Abstract:
:Processes that regulate quiescence, self-renewal, and differentiation of hematopoietic stem cells (HSCs) are not well understood. Owing, in part, to the ability of xenobiotic ligands to have persistent effects on the immune system in experimental animals, there has been much work to define a physiological role of the aryl hydrocarbon receptor (AhR) and its relationship to human disease. Persistent AhR activation by dioxin, a potent agonist, results in altered numbers and function of HSCs in mice. HSCs from AhR(-/-) knockout (KO) mice are hyperproliferative and have an altered cell cycle. Aging KO mice show characteristics consistent with premature bone marrow exhaustion. We propose that the increased proliferation of HSCs lacking AhR expression or activity is a result of loss of quiescence, and as such, AhR normally acts as a negative regulator to curb excessive or unnecessary proliferation. Similarly, prolonged and/or inappropriate stimulation of AhR activity may compromise the ability of HSCs to sense environmental signals that allow these cells to balance quiescence, proliferation, migration, and differentiation. These data and others support a hypothesis that deregulation of AhR function has an important role in HSC regulation and in the etiology and/or progression of certain hematopoietic diseases, many of which are associated with aging.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Gasiewicz TA,Singh KP,Bennett JAdoi
10.1111/nyas.12361subject
Has Abstractpub_date
2014-03-01 00:00:00pages
44-50eissn
0077-8923issn
1749-6632journal_volume
1310pub_type
杂志文章,评审abstract::Decreased postural stability is observed in most astronauts immediately following spaceflight. Because ataxia may present postflight operational hazards, it is important to determine the incidence of postural instability immediately following landing and the dynamics of recovery of normal postural equilibrium control....
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1992.tb25253.x
更新日期:1992-05-22 00:00:00
abstract::Nipah virus (NiV) is a highly pathogenic paramyxovirus, which emerged in 1998 from fruit bats in Malaysia and caused an outbreak of severe respiratory disease in pigs and fatal encephalitis in humans with high mortality rates. In contrast to most paramyxoviruses, NiV can infect a large variety of mammalian species. Du...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1196/annals.1408.003
更新日期:2007-04-01 00:00:00
abstract::Emotional or physical stress triggers Tako-tsubo cardiomyopathy in postmenopausal females, which is characterized by an elevation of the ST segment in the electrocardiogram (ECG) and left ventricular apical ballooning in the left ventriculogram (LVG). Immobilization stress (IMO) of rats can reproduce these ECG and LVG...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1196/annals.1296.054
更新日期:2004-06-01 00:00:00
abstract::Mytilus edulis, a marine bivalve mollusc, contains hemocytes that share certain properties with cells of the human monocyte-macrophage lineage. Because of this and previously reported similar responses to opioids between Mytilus hemocytes and human granulocytes, we determined whether Mytilus might also possess monokin...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1992.tb49098.x
更新日期:1992-04-15 00:00:00
abstract::The in vitro lethal activity of two Bacillus thuringiensis strains (IB-16 and IB-61) against Haemonchus contortus histotropic fourth stage larvae (L(4)) was evaluated. Each B. thuringiensis strain was used as soluble proteins at different concentrations. In addition, the in vitro lethal dose (LD(50)) of each strain wa...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1196/annals.1428.077
更新日期:2008-12-01 00:00:00
abstract::After fertilization, the next major hurdle for human reproduction is trophoblast differentiation, which is required for implantation, followed in lockstep by rapid assembly of these embryonic cells into a functional placenta. During this process, cytotrophoblast stem cells invade the uterus, anchoring the conceptus to...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.2003.tb03211.x
更新日期:2003-05-01 00:00:00
abstract::We examined the effects of a nonantimicrobial tetracycline analogue, CMT-8, on bone loss and osteoclasts in ovariectomized (OVX) rats. Three-month-old female rats were OVX, and, one week later, distributed into three groups: sham-operated non-OVX controls, untreated OVX controls, and CMT-8-treated OVX rats. After 145 ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1999.tb07694.x
更新日期:1999-06-30 00:00:00
abstract::Advances in understanding the epidemiology of endometriosis have lagged behind other diseases because of methodologic problems related to disease definition and control selection. Nevertheless, a better picture of the epidemiology of endometriosis has emerged over the past few decades. Prevalence estimates of the dise...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2002.tb02761.x
更新日期:2002-03-01 00:00:00
abstract::These data suggest that shock stress during adolescence increases ETOH consumption and may contribute to an increase in aggression in early adulthood. Interestingly, shock stress without ETOH results in timid behavior in early adulthood. One might speculate that adolescent hamsters "self-medicate" to deal with continu...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1996.tb32539.x
更新日期:1996-09-20 00:00:00
abstract::The implications of recent precision Z-pole, W mass, and weak neutral current data for testing the standard electroweak model, constraining that t quark and Higgs masses, αs (MZ), and grand unification are discussed. A fit to all data yields sin(2)θw(MZ)= 0.2325 ± 0.0024 (on-shell), where the uncertainties are mainly ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1993.tb43885.x
更新日期:1993-06-01 00:00:00
abstract::Patients with vascular dementia are frequently encountered in Japan reaching nearly 50% of those with senile dementia, which is equal to or even slightly higher than patients with Alzheimer's disease. This contrasts with a much lower ratio of patients with vascular dementia in the United States. The majority of vascul...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2002.tb04795.x
更新日期:2002-11-01 00:00:00
abstract::Rapid cooling of small samples is necessary both to cryofixation for electron microscopy and to vitrification for cryopreservation. Several effects on the cooling rates of small samples quenched into liquid nitrogen were studied, including the diameter of samples, the subcooling of liquid nitrogen, the quenching speed...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1998.tb10160.x
更新日期:1998-09-11 00:00:00
abstract::Developing limb or differentiating neural and blood cells are traditional models used to study programmed cell death in mammals. The developing mouse dentition can also be an attractive model for studying apoptosis regulation. Apoptosis is most extant during early odontogenesis in mice. The embryonic tooth pattern is ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1196/annals.1299.083
更新日期:2003-12-01 00:00:00
abstract::Cities modify their local climate, and at the same time they suffer from the local impacts of climate change. Our paper discusses the progress and obstacles in three active research topics that contribute to increasing the capability within the urban climate research community for transferring local climate knowledge ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/nyas.13986
更新日期:2019-01-01 00:00:00
abstract::Fifteen patients with coccidioidal meningitis were treated with high doses of ketoconazole for up to 4 years. Five patients were treated with ketoconazole alone. One clinically failed, one developed hepatotoxicity, and three achieved remission of meningitis. One patient received intrathecal AMB in addition to ketocona...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1988.tb40446.x
更新日期:1988-01-01 00:00:00
abstract::Heparins represent an efficient treatment of acute thrombosis and obstetric complications in antiphospholipid syndrome (APS). Enhanced microvesiculation of cell membranes, as detected by reduced membrane adhesion, can contribute to hypercoagulability in APS. Healthy donor IgG antibodies significantly increased beta2-g...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2009.04745.x
更新日期:2009-09-01 00:00:00
abstract::Although smell loss has several potential etiologies (e.g., head trauma, allergic rhinitis, and enlarged adenoids) that are common among children, studies evaluating the prevalence of olfactory dysfunction in the pediatric population are rare. Several challenges confront the clinician or researcher hoping to evaluate ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2009.03919.x
更新日期:2009-07-01 00:00:00
abstract::Our previous studies of anti-DNA antibodies in SLE have demonstrated a preferential use of V kappa I and V lambda II gene families to encode light chains of antibodies that express the anti-DNA-associated 3I and 8.12 idiotypes, respectively. In this study, we employed PCR to obtain V kappa I and V lambda II germline g...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:
更新日期:1995-09-29 00:00:00
abstract::The alpha-ketoglutarate dehydrogenase complex (KGDHC) is an important mitochondrial constituent, and deficiency of KGDHC is associated with a number of neurological disorders. KGDHC is composed of three proteins, each encoded on a different and well-characterized gene. The sequences of the human proteins are known. Th...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.1999.tb07818.x
更新日期:1999-01-01 00:00:00
abstract::Microgravity experiments on the constrained vapor bubble heat exchanger (CVB) are being developed for the space station. Herein, ground-based experimental studies on condensate removal in the condenser region of the vertical CVB were conducted and the mechanism of condensate removal in microgravity was found to be the...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2002.tb05913.x
更新日期:2002-10-01 00:00:00
abstract::In an ever-changing environment, animals must learn new behavioral strategies for the successful procurement of food, sex, and other needs. Synaptic plasticity within the mesolimbic system, a key reward circuit, affords an animal the ability to adapt and perform essential goal-directed behaviors. Ironically, drugs of ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.2009.05154.x
更新日期:2010-02-01 00:00:00
abstract::Stroke is a common and serious disease. Most studies have shown that basic public knowledge about what a stroke is, symptoms of a stroke, and the proper reaction to a stroke is quite deficient. The fact that a stroke affects cognitive, communicative, and motor functions may partially explain the poor reaction to acute...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.2012.06722.x
更新日期:2012-09-01 00:00:00
abstract::Natural systems cannot be closed to the environment. At the same time there is a necessity for closure in order to build the system. It is this quint-essential tension between openness and closure that drives systems to unfold into further stages or levels of growth and development. In other words, the emergence of or...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2000.tb06268.x
更新日期:2000-01-01 00:00:00
abstract::Moderated by Lisa Miller from Newsweek, evolutionary biologist Kenneth Miller (Brown University) and theologians John Haught (Georgetown University) and Nancey Murphy (Fuller Theological Seminary) discuss the questions Are we immortal? Do our souls exist beyond our bodies? and What scientific evidence is there for mys...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2011.06183.x
更新日期:2011-10-01 00:00:00
abstract::The results of this study suggest that reperfusion of ischemic myocardium may lead to the peroxisomal disorder both functionally and biochemically. An alkyl glycerol such as chimyl alcohol can protect the ischemic heart from the reperfusion injury probably by enhancing the plasmalogen synthesis. ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:
更新日期:1994-06-17 00:00:00
abstract::Modified tumor cells were used to immunize three murine hosts against syngenic ascitic lymphomas: C3H-6C3HED, BALB/c-P1798, and DBA/2-L1210. When the host was capable of a significant immune response against the malignant cells during progressive tumor growth (e.g., C3H vs. 6C3HED), protective immunization against a l...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1976.tb41636.x
更新日期:1976-01-01 00:00:00
abstract::Vaccinia virus encodes secretory proteins termed virokines. One of the major virokines encoded by the N1L open reading frame is the 13.8 kDa protein. A recombinant virus, termed vGK5, lacking this protein when injected intracranially into mice, has one of the highest levels of in vivo attenuation achieved by deletion ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1196/annals.1329.037
更新日期:2004-12-01 00:00:00
abstract::The aim of this study was to evaluate a novel third-generation enzyme-linked immunosorbent assay (ELISA) for the high-sensitivity detection of autoantibodies to proteinase-3 (PR3) in patients with Wegener's granulomatosis (WG). First- and second-generation ELISA for the detection of antineutrophil cytoplasmic antibodi...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2009.04649.x
更新日期:2009-09-01 00:00:00
abstract::Cerebrovascular deposition of amyloid is a frequent observation in Alzheimer's disease patients. It can also be detected sporadically in normal aged individuals and is further found in familial diseases linked to specific gene mutations. The source and mechanism of this pathology are still unknown. It has been suggest...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.2000.tb06381.x
更新日期:2000-04-01 00:00:00
abstract::The dramatic changes in overall mode of life experienced since 1989 by the people in Central and Eastern Europe (CEE) provides a good opportunity to study the aging processes and the status of the elderly. In the 1980s, CEE countries were already at an advanced stage of demographic aging of their populations. The firs...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1196/annals.1396.041
更新日期:2007-10-01 00:00:00