Abstract:
:The slowpoke gene of Drosophila melanogaster encodes a Ca-activated K channel. This gene is expressed in neurons, muscles, tracheal cells, and the copper and iron cells of the midgut. The gene produces a large number of alternative products using tissue-specific transcriptional promoters and alternative mRNA splicing. We have described in great depth how transcription is regulated and are now cataloging the tissue-specificity of different splice variants. It is believed that the diversity of products serves to tailor channel attributes to the needs of specific tissues. Electrophysiological and behavioral assays indicate that at least some of these products produce channels with distinct properties.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Atkinson NS,Brenner R,Bohm RA,Yu JY,Wilbur JLdoi
10.1111/j.1749-6632.1998.tb09057.xsubject
Has Abstractpub_date
1998-11-16 00:00:00pages
296-305eissn
0077-8923issn
1749-6632journal_volume
860pub_type
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