2003-05-01 00:00:00

abstract：:Microgravity experiments on the constrained vapor bubble heat exchanger (CVB) are being developed for the space station. Herein, ground-based experimental studies on condensate removal in the condenser region of the vertical CVB were conducted and the mechanism of condensate removal in microgravity was found to be the...

journal_title：Annals of the New York Academy of Sciences

authors： Zheng L,Wang Y,Wayner PC Jr,Plawsky JL

更新日期：2002-10-01 00:00:00

abstract：:To live beyond the octogenarian years, population and molecular genetic studies of centenarian sibships indicate that genetic factors play an increasingly important role as the limit of life span is approached. These factors are likely to influence basic mechanisms of aging that in turn broadly influence susceptibilit...

journal_title：Annals of the New York Academy of Sciences

authors： Perls T

更新日期：2002-04-01 00:00:00

abstract：:Results obtained from projects in which self-organizing musical structures spontaneously arise through electrical interface between the brain and generative musical systems are surveyed. This provides a springboard for examining important paradigm shifts taking place in our thinking about what musical forms can be and...

journal_title：Annals of the New York Academy of Sciences

authors： Rosenboom D

更新日期：2003-11-01 00:00:00

abstract：:The alpha-ketoglutarate dehydrogenase complex (KGDHC) is an important mitochondrial constituent, and deficiency of KGDHC is associated with a number of neurological disorders. KGDHC is composed of three proteins, each encoded on a different and well-characterized gene. The sequences of the human proteins are known. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Sheu KF,Blass JP

更新日期：1999-01-01 00:00:00