Antihypertensive compounds that modulate the Na-K pump.

abstract：:The bystander is defined as an active and involved participant in the social architecture of school violence, rather than a passive witness. Bullying is redefined from a triadic (bully-victim-bystander) rather than dyadic (bully-victim) perspective. Teachers, including administrators, and students can promote or ameli...

journal_title：Annals of the New York Academy of Sciences

authors： Twemlow SW,Fonagy P,Sacco FC

更新日期：2004-12-01 00:00:00

abstract：:Fructosamine-3-kinase (FN3K) and the more recently discovered fructosamine-3-kinase-related protein (FN3KRP) appear to protect proteins from nonenzymatic glycation. To gain a better understanding of these enzymes we performed a series of investigations including (1) in silico comparisons of their promoters; (2) real-t...

journal_title：Annals of the New York Academy of Sciences

authors： Conner JR,Beisswenger PJ,Szwergold BS

更新日期：2005-06-01 00:00:00

abstract：:Here we briefly review our studies that have unraveled an important role for the calcium- and calmodulin-sensitive enzyme calcineurin (CN) in bone remodeling. We find that the genetic deletion of the calcineurin Aalpha isoform results in osteoporosis, which is recapitulated in humans following calcineurin inhibitor th...

journal_title：Annals of the New York Academy of Sciences

authors： Sun L,Zhu LL,Zaidi N,Yang G,Moonga BS,Abe E,Iqbal J,Epstein S,Blair HC,Huang CL,Zaidi M

更新日期：2007-11-01 00:00:00

abstract：:Some syphilitic sera still fluoresce with Reiter treponemes as the antigen after treatment with the sorbent used in the FTA-ABS test; this finding indicates incomplete removal of group antitreponemal antibody. Levels of this antibody in normal sera have been studied in relation to the titration of sorbent for use in t...

journal_title：Annals of the New York Academy of Sciences

authors： Wilkinson AE,Johnston NA

更新日期：1975-06-30 00:00:00

abstract：:Curcumin (diferuloylmethane) is a nontoxic dietary pigment in tumeric and curry and a potent inhibitor of the common transcription factor Nuclear Factor kappaB (NF-kappaB) in several cell types. It is well established that some of the catabolic effects of the proinflammatory cytokines interleukin-1beta (IL-1beta) and ...

journal_title：Annals of the New York Academy of Sciences

authors： Schulze-Tanzil G,Mobasheri A,Sendzik J,John T,Shakibaei M

更新日期：2004-12-01 00:00:00

abstract：:We are performing genomic searches in randomly ascertained families to identify new quantitative trait loci (QTLs) that influence atherosclerosis and its risk factors. The genetic markers used for genomic searches are random microsatellite markers distributed throughout the human chromosomes. These markers are used fo...

journal_title：Annals of the New York Academy of Sciences

authors： Hixson JE,Blangero J

更新日期：2000-05-01 00:00:00

abstract：:Tight junction (TJ) properties are determined by membrane protein complexes of neighboring cells that form both a barrier and a selective pathway for paracellular substrate transport. Our previous work supports the view that paracellular permeability changes in the thick ascending limb (TAL) may underlie the mechanism...

journal_title：Annals of the New York Academy of Sciences

authors： Shan Q,Himmerkus N,Hou J,Goodenough DA,Bleich M

更新日期：2009-05-01 00:00:00

abstract：:We have evaluated the performance of a novel line-blot immunoassay (LIA; Mikrogen) and compared results with those obtained by CIE (in-house), ELISA (Pharmacia Diagnostics), and FEIA (Pharmacia Diagnostics). Sera from systemic lupus erythematosus (SLE) patients (n = 123), systemic sclerosis patients (n = 25), and heal...

journal_title：Annals of the New York Academy of Sciences

authors： Damoiseaux J,Boesten K,Giesen J,Austen J,Tervaert JW

更新日期：2005-06-01 00:00:00

abstract：:Older age is associated with functional declines throughout the body, including some aspects of cognitive performance. While dementia develops in only some elderly individuals, declines in cognitive functioning have an impact on daily living for many others. There are individual differences in age-related cognitive ch...

journal_title：Annals of the New York Academy of Sciences

authors： Moffat SD

更新日期：2005-12-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) and plasma exchange (PLEX) are used to treat myasthenia gravis (MG) but with little trial evidence. While a class I study provided evidence for the efficacy of IVIG treatment, the empirical support for PLEX has been less convincing until recently. In a randomized controlled single-mas...

journal_title：Annals of the New York Academy of Sciences

authors： Bril V,Barnett-Tapia C,Barth D,Katzberg HD

更新日期：2012-12-01 00:00:00

abstract：:Many autoimmune diseases are chronic conditions that progress over the course of years, and are characterized by the presence of autoantibodies that precede the overt disease by months or years. As examples, the presence of two islet cell antibodies (ICA) are associated with a 50% risk of developing diabetes mellitus ...

journal_title：Annals of the New York Academy of Sciences

authors： Harel M,Shoenfeld Y

更新日期：2006-06-01 00:00:00

abstract：:Previous reports have shown that there are age-related reductions in muscarinic receptor (mAChR) sensitivity to agonist stimulation. Our research has elucidated the mechanisms involved in this loss. These studies have shown that this decline is the result of decreases in mAChR concentration, reductions in the number o...

journal_title：Annals of the New York Academy of Sciences

authors： Joseph JA,Cutler R,Roth GS

更新日期：1993-09-24 00:00:00

abstract：:We created a toolbox of recombinant, microbial lipases, which allows us in combination with a lipase database to choose among the overexpressed lipases the most appropriate for a specific application and to improve it further via mutagenesis. By systematic comparison of geometry and properties of the scissile fatty ac...

journal_title：Annals of the New York Academy of Sciences

authors： Schmidt-Dannert C,Pleiss J,Schmid RD

更新日期：1998-12-13 00:00:00

abstract：:This article reviews research on the Finnish model of peer-group mentoring (PGM). The theoretical foundation of the model is based on the constructivist theory of learning, the concept of autonomy in teaching profession, peer learning, and narrative identity work. The model has been disseminated nationwide in the educ...

journal_title：Annals of the New York Academy of Sciences

authors： Tynjälä P,Pennanen M,Markkanen I,Heikkinen HLT

更新日期：2021-01-01 00:00:00

abstract：:Clinically potent skeletal muscle relaxants are used primarily for their effects on the central nervous system. But they also have direct effects on muscle contraction that possibly involve Ca2+ channels. We compared the effects of dantrolene, an agent known to have a direct action on vertebrate skeletal muscle, with ...

journal_title：Annals of the New York Academy of Sciences

authors： Helland LA,Lopez JR,Taylor SR,Trube G,Wanek LA

更新日期：1988-01-01 00:00:00

abstract：:The quasibiennial oscillation (QBO) dominates the variability of the equatorial stratosphere and also affects the circulation and temperature of the extratropical region. In this paper we review previous work showing that the mid- to high-latitude circulation is weaker (stronger) when QBO easterlies (westerlies) domin...

journal_title：Annals of the New York Academy of Sciences

authors： Peña-Ortiz C,García-Herrera R,Ribera P,Calvo N

更新日期：2008-12-01 00:00:00

abstract：:The distinction between episodic and semantic memory has become very popular since it was first proposed by Tulving in 1972. So far, very few neuropsychological, psychophysical, and imaging studies have related to the mnemonic aspects of music, notably on the long-term memory features, and practically nothing is known...

journal_title：Annals of the New York Academy of Sciences

authors： Platel H

更新日期：2005-12-01 00:00:00

abstract：:Abdominal aortic aneurysms (AAA) are characterized by the destruction of the extracellular matrix (ECM) of the aortic wall, particularly its elastin elements. The fibrinolytic system is known to mediate proteolysis within the ECM. Plasmin, which is generated by plasminogen activators (PA), is capable of destroying the...

journal_title：Annals of the New York Academy of Sciences

authors： Reilly JM

更新日期：1996-11-18 00:00:00

abstract：:Rapamycin (RAPA), an inhibitor of mTORC signaling, has been shown to extend life span in mice and other organisms. Recently, animal and human studies have suggested that inhibition of mTORC signaling can alleviate or prevent the development of cardiomyopathy. In view of this, we used a murine model of type 2 diabetes ...

journal_title：Annals of the New York Academy of Sciences

authors： Reifsnyder PC,Ryzhov S,Flurkey K,Anunciado-Koza RP,Mills I,Harrison DE,Koza RA

更新日期：2018-04-01 00:00:00

abstract：:The damaging effects of superoxide in mitochondria leading to pathological disorders and aging are well documented and usually ascribed to superoxide's role as a precursor of reactive free radical species. However, the latest findings point out the importance of the nucleophilic properties of superoxide and its abilit...

journal_title：Annals of the New York Academy of Sciences

authors： Afanas'Ev IB

更新日期：2004-06-01 00:00:00

abstract：:The free radical theory of aging proposes that oxidative stress is one of the determinants of an organism's life span. In Caenorhabditis elegans, genetic or environmental changes have been shown to modulate life span. Here we discuss whether changes in the generation and destruction of free radicals are implicated in ...

journal_title：Annals of the New York Academy of Sciences

authors： Honda Y,Honda S

更新日期：2002-04-01 00:00:00

abstract：:Mass production of Ehrlichia ruminantium variants from different regions of sub-Saharan Africa is one of the difficulties that must be overcome in producing a heartwater vaccine. Vaccine productivity can be limited by endogenous induction of interferon (IFN), which inhibits the propagation of Ehrlichia ruminantium (ER...

journal_title：Annals of the New York Academy of Sciences

authors： Pedregal A,de Sousa DR,Nguyen HN,das Neves EA,Lowagie S,Marique T,Kagye N,Guerra IT,Kamba Y,Totte P,Vachiéry N,Lefrançois T,Martinez D,Yourassowsky C,Callens N,Monnom O,Dubois F,Wérenne J

更新日期：2008-12-01 00:00:00

abstract：:Aberrations in estrogen signaling increase breast cancer risk. Molecular mechanisms that impact breast cancer initiation, promotion, and progression can be investigated using genetically engineered mouse models. Increasing estrogen receptor alpha (ERα) expression levels twofold is sufficient to initiate and promote br...

journal_title：Annals of the New York Academy of Sciences

authors： Furth PA,Cabrera MC,Díaz-Cruz ES,Millman S,Nakles RE

更新日期：2011-07-01 00:00:00

abstract：:In 2014, there was an outbreak of beriberi on Kuria, a remote atoll in Kiribati, a small Pacific Island nation. A thiamine-poor diet consisting mainly of rice, sugar, and small amounts of fortified flour was likely to blame. We aimed to design a food fortification strategy to improve thiamine intakes in Kuria. We surv...

journal_title：Annals of the New York Academy of Sciences

authors： Green TJ,Whitfield KC,Daniels L,Brown RC,Houghton LA

更新日期：2021-01-12 00:00:00

abstract：:In his First Law (of thermodynamics), Clausius emphasized the equivalence of heat and work-conservation of energy was mentioned only indirectly. Today, the main emphasis is put on energy conservation, but the equivalence of heat and work has proven not only to be superfluous, but also highly destructive. Because of th...

journal_title：Annals of the New York Academy of Sciences

authors： Job G,Lankau T

更新日期：2003-05-01 00:00:00

abstract：:Venous thromboembolic events, such as pulmonary embolism, deep venous thrombosis, and portal vein thrombosis, have been observed in adult thalassemia patients, mainly in beta-thalassemia intermedia. The clinical findings are consistent with the observation of several alterations that indicate a state of activation of ...

journal_title：Annals of the New York Academy of Sciences

authors： Cappellini MD,Grespi E,Cassinerio E,Bignamini D,Fiorelli G

更新日期：2005-01-01 00:00:00

abstract：:The general aim of this experiment was to investigate the processes involved in reading musical notation and to study the relationship between written music and its auditory representation. Our main interest was to determine if musicians can develop expectancies for plausible or implausible auditory events on the sole...

journal_title：Annals of the New York Academy of Sciences

authors： Schön D,Besson M

更新日期：2003-11-01 00:00:00

abstract：:Controls and calibrators in autoimmune assays are typically developed from patient sera. However, the use of sera is accompanied by a number of disadvantages, such as lack of monospecificity, lack of assay comparability, and supply limitations. Ideally, the control reagent would be an antigen-specific human monoclonal...

journal_title：Annals of the New York Academy of Sciences

authors： Knappik A,Capuano F,Frisch C,Ylera F,Bonelli F

更新日期：2009-09-01 00:00:00

abstract：:We have successfully expressed the active tyrosinase of Streptomyces antibioticus in Escherichia coli under the control of the trp promoter by fusing the sequence to the ORF438 gene. Because our attempt to connect the polycistronic gene of ORF438 and tyrosinase directly to the trp promoter of E. coli resulted in the e...

journal_title：Annals of the New York Academy of Sciences

authors： Han K,Hong J,Lim HC,Kim CH,Park Y,Cho JM

更新日期：1994-05-02 00:00:00

abstract：:The concentration of materials and energy within cities is an inevitable consequence of dense populations and their per capita requirements for food, fiber, and fuel. As the world population becomes increasingly urban over the coming decades, urban areas will dramatically affect the distribution of nutrients across th...

journal_title：Annals of the New York Academy of Sciences

authors： Bernhardt ES,Band LE,Walsh CJ,Berke PE

更新日期：2008-01-01 00:00:00