Genetic responses to free radicals. Homeostasis and gene control.

abstract：:Although fetal nigral transplants have been shown to survive grafting into the striatum, increased [(18)F]6-fluroro-L-3,4-dihydroxyphenylalanine ((18)F-DOPA) uptake and improved motor function in open-label assessments have failed to establish any clinical benefits in double-blind, sham-controlled studies. To understa...

journal_title：Annals of the New York Academy of Sciences

authors： Chu Y,Kordower JH

更新日期：2010-01-01 00:00:00

abstract：:It has been hypothesized that a central even in the early pathogenesis of sporadic Alzheimer disease (SAD) is the dysfunction of the neuronal insulin receptor signal transduction. To prove this, this receptor was inhibited by a triplicate icv application of STZ. Insulin binding sites were upregulated as in SAD. With r...

journal_title：Annals of the New York Academy of Sciences

authors： Hoyer S,Lee SK,Löffler T,Schliebs R

更新日期：2000-01-01 00:00:00

abstract：:Studies of the ability of the EPR spin trap DEPMPO to detect both superoxide and hydroxyl radicals produced by systems in vitro and in vivo are presented. Experiments using free radical-generating systems confirmed the suitability of the EPR spin trapping technique but also revealed the existence of an undesirable con...

journal_title：Annals of the New York Academy of Sciences

authors： Mojović M,Vuletić M,Bacić GG

更新日期：2005-06-01 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) participates in the regulation of endochondral bone development. After the cartilage mold is established in fetal life, perichondrial cells and chondrocytes at the ends of the mold synthesize PTHrP. This ligand then acts on PTH/PTHrP receptors on chondrocytes. As chondrocyte...

journal_title：Annals of the New York Academy of Sciences

authors： Kronenberg HM

更新日期：2006-04-01 00:00:00

abstract：:Gene expression regulation, in particular at the level of transcription, has been demonstrated to play a key role in the development of human diseases, including cancer, and in bacteria it is crucial for proliferation as well as for pathogenicity. Transcriptional regulation is based on complex networks of interactions...

journal_title：Annals of the New York Academy of Sciences

authors： Zorrilla S,Lillo MP,Chaix D,Margeat E,Royer CA,Declerck N

更新日期：2008-01-01 00:00:00

abstract：:Unfortunately, all of the problems of the hemophiliac have not been solved by the availability of concentrated factor VIII products. Patients still are faced with the crippling effects of arthritis, problems with employment, problems with ignorance (both medical and lay), and an increased risk of premature death even ...

journal_title：Annals of the New York Academy of Sciences

authors： Breckenridge RT

更新日期：1975-01-20 00:00:00

abstract：:T-lymphocytes from three species of New World monkeys were susceptible to transformation in vitro with human T-cell leukemia virus. Marmoset T-lymphocytes transformed in vitro with HVS or HVA, T-lymphotropic herpesviruses of New World monkeys, were also transformed with HTLV resulting in doubly transformed T-cells. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Falk LA Jr,Byington R,Silva DP

更新日期：1984-01-01 00:00:00

abstract：:Mitochondrial dysfunction, due to either environmental or genetic factors, can result in excessive production of reactive oxygen species, triggering the apoptotic death of dopaminergic cells in Parkinson's disease. Mitochondrial free radical production is promoted by the inhibition of electron transport at any point d...

journal_title：Annals of the New York Academy of Sciences

authors： Fiskum G,Starkov A,Polster BM,Chinopoulos C

更新日期：2003-06-01 00:00:00

abstract：:The neuroprotective action of l-carnitine (LC) in the rat model of 3-nitropropionic acid (3-NPA)-induced mitochondrial dysfunction was examined. 3-NPA is known to produce decreases in neuronal ATP levels via inhibition of the succinate dehydrogenase (SDH) at complex II of the mitochondrial electron transport chain. SD...

journal_title：Annals of the New York Academy of Sciences

authors： Binienda ZK

更新日期：2003-05-01 00:00:00

abstract：:We have examined the expression of several genes whose transcripts have increased levels in Alzheimer's disease and have found heterogeneity in these levels in different patients with this condition. The level of expression of these genes was compared to different clinical and pathological aspects of the disease. A ca...

journal_title：Annals of the New York Academy of Sciences

authors： Duguid JR,Trzepacz C,Kemper T,Tourtellote WW,Volicer L

更新日期：1993-05-28 00:00:00

abstract：:Three distinct pathological conditions, related to different means by which dense intralabyrinthine particles interfere with the function of a semicircular canal and cause nystagmus and vertigo, are amenable to treatment with repositioning maneuvers. Known as benign paroxysmal positional vertigo and variants, these co...

journal_title：Annals of the New York Academy of Sciences

authors： Epley JM

更新日期：2001-10-01 00:00:00

abstract：:Clumps of corona cells were separated from oocytes at the moment of fertilization control and were subsequently processed and cut into 1-mu sections to study their general morphologic patterns. This study revealed an extensive phagocytosis of spermatozoa by corona cells. Clumps of mural granulosa cells of comparable s...

journal_title：Annals of the New York Academy of Sciences

authors： Pijnenborg R,Gordts S,Ongkowidjojo R,Brosens I

更新日期：1985-01-01 00:00:00

abstract：:The historical reasons for the introduction of tick control during the nineteenth century are reviewed. Background and concepts for the choice between long-term tick control and tick eradication are compared. Case studies of large-scale tick control or eradication programs in Africa, Australia, the United States, and ...

journal_title：Annals of the New York Academy of Sciences

authors： Pegram RG,Wilson DD,Hansen JW

更新日期：2000-01-01 00:00:00

abstract：:We compared 10 episodes (8 patients) of Q fever endocarditis with 27 episodes (27 patients) of native valve endocarditis. Patients with Q fever endocarditis were more likely to have weight loss (p less than 0.003), experience fatigue (p less than 0.07), have clubbing of the fingers (p less than 0.005), have a diastoli...

journal_title：Annals of the New York Academy of Sciences

authors： Marrie TJ

更新日期：1990-01-01 00:00:00

abstract：:The purpose of this article is to review recent findings regarding the mechanisms by which GM1 may mimic or potentiate certain actions of neurotrophic factors, including promotion of neuronal survival. It is proposed that the neuroprotective activity of GM1 is due, at least in part, to its ability to favor the dimeriz...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrari G,Greene LA

更新日期：1998-06-19 00:00:00

abstract：:It has been proposed that spacetime should be regarded as an evolving block universe, bounded to the future by the present time, which continually extends to the future. This future boundary is defined at each time by measuring proper time along Ricci eigenlines from the start of the universe. A key point, then, is th...

journal_title：Annals of the New York Academy of Sciences

authors： Ellis GF

更新日期：2014-10-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) and IGF-I receptor (IGF-IR), despite their well-known roles in cell survival and proliferation, can also weakly enhance apoptosis. To study the relationships between the IGF-IR and Bax as well as Bak, 144 cases of colorectal cancer were examined by immunohistochemistry, using the a...

journal_title：Annals of the New York Academy of Sciences

authors： Koda M,Reszec J,Sulkowska M,Kanczuga-Koda L,Sulkowski S

更新日期：2004-12-01 00:00:00

abstract：:We cloned a kappa 3-related opioid receptor, and although it is still not clear whether this clone corresponds to the kappa 3 receptor itself or is a related gene product, the extensive antisense mapping and the antibody immunoreactivity strongly associate this clone with the kappa 3 receptor. Our approach also indica...

journal_title：Annals of the New York Academy of Sciences

authors： Pasternak GW,Pan YX,Cheng J

更新日期：1995-05-10 00:00:00

abstract：:Bacterial cell division is facilitated by the divisome, a dynamic multiprotein assembly localizing at mid-cell to synthesize the stress-bearing peptidoglycan and to constrict all cell envelope layers. Divisome assembly occurs in two steps and involves multiple interactions between more than 20 essential and accessory ...

journal_title：Annals of the New York Academy of Sciences

authors： Egan AJ,Vollmer W

更新日期：2013-01-01 00:00:00

abstract：:The aim of this work was to study the role of glucocorticoids in the insulin-like growth factor binding protein (IGFBP)-3 response to endotoxin. Lipopolysaccharide (LPS) administration decreased IGFBP-3 serum levels as well as hepatic IGFBP-3 gene expression in both adrenalectomized and sham-operated rats. These data ...

journal_title：Annals of the New York Academy of Sciences

authors： Priego T,Ibañez De Cáceres I,Martín AI,Villanúa MA,López-Calderón A

更新日期：2002-11-01 00:00:00

abstract：:The results of a series of experiments aimed at directly comparing the prosodic level of processing in language with the melodic level of processing in music are reported. The first series of experiments was conducted on adults, musicians and nonmusicians, and the second one on 7- to 9-year-old musician and nonmusicia...

journal_title：Annals of the New York Academy of Sciences

authors： Magne C,Schön D,Besson M

更新日期：2003-11-01 00:00:00

abstract：:Infection by different Leishmania spp. in cats has been reported in many countries. In Spain, since the first Leishmania infection described in 1933, sporadic clinical cases in cats have been reported. Various serologic studies performed in other areas of Spain have shown seroprevalences ranging between 1.7 and 60%. T...

journal_title：Annals of the New York Academy of Sciences

authors： Ayllon T,Tesouro MA,Amusategui I,Villaescusa A,Rodriguez-Franco F,Sainz A

更新日期：2008-12-01 00:00:00

abstract：:During food shortage, organisms activate defense mechanisms to maximize their chance of survival. At least in part, these responses are triggered by changes in hormonal status and neural status during starvation. The hypothalamus is organized as a collection of distinct autonomously active nuclei and is considered to ...

journal_title：Annals of the New York Academy of Sciences

authors： Chiba T,Fujita S,Kubota H,Inoue D,Mizuno A,Komatsu T,Yamaza H,Higami Y,Shimokawa I

更新日期：2007-11-01 00:00:00

abstract：:The existence of a covalent intermediate in topoisomerase I catalysis allows uncoupling of the cleavage and ligation half-reactions on partially single-stranded DNA substrates containing a highly preferred interaction site. Using this model DNA substrate system we have demonstrated that the cleavage reaction requires ...

journal_title：Annals of the New York Academy of Sciences

authors： Christiansen K,Westergaard O

更新日期：1996-12-13 00:00:00

abstract：:A permanent decrease was seen in the prevalence of lice infestation among population of the Ukraine from 1990-2004. The prevalence of lice infestation among children under 14 years of age was 6-27 times more than that in adults. The highest figures were among children 7-14 years old. During all of the observation peri...

journal_title：Annals of the New York Academy of Sciences

authors： Kurhanova I

更新日期：2006-10-01 00:00:00

abstract：:In the present research, the relationship between various semantic memory functions and episodic odor memory across the adult life span is addressed. In contrast to earlier evidence that odors may be encoded and stored as unique, nonlinguistic whole percepts, the present work suggests that episodic odor information is...

journal_title：Annals of the New York Academy of Sciences

authors： Larsson M,Bäckman L

更新日期：1998-11-30 00:00:00

abstract：:Nerve agents (NAs) produce acute and long-term brain injury and dysfunction, as evident from the Japan and Syria incidents. Magnetic resonance imaging (MRI) is a versatile technique to examine such chronic anatomical, functional, and neuronal damage in the brain. The objective of this study was to investigate long-ter...

journal_title：Annals of the New York Academy of Sciences

authors： Reddy SD,Wu X,Kuruba R,Sridhar V,Reddy DS

更新日期：2020-11-01 00:00:00

abstract：:According to the fetal origin of adult diseases hypothesis, the intrauterine environment through developmental plasticity may permanently influence long-term health and disease. Therefore, intrauterine growth restriction (IUGR), due either to maternal, placental, or genetic factors, may permanently alter the endocrine...

journal_title：Annals of the New York Academy of Sciences

authors： Kanaka-Gantenbein C

更新日期：2010-09-01 00:00:00

abstract：:By virtue of the progress in proteomics, the involvement of posttranslational modifications in aging has been more clearly demonstrated in recent years. We describe here that (1) carbonylation, a hallmark of protein oxidation in general, is paradoxically decreased in histone with aging and increased by calorie restric...

journal_title：Annals of the New York Academy of Sciences

authors： Nakamura A,Kawakami K,Kametani F,Nakamoto H,Goto S

更新日期：2010-06-01 00:00:00

abstract：:Opsoclonus-myoclonus syndrome (OMS) is a rare neurologic disorder comprising the main symptoms of eye-movement disturbances, muscle jerks, and severe ataxia. In children and adults, some cases are associated with a tumor as a paraneoplastic syndrome, whereas in children the paraneoplastic form is almost exclusively as...

journal_title：Annals of the New York Academy of Sciences

authors： Kirsten A,Beck S,Fühlhuber V,Kaps M,Kreutz T,Korfei M,Schmitt S,Preissner KT,Blaes F

更新日期：2007-09-01 00:00:00