Lewy body pathology in fetal grafts.

abstract：:Indoor air pollution occurs as an undesirable consequence of urbanization, energy conservation, indoor bioaerosol contamination, and use of synthetic materials and new technologies, and has become a worldwide concern. It is important to comprehend not only the diversity of pollutant hazards but also to develop novel m...

journal_title：Annals of the New York Academy of Sciences

authors： Brooks BO,Aldrich FD,Utter GM,DeBroy JA,Schimke RD

更新日期：1992-04-30 00:00:00

abstract：:Valproic acid (VA), a histone deacetylase inhibitor (HDACI), in vitro induces differentiation of promyelocyte leukemia cell (HL-60) and proliferation arrest and apoptosis of various leukemia cell lines. In MOLT-4 cells (human T lymphocyte leukemia) the cell cycle arrest is caused by 2 mM VA, while 4 mM VA induces main...

journal_title：Annals of the New York Academy of Sciences

authors： Záskodová D,Rezácová M,Vávrová J,Vokurková D,Tichy A

更新日期：2006-12-01 00:00:00

abstract：:Here we briefly review our studies that have unraveled an important role for the calcium- and calmodulin-sensitive enzyme calcineurin (CN) in bone remodeling. We find that the genetic deletion of the calcineurin Aalpha isoform results in osteoporosis, which is recapitulated in humans following calcineurin inhibitor th...

journal_title：Annals of the New York Academy of Sciences

authors： Sun L,Zhu LL,Zaidi N,Yang G,Moonga BS,Abe E,Iqbal J,Epstein S,Blair HC,Huang CL,Zaidi M

更新日期：2007-11-01 00:00:00

abstract：:The biological consequences of chronic consumption of Maillard reaction products (MRPs) on renal function in health and renal disease are still incompletely understood. We investigated the metabolic and renal effects of a diet with varying MRP content in healthy and subtotally nephrectomized rats. Male Wistar rats wer...

journal_title：Annals of the New York Academy of Sciences

authors： Sebeková K,Hofmann T,Boor P,Sebeková K Jr,Ulicná O,Erbersdobler HF,Baynes JW,Thorpe SR,Heidland A,Somoza V

更新日期：2005-06-01 00:00:00

abstract：:Endometrial carcinoma is the most common cancer of the female reproductive organs in the United States. International comparisons reveal that the incidence of endometrial cancer vary widely between different countries with the highest rates observed in North America and Northern Europe, intermediate rates in Eastern E...

journal_title：Annals of the New York Academy of Sciences

authors： Akhmedkhanov A,Zeleniuch-Jacquotte A,Toniolo P

更新日期：2001-09-01 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) are the largest known family of cell surface receptors, and they control many important physiological events, including sensory perception, chemotaxis, neurotransmission, and energy homeostasis. However, GPCR signaling can be difficult to study in vivo because of the multitude of GP...

journal_title：Annals of the New York Academy of Sciences

authors： Srinivasan S,Vaisse C,Conklin BR

更新日期：2003-06-01 00:00:00

abstract：:With the progressive aging of the world's population, immunosenescence is rapidly becoming a clinical concern as it accounts for a higher incidence of severe infections and poor response to vaccines. To identify nutritional approaches that may counteract immunosenescence is of obvious importance in clinical practice. ...

journal_title：Annals of the New York Academy of Sciences

authors： Freeman SL,Fisher L,German JB,Leung PS,Prince H,Selmi C,Naguwa SM,Gershwin ME

更新日期：2010-03-01 00:00:00

abstract：:Despite the global transition to overnutrition, stunting affected approximately 159 million children worldwide in 2014, while an estimated 50 million children were wasted. India is an important front in the fight against malnutrition and is grappling with the coexistence of undernutrition, overnutrition, and micronutr...

journal_title：Annals of the New York Academy of Sciences

authors： Shankar B,Agrawal S,Beaudreault AR,Avula L,Martorell R,Osendarp S,Prabhakaran D,Mclean MS

更新日期：2017-05-01 00:00:00

abstract：:Current evidence from genetic and epidemiological studies supports the view that Alzheimer's disease (AD) is a heterogeneous disorder. While the disease is pathologically defined by the presence of specified lesions in form of amyloid plaques and neurofibrillary tangles within the parenchyma, other features of patholo...

journal_title：Annals of the New York Academy of Sciences

authors： Cohen DL,Hedera P,Premkumar DR,Friedland RP,Kalaria RN

更新日期：1997-09-26 00:00:00

abstract：:Although much is known about the pleiotropic effects mediated by relaxin, the exact signaling pathways involved remain relatively elusive. This study examines LGR7 and LGR8 signaling using reporter gene technology. The greatest response was observed at the CRE reporter (indicates activation of cAMP-PKA and p38/JNK pat...

journal_title：Annals of the New York Academy of Sciences

authors： Halls ML,Bathgate RA,Roche PJ,Summers RJ

更新日期：2005-05-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal peptide (VIP), and peptide histidine-isoleucine (PHI) are members of a superfamily of structurally related peptides widely distributed in the body and displaying pleiotropic biological activities. All these peptides are known to act via ...

journal_title：Annals of the New York Academy of Sciences

authors： Dejda A,Jozwiak-Bebenista M,Nowak JZ

更新日期：2006-07-01 00:00:00

abstract：:Syndrome X is a clinical syndrome in which multiple risks cluster in an individual, and it is a common basis of vascular disease in the industrial countries. The molecular basis of Syndrome X, however, has not been elucidated. We have analyzed body fat distribution using CT scan and have shown that people who have acc...

journal_title：Annals of the New York Academy of Sciences

authors： Matsuzawa Y,Funahashi T,Nakamura T

更新日期：1999-11-18 00:00:00

abstract：:In mammals, females have a pair of X chromosomes, whereas males have one X chromosome and one Y chromosome, which is much smaller and contains fewer genes than a X chromosome. One of the pair of X chromosomes is inactivated in females. The inactivated X chromosome is late-replicating, heterochromatic, and genetically ...

journal_title：Annals of the New York Academy of Sciences

authors： Kosmaidou-Aravidou Z

更新日期：1997-06-17 00:00:00

abstract：:The tick-borne protozoan parasite Theileria annulata causes tropical theileriosis, a severe leukoproliferative disease of cattle, which naive susceptible animals fail to control. The parasite infects and transforms macrophages, developing in the local draining lymph node. IFN gamma has been shown to block parasite dev...

journal_title：Annals of the New York Academy of Sciences

authors： Campbell JD,Nichani AK,Brown DJ,Glass EJ,Spooner RL

更新日期：1998-06-29 00:00:00

abstract：:Transmission of HIV from mothers to children may occur through the transplacental, intrapartum, or breastfeeding routes. Adequate nutritional status may reduce vertical transmission by affecting several maternal or fetal and child risk factors for transmission including enhancing systemic immune function in the mother...

journal_title：Annals of the New York Academy of Sciences

authors： Fawzi W

更新日期：2000-11-01 00:00:00

abstract：:We are performing genomic searches in randomly ascertained families to identify new quantitative trait loci (QTLs) that influence atherosclerosis and its risk factors. The genetic markers used for genomic searches are random microsatellite markers distributed throughout the human chromosomes. These markers are used fo...

journal_title：Annals of the New York Academy of Sciences

authors： Hixson JE,Blangero J

更新日期：2000-05-01 00:00:00

abstract：:Accumulating evidence indicates that regulatory T cells play a crucial role in preventing autoimmunity. To examine the processes by which regulatory CD4(+) T cells are produced during immune repertoire formation, we have developed transgenic mice that express the influenza virus hemagglutinin (HA) and coexpress major ...

journal_title：Annals of the New York Academy of Sciences

authors： Caton AJ,Cozzo C,Larkin J 3rd,Lerman MA,Boesteanu A,Jordan MS

更新日期：2004-12-01 00:00:00

abstract：:Copper is an important cofactor in numerous biological processes in all living organisms. However, excessive copper can be extremely toxic, so it is vital that the copper level within a cell is tightly regulated. The damaging effect of copper is seen in several hereditary forms of copper toxicity in humans and animals...

journal_title：Annals of the New York Academy of Sciences

authors： Fedoseienko A,Bartuzi P,van de Sluis B

更新日期：2014-05-01 00:00:00

abstract：:Processes that regulate quiescence, self-renewal, and differentiation of hematopoietic stem cells (HSCs) are not well understood. Owing, in part, to the ability of xenobiotic ligands to have persistent effects on the immune system in experimental animals, there has been much work to define a physiological role of the ...

journal_title：Annals of the New York Academy of Sciences

authors： Gasiewicz TA,Singh KP,Bennett JA

更新日期：2014-03-01 00:00:00

abstract：:In the present study we analyzed the morphology of testes and efferent ducts as well as the localization of androgen receptors (AR) in the tissues of XY, YY, and XX male rainbow trout Oncorhynchus mykiss Walbaum. Testes of the XX trout differed distinctly from those of XY and YY males; the interstitial space was very ...

journal_title：Annals of the New York Academy of Sciences

authors： Galas JF,Hejmej A,Glogowski J,Bilińska B

更新日期：2009-04-01 00:00:00

abstract：:Factors which modify the relationship between body temperature and skin blood flow during exercise in heat were studied. Direct measurement of right atrial pressure during exercise in heat showed that the leveling off of forearm blood flow took place when blood temperature exceeded 38 degrees C and central venous pres...

journal_title：Annals of the New York Academy of Sciences

authors： Nagashima K,Yoshida T,Nose H,Takamata A,Morimoto T

更新日期：1997-03-15 00:00:00

abstract：:A male factor is implicated in about 50% of couples treated with advanced assisted reproductive techniques (in vitro fertilization [IVF] or intracytoplasmic sperm injection [ICSI]). An important function of spermatozoa is to deliver the paternal genome to the oocyte. However, neither the routine testing of male fertil...

journal_title：Annals of the New York Academy of Sciences

authors： Patrizio P,Sanguineti F,Sakkas D

更新日期：2008-04-01 00:00:00

abstract：:Considerable clinical and experimental evidence indicates that loss of vestibular function results in cognitive deficits, especially deficits in spatial memory. These studies demonstrate the importance of balance for the most fundamental of cognitive processes and suggest that information about head acceleration and o...

journal_title：Annals of the New York Academy of Sciences

authors： Smith PF,Brandt T,Strupp M,Darlington CL,Zheng Y

更新日期：2009-05-01 00:00:00

abstract：:Weight reduction through caloric restriction (CR) or exercise can have opposite effects on bone. This study investigated the effects of comparable weight reduction through CR and/or exercise on body composition and bone structure in an obese rat model. Male 6-week-old rats were fed either a normal-fat diet for 6 month...

journal_title：Annals of the New York Academy of Sciences

authors： Cao JJ

更新日期：2018-12-01 00:00:00

abstract：:Methamphetamine (METH) is one of the major drugs of abuse that is postulated to cause neurotoxicity by depleting dopamine (DA) and its metabolites, high-affinity DA uptake sites, and the activity of tyrosine hydroxylase. The present study was undertaken to investigate whether the relatively selective, neuronal nitric ...

journal_title：Annals of the New York Academy of Sciences

authors： Ali SF,Itzhak Y

更新日期：1998-05-01 00:00:00

abstract：:The human organism is in a state of dynamic equilibrium, homeostasis. The stress system is activated when homeostasis is challenged by extrinsic or intrinsic forces, the stressors. This system, whose central component is the central nervous system (CNS) and includes corticotropin-releasing hormone (CRH) and noradrener...

journal_title：Annals of the New York Academy of Sciences

authors： Stratakis CA,Chrousos GP

更新日期：1995-12-29 00:00:00

abstract：:There is now good evidence that in the AD brain, a number of neurotransmitter effector systems are defective. Such abnormalities include defective G, protein and protein kinase C function as well as a drastically reduced level of receptors for the second messenger Ins(1,4,5) P3. Such changes are probably not restricte...

journal_title：Annals of the New York Academy of Sciences

authors： Fowler CJ,Garlind A,O'Neill C,Cowburn RF

更新日期：1996-06-15 00:00:00

abstract：:The pregnant uterus is unique because of the dramatic functional changes that occur in the peripartum period. To promote the concept that we have a relatively poor understanding of the physiology of parturition, we will posit 10 facts that are so obvious and so clearly accepted as facts that they probably are not even...

journal_title：Annals of the New York Academy of Sciences

authors： Young RC

更新日期：2007-04-01 00:00:00

abstract：:In many scientific and technical applications, a three-dimensional (3D) object must be reconstructed, either to assist in understanding the object's structure or to ease its automatic handling and analysis. Volume reconstruction has been used in health care to diagnose, simulate, facilitate surgical planning, develop ...

journal_title：Annals of the New York Academy of Sciences

authors： Masero V,León-Rojas JM,Moreno J

更新日期：2002-12-01 00:00:00

abstract：:This paper reports CFD-simulations of the turbulent flow, pressure loss and heat transfer occurring in ribbed passages. The channel section is rectangular, with an aspect ratio of 2.04. Ribs are square cross-section, their height is 10% of the channel height, and their inclination is varied from 90 degrees to 33 degre...

journal_title：Annals of the New York Academy of Sciences

authors： Hermanson K,Parneix S,von Wolfersdorf J,Semmler K

更新日期：2001-05-01 00:00:00