Engineering cellular trafficking via glycosyltransferase-programmed stereosubstitution.

abstract：:Many studies have now indicated that micronutrients, such as the carotenoids, tocopherols, and ascorbic acid, can prevent mutagenesis, genotoxic effects, or malignant transformation in bacteria and mammalian tissue, either in cell culture or in organ culture. In addition, multiple papers report that some of these micr...

journal_title：Annals of the New York Academy of Sciences

authors： Krinsky NI

更新日期：1993-05-28 00:00:00

abstract：:An attempt has been made to describe several actions of progesterone related to the preparation of the uterus for decidualization. These actions result from classical ligand-receptor interactions as well as from nonreceptor-mediated changes, that is, those imposed by metabolic inactivation of the steroid. By opposing ...

journal_title：Annals of the New York Academy of Sciences

authors： Yochim JM

更新日期：1986-01-01 00:00:00

abstract：:TGF beta is a cytokine which is involved with the regulation of different aspects of host defense responses to injury. Overexpression of TGF beta can lead to the conversion of its protective functions to pathogenetic manifestations. TGF beta is a potent factor in promoting anabolic aspects in connective tissue metabol...

journal_title：Annals of the New York Academy of Sciences

authors： Lotz M,Seth P

更新日期：1993-06-23 00:00:00

abstract：:This chapter discusses the influence of drama in the author's background in conceptualizing psychoanalytic theory and practice. The history of ideas relevant to a dramaturgical analysis from Freud to Kohut's revolution, with additional modifications by relational psychoanalysis, is explored. The author poses a trimoda...

journal_title：Annals of the New York Academy of Sciences

authors： Ringstrom PA

更新日期：2009-04-01 00:00:00

abstract：:Mouse models with targeted deletion of the genes encoding the enzyme 25-hydroxyvitamin D 1alpha-hydroxylase [1alpha(OH)ase], and the vitamin D receptor (VDR), have provided considerable insight into the regulation of mineral and skeletal physiology by 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. Dietary manipulation induce...

journal_title：Annals of the New York Academy of Sciences

authors： Goltzman D

更新日期：2010-03-01 00:00:00

abstract：:The processing of pitch, a central aspect of music perception, is neurally dissociable from other perceptual functions. Studies using behavioral-lesion techniques as well as brain imaging methods demonstrate that tonal processing recruits mechanisms in areas of the right auditory cortex. Specifically, the right primar...

journal_title：Annals of the New York Academy of Sciences

authors： Zatorre RJ

更新日期：2001-06-01 00:00:00

abstract：:Frozen-hydrated microtubules have been studied by cryoelectron microscopy. We have described some structural features of microtubules, their relationship with the computed or X ray diffraction patterns, and the influence of the contrast transfer function. ...

journal_title：Annals of the New York Academy of Sciences

authors： Mandelkow E,Mandelkow EM

更新日期：1986-01-01 00:00:00

abstract：:Adaptation to different host taxa is a key driver of insect diversification. Herbivorous insects are classic models for ecological and evolutionary research, but it is recent advances in sequencing, statistics, and molecular technologies that have cleared the way for investigations into the proximate genetic mechanism...

journal_title：Annals of the New York Academy of Sciences

authors： Vertacnik KL,Linnen CR

更新日期：2017-02-01 00:00:00

abstract：:Immunosuppressive therapy and clinical evolution were studied in 49 patients (29 females) with antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. The mean age of patients at presentation was 55 years, and the mean (+/-SD) follow-up was 43 months (+/-33) (range, 3-140). Among the 49 patients, 10 ...

journal_title：Annals of the New York Academy of Sciences

authors： Kokolina E,Alexopoulos E,Dimitriadis C,Vainas A,Giamalis P,Papagianni A,Ekonomidou D,Memmos D

更新日期：2005-06-01 00:00:00

abstract：:Despite intense efforts, little is known about the etiology of prostate cancer, and treatment of advanced forms of the disease has had limited success. Nonetheless, epidemiologic studies combined with animal model and in vitro experiments indicate that natural components of the diet, including n-3 PUFA, the carotenoid...

journal_title：Annals of the New York Academy of Sciences

authors： Cohen LA

更新日期：2002-06-01 00:00:00

abstract：:In adult Lurcher mice virtually all cerebellar Purkinje cells have degenerated as a direct consequence of mutant gene action, providing a natural model for studying the effect of cerebellar cortical lesions on the generation of compensatory eye movements. Lurcher mice possess both optokinetic (OKR) and vestibular (VOR...

journal_title：Annals of the New York Academy of Sciences

authors： Van Alphen AM,Schepers T,Luo C,De Zeeuw CI

更新日期：2002-12-01 00:00:00

abstract：:Long-term repopulating hematopoietic stem cells can be separated from cells which provided radioprotection (short-term repopulating cells) on the basis of size. This might be a result of the quiescent nature of long-term repopulating cells. To define the activity of these populations we utilized a dye, PKH26, which in...

journal_title：Annals of the New York Academy of Sciences

authors： Lanzkron SM,Collector MI,Sharkis SJ

更新日期：1999-04-30 00:00:00

abstract：:In amphibians, alpha-MSH secreted by the pars intermedia of the pituitary plays a pivotal role in the process of skin color adaptation. Reciprocally, the skin of amphibians contains a number of regulatory peptides, some of which have been found to regulate the activity of pituitary melanotrope cells. In particular, th...

journal_title：Annals of the New York Academy of Sciences

authors： Vaudry H,Chartrel N,Desrues L,Galas L,Kikuyama S,Mor A,Nicolas P,Tonon MC

更新日期：1999-10-20 00:00:00

abstract：:Membrane bioreactors can be operated with intermittent permeation and continuous aeration. Aeration close to the surface of a submerged membrane helps to maintain a membrane surface that is free from fouling. The conditions under which this occurs depend on the interaction between flux and aeration rate. Increased flu...

journal_title：Annals of the New York Academy of Sciences

authors： Howell JA,Arnot TC,Chua HC

更新日期：2003-03-01 00:00:00

abstract：:As insulin is a major autoantigen in autoimmune diabetes and because the insulin gene region locus in humans has been linked to diabetes risk, we have bred insulin gene knockouts onto the NOD mouse. Mice differ from humans in terms that they express two nonallelic genes of insulin. Insulin 2 is the murine homologue of...

journal_title：Annals of the New York Academy of Sciences

authors： Paronen J,Moriyama H,Abiru N,Sikora K,Melanitou E,Babu S,Bao F,Liu E,Miao D,Eisenbarth GS

更新日期：2003-11-01 00:00:00

abstract：:Translational medicine describes a bench-to-bedside approach that eventually converts findings from basic scientific studies into real-world clinical research. It encompasses new treatments, advanced equipment, medical procedures, preventive and diagnostic approaches creating a bridge between basic studies and clinica...

journal_title：Annals of the New York Academy of Sciences

authors： Amirmahani F,Ebrahimi N,Molaei F,Faghihkhorasani F,Jamshidi Goharrizi K,Mirtaghi SM,Borjian-Boroujeni M,Hamblin MR

更新日期：2021-01-06 00:00:00

abstract：:Our paper reviews recent progress in the study and understanding of observed trends in extreme rainfall events in the Metropolitan Area of São Paulo (MASP). These are discussed in relation to hydrometeorological hazards that trigger natural disasters, such as flash floods, landslides, and droughts, that affect the pop...

journal_title：Annals of the New York Academy of Sciences

authors： Marengo JA,Alves LM,Ambrizzi T,Young A,Barreto NJC,Ramos AM

更新日期：2020-07-01 00:00:00

abstract：:Development of tick vaccines provides new opportunities for control of tick infestations and tick-borne diseases. Recently, the tick-protective protein, subolesin, was identified in a cell line derived from Ixodes scapularis by expression library immunization and a mouse model of tick infestations. While subolesin was...

journal_title：Annals of the New York Academy of Sciences

authors： Blouin EF,Manzano-Roman R,de la Fuente J,Kocan KM

更新日期：2008-12-01 00:00:00

abstract：:It has been proposed that spacetime should be regarded as an evolving block universe, bounded to the future by the present time, which continually extends to the future. This future boundary is defined at each time by measuring proper time along Ricci eigenlines from the start of the universe. A key point, then, is th...

journal_title：Annals of the New York Academy of Sciences

authors： Ellis GF

更新日期：2014-10-01 00:00:00

abstract：:A recent study based on the SPoARC effect (spatial position association response codes) showed that culture heavily shapes cognition and more specifically the way thought is organized; when Western adults are asked to keep in mind a sequence of colors, they mentally organize them from left to right, whereas right-to-l...

journal_title：Annals of the New York Academy of Sciences

authors： Guida A,Mosinski F,Cipora K,Mathy F,Noël Y

更新日期：2020-10-01 00:00:00

abstract：:Gene therapy as an immunomodulatory approach has the potential to treat various inherited and acquired immune-based human diseases. However, its clinical application has several challenges, varying from the efficiency of gene transfer, control of gene expression, cell and tissue targeting, and safety concerns associat...

journal_title：Annals of the New York Academy of Sciences

authors： Singh NP,Yolcu ES,Askenasy N,Shirwan H

更新日期：2005-11-01 00:00:00

abstract：:Oral and nasal administration of nicotinic acetylcholine receptor (AChR) to Lewis rats prior to myasthenogenic immunization with AChR and complete Freund's adjuvant (CFA) resulted in prevention or marked decrease of the severity of experimental autoimmune myasthenia gravis (EAMG) and suppression of AChR-specific B-cel...

journal_title：Annals of the New York Academy of Sciences

authors： Ma CG,Zhang GX,Xiao BG,Wang ZY,Link J,Olsson T,Link H

更新日期：1996-02-13 00:00:00

abstract：:The ability of modern medicine to prolong life has raised a variety of difficult legal, ethical, and social issues on which reasonable minds can differ. Among these are the morality of euthanasia in cases of deep coma or irreversible injury, as well as the Dead Donor Rule with respect to organ harvesting and transplan...

journal_title：Annals of the New York Academy of Sciences

authors： Paulson S,Comfort CP,Lee BC,Shemie S,Solomon MZ

更新日期：2014-11-01 00:00:00

abstract：:Violence against women has been a problem in human cultures for centuries. This is still the case both in developed and in developing countries, but it is in developing countries where the problem is aggravated as the result of cultural norms that are tolerant of men exerting power over women and girls as a commonly a...

journal_title：Annals of the New York Academy of Sciences

authors： Pick S,Contreras C,Barker-Aguilar A

更新日期：2006-11-01 00:00:00

abstract：:One of the most remarkable aspects of the immune system is its ability to fashion an immune response most appropriate to the activating stimulus. Although the immune system possesses a number of adaptations to accomplish this, an important theme is local immune regulation by site-specific expression of receptors and l...

journal_title：Annals of the New York Academy of Sciences

authors： Shao L,Allez M,Park MS,Mayer L

更新日期：2006-08-01 00:00:00

abstract：:RAS interacts with multiple targets in the cell and controls at least two signaling pathways, one regulating extracellular signal-regulated kinase (ERK) activation and the other controlling membrane ruffling formation. These two pathways appear to act synergistically to cause transformation. Human smooth muscle alpha-...

journal_title：Annals of the New York Academy of Sciences

authors： Kumar CC,Ohashi K,Nagata K,Walsh A,Bar-Sagi D,Mizuno K

更新日期：1999-01-01 00:00:00

abstract：:The tick-borne protozoan parasite Theileria annulata causes tropical theileriosis, a severe leukoproliferative disease of cattle, which naive susceptible animals fail to control. The parasite infects and transforms macrophages, developing in the local draining lymph node. IFN gamma has been shown to block parasite dev...

journal_title：Annals of the New York Academy of Sciences

authors： Campbell JD,Nichani AK,Brown DJ,Glass EJ,Spooner RL

更新日期：1998-06-29 00:00:00

abstract：:Apoptosis in T and B lymphocytes is a major element controlling the immune response. Activation induced cell death (AICD) in T cells is a main mechanism for maintaining peripheral tolerance and for limiting an ongoing immune response. AICD is initiated by antigen reengagement of the T cell receptor (TCR), and mediated...

journal_title：Annals of the New York Academy of Sciences

authors： Delgado M,Ganea D

更新日期：2000-01-01 00:00:00

abstract：:The envelope glycoprotein complex (Env), encoded by the human immunodeficiency virus (HIV-1), kills uninfected cells expressing CD4 and/or the chemokine receptor CXCR4 or CCR5, via at least three independent mechanisms. First, the soluble Env product gp120 can induce the apoptotic cell death of lymphocytes, neurons, a...

journal_title：Annals of the New York Academy of Sciences

authors： Castedo M,Perfettini JL,Andreau K,Roumier T,Piacentini M,Kroemer G

更新日期：2003-12-01 00:00:00

abstract：:The understanding and control of embryo implantation represents the major challenge for assisted reproductive technologies. Along with developments in basic research and efforts to optimize embryo quality, the improvement of noninvasive and reliable methods to assess uterine receptivity constitutes an important step t...

journal_title：Annals of the New York Academy of Sciences

authors： Fanchin R

更新日期：2001-09-01 00:00:00