Abstract:
:Macrolide and polyether biosynthesis in actinomycetes is regulated at the level of precursor supply by effects of nutrients on the sources of the low-molecular-weight fatty acids used to build the carbon framework of these antibiotics. Ammonium ion appears to suppress the first enzymes of valine and threonine catabolism and also inhibits their activity. Disruption of the valine dehydrogenase (vdh) gene of Streptomyces coelicolor destroys its ability to grow on branched-chain amino acids as the sole nitrogen source in a minimal medium but has no effect on the biosynthesis of the acetate-derived antibiotic, actinorhodin. Expression of the vdh gene is repressed by > 25 mM ammonium ion or glucose but not by valine, glycerol, or maltose. Vdh enzyme activity is stimulated by valine induction. These results suggest that the inhibition of valine catabolism by ammonium and/or glucose could explain why macrolide production is inhibited by ammonium ion.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Tang L,Zhang YX,Hutchinson CRdoi
10.1111/j.1749-6632.1994.tb47382.xsubject
Has Abstractpub_date
1994-05-02 00:00:00pages
105-16eissn
0077-8923issn
1749-6632journal_volume
721pub_type
杂志文章abstract::Methamphetamine (METH) is a widely used "club drug" that produces neural damage in the brain, including the loss of some neurons. METH-induced striatal neuronal loss has been attenuated by pretreatment with the neurokinin-1 receptor antagonist WIN-51,708 in mice. Using a histologic method, we have observed the interna...
journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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更新日期:2000-01-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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更新日期:1986-01-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1976.tb41668.x
更新日期:1976-01-01 00:00:00
abstract::The human organism is continuously in close contact with microorganisms, especially bacteria. In the present work, by means of a real-time polymerase chain reaction (PCR) technique, we looked for the presence of a distinct bacterial gene in human cells. To this end, we cultured a human cell line, HL60, in a supernatan...
journal_title:Annals of the New York Academy of Sciences
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