Centrally mediated ocular hypotension: potential role of imidazoline receptors.

abstract：:We cloned a kappa 3-related opioid receptor, and although it is still not clear whether this clone corresponds to the kappa 3 receptor itself or is a related gene product, the extensive antisense mapping and the antibody immunoreactivity strongly associate this clone with the kappa 3 receptor. Our approach also indica...

journal_title：Annals of the New York Academy of Sciences

authors： Pasternak GW,Pan YX,Cheng J

更新日期：1995-05-10 00:00:00

abstract：:Organisms minimize genetic damage through complex pathways of DNA repair. Yet a gene family--the AID/APOBECs--has evolved in vertebrates with the sole purpose of producing targeted damage in DNA/RNA molecules through cytosine deamination. They likely originated from deaminases involved in A>I editing in tRNAs. AID, th...

journal_title：Annals of the New York Academy of Sciences

authors： Conticello SG

更新日期：2012-09-01 00:00:00

abstract：:The class of adhesion G protein-coupled receptors (aGPCRs), with 33 human homologs, is the second largest family of GPCRs. In addition to a seven-transmembrane α-helix-a structural feature of all GPCRs-the class of aGPCRs is characterized by the presence of a large N-terminal extracellular region. In addition, all aGP...

journal_title：Annals of the New York Academy of Sciences

authors： Liebscher I,Ackley B,Araç D,Ariestanti DM,Aust G,Bae BI,Bista BR,Bridges JP,Duman JG,Engel FB,Giera S,Goffinet AM,Hall RA,Hamann J,Hartmann N,Lin HH,Liu M,Luo R,Mogha A,Monk KR,Peeters MC,Prömel S,Ressl S,Sc

更新日期：2014-12-01 00:00:00

abstract：:The primary objective of this review is to suggest a major role of cytogenetic pathology in the genesis of both the neoplastic phenotype and the senescent phenotype of aging mammalian organisms. It is hypothesized that allelic variation at a number of genetic loci that have the potential to modulate various types of c...

journal_title：Annals of the New York Academy of Sciences

authors： Martin GM

更新日期：1991-01-01 00:00:00

abstract：:The mesodiencephalic junction is the site of the prenuclear control of vertical eye motion. We measured vertical saccades, smooth pursuit (SP), the vertical vestibulo-ocular reflex (VOR), and its interactions with vision during active head motion in 21 patients with midbrain lesions causing palsy of vertical saccades,...

journal_title：Annals of the New York Academy of Sciences

authors： Sharpe JA,Kim JS

更新日期：2002-04-01 00:00:00

abstract：:Although fetal nigral transplants have been shown to survive grafting into the striatum, increased [(18)F]6-fluroro-L-3,4-dihydroxyphenylalanine ((18)F-DOPA) uptake and improved motor function in open-label assessments have failed to establish any clinical benefits in double-blind, sham-controlled studies. To understa...

journal_title：Annals of the New York Academy of Sciences

authors： Chu Y,Kordower JH

更新日期：2010-01-01 00:00:00

abstract：:This review covers aspects of the cardiac mechanotransduction field at different levels, and advocates the possibility that mechanoelectro-chemical transduction forms part of a network of mechanically linked integration in heart-mechanically mediated integration (MMI). It assembles evidence and observations in the lit...

journal_title：Annals of the New York Academy of Sciences

authors： Lab MJ

更新日期：2006-10-01 00:00:00

abstract：:We studied the GABAergic control of the spinal locomotor network using an isolated brain stem/spinal cord from newborn rats, in which locomotor-like activity was recorded. We demonstrate that endogenously released GABA controls the locomotor network, by decreasing or completely abolishing all locomotor-like activity. ...

journal_title：Annals of the New York Academy of Sciences

authors： Cazalets JR,Bertrand S,Sqalli-Houssaini Y,Clarac F

更新日期：1998-11-16 00:00:00

abstract：:The development of type 1 diabetes is, in part, dictated by the failure of regulatory T cells to maintain peripheral tolerance. As such, therapies aimed at correcting the declining function of regulatory T cells have been the subject of intense investigation. In this review, we discuss the potential of regulatory T ce...

journal_title：Annals of the New York Academy of Sciences

authors： Richer MJ,Horwitz MS

更新日期：2009-09-01 00:00:00

abstract：:Tick burdens cause direct damage to hosts and transmit several disease agents, the majority of which are secreted into feeding lesions through tick salivary glands. Reduced incidence of naturally transmitted tick-borne diseases was recently observed among cattle immunized with tick salivary gland extracts (TSGE). The ...

journal_title：Annals of the New York Academy of Sciences

authors： Jittapalapong S,Phichitrasilp T,Chanphao H,Rerkamnuychoke W,Stich RW

更新日期：2008-12-01 00:00:00

abstract：:This paper explores aspects of the role that laboratory instruments have played in establishing psychology as a science. Comparisons of earlier instruments with their more modern counterparts indicate that many problems and methods still of interest today were explored in the laboratories of psychology's pioneers. Suc...

journal_title：Annals of the New York Academy of Sciences

authors： Caudle FM

更新日期：1983-01-01 00:00:00

abstract：:This paper discusses experimental research aimed at defining a base drag reduction device based on splitter plates. The unsteady three-dimensional nature of the flow is studied by Schlieren photography, particle image velocimetry, and measurement of the total unsteady lift and drag loads. ...

journal_title：Annals of the New York Academy of Sciences

authors： Neau L,Pruvost J,Rodriguez O,Loc TP

更新日期：2002-10-01 00:00:00

abstract：:Regardless of how creative, innovative, and elegant our computational methods, the ultimate proof of an algorithm's worth is the experimentally validated quality of its predictions. Unfortunately, this truism is hard to reduce to practice. Usually, modelers produce hundreds to hundreds of thousands of predictions, mos...

journal_title：Annals of the New York Academy of Sciences

authors： Stolovitzky G,Prill RJ,Califano A

更新日期：2009-03-01 00:00:00

abstract：:This study investigates the effects of agmatine on naloxone-precipitated withdrawal syndrome in morphine-dependent guinea pig ileum. Male guinea pigs that were starved for 24 hours were decapitated after cervical dislocation, and terminal portions of the ilea were removed. Segments were fixed at a resting tension of 1...

journal_title：Annals of the New York Academy of Sciences

authors： Aricioglu F,Ercil E,Dulger G

更新日期：2003-12-01 00:00:00

abstract：:It is imperative that operating personnel and regulatory agencies have secure, advance, and accurate knowledge of the true surface properties of materials to be contacted with flowing blood. The actual devices must be characterized in their sterile, immediate pre-exposure states. Although very sensitive electronic ins...

journal_title：Annals of the New York Academy of Sciences

authors： Baier RE

更新日期：1987-01-01 00:00:00

abstract：:This paper presents a review of the publicly available knowledge base concerning turbine blade tip heat transfer, from the early fundamental research which laid the foundations of our knowledge, to current experimental and numerical studies utilizing engine-scaled blade cascades and turbine rigs. Focus is placed on hi...

journal_title：Annals of the New York Academy of Sciences

authors： Bunker RS

更新日期：2001-05-01 00:00:00

abstract：:The behavior of neurons in the basal ganglia is severely disrupted in Parkinson's disease (PD). In nonhuman parkinsonian primate models, the disturbance in neurons in basal ganglia output structures include increased firing, bursting, an augmented synchrony, correlated activity, and a tendency towards loss of specific...

journal_title：Annals of the New York Academy of Sciences

authors： Hamani C,Lozano AM

更新日期：2003-06-01 00:00:00

abstract：:The proximate hurdle for cell trafficking to any anatomic site is the initial attachment of circulating cells to target tissue endothelium with sufficient strength to overcome prevailing forces of blood flow. E-selectin, an endothelial molecule that is inducibly expressed at all sites of inflammation, is a potent effe...

journal_title：Annals of the New York Academy of Sciences

authors： Sackstein R

更新日期：2012-04-01 00:00:00

abstract：:Taxonomic characterization of organisms in the genera Theileria and Babesia was originally based on observations of morphology and certain general phenotypic characteristics, which enabled many parasites to be unequivocally assigned to a particular genus. However, application of molecular genetic techniques, such as t...

journal_title：Annals of the New York Academy of Sciences

authors： Allsopp MT,Allsopp BA

更新日期：2006-10-01 00:00:00

abstract：:Ginkgo biloba extract EGb 761 has been used for many years to treat age-related cognitive disorders including Alzheimer's disease. EGb 761 given shortly after initiating mitochondrial damage by sodium nitroprusside (nitric oxide donor) improved the mitochondrial membrane potential of PC12 cells significantly and dose ...

journal_title：Annals of the New York Academy of Sciences

authors： Eckert A,Keil U,Scherping I,Hauptmann S,Müller WE

更新日期：2005-11-01 00:00:00

abstract：:A new autoimmune disease affecting the neuromuscular junction has been defined. Acquired neuromyotonia is associated with antibodies to voltage-gated potassium channels that act, at least in part, by reducing potassium channel function with resulting neuronal hyperactivity. This condition is quite frequently associate...

journal_title：Annals of the New York Academy of Sciences

authors： Vincent A,Jacobson L,Plested P,Polizzi A,Tang T,Riemersma S,Newland C,Ghorazian S,Farrar J,MacLennan C,Willcox N,Beeson D,Newsom-Davis J

更新日期：1998-05-13 00:00:00

abstract：:Intracerebral administration of the excitotoxin ibotenate to new-born mice induced white-matter lesions mimicking the periventricular leukomalacia occurring in human premature babies. In this model, co-injection of vasoactive intestinal peptide (VIP) prevented white-matter lesions. VIP did not prevent the initial appe...

journal_title：Annals of the New York Academy of Sciences

authors： Gressens P

更新日期：1999-01-01 00:00:00

abstract：:We have established several tumor T cell lines, both from the skin and from the blood of a patient with an MHC class II-/class I+, CD4+ cutaneous T cell lymphoma (CTCL). These cell lines, like the initial tumor cells, had a CD3+CD4+CD8- phenotype. We also isolated two cytotoxic T lymphocyte clones from the tumor site ...

journal_title：Annals of the New York Academy of Sciences

authors： Bagot M,Nikolova M,Schirm-Chabanette F,Wechsler J,Boumsell L,Bensussan A

更新日期：2001-09-01 00:00:00

abstract：:The implications of recent precision Z-pole, W mass, and weak neutral current data for testing the standard electroweak model, constraining that t quark and Higgs masses, αs (MZ), and grand unification are discussed. A fit to all data yields sin(2)θw(MZ)= 0.2325 ± 0.0024 (on-shell), where the uncertainties are mainly ...

journal_title：Annals of the New York Academy of Sciences

authors： Langacker P

更新日期：1993-06-01 00:00:00

abstract：:In order to better understand the enhancing effects of lowered oxygen (O2) tension on the growth in vitro of granulocyte-macrophage progenitor cells (CFU-GM), the effects of oxidizing species derived from molecular O2 were assessed on CFU-GM. Low density or nonadherent low density normal human bone marrow cells were p...

journal_title：Annals of the New York Academy of Sciences

authors： Broxmeyer HE,Cooper S,Gabig T

更新日期：1989-01-01 00:00:00

abstract：:Anaplasma marginale and A. phagocytophylum are intracellular rickettsiae that cause bovine anaplasmosis and human granulocytic anaplasmosis, respectively. The ultimate vaccine for the control of anaplasmosis would be one that reduces infection and transmission of the pathogen by ticks. Effective vaccines for control o...

journal_title：Annals of the New York Academy of Sciences

authors： de la Fuente J,Ayoubi P,Blouin EF,Almazán C,Naranjo V,Kocan KM

更新日期：2006-10-01 00:00:00

abstract：:In many tissue types, wound healing involves cell division and migration over and into the wound area to cover and remodel the wound. LPA and other members of the phospholipid lipid growth factor (PLGF) family stimulate many of the activities involved in wound healing. In the rabbit cornea, we have found that keratocy...

journal_title：Annals of the New York Academy of Sciences

authors： Watsky MA,Griffith M,Wang DA,Tigyi GJ

更新日期：2000-04-01 00:00:00

abstract：:Cancer chemoprevention entails the ingestion of dietary or pharmaceutical agents that can prevent, delay, or reverse the process of carcinogenesis. With support provided by the National Cancer Institute, we have been actively engaged in the systematic discovery and characterization of natural chemopreventive agents. T...

journal_title：Annals of the New York Academy of Sciences

authors： Pezzuto JM

更新日期：2011-01-01 00:00:00

abstract：:How can a psychoanalyst account for and recount the process of understanding the therapeutic endeavor? What happens in those moments, co-created by patient and analyst, when the consultation room comes "alive" in ways that defy easy or simplistic answers? How does an analyst come to understand psychoanalytic treatment...

journal_title：Annals of the New York Academy of Sciences

authors： Gotthold JJ

更新日期：2009-04-01 00:00:00

abstract：:We and others recently showed that fever induced by intravenously or intraperitoneally injected lipopolysaccharide (LPS) may involve brain signaling via hepatic vagal afferents. This suggests that LPS fever may be initiated by mediators released mainly by cells in the liver, presumably macrophages (Kupffer cells, Kc)....

journal_title：Annals of the New York Academy of Sciences

authors： Blatteis CM,Sehic E,Li S

更新日期：1998-09-29 00:00:00