Effect of valproic acid, a histone deacetylase inhibitor, on cell death and molecular changes caused by low-dose irradiation.

abstract：:Although pancreatic adenocarcinoma has become one of the best characterized malignant diseases, severe diagnostic and therapeutic problems are still associated with this disease. The establishment of a molecular model of pancreatic carcinogenesis may provide tools that could result in earlier diagnosis of this disease...

journal_title：Annals of the New York Academy of Sciences

authors： Jesnowski R,Müller P,Schareck W,Liebe S,Löhr M

更新日期：1999-06-30 00:00:00

abstract：:The superior soft tissue contrast and multiplanar capability of magnetic resonance imaging has contributed to earlier diagnosis and implementation of effective treatment for a variety of arthropathies. Owing to overlapping clinical signs and symptoms, MRI plays a role in delineating the features and stages of these co...

journal_title：Annals of the New York Academy of Sciences

authors： Momeni M,Brindle K

更新日期：2009-02-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a complex clinical entity. In contrast to previously limited diagnostic definitions, it is now apparent that COPD is a clinically and biologically heterogeneous disease process, overlapping with other airways diseases like chronic asthma. As such, symptomatic response to...

journal_title：Annals of the New York Academy of Sciences

authors： Rooney C,Sethi T

更新日期：2015-06-01 00:00:00

abstract：:Since the early 1980s biologists have recognized that skeletal muscle generates free radicals. Of particular interest are two closely related redox cascades--reactive oxygen species (ROS) and nitric oxide (NO) derivatives. The ROS cascade is initiated by superoxide anion radicals derived from the mitochondrial electro...

journal_title：Annals of the New York Academy of Sciences

authors： Reid MB,Durham WJ

更新日期：2002-04-01 00:00:00

abstract：:We review the effects of two transcription factor decoy oligonucleotides on apoptosis of human osteoclasts (OCs). The first decoy molecule was designed to inhibit nuclear factor kappa-B (NF-kappaB) binding to target sequence, the second to increase estrogen receptor (ER) alpha expression. We found that both decoy mole...

journal_title：Annals of the New York Academy of Sciences

authors： Piva R,Penolazzi L,Zennaro M,Bianchini E,Magri E,Borgatti M,Lampronti I,Lambertini E,Tavanti E,Gambari R

更新日期：2006-12-01 00:00:00

abstract：:We have employed antisense methods to study the transcriptional functions of c-fos protein (Fos). Clones expressing inducible anti-fos RNA have been employed to inhibit c-fos expression, resulting in activation of c-fos transcription by inhibiting its normal repressor function. The sites of negative regulation by Fos ...

journal_title：Annals of the New York Academy of Sciences

authors： Holt JT

更新日期：1992-10-28 00:00:00

abstract：:Coccidioides causes coccidioidomycosis in the southwestern United States. Its clinical manifestations range from the primary asymptomatic to progressive pulmonary and extrapulmonary disease. Because of endemicity, frequent relapse, and virulent nature of Coccidioides, there is an urgent need for the development of eff...

journal_title：Annals of the New York Academy of Sciences

authors： Awasthi S

更新日期：2007-09-01 00:00:00

abstract：:The envelope glycoprotein complex (Env), encoded by the human immunodeficiency virus (HIV-1), kills uninfected cells expressing CD4 and/or the chemokine receptor CXCR4 or CCR5, via at least three independent mechanisms. First, the soluble Env product gp120 can induce the apoptotic cell death of lymphocytes, neurons, a...

journal_title：Annals of the New York Academy of Sciences

authors： Castedo M,Perfettini JL,Andreau K,Roumier T,Piacentini M,Kroemer G

更新日期：2003-12-01 00:00:00

abstract：:Animal trials of many pharmacological neuroprotective agents have been quite successful, whereas trials in humans have been uniformly disappointing. A major difference between laboratory research in animals and clinical research in humans is the amount and/or quality of data obtained. The goal of this presentation is ...

journal_title：Annals of the New York Academy of Sciences

authors： Andrews RJ

更新日期：2005-08-01 00:00:00

abstract：:The term sepsis describes a potentially lethal clinical condition that develops as a result of a dysregulated host response to bacterial infection. The most common bacterial component implicated in initiating the septic syndrome is a cell wall molecule derived from Gram-negative bacteria, known as lipopolysaccharide (...

journal_title：Annals of the New York Academy of Sciences

authors： Bosshart H,Heinzelmann M

更新日期：2007-01-01 00:00:00

abstract：:The purpose of this paper is to review the advances in electromagnetic levitation techniques as tools for determination of the thermophysical properties of molten metals under standard gravity and microgravity conditions. We show that a combination of containerless processing and microgravity offers the exclusive poss...

journal_title：Annals of the New York Academy of Sciences

authors： Bakhtiyarov SI,Overfelt RA

更新日期：2002-10-01 00:00:00

abstract：:Full-grown amphibian oocytes, arrested in prophase I or meiosis, respond in vitro to progesterone and certain other steroids. They undergo an apparently normal sequence of nuclear maturation and cytoplasmic differentiation, which are necessary precedents for fertilization and embryogenesis. Individual oocytes or popul...

journal_title：Annals of the New York Academy of Sciences

authors： Schuetz AW

更新日期：1977-03-11 00:00:00

abstract：:Science is concerned not just with objects but also with their various aspects, such as their colors, temperatures, sizes, and shapes. These aspects, or properties, are generally thought to be of at least two kinds: primary properties, such as shape, size, and motion and secondary ones, such as temperature and color. ...

journal_title：Annals of the New York Academy of Sciences

authors： Vollmer SH

更新日期：2003-05-01 00:00:00

abstract：:This paper presents a video-based eye-tracking method, ideally deployed via a mobile device or laptop-based webcam, as a tool for measuring brain function. Eye movements and pupillary motility are tightly regulated by brain circuits, are subtly perturbed by many disease states, and are measurable using video-based met...

journal_title：Annals of the New York Academy of Sciences

authors： Adhikari S,Stark DE

更新日期：2017-01-01 00:00:00

abstract：:To date, the precise etiology of inflammatory bowel disease (IBD) remains largely unknown; however, it is well accepted that IBD results from a dysregulated mucosal immune response to environmental factors in genetically susceptible hosts. The primary defect, in at least a subpopulation of IBD patients, may be due to ...

journal_title：Annals of the New York Academy of Sciences

authors： Reuter BK,Pizarro TT

更新日期：2009-05-01 00:00:00

abstract：:Experimental data together with clinical studies have generated information about the association between sympathetic nervous system activity and immunity as measured by in vitro correlates of cellular immune function. In addition, studies on the in vivo role of central CRF in coordinating sympathetic outflow and modu...

journal_title：Annals of the New York Academy of Sciences

authors： Irwin M

更新日期：1993-10-29 00:00:00

abstract：:Hereditary adrenal pheochromocytoma is caused by germline mutations in RET, VHL, SDHB, SDHD, and NF1. As these genes differ in function, so may their pheochromocytoma phenotypes, suggesting gene-specific patterns of age-related progression to pheochromocytoma. This possibility was explored for gene carriers with a lif...

journal_title：Annals of the New York Academy of Sciences

authors： Machens A,Brauckhoff M,Gimm O,Dralle H

更新日期：2006-08-01 00:00:00

abstract：:The presence of R. prowazekii in lice using R. prowazekii-specific qPCR cassettes showed the changes of the rickettsial burden in the lice post-infection. ...

journal_title：Annals of the New York Academy of Sciences

authors： Rozmajzl PJ,Houhamdi L,Jiang J,Raoult D,Richards AL

更新日期：2006-10-01 00:00:00

abstract：:In plants, the photons of light are absorbed at the level of the photosystems in the chloroplasts. The functioning of the photosynthetic electron transfer chain linked to this process is required to generate NADPH and ATP. In addition, the light signal promotes a regulatory cascade, situated in the stroma, that involv...

journal_title：Annals of the New York Academy of Sciences

authors： Jacquot JP,Rouhier N,Gelhaye E

更新日期：2002-11-01 00:00:00

abstract：:Monoclonal antibodies reactive with desmin (D3 and D76) have been generated and their specificities validated by immunoblots, RIAs, and immunocytochemistry. No cross-reaction with other IFPs has been observed. The McAbs recognized different epitopes but both reside in the amino-terminal rod domain of desmin. Whereas M...

journal_title：Annals of the New York Academy of Sciences

authors： Fischman DA,Danto SI

更新日期：1985-01-01 00:00:00

abstract：:Force and shortening in striated muscle are driven by a structural working stroke in the globular portion of the myosin molecules-the myosin head-that cross-links the myosin-containing filaments and the actin-containing filaments. We use time-resolved X-ray diffraction in single fibers from frog skeletal muscle to lin...

journal_title：Annals of the New York Academy of Sciences

authors： Reconditi M,Linari M,Lucii L,Stewart A,Sun YB,Narayanan T,Irving T,Piazzesi G,Irving M,Lombardi V

更新日期：2005-06-01 00:00:00

abstract：:Anemia affects over 800 million women and children globally. Defined as a limited or insufficient functional red blood cell supply in peripheral blood, anemia causes a reduced oxygen supply to tissues and can have serious health consequences for women and children. Hemoglobin (Hb) concentration is most commonly measur...

journal_title：Annals of the New York Academy of Sciences

authors： Karakochuk CD,Hess SY,Moorthy D,Namaste S,Parker ME,Rappaport AI,Wegmüller R,Dary O,HEmoglobin MEasurement (HEME) Working Group.

更新日期：2019-08-01 00:00:00

abstract：:The Cape Town Case Study (CTCS) was a multi-institutional collaborative project initiated by CUBES, a knowledge networking initiative of UNESCO's Ecological Sciences Division and the Earth Institute at Columbia University. Cape Town was selected as a CUBES site on the basis of its high biological and cultural signific...

journal_title：Annals of the New York Academy of Sciences

authors： Stanvliet R,Jackson J,Davis G,De Swardt C,Mokhoele J,Thom Q,Lane BD

更新日期：2004-06-01 00:00:00

abstract：:The life expectancy of patients with thalassemia major has significantly increased in recent years, as reported by several groups in different countries. However, complications are still frequent and affect the patients' quality of life. In a recent study from the United Kingdom, it was found that 50% of the patients ...

journal_title：Annals of the New York Academy of Sciences

authors： Borgna-Pignatti C,Cappellini MD,De Stefano P,Del Vecchio GC,Forni GL,Gamberini MR,Ghilardi R,Origa R,Piga A,Romeo MA,Zhao H,Cnaan A

更新日期：2005-01-01 00:00:00

abstract：:The quest for new control strategies for ticks can profit from high throughput genomics. In order to identify genes that are involved in oogenesis and development, in defense, and in hematophagy, the transcriptomes of ovaries, hemocytes, and salivary glands from rapidly ingurgitating females, and of salivary glands fr...

journal_title：Annals of the New York Academy of Sciences

authors： Santos IK,Valenzuela JG,Ribeiro JM,de Castro M,Costa JN,Costa AM,da Silva ER,Neto OB,Rocha C,Daffre S,Ferreira BR,da Silva JS,Szabó MP,Bechara GH

更新日期：2004-10-01 00:00:00

abstract：:Acetaldehyde covalently binds to purified tubulin in vitro to form both stable and unstable adducts. The formation of stable adducts can be greatly facilitated by the inclusion of the relatively gentle and Schiff base specific reducing agent, sodium cyanoborohydride. Although the tubulin molecule has multiple lysine r...

journal_title：Annals of the New York Academy of Sciences

authors： Tuma DJ,Jennett RB,Sorrell MF

更新日期：1987-01-01 00:00:00

abstract：:Liquid membrane reactors are well known for metal extraction. This technology may also be applied to the immobilization of enzymes in enzyme emulsions. The use of liquid membrane reactors for enzymatic bioconversions has several advantages in comparison to solid membrane reactors and conventional immobilization techni...

journal_title：Annals of the New York Academy of Sciences

authors： Scheper T,Makryaleas K,Nowottny C,Likidis Z,Tsikas D,Schügerl K

更新日期：1987-01-01 00:00:00

abstract：:Most research on reading skill acquisition in deaf individuals has been conducted from the perspective of a hearing child learning to read. This approach may limit our understanding of how a deaf child approaches the task of learning to read and successfully acquires reading skills. An alternative approach is to consi...

journal_title：Annals of the New York Academy of Sciences

authors： Dye MW,Hauser PC,Bavelier D

更新日期：2008-12-01 00:00:00

abstract：:A previous review of alternative treatments (Tx) of ADHD--those other than psychoactive medication and behavioral/psychosocial Tx--was supplemented with an additional literature search focused on adults with ADHD. Twenty-four alternative Tx were identified, ranging in scientific documentation from discrediting control...

journal_title：Annals of the New York Academy of Sciences

authors： Arnold LE

更新日期：2001-06-01 00:00:00

abstract：:The immunotherapeutic agent ipilimumab has helped address a significant unmet need in the treatment of advanced melanoma. Ipilimumab is a fully human monoclonal antibody that targets cytotoxic T-lymphocyte antigen-4 (CTLA-4), thereby augmenting antitumor immune responses. After decades in which a number of clinical tr...

journal_title：Annals of the New York Academy of Sciences

authors： Wolchok JD,Hodi FS,Weber JS,Allison JP,Urba WJ,Robert C,O'Day SJ,Hoos A,Humphrey R,Berman DM,Lonberg N,Korman AJ

更新日期：2013-07-01 00:00:00