Correlating the pharmacology and molecular biology of opioid receptors. Cloning and antisense mapping a kappa 3-related opiate receptor.

abstract：:Until now, neoadjuvant therapy plus surgical resection of the primary tumor and potential metastatic lymph nodes (LNs) has been the current optimal treatment for locally advanced thoracic esophageal cancer (EC). LN metastasis is one of the most negative prognostic factors for thoracic esophageal squamous cell carcinom...

journal_title：Annals of the New York Academy of Sciences

authors： Wang Z,Mao Y,Gao S,Li Y,Tan L,Daiko H,Liu S,Chen C,Koyanagi K,He J

更新日期：2020-12-01 00:00:00

abstract：:The clinical significance of lymphocytic esophagitis (LyE), which is characterized by the prominence of peripapillary intraepithelial lymphocytes (IELs) without significant granulocytosis, remains poorly understood. During the last few years, plausible clinical correlates and novel approaches for stratification of LyE...

journal_title：Annals of the New York Academy of Sciences

authors： Lisovsky M,Westerhoff M,Zhang X

更新日期：2016-10-01 00:00:00

abstract：:The slowpoke gene of Drosophila melanogaster encodes a Ca-activated K channel. This gene is expressed in neurons, muscles, tracheal cells, and the copper and iron cells of the midgut. The gene produces a large number of alternative products using tissue-specific transcriptional promoters and alternative mRNA splicing....

journal_title：Annals of the New York Academy of Sciences

authors： Atkinson NS,Brenner R,Bohm RA,Yu JY,Wilbur JL

更新日期：1998-11-16 00:00:00

abstract：:This study examined the functional response to human relaxin 2 (H2 relaxin), human relaxin 3 (H3 relaxin), porcine relaxin, and human INSL3 in the cytosensor microphysiometer, using CHO-K1 cells stably expressing human GPCR135. CHO-K1 cells stably expressing GPCR135 were generated by the serial dilution method and rec...

journal_title：Annals of the New York Academy of Sciences

authors： Van der Westhuizen ET,Sexton PM,Bathgate RA,Summers RJ

更新日期：2005-05-01 00:00:00

abstract：:Most of the plasma suppressive activity was associated with alpha 2M in both normal subjects and cancer patients. alpha 2M binding to physiological levels of proteases was associated with an increase in the ability to suppress lymphocyte reactivity in the TEEM test. alpha 2M binding to proteases released a peptide tha...

journal_title：Annals of the New York Academy of Sciences

authors： Alomran A,Shenton BK,Donnelly PK,Francis DM,Proud G,Taylor RM

更新日期：1983-01-01 00:00:00

abstract：:Child maltreatment (CM) not only has detrimental and lifelong psychological consequences, but also can lead to lasting alterations in core physiological systems--a biological memory of CM. Furthermore, some of these alterations might even be transmitted to the next generation. This article describes current knowledge ...

journal_title：Annals of the New York Academy of Sciences

authors： Schury K,Kolassa IT

更新日期：2012-07-01 00:00:00

abstract：:Our studies have shown that the acyclic nucleotide analogues PMEA and HPMPC are able to penetrate into cells and are then activated to mono- and diphosphate derivatives. The latter correspond to triphosphate analogues and presumably serve an important role in the biological activity exerted by these antiviral agents. ...

journal_title：Annals of the New York Academy of Sciences

authors： Bronson JJ,Ho HT,De Boeck H,Woods K,Ghazzouli I,Martin JC,Hitchcock MJ

更新日期：1990-01-01 00:00:00

abstract：:Cognitive training, physical activity, and exercise have often been reported to improve cognitive performance in older adults. This paper reviews some seminal and recent studies using these approaches to improve cognition and physical functioning in healthy older adults and in patients suffering from non-neurological ...

journal_title：Annals of the New York Academy of Sciences

authors： Bherer L

更新日期：2015-03-01 00:00:00

abstract：:We reevaluated the exchange stoichiometry of the Na(+)/Ca(2+) exchange current by measuring its reversal potential. The exchange current was measured from the inside-out macropatch excised from intact sarcolemma of guinea pig ventricular myocytes. This method provides more accurate control of extracellular and cytopla...

journal_title：Annals of the New York Academy of Sciences

authors： Matsuoka S

更新日期：2002-11-01 00:00:00

abstract：:A major challenge in systems biology is to evaluate the feasibility of a biological research project prior to its realization. Since experiments are animals-, cost- and time-consuming, approaches allowing researchers to discriminate alternative hypotheses with a minimal set of experiments are highly desirable. Given a...

journal_title：Annals of the New York Academy of Sciences

authors： Maiwald T,Kreutz C,Pfeifer AC,Bohl S,Klingmüller U,Timmer J

更新日期：2007-12-01 00:00:00

abstract：:Epidermal growth factor (EGF) and its structurally related proteins are involved in the developmental regulation of various brain neurons, including midbrain dopaminergic neurons. We recently reported EGF and EGF-receptor abnormalities in both the brain tissues and blood of schizophrenic patients. Administration of EG...

journal_title：Annals of the New York Academy of Sciences

authors： Mizuno M,Malta RS Jr,Nagano T,Nawa H

更新日期：2004-10-01 00:00:00

abstract：:SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates dif...

journal_title：Annals of the New York Academy of Sciences

authors： Corradini I,Verderio C,Sala M,Wilson MC,Matteoli M

更新日期：2009-01-01 00:00:00

abstract：:Antibodies to double-stranded desoxyribonucleic acid (dsDNA) and to the polymyositis/scleroderma (PM/Scl) complex are regarded as serological markers for systemic lupus erythematosus (SLE) and PM/Scl overlap syndrome, respectively. In a previous study, serum samples were identified that contained antibodies specific f...

journal_title：Annals of the New York Academy of Sciences

authors： Mahler M,Greidinger EL,Szmyrka M,Kromminga A,Fritzler MJ

更新日期：2007-08-01 00:00:00

abstract：:The plasma levels and the glycosylation of acute-phase proteins (APP) are subject to marked changes during acute and chronic inflammation. The pathophysiological variations in different glycoforms of APP in serum most likely result from changes in the glycosylation process during their biosynthesis in the parenchymal ...

journal_title：Annals of the New York Academy of Sciences

authors： Van Dijk W,Mackiewicz A

更新日期：1995-07-21 00:00:00

abstract：:The New York Stem Cell Foundation's "Fifth Annual Translational Stem Cell Research Conference" convened on October 12-13, 2010 at the Rockefeller University in New York City. The conference attracted over 400 scientists, patient advocates, and stem cell research supporters from 16 countries. In addition to poster and ...

journal_title：Annals of the New York Academy of Sciences

authors： Marshall C,Wang GK,Cimetta E,Talchai C,Egli D,Shim JW,Martin I,Ahmad F,Sproul A,Chen T,Fossati V,McKeon D,Smith K,Solomon SL

更新日期：2011-05-01 00:00:00

abstract：:Conservation translocation of species varies from restoring historic populations to managing the relocation of imperiled species to new locations. We review the literature in three areas--translocation, managed relocation, and conservation decision making--to inform conservation translocation under changing climates. ...

journal_title：Annals of the New York Academy of Sciences

authors： Schwartz MW,Martin TG

更新日期：2013-05-01 00:00:00

abstract：:Previous studies have suggested that metabolic inhibition is neuroprotective, but little evidence has been provided to support this proposal. Using the in vitro rabbit retina preparation as an established model of the central nervous system (CNS), we measured the rate of glucose utilization and lactate production, and...

journal_title：Annals of the New York Academy of Sciences

authors： Maynard KI,Quiñones-Hinojosa A,Malek JY

更新日期：1999-01-01 00:00:00

abstract：:Apolipoprotein E is a plasma cholesterol and phospholipid transporter which plays a central role in lipoprotein metabolism in the brain. Apolipoprotein E is a polymorphic protein with three common alleles in the general population, designated epsilon 2, epsilon 3 and epsilon 4 coding for proteins ApoE2, ApoE3 and ApoE...

journal_title：Annals of the New York Academy of Sciences

authors： Beffert U,Poirier J

更新日期：1996-01-17 00:00:00

abstract：:Activation of cyclic nucleotide-gated (CNG) channels represents the final step in the transduction pathways in both vision and olfaction. Over the past several years, CNG channels have been found in a variety of other cell types where they might fulfill various physiological functions. The olfactory and photoreceptor ...

journal_title：Annals of the New York Academy of Sciences

authors： Broillet MC,Firestein S

更新日期：1999-04-30 00:00:00

abstract：:An aqueous solution of L-glutamine (50 mmol/L) and methylglyoxal (100 mmol/L) was incubated at 120 degrees C for 3 h in a 200 mmol/L phosphate buffer (pH 7.4). Four major fluorophores were revealed on the HPLC chromatogram. The same four fluorophores were obtained from the heating of a mixture of ammonia and methylgly...

journal_title：Annals of the New York Academy of Sciences

authors： Niquet C,Pilard S,Mathiron D,Tessier FJ

更新日期：2008-04-01 00:00:00

abstract：:To date, the precise etiology of inflammatory bowel disease (IBD) remains largely unknown; however, it is well accepted that IBD results from a dysregulated mucosal immune response to environmental factors in genetically susceptible hosts. The primary defect, in at least a subpopulation of IBD patients, may be due to ...

journal_title：Annals of the New York Academy of Sciences

authors： Reuter BK,Pizarro TT

更新日期：2009-05-01 00:00:00

abstract：:There are multiple lines of compelling evidence supporting the beneficial effect of exercise on the prevention and/or improvement of certain chronic diseases. However, exhaustive or intense exercise causes oxygen free radical generation and oxidative stress, which can lead to injuries and chronic fatigue as well as in...

journal_title：Annals of the New York Academy of Sciences

authors： Kim SY,Jun TW,Lee YS,Na HK,Surh YJ,Song W

更新日期：2009-08-01 00:00:00

abstract：:Tight junctions of epithelial and endothelial cells form selective barriers that regulate paracellular transport of solutes, immune cells, and drugs. Tight junctions consist of proteins that physically "seal" the tight junction but also form channels that allow for permeation between the cells, resulting in epithelial...

journal_title：Annals of the New York Academy of Sciences

authors： Schulzke JD,Fromm M

更新日期：2009-05-01 00:00:00

abstract：:Communication by chemical (pheromone) signals is important in many species, including mammals. Chemosensory and hormonal systems can interact in at least two ways: (i) chemosensory input, especially but not exclusively that through the vomeronasal organ, may elicit hormonal release, which, in turn, may facilitate beha...

journal_title：Annals of the New York Academy of Sciences

authors： McClintock MK

更新日期：1998-11-30 00:00:00

abstract：:This study describes the features of the marginal zone (MZ) B cells of human tonsils and spleens and compares them with those of the follicular mantle (FM) B cells from the same tissues. The two B cell subpopulations displayed marked differences in phenotype, in response capacity to T cell-independent antigens and pol...

journal_title：Annals of the New York Academy of Sciences

authors： Dono M,Zupo S,Colombo M,Massara R,Gaidano G,Taborelli G,Ceppa P,Burgio VL,Chiorazzi N,Ferrarini M

更新日期：2003-04-01 00:00:00

abstract：:Melatonin is a hormone secreted by the pineal gland, mostly in the dark period of the light/dark cycle, with corresponding fluctuations reflected in the plasma melatonin levels. This hormone plays a critical role in the regulation of various neural and endocrine processes that are synchronized with daily change in pho...

journal_title：Annals of the New York Academy of Sciences

authors： Lahiri DK,Chen D,Lahiri P,Rogers JT,Greig NH,Bondy S

更新日期：2004-12-01 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) is an increasingly popular noninvasive neuromodulatory tool in the fields of cognitive and clinical neuroscience and psychiatry. It is an inexpensive, painless, and safe brain-stimulation technique that has proven to be effective in modulating cognitive and sensory-percep...

journal_title：Annals of the New York Academy of Sciences

authors： Sellaro R,Nitsche MA,Colzato LS

更新日期：2016-04-01 00:00:00

abstract：:In thalassemia, iron overload is the joint outcome of excessive iron absorption and transfusional siderosis. While iron absorption is limited by a physiologic ceiling of about 3 mg/d, plasma iron turnover in thalassemia may be 10 to 15 times normal, caused by the wasteful, ineffective erythropoiesis of an enormously e...

journal_title：Annals of the New York Academy of Sciences

authors： Hershko C,Link G,Cabantchik I

更新日期：1998-06-30 00:00:00

abstract：:In a prospective investigation of perioperative cardiac edema formation requiring a delayed sternal closure, we identified thrombin increase combined with a simultaneous decrease of factor XIII as a probable cause. After experimental studies additionally revealed that factor XIII could protect endothelial barrier func...

journal_title：Annals of the New York Academy of Sciences

authors： Wozniak G,Noll T,Akintürk H,Thul J,Müller M

更新日期：2001-01-01 00:00:00

abstract：:A hallmark of success for early career biomedical researchers is the acquisition of research funding. There are marked disparities among principal investigators who submit grants and the likelihood of receiving national funding. The National Research Mentoring Network was funded by the National Institutes of Health to...

journal_title：Annals of the New York Academy of Sciences

authors： Harwood EM,Jones AR,Erickson D,Buchwald D,Johnson-Hemming J,Jones HP,Manson S,McGee R,Smith A,Steer CJ,Vishwanatha JK,Weber-Main AM,Okuyemi KS

更新日期：2019-06-01 00:00:00