Agmatine inhibits naloxone-induced contractions in morphine-dependent Guinea pig ileum.

Abstract:

:This study investigates the effects of agmatine on naloxone-precipitated withdrawal syndrome in morphine-dependent guinea pig ileum. Male guinea pigs that were starved for 24 hours were decapitated after cervical dislocation, and terminal portions of the ilea were removed. Segments were fixed at a resting tension of 1 g in an organ bath containing 1 x 10(-6) M morphine in Tyrode solution at 37 degrees C, which was bubbled with 95% O(2) and 5% CO(2). Tissues were incubated in morphine containing Tyrode solution for 4 hours before agmatine was added. Naloxone and agmatine had no effect on naive ilea. Naloxone (1 x 10(-6) M) contracted morphine-dependent ilea. Agmatine significantly inhibited the contractile response to naloxone in a dose-dependent manner (1 x 10(-7) M, 44%; 1 x 10(-6) M, 80%; 1 x 10(-5) M, 95%). This effect of agmatine was partly abolished by pretreatment with yohimbine and was almost completely abolished by idazoxan.

journal_name

Ann N Y Acad Sci

authors

Aricioglu F,Ercil E,Dulger G

doi

10.1196/annals.1304.016

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

147-51

eissn

0077-8923

issn

1749-6632

journal_volume

1009

pub_type

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