Insulin-like growth factor-I receptor correlates with connexin 26 and Bcl-xL expression in human colorectal cancer.

abstract：:The activator protein-1 (AP-1) binding activities in the three brain regions (striatum, nucleus accumbens, cingulate cortex) increased after a single methamphetamine (METH, 4 mg/kg) injection and reached maximum levels after 180 min. Pretreatment with SCH 23390 (0.5 mg/kg), a selective dopamine D1 receptor antagonist,...

journal_title：Annals of the New York Academy of Sciences

authors： Akiyama K,Ishihara T,Kashihara K

更新日期：1996-10-31 00:00:00

abstract：:Thromboembolic and infectious events were found to be major complications of long-term total artificial heart implantation in two patients. Similar complications have been reported in other patients, as well as in animal studies. The thromboembolic events and the infectious complications appear to be interrelated. On ...

journal_title：Annals of the New York Academy of Sciences

authors： Ward RA,Wellhausen SR,Dobbins JJ,Johnson GS,DeVries WC

更新日期：1987-01-01 00:00:00

abstract：:Alternative splicing of RNA transcripts is a general characteristic for NCX genes in mammals, mollusks, and arthropods. Among the family of three NCX genes in mammals, the NCX1 gene contains six exons, namely, A, B, C, D, E, and F, that make up the alternatively spliced region. Studies of the NCX1 gene transcripts sug...

journal_title：Annals of the New York Academy of Sciences

authors： Schulze DH,Polumuri SK,Gille T,Ruknudin A

更新日期：2002-11-01 00:00:00

abstract：:There is an urgent need for surrogate biomarkers in clinical diagnostics but also preclinical in toxicology of chemicals and efficacy testing of pharmaceuticals. On the background of the emerging fields of systems biology and theranostics, the importance of time scales and the synchronization of complex biological rea...

journal_title：Annals of the New York Academy of Sciences

authors： Schrattenholz A,Soskić V,Groebe K

更新日期：2010-06-01 00:00:00

abstract：:Central administration of galanin produces performance deficits on a variety of rodent learning and memory tasks. Galanin impairs acquisition and/or retention of the Morris water task, delayed nonmatching to position, T-maze delayed alternation, starburst radial maze, and passive avoidance in normal rats. A primary si...

journal_title：Annals of the New York Academy of Sciences

authors： McDonald MP,Gleason TC,Robinson JK,Crawley JN

更新日期：1998-12-21 00:00:00

abstract：:In all patients and volunteers, the levels of immunoreactive SP measured in saliva were about 100 times higher than the levels measured in plasma. SP per mg protein was consistently lower in both plasma and saliva of chronic pain patients than in healthy volunteers. These findings suggest that a simple noninvasive obj...

journal_title：Annals of the New York Academy of Sciences

authors： Parris WC,Sastry BV,Kambam JR,Naukam RJ,Johnson BW

更新日期：1993-09-20 00:00:00

abstract：:Infertility is defined as the inability of a couple to conceive despite trying for a year, and it affects approximately 15% of the reproductive-age population. It is considered a genetically lethal factor, as the family lineage stops at that individual with no progeny produced. A genetic defect associated with an infe...

journal_title：Annals of the New York Academy of Sciences

authors： Hwang K,Yatsenko AN,Jorgez CJ,Mukherjee S,Nalam RL,Matzuk MM,Lamb DJ

更新日期：2010-12-01 00:00:00

abstract：:The human moral nature has perplexed laymen and academics for millennia. Recent developments in cognitive neuroscience are opening new venues for unveiling the complex psychological and neurobiological mechanisms underling human morality and its impairments. Here we review these lines of evidence and key topics of deb...

journal_title：Annals of the New York Academy of Sciences

authors： Moll J,De Oliveira-Souza R,Zahn R

更新日期：2008-03-01 00:00:00

abstract：:There is a significant increase in the percentage and absolute number of activated lymphocytes (OKT10+, IL2R1+) after ECT treatment of major depressive disorder. There is an acute decrease in the absolute number of total lymphocytes, T8+ and Leu11+ cells one hour after a single ECT. ...

journal_title：Annals of the New York Academy of Sciences

authors： Fischler B,Bocken R,Schneider I,De Waele M,Thielemans K,Derde MP

更新日期：1992-04-15 00:00:00

abstract：:Previous reports have shown that there are age-related reductions in muscarinic receptor (mAChR) sensitivity to agonist stimulation. Our research has elucidated the mechanisms involved in this loss. These studies have shown that this decline is the result of decreases in mAChR concentration, reductions in the number o...

journal_title：Annals of the New York Academy of Sciences

authors： Joseph JA,Cutler R,Roth GS

更新日期：1993-09-24 00:00:00

abstract：:Nephroblastoma overexpressed (Nov), a member of the CCN family of proteins, is expressed by osteoblasts and its transcription is regulated by transforming growth factor (TGF)-beta and bone morphogenetic proteins (BMP). CCN proteins can interact with TGF-beta, BMPs, and Wnt. We explored the function of Nov in skeletal ...

journal_title：Annals of the New York Academy of Sciences

authors： Canalis E

更新日期：2007-11-01 00:00:00

abstract：:The computation of ITD begins with preservation of the phase angle of spectral components by eighth-nerve fibers and by cells of the nucleus magnocellularis. At the level of the nucleus laminaris, the difference in phase angle of corresponding spectral components in the left and right ears is extracted. At the next le...

journal_title：Annals of the New York Academy of Sciences

authors： Takahashi TT

更新日期：1989-01-01 00:00:00

abstract：:The strategy of "manufacturing uncertainty" has been used with great success by polluters and manufacturers of dangerous products to oppose public health and environmental regulation. This strategy entails questioning the validity of scientific evidence on which the regulation is based. While this approach is most ide...

journal_title：Annals of the New York Academy of Sciences

authors： Michaels D

更新日期：2006-09-01 00:00:00

abstract：:Neurologic symptoms were the earliest and most prominent symptoms recorded in Michigan farm residents exposed to PBB as compared to a non-PBB exposed control farm population in Wisconsin. In Michigan (particularly among males) those who exhibited the most marked symptoms tended to show diminished performance as assess...

journal_title：Annals of the New York Academy of Sciences

authors： Valciukas JA,Lilis R,Anderson HA,Wolff MS,Petrocci M

更新日期：1979-05-31 00:00:00

abstract：:B beta Arg166 to Cys substitution was identified in an abnormal fibrinogen named fibrinogen Longmont. The proband, a young woman, and her mother were heterozygous; both experienced episodes of severe hemorrhage at childbirth. The neo-Cys residues were found to be disulfide-bridged to either an isolated Cys amino acid ...

journal_title：Annals of the New York Academy of Sciences

authors： Lounes KC,Lefkowitz JB,Coates AI,Hantgan RR,Henschen-Edman A,Lord ST

更新日期：2001-01-01 00:00:00

abstract：:Expression of human prolactin in the mammary gland, one of the main target organs of this hormone, leads to the formation of an autocrine-paracrine proliferative loop in this tissue. Involvement of prolactin in normal and neoplastic mammary development triggered the interest in transcriptional regulation of the human ...

journal_title：Annals of the New York Academy of Sciences

authors： Baudhuin A,Manfroid I,Van De Weerdt C,Martial JA,Muller M

更新日期：2002-11-01 00:00:00

abstract：:Investigation of blood-brain barrier permeability and metabolic processes, and their regulation by endogenous or exogenous factors, will be important for development of efficient and selective delivery of therapeutic agents to the central nervous system. Primary cultures of brain microvessel endothelial cells offer a ...

journal_title：Annals of the New York Academy of Sciences

authors： Audus KL,Borchardt RT

更新日期：1987-01-01 00:00:00

abstract：:Rheumatoid arthritis is the most common of a number of diseases in which inflammation and tissue destruction is driven by an autoimmune process. Current therapy is inadequate, and this has prompted major research efforts, both in academia and industry, to understand more about the pathogenesis, and hence provide the r...

journal_title：Annals of the New York Academy of Sciences

authors： Feldmann M,Brennan FM,Elliott MJ,Williams RO,Maini RN

更新日期：1995-09-07 00:00:00

abstract：:Homozygous beta thalassemia affects thousands of people around the world. Current management of this condition includes regular transfusion of red cells, which leads to transfusional iron overload requiring chelation therapy: increasing hemoglobin levels while decreasing or eliminating iron overload is therefore a maj...

journal_title：Annals of the New York Academy of Sciences

authors： Dover GJ

更新日期：1998-06-30 00:00:00

abstract：:Gene regulation mechanisms have evolved allowing cells to finetune the level of "endogenous" oxidative stress and to cope with increased free radicals from external sources. Levels of H2O2 are tightly controlled in E. coli by OxyR, which is activated by H2O2 to increase scavenging activities and limit H2O2 generation ...

journal_title：Annals of the New York Academy of Sciences

authors： González-Flecha B,Demple B

更新日期：2000-01-01 00:00:00

abstract：:Reproduction usually is characterized by a mean-population fecundity pattern. Such a pattern has a maximum at earlier ages and a subsequent gradual decline in egg production. It is shown that individual fecundity trajectories do not follow such a pattern. In particular, the regular individual fecundity pattern has no ...

journal_title：Annals of the New York Academy of Sciences

authors： Novoseltsev VN,Arking R,Carey JR,Novoseltseva JA,Yashin AI

更新日期：2004-06-01 00:00:00

abstract：:How can people adaptively analyze and "work through" negative feelings without ruminating? This paper will briefly review findings from an integrative program of research, which suggests that a critical factor determining whether people's attempts to adaptively reason about negative experiences succeed or fail is the ...

journal_title：Annals of the New York Academy of Sciences

authors： Kross E

更新日期：2009-06-01 00:00:00

abstract：:To study the role of the LDL receptor pathway for the maintenance of alpha-tocopherol concentrations in tissues of intact animals, we have compared vitamin E levels in plasma and tissues of normal rabbits and WHHL rabbits. WHHL rabbits are deficient in LDL receptor activity. For WHHL rabbits, alpha-tocopherol plasma c...

journal_title：Annals of the New York Academy of Sciences

authors： Cohn W,Kuhn H

更新日期：1989-01-01 00:00:00

abstract：:Rats inoculated once with nicotinic acetylcholine receptor and adjuvants had two episodes of weakness, the first being acute and transient, starting on day 8, and remitting in a few days, the second, chronic, progressive, and appearing after day 20. In the acute phase, the compound action potential and twitch evoked ...

journal_title：Annals of the New York Academy of Sciences

authors： Lambert EH,Lindstrom JM,Lennon VA

更新日期：1976-01-01 00:00:00

abstract：:Considerable clinical and experimental evidence indicates that loss of vestibular function results in cognitive deficits, especially deficits in spatial memory. These studies demonstrate the importance of balance for the most fundamental of cognitive processes and suggest that information about head acceleration and o...

journal_title：Annals of the New York Academy of Sciences

authors： Smith PF,Brandt T,Strupp M,Darlington CL,Zheng Y

更新日期：2009-05-01 00:00:00

abstract：:Heparins represent an efficient treatment of acute thrombosis and obstetric complications in antiphospholipid syndrome (APS). Enhanced microvesiculation of cell membranes, as detected by reduced membrane adhesion, can contribute to hypercoagulability in APS. Healthy donor IgG antibodies significantly increased beta2-g...

journal_title：Annals of the New York Academy of Sciences

authors： Frank M,Sodin-Semrl S,Rozman B,Potocnik M,Kralj-Iglic V

更新日期：2009-09-01 00:00:00

abstract：:Approximately 40 to 50 infants and children with similar epidemiologic, clinical, and laboratory features of AIDS have been described. The occurrence of significant numbers of patients with PAIDS in geographic areas that are associated with similar risk factors and clinical features of AIDS suggests a common cause. Im...

journal_title：Annals of the New York Academy of Sciences

authors： Ammann AJ,Wara DW,Cowan MJ

更新日期：1984-01-01 00:00:00

abstract：:This publication provides a brief summary of a presentation given at the NICHD Anniversary Symposium that was designed to describe the research progress of the O'Malley laboratory over the past 30 years of its NICHD funding. It highlights a few of the lab's major discoveries during the course of the pursuit of its lon...

journal_title：Annals of the New York Academy of Sciences

authors： O'Malley BW

更新日期：2004-12-01 00:00:00

abstract：:We have shown that the medial preoptic area (MPO) in the hypothalamus is a major site where interferon (IFN)-alpha acts to induce suppression of splenic natural killer (NK) cell activity through an activation of sympathetic nervous system (SNS) in rats. Here, we discuss the hypothalamic mechanisms of the cytokine acti...

journal_title：Annals of the New York Academy of Sciences

authors： Katafuchi T,Duan S,Take S,Yoshimura M

更新日期：2009-02-01 00:00:00

abstract：:We have developed a rabbit model of in utero exposure to intravenous injections of cocaine given twice daily to dams from gestational days 8-29. At the doses employed (4 mg/kg, injected twice daily), no differences were found in the body weight gain of dams, time to delivery, litter size, and body weight or other phys...

journal_title：Annals of the New York Academy of Sciences

authors： Romano AG,Harvey JA

更新日期：1998-06-21 00:00:00