The development of lurasidone for bipolar depression.

abstract：:Washington State's law for sexually violent predators was enacted in 1990; since then, 14 other states have passed similar laws authorizing civil commitment for dangerous sexual offenders following their prison terms. Although the law has survived constitutional challenges at both the state and in the U.S. Supreme Cou...

journal_title：Annals of the New York Academy of Sciences

authors： Lieb R

更新日期：2003-06-01 00:00:00

abstract：:Fetal nucleated red blood cells (NRBCs) entering maternal circulation during pregnancy constitute a potential source of material for safe and reliable noninvasive prenatal diagnosis. The increased prevalence of beta-thalassemia mutations in countries like Greece may create a problem, making it difficult to distinguish...

journal_title：Annals of the New York Academy of Sciences

authors： Mavrou A,Kolialexi A,Antsaklis A,Krikos X,Koratzis A,Metaxotou C

更新日期：2001-09-01 00:00:00

abstract：:The class of adhesion G protein-coupled receptors (aGPCRs), with 33 human homologs, is the second largest family of GPCRs. In addition to a seven-transmembrane α-helix-a structural feature of all GPCRs-the class of aGPCRs is characterized by the presence of a large N-terminal extracellular region. In addition, all aGP...

journal_title：Annals of the New York Academy of Sciences

authors： Liebscher I,Ackley B,Araç D,Ariestanti DM,Aust G,Bae BI,Bista BR,Bridges JP,Duman JG,Engel FB,Giera S,Goffinet AM,Hall RA,Hamann J,Hartmann N,Lin HH,Liu M,Luo R,Mogha A,Monk KR,Peeters MC,Prömel S,Ressl S,Sc

更新日期：2014-12-01 00:00:00

abstract：:Higher levels of body fat are associated with increased risk for development of numerous adverse health conditions. Phytochemicals are potential agents to inhibit differentiation of preadipocytes, stimulate lipolysis, and induce apoptosis of existing adipocytes, thereby reducing adipose tissue mass. Resveratrol decrea...

journal_title：Annals of the New York Academy of Sciences

authors： Baile CA,Yang JY,Rayalam S,Hartzell DL,Lai CY,Andersen C,Della-Fera MA

更新日期：2011-01-01 00:00:00

abstract：:CD40 ligand (CD40L) is expressed by activated T cells and interacts with the CD40 molecule present on B cells and endothelial cells, promoting immunoglobulin switching in the former and cytokine upregulation in the latter. CD40L exists in both a soluble (sCD40L) and a membrane-bound form. Because primary biliary cirrh...

journal_title：Annals of the New York Academy of Sciences

authors： Oertelt S,Invernizzi P,Selmi C,Podda M,Gershwin ME

更新日期：2005-06-01 00:00:00

abstract：:In this paper, I have introduced and solved a simple deterministic model of eye tracking that produces rich dynamical behavior. Some of its main features, notably the existence of a chaotic regime, are reminiscent of the anomalies reported in smooth pursuit eye tracking experiments with schizophrenia patients. By obta...

journal_title：Annals of the New York Academy of Sciences

authors： Huberman BA

更新日期：1987-01-01 00:00:00

abstract：:Enhanced levels of plasminogen activator inhibitor-1 (PAI-1) are considered to be a risk factor for pathological conditions associated with hypoxia or hyperinsulinemia. The expression of the PAI-1 gene is increased by insulin in different cells, although, the molecular mechanisms behind insulin-induced PAI-1 expressio...

journal_title：Annals of the New York Academy of Sciences

authors： Dimova EY,Kietzmann T

更新日期：2006-12-01 00:00:00

abstract：:The aim of this study was to evaluate a novel third-generation enzyme-linked immunosorbent assay (ELISA) for the high-sensitivity detection of autoantibodies to proteinase-3 (PR3) in patients with Wegener's granulomatosis (WG). First- and second-generation ELISA for the detection of antineutrophil cytoplasmic antibodi...

journal_title：Annals of the New York Academy of Sciences

authors： Roggenbuck D,Buettner T,Hoffmann L,Schmechta H,Reinhold D,Conrad K

更新日期：2009-09-01 00:00:00

abstract：:Familial glucocorticoid resistance (FGR) is a rare hereditary disorder characterized by hypercortisolism and the absence of stigmata of Cushing's syndrome. The inability of glucocorticoids to exert their effects on target tissues is compensated for by increases in circulating corticotropin (ACTH) and cortisol, the for...

journal_title：Annals of the New York Academy of Sciences

authors： Stratakis CA,Karl M,Schulte HM,Chrousos GP

更新日期：1994-11-30 00:00:00

abstract：:Recently, cell-free fetal DNA has been found in maternal plasma and serum. This discovery opens up a new field of investigation and provides an easily accessible source of fetal genetic material for prenatal diagnosis. Prenatal diagnostic applications of fetal DNA in maternal plasma include the investigation of sex-li...

journal_title：Annals of the New York Academy of Sciences

authors： Lo YM

更新日期：2000-04-01 00:00:00

abstract：:The gain of function phenotypes exhibited by the heterozygous Tr, Tr-J, and CMT1A mutations indicate that these mutations interfere with more than the function of a single PMP22 allele. The identification of proteins that interact with PMP22 and that are sensitive both to stoichiometry and the effects of the mutations...

journal_title：Annals of the New York Academy of Sciences

authors： Snipes GJ,Orfali W,Fraser A,Dickson K,Colby J

更新日期：1999-09-14 00:00:00

abstract：:Differentiation of specific epithelial cell lineages during development, as well as epithelial plasticity in response to heterologous cell-to-cell cross talk during adult life, accounts for the large variety of functions which are performed by the mucosal surfaces found in the human body. Among its functions, the dige...

journal_title：Annals of the New York Academy of Sciences

authors： Hamzaoui N,Pringault E

更新日期：1998-11-17 00:00:00

abstract：:Multiple subsets of nociceptive, parasympathetic, and sympathetic nerves innervate human nasal mucosa. These play carefully coordinated roles in regulating glandular, vascular, and other processes. These functions are vital for cleaning and humidifying ambient air before it is inhaled into the lungs. The recent identi...

journal_title：Annals of the New York Academy of Sciences

authors： Baraniuk JN,Merck SJ

更新日期：2009-07-01 00:00:00

abstract：:Liver cirrhosis is a condition in which overnutrition, edema, and undernutrition can coexist simultaneously, or successively, over a period of time, giving rise to alterations in body composition, as well as systemic and multiorgan manifestations. We undertook a cross-sectional study of body composition in 198 adult p...

journal_title：Annals of the New York Academy of Sciences

authors： Strauss BJ,Gibson PR,Stroud DB,Borovnicar DJ,Xiong DW,Keogh J

更新日期：2000-05-01 00:00:00

abstract：:Previous studies have established that methanolic extracts of bovine brain and lung possess CDS activity with an agonist-like profile at alpha(2)-adrenoceptor binding sites (i.e., greater potency against [(3)H]-clonidine sites than against [(3)H]-RX-821001 sites). Following prolonged reflux in ethylacetate, monovalent...

journal_title：Annals of the New York Academy of Sciences

authors： Pinthong D,Kendall DA,Wilson VG

更新日期：2003-12-01 00:00:00

abstract：:The central nervous system (CNS) plays a vital role in regulating energy balance and metabolism. Over the last 50 years, studies in animal models have allowed us to identify critical CNS regions involved in these processes and even crucial cell populations. Now, techniques for genetically and anatomically targeted man...

journal_title：Annals of the New York Academy of Sciences

authors： Devarakonda K,Stanley S

更新日期：2018-01-01 00:00:00

abstract：:Thymic epithelial and nurse cells from different species express a repertoire of neuroendocrine polypeptide precursors. This repertoire exerts a dual role in T-lymphocyte selection according to their status either as cryptocrine signals or as neuroendocrine self-antigens of the peptide sequences that are processed fro...

journal_title：Annals of the New York Academy of Sciences

authors： Geenen V,Martens H,Vandersmissen E,Achour I,Kecha O,Franchimont D

更新日期：1998-05-01 00:00:00

abstract：:Continuous infusion (CI) of coagulation factor concentrates has been used since the early 1990s. Recent reports of the occurrence of an inhibitor after CI have raised concerns about this method of treatment. We conducted a retrospective study to investigate the development of inhibitors after CI of Factor VIII concent...

journal_title：Annals of the New York Academy of Sciences

authors： von Auer Ch,Oldenburg J,von Depka M,Escuriola-Ettinghausen C,Kurnik K,Lenk H,Scharrer I

更新日期：2005-06-01 00:00:00

abstract：:A radioimmunoassay method (RIA) with specific antisera for human and rat alpha fetoprotein (AFP) was used to study the evolution of AFP levels in humans and rats, respectively, throughout the life span. Sera of 66 rats, aged 3-70 weeks, as well as sera of 201 clinically well children, 192 healthy blood donors, and 16...

journal_title：Annals of the New York Academy of Sciences

authors： Masseyeff R,Gilli J,Krebs B,Calluaud A,Bonet C

更新日期：1975-08-22 00:00:00

abstract：:Mouse Schwann cells and rat RN22 schwannoma cells cultured in the absence of neurons and fibroblasts produce typical basement membrane proteins. Heparan sulfate proteoglycan (low density form), nidogen, and protein BM-40 were identified by radioimmunoassays, immunoblotting, and by immunoprecipitation after metabolic l...

journal_title：Annals of the New York Academy of Sciences

authors： Dziadek M,Edgar D,Paulsson M,Timpl R,Fleischmajer R

更新日期：1986-01-01 00:00:00

abstract：:Despite the great strides made in understanding the basic biology of cancer and the multiple approaches to cancer therapy that have been utilized, cancer remains a major cause of death worldwide. The two properties that define the most successful tumors are low antigenicity, enabling cancer cells to escape immune syst...

journal_title：Annals of the New York Academy of Sciences

authors： Al-Ramadi BK,Fernandez-Cabezudo MJ,El-Hasasna H,Al-Salam S,Attoub S,Xu D,Chouaib S

更新日期：2008-09-01 00:00:00

abstract：:In this paper, we develop an agent-based model of social influence on body weight. The model's assumptions are grounded in theory and evidence from physiology, social psychology, and behavioral science, and its outcomes are tested against longitudinal data from American youth. We discuss the implementation of the mode...

journal_title：Annals of the New York Academy of Sciences

authors： Hammond RA,Ornstein JT

更新日期：2014-12-01 00:00:00

abstract：:Adult animals that had been subjected to a single prolonged episode of maternal deprivation (MD) [24 h, postnatal day (PND) 9-10] show long-term behavioral alterations that resemble specific symptoms of schizophrenia. Moreover, at adolescence MD rats showed depressive-like behavior and altered motor responses. Accordi...

journal_title：Annals of the New York Academy of Sciences

authors： De la Fuente M,Llorente R,Baeza I,De Castro NM,Arranz L,Cruces J,Viveros MP

更新日期：2009-02-01 00:00:00

abstract：:The first evidence for the role of the protein elongation factor eEF1A2 in tumorigenesis was reported by Anand and colleagues who demonstrated that eEF1A2 is overexpressed in about 30% of ovarian tumors and some established ovarian cancer cells. This abnormal expression correlates with a poor prognosis. Since this dis...

journal_title：Annals of the New York Academy of Sciences

authors： Lee MH,Surh YJ

更新日期：2009-08-01 00:00:00

abstract：:Many therapeutic options exist for the management of patients with Ménière's disease. In the last few years, the use of intratympanic gentamicin has been investigated as an alternative treatment to vestibular nerve section or labyrinthectomy. In humans, the concentration of gentamicin used for intratympanic treatment ...

journal_title：Annals of the New York Academy of Sciences

authors： Quaranta A,Aloisi A,De Benedittis G,Scaringi A

更新日期：1999-11-28 00:00:00

abstract：:Macrolide and polyether biosynthesis in actinomycetes is regulated at the level of precursor supply by effects of nutrients on the sources of the low-molecular-weight fatty acids used to build the carbon framework of these antibiotics. Ammonium ion appears to suppress the first enzymes of valine and threonine cataboli...

journal_title：Annals of the New York Academy of Sciences

authors： Tang L,Zhang YX,Hutchinson CR

更新日期：1994-05-02 00:00:00

abstract：:The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the relationship between stem cells, cancer, and the esophagus; the behavior of esophageal stem cells; and the role of genetics and epigenetics in approaches to translational research. ...

journal_title：Annals of the New York Academy of Sciences

authors： Croagh D,Frede J,Jones PH,Kaur P,Partensky C,Phillips WA

更新日期：2014-09-01 00:00:00

abstract：:Recent in vivo studies suggest a role for relaxin-3 in feeding and stress. To further elucidate the function of relaxin-3 in the central nervous system, we have employed a complementary approach, based on RNA interference, to modulate relaxin-3 expression. We have designed, constructed, and characterized three microRN...

journal_title：Annals of the New York Academy of Sciences

authors： Callander GE,Thomas WG,Bathgate RA

更新日期：2009-04-01 00:00:00

abstract：:The aim of this study was to evaluate the possible neuroprotective effects of thymosin beta(4) in different models of excitotoxicity. The application of thymosin beta(4) significantly attenuated glutamate-induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices. In in vivo experiment...

journal_title：Annals of the New York Academy of Sciences

authors： Popoli P,Pepponi R,Martire A,Armida M,Pèzzola A,Galluzzo M,Domenici MR,Potenza RL,Tebano MT,Mollinari C,Merlo D,Garaci E

更新日期：2007-09-01 00:00:00

abstract：:Although fetal nigral transplants have been shown to survive grafting into the striatum, increased [(18)F]6-fluroro-L-3,4-dihydroxyphenylalanine ((18)F-DOPA) uptake and improved motor function in open-label assessments have failed to establish any clinical benefits in double-blind, sham-controlled studies. To understa...

journal_title：Annals of the New York Academy of Sciences

authors： Chu Y,Kordower JH

更新日期：2010-01-01 00:00:00